Accession Number

Biological molecules that possess catalytic activity. They may occur naturally or be synthetically created. Enzymes are usually proteins, however CATALYTIC RNA and CATALYTIC DNA molecules have also been identified.

ATC Classification
DrugDrug Description
AlteplaseA recombinant form of human tissue plasminogen activator used in the emergency treatment of myocardial infarction, ischemic stroke, and pulmonary emboli.
UrokinaseA low molecular weight form of human urokinase used to treat pulmonary embolism and myocardial infarction as well as to clear IV lines.
AnistreplaseA form of recombinant human tissue plasminogen activator used in the emergency treatment of myocardial infarction and pulmonary emboli.
Collagenase clostridium histolyticumA collagenase enzyme used to promote debridement of necrotic tissue in burns and skin ulcers as well as to treat Dupuytren's contracture and Peyronie's disease.
Hyaluronidase (ovine)A purified form of sheep hyaluronidase enzyme used as an adjunct in subcutaneous rehydration therapy and to increase absorption of other drugs and radiopaque imaging agents.
StreptokinaseA purified fibrinolytic bacterial protein used to breakdown thrombosis in myocardial infarction, pulmonary embolism, and venous thromboembolism.
Agalsidase betaA recombinant human alpha-galactosidase indicated to treat Fabry disease, a genetic deficiency in the enzyme leading to buildup of globotriaosylceramide.
Alglucosidase alfaAn acid alpha- glucosidase (GAA) derivative used as an enzyme replacement therapy for the treatment of Pompe disease in infants and pediatric patients caused by GAA deficiency.
AncrodAn anticoagulant purified from the venom of the Malayan pit viper that functions by inactivating circulating plasma fibrinogen. Not currently approved for use or marketed in any country.
ChymopapainChymopapain is indicated for the development of chemonucleolysis which is used for the digestion of the nucleus pulposus in patients with disc herniation confirmed by myelography. A disc herniation occurs...
SacrosidaseAn enzyme replacement therapy used for the treatment of congenital sucrase-isomaltase deficiency (CSID).
ChymotrypsinA digestive enzyme supplement used as supportive therapy to manage the side effects associated with conventional chemotherapy, radiotherapy, and hormone therapy.
TrypsinA naturally occurring proteolytic enzyme found in the digestive tract of mammals. Used clinically in combination with bromelain and rutosides in the treatment of some inflammatory conditions.
ReteplaseA purified form of human tissue plasminogen activator used in the emergency treatment of myocardial infarction, ischemic stroke, and pulmonary emboli.
TenecteplaseA modified form of recombinant human tissue plasminogen activator used in the emergency treatment of myocardial infarction and pulmonary emboli.
ImigluceraseA form of recombinant human beta-glucocerebrosidase enzyme used to replace the deficient endogenous enzyme in the treatment of Gaucher disease.
AlgluceraseA form of recombinant beta-glucocerebrosidase enzyme used to replace the deficient endogenous enzyme in the treatment of Gaucher disease.
IdursulfaseA purified lysosomal enzyme used as a replacement therapy for Hunter syndrome in pediatric and adult patients.
GalsulfaseA recombinant human enzyme used as replacement enzyme therapy for the treatment of of adults and children with Mucopolysaccharidosis VI, a rare genetic disorder caused by a deficiency of a lysosomal enzyme.
Taliglucerase alfaA hydrolytic lysosomal glucocerebroside specific enzyme, used for long term enzyme replacement therapy in patients with Type 1 Gaucher disease.
Elosulfase alfaA lysosomal glycosaminoglycan (GAG)-specific enzyme indicated as an enzyme replacement therapy for Mucopolysaccharidosis type IV A.
Asfotase alfaAn enzyme replacement therapy used for the treatment of perinatal/infantile and juvenile onset hypophosphatasia (HPP).
Sebelipase alfaA recombinant lysosomal acid lipase used to treat lysosomal acid lipase deficiency.
FibrinolysinFibrinolysin assists with the healing of minor burns, superficial wounds, ulcers, surgical wounds, and superficial hematomas.
