Nervous System
- Name
- Nervous System
- Accession Number
- DBCAT002148
- Description
Not Available
- ATC Classification
- Drugs
Drug Drug Description Butalbital A barbiturate drug used for symptomatic treatment of tension-type headache in various combinations with acetaminophen, aspirin, caffeine, and codeine. Choline A nutrient found in a wide variety of vitamins including pre-natal formulations. Tryptophan An amino acid commonly found as a component of total parenteral nutrition. Fluvoxamine A selective serotonin-reuptake inhibitor used to treat obsessive-compulsive disorder. Amphetamine A CNS stimulant and sympathomimetic agent indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD). Nicotine A stimulatory alkaloid found in tobacco products that is often used for the relief of nicotine withdrawal symptoms and as an aid to smoking cessation. Cevimeline A muscarinic agonist with parasympathomimetic activities that is used for the symptomatic treatment of dry mouth in patients with Sjögren's Syndrome. Lorazepam A short-acting benzodiazepine commonly used to treat panic disorders, severe anxiety, and seizures. Ethchlorvynol A sedative hypnotic agent used for the short-term management of insomnia. Tramadol A centrally-acting opioid agonist and SNRI (serotonin/norepinephrine reuptake inhibitor) used for the management of moderate to severe pain in adults. Caffeine A stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. It is also used in to prevent and treat pulmonary complications of premature birth. Citalopram A selective serotonin reuptake inhibitor (SSRI) used in the treatment of depression. Eletriptan A triptan used for the treatment of migraines. Enflurane A halogenated inhalational anesthetic agent used for the induction and maintenance of anesthesia and for analgesia during labor and delivery. Pregabalin An anticonvulsant drug used to treat neuropathic pain conditions and fibromyalgia, and for the treatment of partial onset seizures in combination with other anticonvulsants. Reboxetine A drug used for the acute treatment of major depression and for maintenance therapy of depression. Benzatropine An anticholinergic drug used to treat Parkinson's disease (PD) and extrapyramidal symptoms, except tardive dyskinesia. Ziprasidone An atypical antipsychotic used to manage schizophrenia, bipolar mania, and agitation in patients with schizophrenia. Methysergide An ergot alkaloid used for the prophylaxis of migraine and cluster headaches. Phenytoin An anticonvulsant drug used in the prophylaxis and control of various types of seizures. Ropinirole A non-ergoline dopamine agonist used to treat the symptoms of Parkinson's disease and Restless Legs Syndrome. Topiramate An anticonvulsant drug used in the control of epilepsy and in the prophylaxis and treatment of migraines. Lidocaine A local anesthetic used in a wide variety of superficial and invasive procedures. Venlafaxine A selective serotonin and norepinephrine reuptake inhibitor (SNRI) used for the treatment of major depression, generalized or social anxiety disorder, and panic disorder. Atomoxetine A selective norepinephrine reuptake inhibitor (SNRI) used in the management of Attention Deficit Hyperactivity Disorder (ADHD). Etomidate A short-acting intravenous anesthetic indicated for the induction of anesthesia and supplementation of subpotent anesthesia during short operative procedures. Morphine An opioid agonist used for the relief of moderate to severe acute and chronic pain. Ropivacaine An amide-type local anesthetic used for local or regional anesthesia during surgery and for short-term management of acute pain. Bupivacaine A local anesthetic used in a wide variety of superficial and invasive procedures. Talbutal For use as a sedative and hypnotic. Pentobarbital A barbiturate drug used to induce sleep, cause sedation, and control certain types of seizures. Valproic acid An anticonvulsant used to control complex partial seizures and both simple and complex absence seizures. Zolmitriptan A member of the triptan class of 5-HT(1B/1D/1F) receptor agonist drugs used for the acute treatment of migraine with or without aura in adults. Acetaminophen An analgesic drug used alone or in combination with opioids for pain management, and as an antipyretic agent. Dihydroergotamine An ergot alkaloid used in the acute treatment of migraine headache and cluster headache. Tolcapone A catechol-O-methyltransferase (COMT) inhibitor used as adjunct therapy in the symptomatic management of idiopathic Parkinson's disease. Hydromorphone An opioid analgesic used to treat moderate to severe pain when the use of an opioid is indicated. Methadone An opioid analgesic indicated for management of severe pain that is not responsive to alternative treatments. Also used to aid in detoxification and maintenance treatment of opioid addiction. Olanzapine An antipsychotic drug used in the management of schizophrenia, bipolar 1 disorder, and agitation associated with these disorders. Metixene Used for the symptomatic treatment of parkinsonism. Protriptyline A tricyclic antidepressant that is indicated in the treatment of depression only under close clinical supervision. Trimethadione An anticonvulsant agent indicated for the control of treatment-refractory petit mal seizures. Clobazam A benzodiazepine used as adjunct treatment in seizures associated with Lennox-Gastaut syndrome. Clozapine An antipsychotic drug used in treatment resistant schizophrenia and to decrease suicide risk in schizophrenic patients. Mirtazapine A tetracyclic antidepressant used in the treatment of major depression and is used off-label as a drug for insomnia and to increase appetite. Meprobamate An anxiolytic drug used for the short-term management of anxiety symptoms. Trihexyphenidyl An antispasmodic drug used as an adjunct drug in the management of parkinsonism and as a treatment for extrapyramidal symptoms caused by drugs affecting the central nervous system (CNS). Tacrine An anticholinesterase drug used for the management of Alzheimer's disease symptoms. Procyclidine An antispasmodic drug used to treat parkinsonism of various types and in the treatment of extrapyramidal symptoms. Sulpiride A selective D2 dopamine receptor antagonist indicated to treat chronic and acute schizophrenia. Profenamine An antidyskinetic phenothiazine used to treat the symptoms of Parkinson's disease. Eszopiclone A sedative-hypnotic used in the treatment of insomnia, improving both the latency phase and the maintenance phase of sleep. Alprazolam A triazolobenzodiazepine with intermediate onset commonly used to treat panic disorders and generalized anxiety in addition to anxiety associated with depression. Loxapine A antipsychotic used for the treatment of schizophrenia. Remoxipride An discontinued atypical antipsychotic selective for dopamine D2 receptors. Pramipexole A non-ergot dopamine agonist used to treat the signs and symptoms of idiopathic Parkinson's disease and Restless Legs Syndrome (RLS). Secobarbital A barbiturate used for the short-term treatment of insomnia. Promazine A phenothiazine used to manage schizophrenia. Methylphenidate A stimulant used in the management of Attention Deficit Hyperactivity Disorder (ADHD). Zolpidem A sedative hypnotic used for the short-term treatment of insomnia to improve sleep latency. Prochlorperazine A phenothiazine derivative used in the treatment of schizophrenia and anxiety and to relieve severe nausea and vomiting. Droperidol A butyrophenone