Herpes Zoster (DBCOND0028191)

Identifiers

Synonyms

Herpes Zoster (HZ) / Herpes zoster / Zoster without complications / Acute posterior ganglionitis / Shingles / Zoster [herpes zoster] / Zona / Herpes zoster (disorder) / Herpes zoster NOS / Human alphaherpesvirus 3 (organism) / Herpesvirus 3, Human

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Acyclovir	A guanosine analog used to treat herpes simplex, varicella zoster, herpes zoster.	DNA polymerase catalytic subunittarget DNA polymerase catalytic subunittarget Solute carrier family 22 member 1transporter Solute carrier family 22 member 6transporter Organic anion transporter 3transporter Ileal sodium/bile acid cotransportertransporter Multidrug and toxin extrusion protein 1transporter Multidrug and toxin extrusion protein 2transporter Thymidine kinaseenzyme Guanylate kinaseenzyme Nucleoside diphosphokinaseenzyme Pyruvate Kinasesenzyme Creatine Kinasesenzyme Phosphoglycerate Kinasesenzyme Succinyl-CoA Synthetasesenzyme Phosphoenolpyruvate Carboxykinasesenzyme Adenylosuccinate Synthetasesenzyme Albumincarrier
Brivudine	A drug used to treat herpes zoster.	Thymidine kinase 2, mitochondrialtarget DNA polymerasetarget Thymidine kinasetarget Thymidine kinase, cytosolictarget
Econazole	A topical antifungal used to treat tinea pedis, tinea cruris, tinea corporis, cutaneous candidiasis and tinea versicolor.	Aromataseenzyme Cytochrome P450 2E1enzyme Cytochrome P450 3A4enzyme Lanosterol 14-alpha demethylasetarget Nuclear receptor subfamily 1 group I member 2target
Famciclovir	A nucleoside analog DNA polymerase inhibitor used for the treatment of recurrent cold sores and genital herpes in healthy patients and patients with HIV, and to manage herpes zoster.	DNA polymerase catalytic subunittarget Aldehyde oxidaseenzyme
Lysozyme	An enzyme indicated in the treatment of gastrointestinal disorders in infants, as well as Herpes zoster and Herpes simplex.	No drug targets
Ox bile extract	Not Annotated	No drug targets
Valaciclovir	An guanine nucleoside antiviral used to treat herpes exacerbations.	Thymidine kinasetarget DNA polymerase catalytic subunittarget Solute carrier family 15 member 1transporter Solute carrier family 15 member 2transporter Organic anion transporter 3transporter Solute carrier family 22 member 6transporter Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)transporter Ileal sodium/bile acid cotransportertransporter Guanylate kinaseenzyme Thymidine kinaseenzyme
Varicella zoster vaccine (live/attenuated)	Zostavax vaccine is indicated for the prevention of herpes zoster (shingles) in immunocompetent adults aged 50 years and older. Varivax vaccine is indicated for active immunization for the prevention of...	No drug targets
Varicella zoster vaccine (recombinant)	Varicella zoster vaccine is indicated for the prevention of herpes zoster (HZ) (shingles) in adults aged 50 years and older and in adults aged 18 years and older who are...	No drug targets

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT05871541	A First-in-Human Study to Evaluate JCXH-105, an SrRNA-based Herpes Zoster Vaccine	Varicella zoster vaccine (recombinant)	treatment	1	completed
NCT06581575	A Phase 2 Study to Evaluate JCXH-105, an SrRNA-based Herpes Zoster Vaccine	Varicella zoster vaccine (recombinant)	prevention	2	not_yet_recruiting
NCT04869982	Efficacy, Immunogenicity and Safety Study of GSKs Recombinant Zoster Vaccine Shingrix (GSK1437173A) in Chinese Adults Aged ≥50 Years	No drug interventions	prevention	4	completed
NCT05580458	Safety and Immunogenicity of Recombinant Varicella Zoster Virus Vaccine in People With HIV Who Have a CD4 Count Less Than 300 or Greater Than or Equal to 300 and a Healthy Control Population	Varicella zoster vaccine (recombinant)	prevention	1 / 2	recruiting