KallidinogenaseNot Annotated
BrinaseNot Annotated
BromelainsA protease indicated in the treatment of inflammation and for eschar removal.
SaruplaseNot Annotated
Dornase alfaA synthetic form of human deoxyribonuclease I used to break down extracellular DNA in the lungs, a major source of mucous viscosity in cystic fibrosis.
RasburicaseA recombinant form of urate-oxidase enzyme used to treat hyperuricemia following chemotherapy for leukemias and non-Hodgkin's lymphoma.
LaronidaseA form of recombinant human alpha-L-iduronidase used to treat Hurler and Hurler-Scheie forms of mucopolysaccharidosis, a genetic deficiency of alpha-L-iduronidase.
Velaglucerase alfaAn enzyme replacement therapy used for the long-term treatment of for pediatric and adult patients with type 1 Gaucher disease.
TilactaseA beta-D-galactosidase use to treat lactose intolerance.
Coagulation factor VIIa Recombinant HumanA form of recombinant human coagulation Factor VII used to treat hemophilia A and B.
Botulinum toxin type BA purified form of botulinum toxin type B used to block acetylcholine release in the treatment of cervical dystonia and sialorrhea.
PancrelipaseA purified form of porcine pancreatic lipase, amylase, and protease enzymes used to treat malabsorption associated with pancreatic insufficiency resulting from cystic fibrosis and pancreatitis.
AlfimepraseAlfimeprase is being evaluated as a potential treatment for acute ischemic stroke, catheter occlusion (CO) and acute peripheral arterial occlusion (PAO).
DesmoteplaseInvestigated for use/treatment in cerebral ischemia and strokes.
PraconaseInvestigated for use/treatment in spinal cord injuries.
LanoteplaseInvestigated for use/treatment in myocardial infarction.
PegargiminaseInvestigated for use/treatment in melanoma and hepatocellular carcinoma.
AmediplaseInvestigated for use/treatment in myocardial infarction and thrombosis.
OcriplasminA proteolytic enzyme used to treat symptomatic vitreomacular adhesion by dissolving the protein matrix responsible for the adhesion between the vitreous and macula.
GlucarpidaseA carboxypeptidase enzyme used to reduce plasma concentrations of methotrexate in patients with impaired renal function.
BatroxobinNo approved indications. Batroxobin is a defibrongenating agent which has been observed to reduce fibrinogen levels and thus reduce clot risk when used intravenously.
PegloticaseA recombinant uricase used for the treatment of chronic gout in adult patients refractory to conventional therapy.
PapainA proteolytic enzyme derived from papaya used for its anti-inflammatory properties.
ThrombinA coagulation factor used to stop bleeding during surgery.
Rusalatide acetateChrysalin has been used in trials studying the treatment of Radius Fracture.
VonapanitaseVonapanitase is under investigation for the treatment of Chronic Kidney Disease.
Stem bromelainThe primary medical purpose for which stem bromelain (SB) is currently indicated for is the removal of eschar in adults with deep partial- and full-thickness thermal burns [FDA Label]. Besides...
Vatreptacog alfaVatreptacog Alfa (Activated) has been used in trials studying the treatment of Haemophilia B, Haemophilia A, Congenital Bleeding Disorder, Haemophilia A With Inhibitors, and Haemophilia B With Inhibitors.
MonteplaseMonteplase has been used in trials studying the treatment of Pulmonary Embolism.
PepsinA protease indicated in the treatment of digestive disorders.
Ferric pyrophosphate citrateA soluble iron compound used to maintain hemoglobin levels in patients undergoing hemodialysis.
Drotrecogin alfaA form of recombinant activated human protein C used to reduce mortality in patients with severe sepsis by inhibiting coagulation Factors V and VIII.
DesoxyribonucleaseDesoxyribonuclease is a crystalline enzyme that aids in the digestion of the thymus nucleic acid. The mechanism of action of the enzyme involves the splitting of thymus nucleic acid into...