derivative and dopamine antagonist used to prevent and treat postoperative nausea and vomiting. Meperidine An opioid agonist with analgesic and sedative properties used to manage severe pain. Imipramine A tricyclic antidepressant indicated for the treatment of depression and to reduce childhood enuresis. Metharbital Metharbital is used for the treatment of epilepsy. Fluoxetine A selective serotonin reuptake inhibitor used to treat major depressive disorder, bulimia, OCD, premenstrual dysphoric disorder, panic disorder, and bipolar I. Methohexital An anesthetic used to induce deep sedation. Chlordiazepoxide A benzodiazepine used to treat the withdrawal symptoms of acute alcoholism, to treat preoperative anxiety, and to treat anxiety over a short term period. Duloxetine A serotonin norepinephrine reuptake inhibitor used to treat generalized anxiety disorder, neuropathic pain, osteoarthritis, and stress incontinence. Chlorpromazine A phenothiazine antipsychotic used to treat nausea, vomiting, preoperative anxiety, schizophrenia, bipolar disorder, and severe behavioral problems in children. Buspirone An anxiolytic agent used for short-term treatment of generalized anxiety and second-line treatment of depression. Entacapone A selective reversible catechol-O-methyltransferase inhibitor for the treatment of Parkinson's disease. Oxycodone An opioid used in the management of moderate to severe pain. Haloperidol An antipsychotic agent used to treat schizophrenia and other psychoses, as well as symptoms of agitation, irritability, and delirium. Triflupromazine Used mainly in the management of psychoses. Also used to control nausea and vomiting. Dextromethorphan An NMDA receptor antagonist used to treat cases of dry cough. Mephenytoin A phenylhydantoin used to treat refractory partial epilepsy. Nortriptyline A tricyclic antidepressant used in the treatment of depression. Amoxapine A tricyclic antidepressant used in the treatment of neurotic or reactive depressive disorders and endogenous or psychotic depression. Pyridostigmine A cholinesterase inhibitor used for symptomatic treatment of myasthenia gravis and congenital myasthenic syndromes and to reverse neuromuscular blockade by nondepolarizing muscle relaxants. Adinazolam For the treatment of anxiety and status epilepticus. Lamotrigine A phenyltriazine antiepileptic used to treat some types of epilepsy and bipolar I disorder. Hydroxyzine An antihistamine used to treat anxiety and tension associated with psychoneuroses, as well as allergic conditions such as pruritus and chronic urticaria. Cinnarizine A drug used for the management of labyrinthine disorder symptoms, including vertigo, tinnitus, nystagmus, nausea, and vomiting. Lisuride For the management of Parkinson's Disease Ethosuximide An anticonvulsant used to treat petit mal seizures. Thiopental A barbiturate used to induce general anesthesia, treat convulsions, and reduce intracranial pressure. Butorphanol An opioid agonist-antagonist used to treat moderate to severe pain. Paramethadione Used for the control of absence (petit mal) seizures that are refractory to treatment with other medications. Fluphenazine A phenothiazine used to treat patients requiring long-term neuroleptic therapy. Dexmedetomidine An alpha-2 agonist used for sedation during various procedures. Dextropropoxyphene An opioid analgesic used to treat mild to moderate pain. Pentazocine An analgesic used to treat moderate to severe pain. Trazodone A serotonin uptake inhibitor used to treat major depressive disorder. Acamprosate A medication used to maintain alcohol abstinence in patients with alcohol dependence. Galantamine A cholinesterase inhibitor used to manage mild to moderate dementia associated with Alzheimer's Disease. Thioridazine A phenothiazine antipsychotic used to treat schizophrenia and generalized anxiety disorder. Midazolam A short-acting injectable benzodiazepine with rapid onset that is commonly used in seizures, anesthesia and anxiety disorders. Flurazepam A long-acting benzodiazepine with a rapid onset of action that is commonly used to treat insomnia. Ergotamine An alpha-1 selective adrenergic agonist vasoconstrictor used to treat migraines with or without aura and cluster headaches. Naltrexone A narcotic antagonist used in opioid overdose. Sufentanil An opioid used to induce and maintain anesthesia, to act as an analgesic in labor and delivery, and to treat severe, acute pain. Apomorphine A morphine derivative D2 dopamine agonist used to treat hypomobile "off" episodes of advanced Parkinson's disease. Paroxetine A selective serotonin reuptake inhibitor used to treat major depressive disorder, panic disorder, OCD, social phobia, generalized anxiety disorder, the vasomotor symptoms of menopause, and premenstrual dysphoric disorder. Trimipramine A tricyclic antidepressant used to treat depression. Risperidone A second-generation antipsychotic medication used to treat a number of mental health disorders including schizophrenia, bipolar mania, psychosis, or as an adjunct in severe depression. Riluzole A glutamate antagonist used to treat amyotrophic lateral sclerosis. Modafinil A stimulant used to improve wakefulness in patients with sleep apnea, narcolepsy, or shift work disorder. Prilocaine A local anesthetic used in dental procedures. Tranylcypromine A monoamine oxidase inhibitor used to treat major depressive disorder. Isoflurane An inhaled general anesthetic used in surgery. Ethotoin A hydantoin antiepileptic used to control tonic-clonic and complex partial seizures. Oxcarbazepine An anti-epileptic used in the treatment of partial-onset seizures. Propiomazine Propiomazine is largely used for its antihistamininc sleep inducing effects in treating insomnia. Phenelzine A monoamine oxidase inhibitor used to treat atypical, nonendogenous, or neurotic depression. Primidone An antiepileptic used to treat grand mal, psychomotor, and focal epileptic seizures. Halazepam Used to relieve anxiety, nervousness, and tension associated with anxiety disorders. Alfentanil An opioid agonist used to induce and maintain anesthesia, as well as an analgesic. Minaprine For the treatment of depression Biperiden A muscarinic receptor antagonist used to treat parkinsonism and control extrapyramidal side effects of neuroleptic drugs. Fentanyl An opioid analgesic used in anesthesia, for breakthrough cancer pain, or round the clock pain management. Propofol A medication used in general anesthesia and for sedation. Diazepam A long-acting benzodiazepine with rapid onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawal, and seizures. Trifluoperazine A phenothiazine used to treat depression, anxiety, and agitation. Phensuximide For the treatment of epilepsy. Progabide Indicated for the treatment of epilepsy. Oxazepam An intermediate-acting benzodiazepine with slow onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawals, and insomnia. Donepezil An acetylcholinesterase inhibitor used to treat the behavioral and cognitive effects of Alzheimer's Disease and other types of dementia. Nalbuphine An opioid agonist-antagonist used to treat pain, for pre and postoperative analgesia, and for analgesia in labor and delivery. Methylphenobarbital For the relief of anxiety, tension, and apprehension, also used as an anticonvulsant for the treatment of epilepsy. Perphenazine A phenothiazine used to treat schizophrenia as well as nausea and vomiting. Diflunisal An NSAID used to treat mild to moderate pain, inflammation, osteoarthritis, and