NCT06334861	Multidisciplinary Hospital-Territory Vaccine Center: a Model for Achieving the Herpes Zoster Vaccine Coverage	Human varicella-zoster immune globulin	Not Available	Not Available	completed
NCT06335849	A Safety and Immunogenicity Trial of the Recombinant Zoster Vaccine （CHO Cell）, LYB004 in Adults Aged 50 to 70 Years	Varicella zoster vaccine (recombinant)	prevention	1	recruiting
NCT05639803	A Clinical Trial of PEGIFNα1b in Chinese Healthy Adults	No drug interventions	treatment	1	completed
NCT00831103	A Phase 2b Trial of EPB-348 for the Treatment of Herpes Zoster	Valaciclovir Valomaciclovir Valomaciclovir stearate	treatment	2	completed
NCT01165203	Study to Evaluate GSK Biologicals' Herpes Zoster Vaccine GSK1437173A in Human Immunodeficiency Virus (HIV)-Infected Subjects	Human varicella-zoster immune globulin Varicella zoster vaccine (recombinant)	prevention	2	completed
NCT06344403	Clinical Efficacy and Safety of Tender Point Infiltration (TPI) for Acute and Subacute Zoster Associated Pain	No drug interventions	treatment	Not Available	recruiting
NCT00526864	Measuring Herpes Zoster and PHN Associated Burden of Illness and Health Care Utilization Costs in Thailand	No drug interventions	Not Available	Not Available	completed
NCT03809702	Efficacy of Pregabalin for the Treatment of Acute Herpetic Neuralgia	Pregabalin	treatment	4	completed
NCT05856084	Immunogenicity and Safety of Recombinant Herpes Zoster Vaccine (CHO Cells) in Healthy Subjects Aged 30 Years and Above	Human varicella-zoster immune globulin Varicella zoster vaccine (recombinant)	prevention	2	active_not_recruiting
NCT03016884	Safety and Tolerability of Herpes Zoster Vaccine Rheumatologic Patients	Human varicella-zoster immune globulin Varicella zoster vaccine (live/attenuated)	prevention	4	unknown_status
NCT00652184	Study to Compare Efficacy of Topical ARYS-01 (Sorivudine) Cream 3%, Oral Valaciclovir and Combination ARYS-01 Cream 3%/Oral Valaciclovir for Treatment of Herpes Zoster (Shingles)	Sorivudine Valaciclovir	treatment	2	unknown_status
NCT01600079	ZOSTAVAX™ (Zoster Vaccine Live) Long-term Effectiveness Study (V211-024)	Human varicella-zoster immune globulin Varicella zoster vaccine (live/attenuated)	Not Available	Not Available	completed
NCT06207487	Evaluation of Herpes Zoster Characteristics and Costs in Cancer Population.	No drug interventions	Not Available	Not Available	not_yet_recruiting
NCT01954251	Study to Evaluate the Immunogenicity and Safety of GlaxoSmithKline (GSK) Biologicals' Herpes Zoster Vaccine GSK1437173A When Co-administered With GSK Biologicals' Seasonal Influenza Vaccine GSK2321138A in Adults Aged 50 Years and Older	Human varicella-zoster immune globulin Influenza A virus A/Brisbane/59/2007 (H1N1) hemagglutinin antigen (formaldehyde inactivated) Influenza A virus A/Uruguay/716/2007(H3N2) hemagglutinin antigen (formaldehyde inactivated) Influenza B virus B/Brisbane/60/2008 hemagglutinin antigen (formaldehyde inactivated) Varicella zoster vaccine (recombinant)	prevention	3	completed
NCT01245751	Safety, Tolerability, and Immunogenicity of a Booster Dose of Zoster Vaccine, Live (V211-029)	Human varicella-zoster immune globulin Varicella zoster vaccine (live/attenuated)	prevention	3	completed
NCT04334577	Study on Efficacy of Attenuated Zoster Vaccine, Live	Human varicella-zoster immune globulin	prevention	3	completed
NCT01165177	Study to Evaluate Efficacy, Safety and Immunogenicity of GSK Biologicals' Herpes Zoster (HZ) Vaccine GSK1437173A in Adults Aged 50 Years and Older	Human varicella-zoster immune globulin Varicella zoster vaccine (recombinant)	prevention	3	completed
NCT00434577	Safety and Immunogenicity of the Zoster Vaccine GSK1437173A in Elderly Subjects	Human varicella-zoster immune globulin Varicella zoster vaccine (recombinant)	prevention	2	completed