Protein CA medication used to treat protein C deficiency leading to purpura fulminans or coumarin-induced skin necrosis.
Alpha-1-proteinase inhibitorA purified form of human alpha-1 proteinase inhibitor used to treat emphysema patients with associated alpha-1 proteinase inhibitor deficiency.
Andexanet alfaA recombinant Factor Xa used to reverse anticoagulation caused by rivaroxaban and apixaban.
SutilainSutilain was indicated, in the form of an ointment, as a biochemical debridement of second and third-degree burns, incisional traumatic and pyrogenic wounds and ulcers occurring due to peripheral vascular...
HyaluronidaseAn enzyme used to improve the absorption and dispersion of parenterally administered fluids, drugs, and contrast agents.
Vestronidase alfaA recombinant beta-glucuronidase used to treat mucopolysaccharidosis VII.
Velmanase alfaA recombinant human lysosomal alpha-mannosidase used to treat non-neurological symptoms of mild to moderate alpha-mannosidosis.
Cerliponase alfaAn enzyme replacement therapy used to treat neuronal ceroid lipofuscinosis type 2 (CLN2) disease, also known as tripeptidyl peptidase 1 (TPP1) deficiency.
NattokinaseNattokinase is under investigation in clinical trial NCT00749801 (Efficacy and Safety of Geneferm Nattokinase).
Thrombin alfaA platelet activating factor used to treat minor bleeding.
PegvaliaseAn enzyme used to treat phenylketonuria in patients with phenylalanine levels that are too high on current treatment.
Pancrelipase lipaseA lipase used to treat pancreatic exocrine insufficiency.
Hyaluronidase (human recombinant)An enzyme used to improve the absorption and dispersion of parenterally administered fluids, drugs, and contrast agents.
Talactoferrin alfaInvestigated for use/treatment in adverse effects (chemotherapy), cancer/tumors (unspecified), diabetic foot ulcers, lung cancer, solid tumors, and ulcers.
Agalsidase alfaA recombinant human alpha-galactosidase indicated to treat Fabry disease, a genetic deficiency in the enzyme leading to buildup of globotriaosylceramide.
Idursulfase betaIdursulfase beta is under investigation in clinical trial NCT01645189 (Safety and Efficacy of Hunterase).
LactoferrinLactoferrin is under investigation in clinical trial NCT03748043 (The Effectiveness of Lactoferrin in Treatment of Iron Deficiency Anemia in Children With Chronic Tonsillitis).
TyrosinaseTyrosinase is a multi-copper-containing multifunctional metalloenzyme with 4 possible oxidation states.[A231829, A231834, A231839] It is responsible for producing melanin pigment across the phylogenetic spectrum.[A231829, A231834, A231839] Within mammals, tyrosinase is...
Botulinum toxin type AA purified form of botulinum toxin type A used to block acetylcholine release in the treatment of chronic sialorrhea, muscle spasticity, and dystonia, as well as in cosmetic applications.
Pancrelipase proteaseA lipase used to treat pancreatic exocrine insufficiency.
ALTU-135Investigated for use/treatment in cystic fibrosis and pancreatic disorders.
Alkaline PhosphataseInvestigated for use/treatment in ulcerative colitis.
LatiglutenaseInvestigated for use/treatment in gastrointestinal diseases and disorders (miscellaneous) and autoimmune diseases such as celiac disease.
Pancrelipase amylaseA lipase used to treat pancreatic exocrine insufficiency.
AviscumineCy 503 is under investigation in clinical trial NCT00658437 (Aviscumine for the Treatment of Malignant Melanoma Stage IV After Failure of Prior Therapy).
SerrapeptaseA protease indicated in the treatment of post-surgical inflammation.
HemicellulaseNot Annotated
ExebacaseExebacase is under investigation in clinical trial NCT03163446 (Safety, Efficacy and Pharmacokinetics of CF-301 vs. Placebo in Addition to Antibacterial Therapy for Treatment of S. Aureus Bacteremia).