rheumatoid arthritis. Flupentixol A thioxanthene neuroleptic used to treat schizophrenia and depression. Triazolam A benzodiazepine used for short term treatment of insomnia. Remifentanil An opioid analgesic used in anesthesia. Tiagabine An antiepileptic used to treat partial seizures. Zonisamide A sulfonamide anticonvulsant used to treat partial seizures. Anileridine An opioid analgesic used to treat moderate to severe pain. Amantadine A medication used to treat dyskinesia in Parkinson's patients receiving levodopa, as well as extrapyramidal side effects of medications. Almotriptan A 5-HT1B/1D receptor agonist used to treat migraines. Buprenorphine A partial opioid agonist used for management of severe pain that is not responsive to alternative treatments. Also used for maintenance treatment of opioid addiction. Mesoridazine A phenothiazine antipsychotic used to treat schizophrenia, organic brain disorders, alcoholism, and psychoneuroses. Maprotiline A tetracyclic antidepressant used to treat depressive illness, major depressive disorder, bipolar disorder, and anxiety associated with depression. Salicylic acid An acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts. Felbamate An anticonvulsant used to treat severe epilepsy. Naratriptan A 5-HT1B/1D receptor agonist used to treat migraines. Rizatriptan A 5-HT1B/1D receptor agonist used to treat migraines. Mepivacaine A local anesthetic used for local or regional analgesia or anesthesia. Zaleplon A sedative used for short term treatment of insomnia in adults. Ramelteon A melatonin receptor agonist used to treat insomnia. Rivastigmine A cholinesterase inhibitor used to treat mild to moderate dementia in Alzheimer's and Parkinson's. Gabapentin An anticonvulsant medication used in the management of peripheral neuropathic pains, postherpetic neuralgia, and partial-onset seizures. Frovatriptan A 5-HT1B/1D receptor agonist used to treat migraines. Levobupivacaine A drug used for nerve block and anesthesia. Bethanechol A muscarinic agonist used to treat postoperative and postpartum nonobstructive functional urinary retention and neurogenic atony of the bladder with retention. Methoxyflurane For use in the induction and maintenance of general anesthesia Selegiline A monoamine oxidase inhibitor used to treat major depressive disorder and Parkinson's. Memantine An NMDA receptor antagonist used to treat moderate to severe dementia in Alzheimer's. Acetophenazine For the treatment of disorganized and psychotic thinking. Also used to help treat false perceptions (e.g. hallucinations or delusions.) Melatonin An endogenous hormone produced by the pineal gland that regulates sleep-wake cycles and when provided exogenously has beneficial effects on sleep-onset latency; available as an over-the-counter supplement. Clonazepam A long-acting benzodiazepine with intermediate onset commonly used to treat panic disorders, severe anxiety, and seizures. Vigabatrin An irreversible GABA transaminase inhibitor used as an adjunct therapy to treat refractory complex partial seizures in patients ≥2 years unresponsive to alternatives. May also be used as monotherapy to treat infantile spasms in infants 1 month to 2 years. Pilocarpine A muscarinic cholinergic agonist used on the eye to treat elevated intraocular pressure, various types of glaucoma, and to induce miosis. Also available orally to treat symptoms of dry mouth associated with Sjogren's syndrome and radiotherapy. Pimozide An antipsychotic used to manage debilitating motor and phonic tics in patients with Tourette's Disorder. Sertraline A selective serotonin reuptake inhibitor (SSRI) indicated to treat major depressive disorder, social anxiety disorder and many other psychiatric conditions. Methyprylon For the treatment of insomnia. Phenacemide Used to control certain seizures in the treatment of epilepsy. Ambenonium A cholinesterase inhibitor that targets both muscarinic and nicotinic receptors indicated for the treatment of myasthenia gravis. Doxepin A psychotropic agent used for the treatment of depression, anxiety, manic-depressive disorder, and insomnia. Nefazodone An antidepressant used in the treatment of depression. Desipramine A tricyclic antidepressant used in the treatment of depression. Thiamylal Used for the production of complete anaesthesia of short duration, for the induction of general anaesthesia, and for inducing a hypnotic state. Bupropion A norepinephrine and dopamine reuptake inhibitor used in the treatment of major depressive disorder (MDD), seasonal affective disorder (SAD), and as an aid to smoking cessation. Halothane A general inhalation anesthetic used for the induction and maintenance of general anesthesia. Chloroprocaine A local anesthetic agent indicated for intrathecal injection in adults for the production of subarachnoid block, or spinal anesthesia. Moclobemide A monoamine oxidase inhibitor used in the treatment of major depressive disorder and bipolar disorder. Phenobarbital A long-lasting barbiturate and anticonvulsant used in the treatment of all types of seizures, except for absent seizures. Escitalopram A selective serotonin re-uptake inhibitor used in the treatment of major depressive disorder (MDD), generalized anxiety disorder (GAD), and other select psychiatric disorders such as obsessive-compulsive disorder (OCD). Pergolide A long-acting dopamine agonist that is uncommonly used for the management of Parkinson's disease, due to the risk for cardiac valvulopathy. Desflurane A general inhalation anesthetic for inpatient and outpatient surgery in adults. Zopiclone A nonbenzodiazepine hypnotic used for the short-term management of insomnia. Bromocriptine A dopamine D2 receptor agonist used for the treatment of galactorrhea due to hyperprolactinemia and other prolactin-related conditions, as well as in early Parkinsonian Syndrome. Levetiracetam A novel anticonvulsant agent used as an adjunct medication to manage partial onset, myoclonic, and generalized tonic-clonic seizures in patients with epilepsy. Dezocine Indicated in the treatment of moderate to severe pain. Estazolam A benzodiazepine used for the short-term management of insomnia. Ketamine A rapid-acting general anesthetic and NMDA receptor antagonist used for induction of anesthesia diagnostic and surgical procedures typically in combination with a muscle relaxant. Quetiapine A psychotropic agent used for the management of bipolar disorder, schizophrenia, and major depressive disorder. Levacetylmethadol For the treatment and management of opiate dependence. It is sometimes used to treat severe pain in terminal patients. Pemoline A central nervous system (CNS) stimulant that was previously used to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy. Levodopa A dopamine precursor used in the management of Parkinson's disease, often in combination with carbidopa, as well as other conditions associated with parkinsonism. Sevoflurane A inhalation anaesthetic agent used for induction and maintenance of general anesthesia during surgical procedures. Aripiprazole An atypical antipsychotic used in the treatment of a wide variety of mood and psychotic disorders, such as schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's syndrome. Chlorprothixene A thioxanthene antipsychotic. Clomipramine A tricyclic antidepressant used in the treatment of obsessive-compulsive disorder and disorders with an obsessive-compulsive component, such as depression, schizophrenia, and Tourette’s