Lolium perenne pollen

Identification

Summary

Lolium perenne pollen is an extract from Lolium perenne pollen used in allergy testing.

Brand Names

Oralair 100, Oralair 300, Oralair Children and Adolescents Sample Kit

Generic Name

Lolium perenne pollen

DrugBank Accession Number

DB10389

Background

Lolium perenne pollen is the pollen of the Lolium perenne plant. Lolium perenne pollen is mainly used in allergenic testing.

Type

Biotech

Groups

Approved

Biologic Classification

Allergenics
Allergen Extract

Synonyms

• Allergenic extract- ryegrass, perennial lolium perenne
• Lolium perenne
• Lolium perenne allergenic extract
• perennial rye grass pollen extract
• Standardized perennial rye grass pollen

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Pharmacology

Indication

Lolium perenne pollen is an allergen extract included in an allergenic testing product called ORALAIR. It is indicated as immunotherapy for the treatment of grass pollen-induced allergic rhinitis with or without conjunctivitis confirmed by positive skin test or in vitro testing for pollen38 specific IgE antibodies for any of the five grass species contained in this product. ORALAIR is approved for use in persons 5 through 65 years of age.¹

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Associated Conditions

Indication Type	Indication	Combined Product Details	Approval Level	Age Group	Patient Characteristics	Dose Form
Used in combination for diagnostic process	Allergic rhinitis due to pollen		••••••••••••
Used in combination for diagnostic process	Allergic rhinitis due to pollen		••••••••••••		••••••••••••••

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Pharmacodynamics

Not Available

Mechanism of action

Not Available

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism

Not Available

Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects

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Toxicity

Not Available

Pathways

Not Available

Pharmacogenomic Effects/ADRs

Not Available

Interactions

Drug Interactions

This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.

• Approved
• Vet approved
• Nutraceutical
• Illicit
• Withdrawn
• Investigational
• Experimental
• All Drugs

Drug	Interaction
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Acebutolol	The risk of a hypersensitivity reaction to Lolium perenne pollen is increased when it is combined with Acebutolol.
Atenolol	The risk of a hypersensitivity reaction to Lolium perenne pollen is increased when it is combined with Atenolol.
Benazepril	The risk or severity of adverse effects can be increased when Benazepril is combined with Lolium perenne pollen.
Betaxolol	The risk of a hypersensitivity reaction to Lolium perenne pollen is increased when it is combined with Betaxolol.
Bisoprolol	The risk of a hypersensitivity reaction to Lolium perenne pollen is increased when it is combined with Bisoprolol.

Food Interactions

Not Available

Products

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Brand Name Prescription Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End	Region	Image
Allergenic Extract - Standardized Grass Pollen - Perennial Rye	Liquid	10000 unit / mL	Intradermal; Subcutaneous	Greer Laboratories	2015-10-14	Not applicable
Allergenic Extract - Standardized Grass Pollen - Perennial Rye	Liquid	100000 unit / mL	Intradermal; Subcutaneous	Greer Laboratories	2000-10-30	Not applicable
Allergenic Extract - Standardized Perennnial Rye Grass Pollen	Liquid	100000 unit / mL	Intradermal; Percutaneous; Subcutaneous	Alk Abello, Inc.	2009-07-30	Not applicable
Center-AL - Lolium Perenne Pollen	Injection, suspension	20000 [PNU]/1mL	Subcutaneous	ALK-Abello, Inc.	1975-01-15	Not applicable
Center-AL - Lolium Perenne Pollen	Injection, suspension	10000 [PNU]/1mL	Subcutaneous	ALK-Abello, Inc.	1975-01-15	2023-05-16