Denileukin diftitoxA recombinant cytotoxic protein based on a combination of diphtheria toxin fragments and interleukin-2 used to treat cutaneous T-cell lymphoma by targeting the interleukin-2 receptor.
Asparaginase Escherichia coliAn asparaginase enzyme from E. coli used as part of treatment regimens for acute lymphoblastic leukemias.
PegaspargaseA modified form of L-asparagine amidohydrolase used to treat acute lymphoblastic leukemia, which is dependent on an external source of asparagine.
PegademaseA modified form of bovine adenosine deaminase used to treat adenosine deaminase deficiency, a condition which leads to the formation of adenosine metabolites which are cytotoxic to lymphocytes.
Sitimagene ceradenovecIntended for the treatment of brain cancer.
RanpirnaseFor the treatment of various forms of cancer.
PEG-uricaseInvestigated for use/treatment in hyperuricemia.
Nelipepimut-SInvestigated for use/treatment in prostate cancer and breast cancer.
ButyrylcholinesteraseNot Available
DiaPep 277Investigated for use/treatment in diabetes mellitus type 1, autoimmune diseases, and diabetes mellitus type 2.
AfliberceptA vascular endothelial growth factor (VEGF) inhibitor used to treat Neovascular (Wet) Age-Related Macular Degeneration (AMD), various types of macular edema and diabetic retinopathy, and metastatic colorectal cancer
Asparaginase Erwinia chrysanthemiAn asparagine-specific enzyme used as part of a chemotherapeutic regimen to treat patients with acute lymphoblastic leukemia and lymphoblastic lymphoma.
Recombinant Cholera Toxin B SubunitRecombinant Cholera Toxin B Subunit is an ingredient in the EMA-authorised product Dukoral.
LuspaterceptAn erythroid maturation agent used to treat anemia secondary to beta thalassemia, myelodysplastic syndromes, and neoplasms.
Olipudase alfaA recombinant human acid sphingomyelinase used to treat Acid Sphingomyelinase Deficiency (ASMD) in children and adults.
Glucose oxidaseGlucose oxidase has been investigated for the treatment of Upper Respiratory Tract Infections.
Factor XIII (human)A purified form of Factor XIII that is used to prevent and treat surgical bleeding in patients with a Factor XIII deficiency.
LysozymeAn enzyme indicated in the treatment of gastrointestinal disorders in infants, as well as Herpes zoster and Herpes simplex.
ElapegademaseA recombinant adenosine deaminase used to treat adenosine deaminase severe combined immune deficiency.
Calaspargase pegolAn asparagine specific enzyme used to treat acute lymphoblastic leukemia.
Pegvorhyaluronidase alfaPegvorhyaluronidase alfa is under investigation in clinical trial NCT02241187 (Two Stage Study Of Single Dose PEGPH20 And Cetuximab In Patients With Pancreatic Adenocarcinoma Prior To Surgical Resection).
DalanterceptDalantercept is under investigation in clinical trial NCT00996957 (Study of ACE-041 in Patients With Advanced Solid Tumors or Relapsed/Refractory Multiple Myeloma).
Marzeptacog alfa (activated)Marzeptacog alfa (activated) is under investigation in clinical trial NCT01439971 (Phase 1 Safety, Pharmacokinetics And Pharmacodynamics Study Of Recombinant Factor VIIa Variant (813d) In Adult Subjects With Hemophilia).
Vocimagene amiretrorepvecVocimagene amiretrorepvec is under investigation in clinical trial NCT02576665 (A Study of Toca 511, a Retroviral Replicating Vector, Combined With Toca FC in Patients With Solid Tumors or Lymphoma (Toca...
Valanafusp alfaValanafusp alfa is under investigation in clinical trial NCT03071341 (Extension Study Evaluating Long Term Safety and Activity of AGT-181 in Children With MPS I).
Coagulation factor XIaCoagulation factor XIa is under investigation in clinical trial NCT01701947 (HEMOLEVEN® Expanded Access Program Prevention of Surgical/Postpartum Hemorrhage Severe Inherited Factor XI Deficiency).