NCT06088745	A Phase Ⅲ Clinical Study to Evaluate Protective Efficacy and Safety of a Recombinant Herpes Zoster Vaccine	Human varicella-zoster immune globulin	prevention	3	recruiting
NCT00550745	ZOSTAVAX™ Safety Study in Subjects ≥ 60 Years of Age (V211-020)	Human varicella-zoster immune globulin	prevention	4	completed
NCT04072497	A Clinical Study of a Zoster Vaccine in Healthy Adults >= 40 Years	Human varicella-zoster immune globulin Varicella zoster vaccine (live/attenuated)	prevention	1 / 2	completed
NCT00900783	A Study of FV-100 Versus Valacyclovir in Patients With Herpes Zoster	Valaciclovir	treatment	2	completed
NCT03563183	A Study to Assess Frailty of Subjects During ZOSTER-006 and ZOSTER-022	No drug interventions	Not Available	Not Available	completed
NCT05952271	Herpes Zoster Hospitalizations in Italy	No drug interventions	Not Available	Not Available	recruiting
NCT01483378	Increasing Use of the Vaccine Against Herpes Zoster/Shingles at NYULMC and Bellevue Hospital	No drug interventions	health_services_research	Not Available	completed
NCT05082688	Age Differences in Influenza and Herpes Zoster Vaccine Responses (INFLUENZA-SHINGRIX)	Human varicella-zoster immune globulin Influenza A virus A/Brisbane/02/2018 IVR-190 (H1N1) antigen (formaldehyde inactivated) Influenza A virus A/South Australia/34/2019 IVR-197 (H3N2) antigen (formaldehyde inactivated) Influenza B virus B/Phuket/3073/2013 live (attenuated) antigen Influenza B virus B/Washington/02/2019 recombinant hemagglutinin antigen Varicella zoster vaccine (recombinant)	basic_science	2	completed
NCT01798056	Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Herpes Zoster (HZ/su) Vaccine in Adults With Solid Tumours Receiving Chemotherapy	Human varicella-zoster immune globulin Varicella zoster vaccine (recombinant)	prevention	3	completed
NCT00642785	Activation of Alternative Cellular Energy (ACE) Pathway in the Therapy of Herpes Virus Infections	No drug interventions	Not Available	Not Available	completed
NCT02735915	Study to Evaluate Immunogenicity and Safety of GSK Biologicals' Herpes Zoster Subunit (HZ/su) Vaccine at 9 and 10 Years After Vaccine Administration and Assessment of Re-vaccination With 2 Additional Doses at 10 Years After Initial Vaccination, in Healthy Subjects Aged 60 Years of Age(YOA) and Older	Human varicella-zoster immune globulin Varicella zoster vaccine (recombinant)	prevention	3	completed
NCT02152800	A Study of Vacyless® Versus Valtrex® in Patients With Herpes Zoster	Valaciclovir	treatment	4	completed
NCT05701800	A Study to Evaluate the Safety, Reactogenicity, and Immunogenicity of mRNA-1468 in Healthy Adults ≥50 Years of Age	Varicella zoster vaccine (recombinant)	prevention	1 / 2	recruiting
NCT05047770	A Study on the Immune Response and Safety of the Shingles Vaccine and the Influenza Vaccine When Either is Given to Healthy Adults at the Same Time or Following a COVID-19 Booster Vaccine	Moderna COVID-19 Vaccine	prevention	3	completed
NCT00921999	Immune Response to Varicella-Zoster Vaccination and Infection	No drug interventions	Not Available	Not Available	completed
NCT04099706	Treatment of Chronic Postherpetic Pain With Autologous Fat Grafting - A RCT	No drug interventions	treatment	Not Available	completed
NCT01086449	Safety and Immunogenicity of GSK Biologicals' Herpes Zoster Vaccine 1437173A in Healthy Ethnic Japanese Adults	Human varicella-zoster immune globulin Varicella zoster vaccine (recombinant)	prevention	1	completed
NCT05769049	The Safety and Immunogenicity Study of the Recombinant Zoster Vaccine (CHO Cell)	Human varicella-zoster immune globulin Varicella zoster vaccine (recombinant)	prevention	1	completed