disorder. Isocarboxazid A monoamine oxidase inhibitor used to treat enduring and debilitating symptoms of depression following inadequate clinical response to other antidepressant drugs. Lisdexamfetamine A central nervous system (CNS) stimulant used to treat attention deficit hyperactivity disorder (ADHD) and moderate to severe eating disorders. Paliperidone An atypical antipsychotic used in the treatment of schizophrenia and other schizoaffective or delusional disorders. Varenicline A partial agonist at nicotinic acetylcholine receptors used as an aid in smoking cessation. Fosphenytoin An antiepileptic agent used for the management of generalized convulsive status epilepticus and prevention and treatment of seizures occurring during neurosurgery. St. John's Wort An herbal ingredient used in non-prescription therapeutic products for the short-term treatment of minor skin irritations, insomnia, depression, and anxiety. Amobarbital A barbiturate derivative used for the induction of sedation during procedures, short-term management of insomnia, and acute management of refractory tonic-clonic seizures. Aprobarbital Aprobarbital is a barbiturate derivative synthesized in the 1920s by Ernst Preiswerk. It was determined that the substance was capable of demonstrating sedative, hypnotic, and anticonvulsant effects. A primary treatment... Butobarbital For the treatment of insomnia. Heptabarbital Used mainly for sedation and hypnosis. Hexobarbital For the induction of anesthesia prior to the use of other general anesthetic agents and for induction of anesthesia for short surgical, diagnostic, or therapeutic procedures associated with minimal painful... Rasagiline An irreversible inhibitor of monoamine oxidase used for the symptomatic management of idiopathic Parkinson's disease as initial monotherapy and as adjunct therapy to levodopa. Ginkgo biloba A herbal supplement found in over-the-counter or unapproved homeopathic products for various health conditions, such as cognitive, neurodegenerative, cardiovascular, and reproductive health disorders. Salsalate A nonsteroidal anti-inflammatory agent used in the symptomatic relief of rheumatoid arthritis, osteoarthritis and related rheumatic disorders. Neostigmine A cholinesterase inhibitor used in the symptomatic treatment of myasthenia gravis by improving muscle tone. Methotrimeprazine A phenothiazine used in the management of psychosis, particular those of schizophrenia, and manic phases of bipolar disorder. Aminophenazone An analgesic drug used to treat acute migraine attacks in combination with ergotamine and caffeine. Glutethimide For the treatment of insomnia. Diamorphine An opioid analgesic agent used in the relief of severe pain associated with surgical procedures, myocardial infarction or pain in the terminally ill and for the relief of dyspnea in acute pulmonary edema. Bezitramide A narcotic analgesic once used for the treatment of severe chronic pain. Fencamfamin For the the treatment of depressive fatigue in convalescence and other debilitated states as well as in the treatment of depressive day-time fatigue, lack of concentration and lethargy. Barbital A long-acting barbiturate that depresses most metabolic processes at high doses. It is used as a hypnotic and sedative and may induce dependence. Barbital is also used in veterinary practice... Camazepam Camazepam has been used in placebo controlled studies for the treatment of patients suffering from anxiety and depression. Dichloralphenazone Dichloralphenazone is a sedative composed of chloral hydrate and phenazone. It is typically found in combination products Nodolor and Midrin containing isometheptene and acetaminophen used for the relief of tension... Dextromoramide An opioid analgesic structurally related to methadone and used in the treatment of severe pain. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1070) Flunitrazepam A benzodiazepine used to manage anxiety disorders and insomnia. Ethyl loflazepate Not Available Dihydrocodeine An opioid analgesic agent used for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate. Cloxazolam Used primarily as an anti-anxiety agent. Typically used short term, and may be given as a single dose of up to 100mcg/kg to reduce anxiety and tension experienced prior to... Bromazepam A short-acting benzodiazepine with intermediate onset commonly used to treat panic disorders and severe anxiety. Clotiazepam A thienodiazepine used to manage anxiety disorders and insomnia. Chloral hydrate A mild hypnotic used for experimental purposes that was previously used for the treatment of insomnia. Fludiazepam Used for the short-term treatment of anxiety disorders. Dextroamphetamine A sympathomimetic agent used in the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. Metamfetamine A sympathomimetic agent used in the treatment of attention deficit hyperactivity disorder (ADHD) and exogenous obesity. Ketazolam A long-acting benzodiazepine used to manage anxiety and insomnia. Prazepam A benzodiazepine used to manage more severe forms of anxiety disorders. Quazepam A long -acting benzodiazepine used to manage insomnia. Cinolazepam A benzodiazepine used to manage severe and debilitating forms of sleep disorders of various origins in adults. Nitrazepam A long-acting benzodiazepine with intermediate onset commonly used to treat panic disorders, severe anxiety, insomnia, and seizures. Periciazine A phenothiazine used with other medications to treat aggressiveness, impulsiveness, and hostility associated with psychiatric conditions such as schizophrenia. Acepromazine Acepromazine was first used in humans in the 1950s as an antipsychotic agent. It is now rarely used in humans. Acepromazine is frequently used in animals as a sedative and... Molindone An antipsychotic used to treat schizophrenia. Pipotiazine An antipsychotic indicated for the management of chronic, non-agitated schizophrenic patients. Thioproperazine An antipsychotic indicated for the management of acute and chronic schizophrenia, including cases that are refractory to more common neuroleptics. May also be used to treat manic syndromes. Thiothixene An antipsychotic indicated for the management of schizophrenia. Zuclopenthixol An antipsychotic indicated for the management of schizophrenia. The acuphase formulation is indicated for initial treatment of acute psychosis or exacerbation of psychosis, while the depot formulation is best for maintenance. Oxitriptan A naturally occurring amino acid that is used to manage post-hypoxic myoclonus. Phenol An antiseptic and disinfectant used in a variety of settings. Phenacetin Used principally as an analgesic. Valpromide A valproic acid derivative used to treat epilepsy and as adjunct therapy for psychomotor agitation, depression, and manic episodes of bipolar disorder. Aniracetam A nootropic drug used to ameliorate memory and attention disturbances accompanying cerebrovascular diseases and degenerative brain disorders. Choline alfoscerate A natural choline that is used to manage declining cognitive function associated with neurodegenerative and vascular diseases. Metamizole An antipyretic and analgesic drug used to relieve severe and persistent fever and pain. Nialamide Withdrawn from the Canadian, US, and UK markets in 1963 due to interactions with food products containing tyrosine. Nomifensine Nomifensine, formerly marketed as Merital capsules, was associated with an increased incidence of hemolytic anemia. The approved application