ReloxaliaseReloxaliase is a crystalline formulation of oxalate decarboxylase derived from Bacillus Subtilis. Reloxaliase is under investigation in clinical trial NCT03456830 (Evaluate ALLN-177 in Patients With Enteric Hyperoxaluria).
Alunacedase alfaAlunacedase alfa is a recombinant and soluble glycosylated form of human ACE2. This recombinant version of the enzyme has antihypertensive and potential antineoplastic activities.
VEGFR2-169VEGFR2-169 is under investigation in clinical trial NCT00655785 (Antiangiogenic Peptide Vaccine Therapy With Gemcitabine in Treating Patient With Pancreatic Cancer (Phase1/2)).
Pegylated Recombinant Human Arginase IPegylated Recombinant Human Arginase I is under investigation in clinical trial NCT03455140 (A Study Evaluating the Safety and Activity of Pegylated Recombinant Human Arginase (BCT-100)).
RibaxamaseRibaxamase is under investigation in clinical trial NCT02563106 (A Study of SYN-004 for the Prevention of c.diff in Patients With a LRTI).
Deoxyribonuclease IDeoxyribonuclease I (DNase I) is a human enzyme responsible for the digestion of extracellular DNA7 . It is normally found in saliva, urine, pancreatic secretions, and blood . Because of...
Pegunigalsidase alfaA recombinant form of human ╬▒-galactosidase-A indicated for long-term enzyme replacement therapy in patients with Fabry disease.
Avalglucosidase alfaA lysosomal glycogen-specific enzyme that is used to treat patients one year of age and older with late-onset Pompe disease, or lysosomal acid alpha-glucosidase (GAA) deficiency.
Botulinum toxin type FNot Annotated
Glyceraldehyde-3-Phosphate DehydrogenaseNot Annotated
CBP-501Not Annotated
SOT-107Investigated for use/treatment in brain cancer.
TERT-572Not Available
AnacaulaseA mix of proteolytic enzymes indicated for eschar removal in adults with deep partial thickness and/or full-thickness thermal burns.
Red blood cell-encapsulated L-asparaginaseRed blood cell-encapsulated L-asparaginase is Asparaginase Escherichia coli encapsulated inside donor-derived red blood cells, which target cancer cells capable of altering asparagine and glutamine metabolism. It is being investigated in...
Atidarsagene autotemcelA gene therapy comprising autologous CD34+ enriched stem cells encoding the human arylsulfatase A (ARSA) gene used to treat metachromatic leukodystrophy (MLD).
PegzilarginasePegzilarginase is under investigation in clinical trial NCT02488044 (A Phase 1/2 Study of AEB1102 in Patients With Arginase I Deficiency).
Cipaglucosidase alfaA recombinant human acid alpha-glucosidase used to treat late-onset Pompe disease in adults.
Tralesinidase alfaTralesinidase alfa is a chimeric fusion protein comprised of recombinant human NAGLU and a modified human insulin-like growth factor 2. It is being investigated for the treatment of mucopolysaccharidosis type...
Apadamtase alfaA recombinant human ADAMTS13 for enzyme replacement therapy in patients with congenital thrombotic thrombocytopenic purpura.
DimericineNot Annotated
XMMME-001-RTANot Annotated
XomaZyme-791Not Annotated
AnanainNot Annotated
ComosainNot Annotated
Liprotamase lipaseNot Annotated
Microbial collagenaseNot Annotated
Pabinafusp alfaPabinafusp alfa is under investigation in clinical trial NCT03568175 (A Study of JR-141 in Patients With Mucopolysaccharidosis II).
Eladocagene exuparvovecA recombinant AAV2 vector containing the human aromatic L-amino acid decarboxylase (AADC) gene indicated for the treatment of AADC deficiency.