NCT02045836	Study to Evaluate Immunogenicity and Safety Study of GSK Biologicals' Herpes Zoster (HZ) Vaccine GSK1437173A When Co-administered With Pneumovax 23™ in Adults Aged 50 Years and Older	Human varicella-zoster immune globulin Streptococcus pneumoniae type 1 capsular polysaccharide antigen Streptococcus pneumoniae type 10a capsular polysaccharide antigen Streptococcus pneumoniae type 11a capsular polysaccharide antigen Streptococcus pneumoniae type 12f capsular polysaccharide antigen Streptococcus pneumoniae type 14 capsular polysaccharide antigen Streptococcus pneumoniae type 15b capsular polysaccharide antigen Streptococcus pneumoniae type 17f capsular polysaccharide antigen Streptococcus pneumoniae type 18c capsular polysaccharide antigen Streptococcus pneumoniae type 19a capsular polysaccharide antigen Streptococcus pneumoniae type 19f capsular polysaccharide antigen Streptococcus pneumoniae type 2 capsular polysaccharide antigen Streptococcus pneumoniae type 20 capsular polysaccharide antigen Streptococcus pneumoniae type 22F capsular polysaccharide diphtheria CRM197 protein conjugate antigen Streptococcus pneumoniae type 22f capsular polysaccharide antigen Streptococcus pneumoniae type 23f capsular polysaccharide antigen Streptococcus pneumoniae type 3 capsular polysaccharide antigen Streptococcus pneumoniae type 3 capsular polysaccharide diphtheria CRM197 protein conjugate antigen Streptococcus pneumoniae type 33F capsular polysaccharide diphtheria CRM197 protein conjugate antigen Streptococcus pneumoniae type 33f capsular polysaccharide antigen Streptococcus pneumoniae type 4 capsular polysaccharide antigen Streptococcus pneumoniae type 5 capsular polysaccharide antigen Streptococcus pneumoniae type 6b capsular polysaccharide antigen Streptococcus pneumoniae type 7f capsular polysaccharide antigen Streptococcus pneumoniae type 8 capsular polysaccharide antigen Streptococcus pneumoniae type 9n capsular polysaccharide antigen Streptococcus pneumoniae type 9v capsular polysaccharide antigen Varicella zoster vaccine (recombinant)	prevention	3	completed
NCT00886613	A Study to Evaluate Immunity to Varicella Zoster Virus After Immunization With V212 Vaccine or Zostavax (V212-003)	Human varicella-zoster immune globulin Varicella zoster vaccine (live/attenuated)	prevention	1	completed
NCT00689013	The Effect of Pharmacist Intervention on the Use of Zostavax in a Community Pharmacy Setting	No drug interventions	prevention	Not Available	completed
NCT03192319	Optimal Timing of Zoster Vaccine After Hematopoietic Stem Cell Transplantation	Varicella zoster vaccine (live/attenuated)	prevention	Not Available	completed
NCT00546819	ZOSTAVAX™ in Patients on Chronic/Maintenance Corticosteroids (V211-017) (COMPLETED)	Human varicella-zoster immune globulin Varicella zoster vaccine (live/attenuated)	prevention	2	completed
NCT02412917	A Comparative Study of FV-100 vs. Valacyclovir for the Prevention of Post-Herpetic Neuralgia	Valaciclovir	prevention	3	terminated
NCT02052596	Study to Assess the Immunogenicity and Safety of GlaxoSmithKline (GSK) Biologicals' Herpes Zoster Subunit (HZ/su) Vaccine (GSK1437173A) When Co-administered With GSK Biologicals' Diphtheria, Tetanus and Pertussis Vaccine (Boostrix®) in Adults Aged 50 Years and Older	Bordetella pertussis filamentous hemagglutinin antigen (formaldehyde inactivated) Bordetella pertussis pertactin antigen (formaldehyde inactivated) Bordetella pertussis toxoid antigen (formaldehyde, glutaraldehyde inactivated) Clostridium tetani toxoid antigen (formaldehyde inactivated) Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) Human varicella-zoster immune globulin Varicella zoster vaccine (recombinant)	prevention	3	completed
NCT04774458	Prospective Observation of the Fluoroscopy-guided Cervical Epidural Approach Using the Contralateral Oblique View	No drug interventions	treatment	Not Available	completed
NCT00885586	Acupuncture in Herpes Zoster Neuralgia (ACUZoster)	Gabapentin	treatment	4	completed