holder removed Merital capsules from the market on January 23, 1986. FDA... Zimelidine For the treatment of depression. Methaqualone For the treatment of insomnia, and as a sedative and muscle relaxant. Amineptine For the treatment of depression. Flunarizine A selective calcium-entry blocker used as migraine prophylaxis in patients with severe and frequent episodes who have not responded adequately to more common treatments. Fluspirilene An antipsychotic agent used in the treatment of schizophrenia. Tetrabenazine A vesicular monoamine transporter 2 (VMAT) inhibitor used for the management of chorea associated with Huntington's Disease. Milnacipran A selective serotonin and norepinephrine reuptake inhibitor (SNRI) used for the treatment of fibromyalgia and a short-term treatment of major depressive disorder. Iloperidone An atypical antipsychotic agent used for the acute treatment of schizophrenia in adults. Lofexidine A centrally acting alpha2-adrenergic agonist used for the symptomatic treatment of acute opioid withdrawal syndrome to facilitate abrupt opioid discontinuation in adults. Ezogabine An antiepileptic agent used as an adjuvant treatment of partial-onset seizures. Methsuximide A succinimide anticonvulsant that increases the seizure threshold. Primarily used for childhood absence seizures. Functions by suppressing paroxysmal spike-and-wave patterns associated with lapses of consciousness in absence seizures. Rotigotine A non-selective dopamine agonist used for the treatment of Parkinson's Disease and Restless Leg Syndrome. Brivaracetam An anticonvulsant used for the treatment of partial-onset seizures that functions by binding to synaptic vesicle glycoprotein 2A (SV2A) in the brain. Cariprazine An atypical antipsychotic used to treat schizophrenia and acute manic or mixed episodes due to bipolar I disorder. Sertindole An atypical antipsychotic indicated in the treatment of schizophrenia. Mianserin A tetracyclic antidepressant with therapeutic activity similar to amitriptyline used to treat depression and anxiety. Pizotifen A serotonin and tryptamine antagonist indicated for migraine prophylaxis. Rufinamide An antiepileptic drug used as adjunctive therapy to treat seizures associated with Lennox-Gastaut Syndrome (LGS). Tapentadol An opioid used to manage severe pain that has not responded to non-opioid medications, and for which opioid analgesic therapy is appropriate. Asenapine An atypical antipsychotic used to treat patients with bipolar I disorder and patients with schizophrenia. Lacosamide An antiepileptic drug used to treat partial onset seizures in adults. Nalmefene An opioid antagonist used to reduce alcohol consumption in adults with alcohol dependence and treat and prevent opioid overdose. Ziconotide An N-type calcium channel antagonist used to manage patients with severe chronic pain who cannot tolerate, or who have not responded adequately to other treatments such as intrathecal morphine and systemic analgesics. Amisulpride A dopamine D2 receptor antagonist used in the treatment of acute and chronic schizophrenia, and in the prevention and treatment of postoperative nausea and vomiting in adults. Xaliproden Investigated for use/treatment in amyotrophic lateral sclerosis (ALS) and alzheimer's disease. Armodafinil A stimulant used to improve wakefulness in adult patients with excessive sleepiness associated with obstructive sleep apnea, narcolepsy, or shift work disorder. Clomethiazole Investigated for use/treatment in strokes. Propentofylline Investigated for use/treatment in alzheimer's disease. Etilevodopa Investigated for use/treatment in parkinson's disease. Agomelatine Agomelatine is indicated to treat major depressive episodes in adults. Flupirtine Investigated for use/treatment in fibromyalgia. Dalfampridine A potassium channel blocker used for the improvement of motor function in patients with multiple sclerosis (MS). Vilazodone An antidepressant agent used for the treatment of major depressive disorder that targets the 5-HT transporter and 5-HT1A receptors. Laquinimod Investigated for use/treatment in multiple sclerosis. Nitrous oxide An inhalatory gas used as an adjunct to improve oxygenation and reduce the need for extracorporeal membrane oxygenation in certain neonates with hypoxic respiratory failure. Betahistine An antivertigo agent used for the reduction of episodes of vertigo association with Ménière's disease. Desvenlafaxine An antidepressant agent and SNRI used for the treatment of major depressive disorders in adults. Dexmethylphenidate A norepinephrine-dopamine reuptake inhibitor used in the treatment of ADHD in conjunction with other therapies. Ketobemidone For the treatment of all types of severe pain, such as postoperative, cancer, kidney stones and fractures. Triclofos Not Annotated Mebutamate Mebutamate is a sedative and anxiolytic drug with anti-hypertensive (blood pressure lowering) effects comparable to those of other barbiturates but is only around 1/3rd the potency of secobarbital as a... Sulthiame A carbonic anhydrase inhibitor used primarily in benign focal epilepsies of childhood that may be useful as an adjunct therapy in a variety of other refractory epilepsies. Salicylamide Salicylamide is the common name for the substance o-hydroxybenzamide, or amide of salicyl. Salicylamide is a non-prescription drug with analgesic and antipyretic properties. It has similar medicinal uses to aspirin.... Tofisopam For the treatment of anxiety and alcohol withdrawal. Lurasidone An atypical antipsychotic used to treat schizophrenia and depressive episodes associated with bipolar I disorder. Acetylcarnitine An acetylated form of the amino acid derivative L-carnitine that assists in mitochondrial fatty acid metabolism. It is under investigation as a treatment for numerous conditions, including neuropathy, depression, and dementia. Perampanel A non-competitive AMPA glutamate receptor antagonist used to treat partial-onset seizures with or without secondarily generalized seizures, and as adjunctive treatment of primary generalized tonic-clonic seizures in patients with epilepsy. Adrafinil Used to relieve excessive sleepiness and inattention in elderly patients. Glafenine An anthranilic acid derivative with analgesic properties used for the relief of all types of pain. Glafenine is withdrawn from the American market. Dimetotiazine Dimetotiazine has considerable antiemetic & serotonin antagonistic action used mainly in allergic skin conditions. Floctafenine An anti-inflammatory analgesic used to manage mild to moderate acute pain. Etifoxine A benzoxazine class drug primarily used as an anxiolytic, but that also possesses neuroprotective, neuroplastic, and anti-inflammatory properties; these effects are thought to arise due to modulation of GABAergic neurotransmission and neurosteroid synthesis. Etidocaine Etidocaine is marketed under the name Duranest. It is an injectable local anesthetic during surgery, labor, and delivery. Etidocaine has a long duration of activity, but has the main disadvantage... Dimetacrine Dimetacrine is also known as dimethacrine or acripamine. It is marketed under the names Istonil, Istonyl, Linostil, and Miroistonil. Dimetacrine is a tricyclic antidepressant (TCA) with imipramine-like effects used in... Dexetimide A muscarinic antagonist that has been used to treat neuroleptic-induced parkinsonism. Benzetimide is the (-)-enantimorph of dexetimide. Cyamemazine Cyamemazine (Tercian), also known as cyamepromazine, is