Drugs & Drug Targets
AlteplaseFibrinogen alpha chaintarget
AlteplasePlasminogen activator inhibitor 1target
AlteplaseFibrinogen gamma chaintarget
UrokinaseUrokinase plasminogen activator surface receptortarget
UrokinasePlasminogen activator inhibitor 2target
UrokinasePlasminogen activator inhibitor 1target
UrokinasePlasma serine protease inhibitortarget
UrokinaseLow-density lipoprotein receptor-related protein 2target
UrokinaseSuppressor of tumorigenicity 14 proteintarget
UrokinaseMacrophage metalloelastaseenzyme
AnistreplaseFibrinogen alpha chaintarget
AnistreplasePlasminogen activator inhibitor 1target
Collagenase clostridium histolyticumCollagen alpha-1(I) chaintarget
Collagenase clostridium histolyticumCollagen alpha-1(II) chaintarget
Collagenase clostridium histolyticumCollagen alpha-1(III) chaintarget
Hyaluronidase (ovine)Transforming growth factor beta-1target
Hyaluronidase (ovine)Serum albumincarrier
Hyaluronidase (ovine)Hyaluronantarget
StreptokinaseProteinase-activated receptor 1target
StreptokinaseCytosolic phospholipase A2enzyme
Agalsidase betaGlobotriaosylceramidetarget
Agalsidase betaCation-dependent mannose-6-phosphate receptortransporter
Alglucosidase alfaCation-dependent mannose-6-phosphate receptortarget
Alglucosidase alfaGlycogentarget
AncrodFibrinogen alpha chaintarget
ChymopapainBone marrow proteoglycantarget
ReteplaseFibrinogen alpha chaintarget
ReteplasePlasminogen activator inhibitor 1target
TenecteplaseUrokinase plasminogen activator surface receptortarget
TenecteplasePlasminogen activator inhibitor 1target
TenecteplaseFibrinogen alpha chaintarget
TenecteplasePlasminogen activator inhibitor 2target
TenecteplaseKeratin, type II cytoskeletal 8target
TenecteplaseAnnexin A2target
TenecteplaseProlow-density lipoprotein receptor-related protein 1target
IdursulfaseDermatan sulfatetarget
IdursulfaseHeparan sulfatetarget
GalsulfaseDermatan sulfatetarget
Taliglucerase alfaGlucocerebrosidetarget
Asfotase alfaPyrophosphatetarget
FibrinolysinPlasminogen activator inhibitor 1target
FibrinolysinUrokinase-type plasminogen activatortarget
Dornase alfaDNAtarget
RasburicaseUric acidtarget
LaronidaseIduronic acidtarget
Velaglucerase alfaGlucosylceramidasetarget
Coagulation factor VIIa Recombinant HumanCoagulation factor Xtarget
Coagulation factor VIIa Recombinant HumanTissue factortarget
Coagulation factor VIIa Recombinant HumanTissue factor pathway inhibitortarget
Coagulation factor VIIa Recombinant HumanVitamin K-dependent gamma-carboxylasetarget
Coagulation factor VIIa Recombinant HumanCoagulation factor VIItarget
Botulinum toxin type BVesicle-associated membrane protein 1target
Botulinum toxin type BVesicle-associated membrane protein 2target
Botulinum toxin type BSynaptotagmin-2target
PancrelipaseDietary fattarget
PancrelipaseDietary proteintarget
PancrelipaseDietary starchtarget
AlfimepraseFibrinogen alpha chaintarget
AlfimepraseFibrinogen beta chaintarget
LanoteplaseUrokinase plasminogen activator surface receptortarget
LanoteplaseFibrinogen alpha chaintarget
LanoteplaseLaminin subunit alpha-5target
LanoteplaseCoagulation factor Xtarget
LanoteplasePlasminogen activator inhibitor 2target
LanoteplaseKeratin, type II cytoskeletal 8target
LanoteplaseAnnexin A2target
LanoteplaseLaminin subunit beta-1target
LanoteplaseLaminin subunit gamma-1target
LanoteplaseLaminin subunit alpha-1target
LanoteplaseProlow-density lipoprotein receptor-related protein 1target