Mixture Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End	Region	Image
6 Grass Mix	Lolium perenne pollen (20000 [PNU]/1mL) + Agrostis gigantea pollen (20000 [PNU]/1mL) + Dactylis glomerata pollen (20000 [PNU]/1mL) + Festuca pratensis pollen (20000 [PNU]/1mL) + Phleum pratense pollen (20000 [PNU]/1mL) + Poa pratensis pollen (20000 [PNU]/1mL)	Injection, solution	Subcutaneous	ALK-Abello, Inc.	1975-01-15	2023-05-24
6 Grass Mix	Lolium perenne pollen (10000 [PNU]/1mL) + Agrostis gigantea pollen (10000 [PNU]/1mL) + Dactylis glomerata pollen (10000 [PNU]/1mL) + Festuca pratensis pollen (10000 [PNU]/1mL) + Phleum pratense pollen (10000 [PNU]/1mL) + Poa pratensis pollen (10000 [PNU]/1mL)	Injection, solution	Subcutaneous	ALK-Abello, Inc.	1975-01-15	2023-05-24
7 Grass Mix	Lolium perenne pollen (20000 [PNU]/1mL) + Agrostis gigantea pollen (20000 [PNU]/1mL) + Anthoxanthum odoratum (20000 [PNU]/1mL) + Dactylis glomerata pollen (20000 [PNU]/1mL) + Festuca pratensis pollen (20000 [PNU]/1mL) + Phleum pratense pollen (20000 [PNU]/1mL) + Poa pratensis pollen (20000 [PNU]/1mL)	Injection, solution	Subcutaneous	ALK-Abello, Inc.	1975-01-15	2023-05-24
7 Grass Mix	Lolium perenne pollen (10000 [PNU]/1mL) + Agrostis gigantea pollen (10000 [PNU]/1mL) + Anthoxanthum odoratum (10000 [PNU]/1mL) + Dactylis glomerata pollen (10000 [PNU]/1mL) + Festuca pratensis pollen (10000 [PNU]/1mL) + Phleum pratense pollen (10000 [PNU]/1mL) + Poa pratensis pollen (10000 [PNU]/1mL)	Injection, solution	Subcutaneous	ALK-Abello, Inc.	1975-01-15	2023-05-24
7 Standardized Grass Pollen Mix	Lolium perenne pollen (14285.714 [BAU]/1mL) + Agrostis gigantea pollen (14285.714 [BAU]/1mL) + Anthoxanthum odoratum pollen (14285.714 [BAU]/1mL) + Dactylis glomerata pollen (14285.714 [BAU]/1mL) + Festuca pratensis pollen (14285.714 [BAU]/1mL) + Phleum pratense pollen (14285.714 [BAU]/1mL) + Poa pratensis pollen (14285.714 [BAU]/1mL)	Solution	Intradermal; Percutaneous; Subcutaneous	Greer Laboratories, Inc.	1968-09-15	Not applicable

Categories

Drug Categories

• Allergenic Extracts
• Cell-mediated Immunity
• Grass Pollen Allergen Extracts
• Increased Histamine Release
• Increased IgG Production
• Standardized Pollen Allergenic Extract

Classification

Not classified

Affected organisms

Not Available

Chemical Identifiers

UNII

4T81LB52R0

CAS number

Not Available

References

General References

1. FDA Approved Drug Products: ORALAIR 6 (Sweet Vernal, Orchard, Perennial Rye, Timothy, and Kentucky Blue Grass Mixed Pollens Allergen Extract) Tablet for Sublingual Use [Link]

External Links

PubChem Substance

347910564

RxNav

852819

Clinical Trials

Clinical Trials

Phase	Status	Purpose	Conditions	Count
Not Available	Completed	Not Available	Allergic Reaction	1

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Not Available

Dosage Forms

Form	Route	Strength
Solution	Intradermal; Percutaneous; Subcutaneous
Injection, solution	Subcutaneous
Liquid	Intradermal; Subcutaneous	10000 unit / mL
Liquid	Intradermal; Subcutaneous	100000 unit / mL
Liquid	Intradermal; Percutaneous; Subcutaneous	100000 unit / mL
Liquid	Subcutaneous
Injection, suspension	Subcutaneous	10000 [PNU]/1mL
Injection, suspension	Subcutaneous	20000 [PNU]/1mL
Kit	Sublingual
Kit; tablet, orally disintegrating	Sublingual
Tablet	Sublingual	100 [IR]
Tablet	Sublingual	300 [IR]
Tablet, orally disintegrating	Sublingual
Injection, solution	Subcutaneous	10000 [BAU]/1mL
Injection, solution	Subcutaneous	100000 [BAU]/1mL
Solution	Percutaneous	10000 [BAU]/1mL
Solution	Percutaneous	100000 [BAU]/1mL
Tablet	Sublingual
Liquid	Intradermal	100 unit / mL
Liquid	Intradermal	1000 unit / mL
Solution	Percutaneous; Subcutaneous	10000 unit / mL
Solution	Percutaneous; Subcutaneous	100000 unit / mL
Injection, solution	Intradermal
Injection, solution	Percutaneous; Subcutaneous
Injection, solution	Intradermal	100 [BAU]/1mL
Injection, solution	Intradermal	1000 [BAU]/1mL
Injection, solution	Percutaneous; Subcutaneous	10000 [BAU]/1mL
Injection	Cutaneous; Intradermal; Subcutaneous	100000 [BAU]/1mL
Injection, solution	Intradermal; Subcutaneous	10000 [BAU]/1mL
Injection, solution	Intradermal; Subcutaneous	100000 [BAU]/1mL
Injection, solution	Percutaneous	100000 [BAU]/1mL
Injection, solution	Percutaneous; Subcutaneous	100000 [BAU]/1mL
Solution	Intradermal; Percutaneous; Subcutaneous	10000 [BAU]/1mL
Solution	Intradermal; Percutaneous; Subcutaneous	100000 [BAU]/1mL
Injection, solution	Intradermal; Subcutaneous

Prices

Not Available

Patents

Not Available

Properties

State

Not Available

Experimental Properties

Not Available

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Drug created at December 01, 2015 20:03 / Updated at April 17, 2024 06:33