a typical antipsychotic drug of the phenothiazine class used primarily in the treatment of schizophrenia and psychosis-associated anxiety. Cyamemazine actually behaves like an... Barbexaclone Created for the treatment for epilepsy, with the intent of creating an antiepileptic with less sedative properties than phenobarbital. Articaine A local anesthetic used for inducing local, infiltrative, or conductive anesthesia in both simple and complex dental procedures. Beclamide Has been used in the management of epilepsy and epilepsy related behavioural disorders. It was used for generalised tonic-clonic seizures, and was not effective for absence seizures. More recently focus... Captodiame Captodiame is indicated for the treatment of anxiety. Butriptyline Butriptyline is a tricyclic antidepressant which has been used in Europe since 1974. It is the isobutyl side chain homologue of amitriptyline. Brotizolam A benzodiazepine analogue with sedative-hypnotic properties used for short-term treatment of severe or debilitating insomnia. Benzoctamine Benzoctamine is a drug with two main uses. It can be used as a sedative which does not depress the respiratory system, but rather stimulates it. It can also be... Vortioxetine A serotonin modulating antidepressant indicated for the treatment of major depressive disorder (MDD). Tasimelteon A melatonin receptor agonist used to treat Non- 24-Hour Sleep-Wake Disorder. Sodium oxybate A central nervous system depressant used to treat cataplexy and excessive daytime sleepiness (EDS) associated with narcolepsy. Idebenone An analogue of ubiquinone used for the treatment of visual impairment in adolescent and adult patients with Leber’s Hereditary Optic Neuropathy (LHON). Calcium carbimide Calcium carbimide has not been approved by the FDA but the intended indication is for the treatment of alcoholism. This medication was marketed in Canada, United Kingdom and Europe under... Paraldehyde A central nervous system depressant previously used to control convulsions due to various clinical causes, including tetanus, status epilepticus, and convulsive drugs. Stiripentol An antiepileptic agent used in combination with other anticonvulsants to treat seizures associated with Dravet syndrome. Brexpiprazole A serotonin–dopamine activity modulator used in the treatment of major depressive disorder as an adjunct and schizophrenia. Etizolam A thienodiazepine derivative used to treat anxiety and insomnia. Dosulepin A tricyclic antidepressant commonly used only in patients for whom alternative therapies are ineffective due to its toxicity potential. Viloxazine A selective norepinephrine reuptake inhibitor indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD) in adults in children. Etoperidone Etoperidone has been studied for the treatment of depression , tremors in Parkinson, extrapyramidal symptoms and male impotence . It is not certain if it was ever approved and marketed... Piracetam A nootropic cyclic GABA derivative used in myoclonus, sickle cell disease, alcohol dependence, and as a general cognitive enhancer. Melperone An atypical butyrophenone antipsychotic used to treat sleep disorders, confusion, and psychomotor dysfunction associated with geriatric, psychiatric, and alcohol-dependent patients. Zotepine Zotepine, like other atypical antipsychotics, is considered as the first-line treatment in newly diagnosed schizophrenia. It is usually thought to be an option of choice for managing acute schizophrenic episodes... Toloxatone For the treatment of major depressive disorder. Iproclozide For the treatment of depression. Pipamperone Treatment of chronic psychoses and states of aggressiveness of various origins . Propacetamol Propacetamol is a paracetamol prodrug of intravenous administration used to control fever and pain of perioperative period in multimodal analgesia therapy. Tianeptine An atypical tricyclic antidepressant with antidepressant and anxiolytic effects primarily used to treat major depressive disorder. Alfaxalone Alfaxalone, also known as alphaxalone or alphaxolone, is a neuroactive steroid and general anaesthetic. It is used in veterinary practice under the trade name Alfaxan, and is licensed for use... Chloroform Chloroform is an organic small molecule, member of the family of the chloromethanes that presents a formula of CHCl3. It is a colorless, sweet-smelling, dense liquid that is produced on... Pipradrol A central nervous stimulant ingredient in a product used to treat functional fatigue. Amifampridine A voltage gated potassium channel blocker used to treat Lambert-Eaton myasthenic syndrome. Pitolisant An antagonist and inverse agonist at the histamine H3 receptor that is used to treat narcolepsy in adults. Tafamidis A medication used to treat transthyretin-mediated amyloidosis. Esketamine A NMDA receptor antagonist used for treatment-resistant depression. Vinpocetine A synthetic derivative of a vinca alkaloid used to treat neurological symptoms of cerebrovascular disease. Gepirone Gepirone has been used in trials studying the treatment of Cocaine-Related Disorders. Nefopam A non-opioid analgesic used for moderate to severe pain, especially post-surgical pain. Carisbamate Carisbamate has been investigated in Alcohol Abuse, Substance Abuse, and Alcohol Dependence. Bromperidol A first-generation butyrophenone antipsychotic used in the treatment of schizophrenia and other psychotic manifestations. Piribedil A dopamine agonist used with or without levodopa in the treatment of Parkinson's disease. Piritramide A synthetic opioid used in the treatment of severe pain. Perazine A phenothiazine antipsychotic used in the acute and chronic treatment of psychotic disorders. Benperidol A neuroleptic butyrophenone derivative indicated in the treatment of psychoses, manic episodes, and psychomotor agitation. Opipramol A medication to treat general anxiety and somatoform disorders. Pivagabine Pivagabine has been used in trials studying the treatment of Stress and Anxiety. Prothipendyl A neuroleptic agent indicated in the treatment of restlessness and agitation in patients with underlying psychiatric conditions. Tiapride A dopamine D2 and D3 receptor antagonist indicated in the treatment of chorea in Huntington's disease, as well as agitation and anxiety in the elderly or with acute or chronic alcoholism. Tirilazad Tirilazad has been used in trials studying the treatment of Spinal Cord Injury. Pyritinol A vitamin B6 analog indicated as an adjunct therapy in the treatment of a wide variety of disorders of the brain. Valnoctamide Valnoctamide has been used in trials studying the treatment of Mania and Schizoaffective Disorder, Manic Type. Valerian A plant used in some non-prescription natural health products. Butaperazine Butaperazine was approved in 1967 , and possibly discontinued in the 1980s . Medifoxamine Medifoxamine was marketed as an atypical antidepressant, with anxiolyitc properties in France, Spain, and Morrocco in the 1990s but was later withdrawn from the market due to it causing cases... Apronalide Apronalide is approved in Japan. Apronalide has been withdrawn from the market in many other countries due to patient development of thrombocytopenic purpura . Dibenzepin Dibenzepin is approved for use in Europe. Acetylleucine Used for treating vestibular-related imbalance and vertigo. Enibomal Not Annotated Alaproclate Alaproclate was developed as one of the first selective serotonin reuptake inhibitor (SSRI) antidepressants by Astra