LanoteplaseLaminin subunit alpha-3target
PegloticaseUric acidtarget
PapainToll-like receptor 4target
ThrombinProteinase-activated receptor 1target
ThrombinProteinase-activated receptor 4target
ThrombinCoagulation factor XItarget
ThrombinCoagulation factor XIII A chaintarget
ThrombinCoagulation factor XIII B chaintarget
ThrombinFibrinogen alpha chaintarget
ThrombinFibrinogen beta chaintarget
ThrombinFibrinogen gamma chaintarget
ThrombinCoagulation factor Vtarget
ThrombinCoagulation factor VIIItarget
Ferric pyrophosphate citrateFerritin light chaintarget
Ferric pyrophosphate citrateFerritin heavy chaintarget
Ferric pyrophosphate citrateHemoglobin subunit alphatarget
Ferric pyrophosphate citrateHemoglobin subunit betatarget
Drotrecogin alfaCoagulation factor VIIItarget
Drotrecogin alfaCoagulation factor Vtarget
Drotrecogin alfaPlasminogen activator inhibitor 1target
Drotrecogin alfaThrombomodulintarget
Drotrecogin alfaVitamin K-dependent protein Starget
Drotrecogin alfaProthrombintarget
Drotrecogin alfaPlatelet factor 4target
Drotrecogin alfaPlasma serine protease inhibitortarget
Drotrecogin alfaSerpin B6target
Drotrecogin alfaEndothelial protein C receptortarget
Protein CCoagulation factor Vtarget
Protein CCoagulation factor VIIItarget
Alpha-1-proteinase inhibitorNeutrophil elastasetarget
Andexanet alfaTissue factor pathway inhibitortarget
HyaluronidaseHyaluronic acidtarget
HyaluronidaseTransforming growth factor beta-1target
Cerliponase alfaCation-independent mannose-6-phosphate receptortarget
Thrombin alfaCoagulation factor VIIItarget
Thrombin alfaCoagulation factor Vtarget
Thrombin alfaFibrinogen alpha chaintarget
Thrombin alfaFibrinogen beta chaintarget
Thrombin alfaFibrinogen gamma chaintarget
Pancrelipase lipaseDietary fattarget
Hyaluronidase (human recombinant)Hyaluronic acidtarget
Hyaluronidase (human recombinant)Transforming growth factor beta-1target
Agalsidase alfaCation-dependent mannose-6-phosphate receptortransporter
Agalsidase alfaGlobotriaosylceramidetarget
Botulinum toxin type ASynaptosomal-associated protein 25target
Botulinum toxin type ARho-related GTP-binding protein RhoBtarget
Botulinum toxin type ASerum albumincarrier
Pancrelipase proteaseDietary proteintarget
Pancrelipase amylaseDietary starchtarget
Denileukin diftitoxInterleukin-2 receptor subunit alphatarget
Denileukin diftitoxCytokine receptor common subunit gammatarget
Denileukin diftitoxInterleukin-2 receptor subunit betatarget
Asparaginase Escherichia coliL-asparaginetarget
Asparaginase Escherichia coliThyroxine-binding globulincarrier
PegaspargaseThyroxine-binding globulincarrier
PegademaseGrowth factor receptor-bound protein 2target
PEG-uricaseUric acid degradation bifunctional proteintarget
Nelipepimut-SHLA class I histocompatibility antigen, A-3 alpha chaintarget
AfliberceptVascular endothelial growth factor Atarget
AfliberceptPlacenta growth factortarget
AfliberceptVascular endothelial growth factor Btarget
Calaspargase pegolL-asparaginetarget
Pegunigalsidase alfaGlobotriaosylceramidetarget
Avalglucosidase alfaCation-independent mannose-6-phosphate receptortarget
SOT-107Glioma pathogenesis-related protein 1target
AnacaulaseCytochrome P450 2C8enzyme
AnacaulaseCytochrome P450 2C9enzyme
Atidarsagene autotemcelHuman Arylsulfatase A mRNAtarget
Cipaglucosidase alfaCation-independent mannose-6-phosphate receptortarget
Cipaglucosidase alfaAlpha glucosidase (GAA)target
Apadamtase alfavon Willebrand factortarget