AB (now AstraZeneca) in the 1970s. Development was discontinued due to concerns over hepatotoxicity... Propanidid An intravenous anesthetic that has been used for rapid induction of anesthesia and for maintenance of anesthesia of short duration. (From Martindale, The Extra Pharmacopoeia, 30th ed, p918) Quinupramine Quinupramine has been approved in France under the brand name Kinupril, as an antidepressant . Pramiracetam Pramiracetam has been previously approved in some eastern European countries under the brand names Pramistar, Neupramir, and Remen. It was also previously approved in the United States with orphan drug... Tropatepine Tropatepine has been used in France for its antiparkinsons activities . Proxibarbal Proxibarbal is a derivative of barbiturates, which has been used to treat migraines. Proxibarbal was approved in France but was withdrawn from the market due to the risk of inducing... Clothiapine An atypical antipsychotic indicated in the treatment of acute psychosis, exacerbations of chronic psychosis, chronic psychosis, paranoid psychosis, and anxiety. Ethyl chloride A local anesthetic. Sultopride Sultopride is used in Japan, Hong Kong, and Europe to treat schizophrenia. It is of the drug class atypical antipsychotics . Bucetin Bucetin is an analgesic and antipyretic medication which was approved for use in Germany but was withdrawn from the market in 1986 due to renal toxicity caused by the medication. Rimazolium Rimazolium is an experimental analgesic drug . Melevodopa A methyl ester of levodopa indicated in combination with carbidopa for the treatment of Parkinson's disease. Trichloroethylene Trichloroethylene is a halocarbon commonly used as an industrial solvent, not to be confused with the similar 1,1,1-trichloroethane, also known as chlorothene. It has been sold under a variety of... Butanilicaine Not Annotated Pyrithyldione Not Annotated Pinazepam A benzodiazepine indicated in the treatment of anxiety and severe insomnia. Fenozolone Not Annotated Deanol Deanol is commonly referred to as 2-(dimethylamino)ethanol, dimethylaminoethanol (DMAE) or dimethylethanolamine (DMEA). It holds tertiary amine and primary alcohol groups as functional groups. Deanol has been used in the treatment... Viminol An opioid analgesic indicated in the treatment of pain. Pheneturide Not Annotated Bromisoval Not Annotated Vinbarbital Not Annotated Chlorproethazine Not Annotated Melitracen A thioxanthene neuroleptic indicated in the treatment of anxiety, depression, and asthenia. Dihydroergocryptine A dopamine agonist indicated in the treatment of cerebrovascular diseases and atherosclerosis. Neocitrullamon Not Annotated Acetylglycinamide chloral hydrate Not Annotated Oxypertine Not Annotated Lofepramine Not Annotated Pirisudanol Not Annotated Phenglutarimide Not Annotated Medazepam A long-acting benzodiazepine used for its sedative and anxiolytic properties. Prolintane Not Annotated Mazaticol Not Annotated Xenon Not Annotated Nicomorphine Not Annotated Phenibut Not Annotated Oxaflozane Not Annotated Oxetorone Not Annotated Etybenzatropine Not Annotated Meptazinol Not Annotated Iprindole Not Annotated Budipine Not Annotated Levomethadone A long-acting opioid agonist used clinically to manage opioid dependency. It is the racemate of methadone and is twice as potent. Mebicar Not Annotated Veralipride Not Annotated Propyphenazone Not Annotated Gedocarnil Not Annotated Guacetisal Not Annotated Iprazochrome Not Annotated Ethenzamide Not Annotated Nizofenone Not Annotated Bifemelane Not Annotated Trifluperidol Not Annotated Moperone Not Annotated Thiopropazate Not Annotated Emylcamate Not Annotated Allobarbital Not Annotated Metabutethamine Not Annotated Diethyl ether Not Annotated Oxiracetam Not Annotated Phenoperidine Not Annotated Phenazocine Not Annotated Flumedroxone Not Annotated Carbaspirin calcium An NSAID indicated in the treatment of short term pain and fever. Bornaprine An anticholinergic drug indicated in the treatment of hyperhidrosis, dyskinesia, akathisia, parkinsonism, and Parkinson's disease. Fabomotizole Not Annotated Etanautine Not Annotated Loprazolam Loprazolam is an imidazobenzodiazepine with anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties. It is indicated for the short-term treatment of insomnia including difficulty in falling asleep and/or frequent... Benorilate Not Annotated Hexapropymate Not Annotated Fluanisone Not Annotated Ipidacrine Not Annotated Morpholine Not Annotated Mosapramine Not Annotated Niaprazine Niaprazine is a selective brain catecholamine depletor. Vinyl ether Not Annotated Distigmine A cholinesterase inhibitor indicated in the treatment of neurogenic bladder dysfunction or myasthenia gravis. Methylpentynol Not Annotated Cyclobarbital Not Annotated Mephenoxalone A muscle relaxant indicated in the treatment of painful muscle spasms and cramps. Meclofenoxate Not Annotated Vinylbital Not Annotated Imipramine oxide Not Annotated Dixyrazine Not Annotated Tilidine A synthetic opioid indicated in the treatment of severe pain. Fipexide Not Annotated Penfluridol Not Annotated Ethadione Not Annotated Reposal Reposal is a barbiturate derivative invented in the 1960s in Denmark that has sedative, hypnotic and anticonvulsant properties. It was used primarily in the treatment of insomnia. Linopirdine Not Annotated Carbromal Not Annotated Doxefazepam Not Annotated Dipyrocetyl Not Annotated Clopenthixol Clopenthixol is a thioxanthene with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors. Imidazole salicylate Not Annotated Lormetazepam A benzodiazepine indicated in the treatment of anxiety and the induction of anesthesia. Choline salicylate The oral gel is indicated for the relief of pain and discomfort of common mouth ulcers, cold sores, denture sore spots, infant teething and mouth ulcers, and sore spots due... Nordazepam A benzodiazepine indicated in the treatment of insomnia. Cabergoline A dopamine receptor agonist used for the treatment of hyperprolactinemic conditions due to various causes. Codeine An opioid analgesic used to treat moderate to severe pain when the use of an opioid is indicated. Carbamoylcholine A direct acting miotic agent administered ophthalmically to decrease intraocular pressure after cataract surgery, and to induce miosis during surgery. Cinchocaine An anesthetic used for local or regional anesthesia. Clonidine An alpha-2 adrenergic agonist used to treat hypertension and severe cancer pain, among other conditions, and to treat withdrawal symptoms from various substances. It is also used to aid in the diagnosis of pheochromocytoma and to prevent migraines. Dyclonine An topical anesthetic used prior to examination to suppress the gag reflex or for pain relief from canker sores and fever blisters. Sumatriptan A serotonin receptor agonist used to treat migraines and cluster headaches. Procaine A local anesthetic used for anesthesia, peripheral nerve block, and spinal nerve block. Scopolamine A belladonna alkaloid with anticholinergic effects indicated for the treatment of nausea and vomiting associated with motion sickness and postoperative nausea and vomiting (PONV). Disulfiram A carbamate derivative used to treat alcohol addiction. Cocaine An ester local anesthetic used during diagnostic procedures and surgeries in or through the nasal cavities. Benzocaine A topical local anesthetic used for the temporary relief of pain and itching associated with minor burns, sunburn, scrapes and insect bites or minor skin irritations. Orphenadrine A muscarinic antagonist used as an adjunct for the symptomatic relief of musculoskeletal pain and discomfort. Antipyrine An antipyretic agent used for the symptomatic treatment of acute otitis media, most commonly in combination with benzocaine. Fenethylline Not Available Tetracaine A local anaesthetic agent used to induce local analgesia in the eyes and skin during medical procedures. Opium A medication used to treat moderate to severe pain. Nifenazone Not Annotated Emepronium Not Annotated Aloxiprin Not Annotated Eslicarbazepine An antiepileptic indicated as a monotherapy or adjunct therapy in the treatment of epilepsy. Eslicarbazepine acetate An anticonvulsant agent used as an adjunct to treat partial-onset seizures in patients with inadequate clinical response to conventional antiepileptic therapy. Citicoline An endogenous intermediate in the formation of phosphatidylcholine from choline which is thought to have neuroprotective effects. Chlorhexadol Chlorhexadol is a sedative and hypnotic which is regulated in the United States as a Schedule III controlled substance. It is a derivative of chloral hydrate. Ibuprofen An NSAID and non-selective COX inhibitor used to treat mild-moderate pain, fever, and inflammation. Naloxone An opioid receptor antagonist used to rapidly reverse an opioid overdose. Also included in some drug formulations as an abuse deterrent to prevent injection. Pimavanserin A second generation atypical antipsychotic used for the treatment of hallucinations and delusions caused by Parkinson's Disease. Safinamide A MAO-B inhibitor used as an add-on treatment to levodopa/carbidopa for Parkinson's disease during "off" episodes. Cytisine An alkaloid with partial agonist activity at the α4β2 nicotinic acetylcholine receptor used to aid smoking cessation. Suvorexant A orexin receptor antagonist used to treat insomnia that is characterized by difficulties with sleep onset and/or sleep maintenance. Cannabidiol An active cannabinoid used as an adjunctive treatment for the management of seizures associated with Lennox-Gastaut syndrome or Dravet syndrome and symptomatic relief of moderate to severe neuropathic pain or other painful conditions, like cancer. Dexketoprofen An NSAID that is the R(-)-enantiomer of racemic ketoprofen with analgesic and anti-inflammatory properties used for the treatment of mild to moderate pain. Opicapone A catechol-O-methyltransferase inhibitor used as an adjunct treatment for Parkinson's Disease in adults currently receiving levodopa and a dopa decarboxylase inhibitor. Valbenazine A vesicular monoamine transporter 2 inhibitor used to treat tardive dyskinesia. Edaravone A free radical scavenger used to delay the progression of ALS. Erenumab A calcitonin-gene related peptide antagonist used to prevent migraines. Galcanezumab A calcitonin-gene related peptide antagonist used to prevent migraines and treat cluster headaches. Patisiran A transthyretin-directed small interfering RNA used to treat polyneuropathy of hereditary transthyretin-mediated amyloidosis. Bentazepam Not Annotated Lithium carbonate A medication used to treat manic episodes of bipolar disorder. Iproniazid For the treatment of depression (originally intended to treat tuberculosis). Butabarbital A barbiturate drug used as a sedative and hypnotic. Oliceridine A biased opioid agonist indicated for the management of severe acute pain in adult patients. Through preferential activation of G-protein-coupled signalling pathways, oliceridine provides analgesic effect with a comparable or improved safety profile over conventional opioid agonists. Remimazolam An ultra short-acting benzodiazepine used for the induction and maintenence of procedural sedation during short procedures. Fremanezumab A humanized monoclonal antibody directed against human calcitonin-gene related peptide to prevent migraines. Inotersen An antisense oligonucleotide used to treat polyneuropathy of hereditary transthyretin-mediated amyloidosis. Solriamfetol Solriamfetol is indicated for treatment of daytime sleepiness associated with obstructive sleep apnea and narcolepsy, but is not a treatment for the underlying airway obstruction in apnea patients[FDA Label][A176534,A176744]. Clorazepic acid A benzodiazepine used to treat anxiety, partial seizures, and alcohol withdrawal. Levosulpiride indicated to treat dyspepsia, symptoms of Meniere's syndrome, and second line in the treatment of drug-induced nausea and vomiting. Lavender oil Not Annotated Serdexmethylphenidate A prodrug of the CNS stimulant dexmethylphenidate used as a first-line treatment for Attention Deficit Hyperactivity Disorder (ADHD). Celecoxib An NSAID used to treat osteoarthritis, rheumatoid arthritis, acute pain, menstrual symptoms, and to reduce polyps is familial adenomatous polyposis. Fenfluramine Fenfluramine is a phenethylamine that is structurally similar to serotonin. Due to its ability to increase extracellular serotonin levels, modulate serotonergic and other neurologic receptors, and control neurotransmission, it is effective in treating pharmacoresistant seizures. Meloxicam An NSAID used to treat osteoarthritis in adults, rheumatoid arthritis in adults, and juvenile rheumatoid arthritis in pediatrics. Oxymorphone An opioid analgesic used in the management of moderate-to-severe pain and for analgesic therapies. Arimoclomol Investigated for use/treatment in amyotrophic lateral sclerosis (ALS), diabetes mellitus type 2, neurologic disorders, and neuropathy (diabetic). Ganaxolone A neuroactive steroid GABA-A receptor modulator used for the treatment of seizures associated with CDKL5 deficiency disorder (CDD). Lumateperone A novel 2nd generation antipsychotic used to manage both positive and negative symptoms in patients with schizophrenia. Cenobamate A small molecule drug indicated to treat partial onset seizures in adults. Levomilnacipran A selective serotonin and norepinephrine reuptake inhibitor (SNRI) used to treat major depressive disorder (MDD). Lasmiditan An oral 5HT1F agonist used for the acute treatment of migraine headache with or without aura. Istradefylline A selective adenoside A2A receptor antagonist indicated in adjunct to levodopa and carbidopa for the treatment of Parkinson's Disease. Mirogabalin Mirogabalin has been used in trials studying the treatment of Post-herpetic Neuralgia, Pain Associated With Fibromyalgia, and Diabetic peripheral neuropathic pain. Lemborexant A dual orexin antagonist indicated for the treatment of sleep-onset and/or sleep maintenance insomnia. Deutetrabenazine A vesicular monoamine transporter 2 inhibitor used for the symptomatic treatment of tardive dyskinesia and chorea associated with Huntington's disease. Aducanumab A monoclonal antibody indicated in the treatment of Alzheimer's disease. Tanezumab Tanezumab has been investigated for the treatment of Osteoarthritis, Knee and Neuralgia, Postherpetic. Rimegepant An oral CGRP receptor antagonist used for the acute treatment of migraines with or without aura in adults. Eptinezumab A monoclonal antibody directed against CGRP infused every 3 months for the preventive treatment of migraine in adults. Ubrogepant An oral CGRP antagonist used in the acute treatment of migraine with or without aura. Mexazolam A benzodiazepine indicated to treat anxiety with or without psychoneurotic conditions. Atogepant An oral CGRP antagonist used for the preventative therapy of episodic migraine headaches. - Drugs & Drug Targets