NCT01521286	Study to Estimate the Burden of Herpes Zoster and Postherpetic Neuralgia in Spain	No drug interventions	Not Available	Not Available	completed
NCT00851786	Live Zoster Vaccine in HIV-Infected Adults on Antiretroviral Therapy	Varicella zoster vaccine (live/attenuated)	prevention	2	completed
NCT04176939	A Study to Test GlaxoSmithKline's (GSK) Herpes Zoster (HZ) Subunit Vaccine's Long-term Immune Response in Previously Vaccinated Kidney Transplant Adults and Then to Test if 2 Additional Doses of the Vaccine Are Safe and Able to Generate an Immune Response	Varicella zoster vaccine (recombinant)	prevention	3	active_not_recruiting
NCT02979639	Study to Evaluate the Impact of Reactogenicity on Quality of Life (QoL), After Administration of GlaxoSmithKline (GSK) Biologicals' Candidate Herpes Zoster Subunit (HZ/su) Vaccine (GSK1437173A) in Adults ≥ 50 Years of Age	Human varicella-zoster immune globulin Varicella zoster vaccine (recombinant)	prevention	3	completed
NCT02902822	Tele-dermatology of Skin Cancer in a Cohort of Local Health Authority Employees in the Province of Bergamo	No drug interventions	diagnostic	Not Available	completed
NCT00300222	Study of NGX-4010 for the Treatment of Postherpetic Neuralgia	Capsaicin	treatment	3	completed
NCT01601925	Distances From Cricoid Cartilage to the Targets of Stellate Ganglion Block	No drug interventions	treatment	Not Available	unknown_status
NCT00492648	Month 30 & 42 Extension Studies of CRD-004 Primary Study	No drug interventions	prevention	2	completed
NCT03239665	Vaccination Education Through Pharmacists and Senior Centers (VEPSC)	No drug interventions	prevention	Not Available	completed
NCT01751165	Safety and Immunogenicity of Different Dosing Schedules of GlaxoSmithkline (GSK) Biologicals' Herpes Zoster (HZ) Vaccine in Adults 50 Years of Age or Older	Human varicella-zoster immune globulin Varicella zoster vaccine (recombinant)	prevention	3	completed
NCT01295320	Study of Long Term Immune Responses and Safety of the GSK Herpes Zoster Vaccine in Healthy Subjects	No drug interventions	prevention	2	completed
NCT00487682	Dose-finding Study of ASP2151 in Subjects With Herpes Zoster	Amenamevir Valaciclovir	treatment	2	completed
NCT00322231	A Study of an Investigational Zoster Vaccine, in Subjects With a History of Herpes Zoster (V211-014)	Human varicella-zoster immune globulin Varicella zoster vaccine (live/attenuated)	prevention	3	completed
NCT02723773	A Long-term Follow-up Study (ZOE-LTFU) of Two Studies 110390 (ZOSTER-006) and 113077 (ZOSTER-022) to Assess the Efficacy, Safety, and Immunogenicity Persistence of GSK Biologicals' Herpes Zoster Subunit (HZ/su) Vaccine and Assessment of 1 or 2 Additional Doses in Two Subgroups of Older Adults	Human varicella-zoster immune globulin Varicella zoster vaccine (recombinant)	prevention	3	completed
NCT05991427	A Study to Evaluate the Safety and Immunogenicity of ChAdOx1-VZV in Healthy Adults Aged 50-65 Years	Human varicella-zoster immune globulin Varicella zoster vaccine (recombinant)	prevention	1	recruiting
NCT02852876	Study to Evaluate the Safety and Pharmacokinetics of Single Doses of ASP2151 in Healthy Male Subjects and the Effects of Food	Amenamevir	basic_science	1	completed
NCT06409494	Clinical Trial to Evaluate EuHZV in Healthy Adults Aged 50 to 69 Years	Varicella zoster vaccine (recombinant)	prevention	1	recruiting
NCT03798691	Immunogenicity of Herpes Zoster Subunit Vaccine in Inflammatory Bowel Disease Patients Treated With Vedolizumab	Human varicella-zoster immune globulin Varicella zoster vaccine (recombinant)	basic_science	4	active_not_recruiting
NCT05371080	A Study on the Long-term Efficacy, Safety and Persistence of Immune Response of a Vaccine Against Herpes Zoster in Older Adults	No drug interventions	prevention	3	active_not_recruiting
NCT01165229	Study to Evaluate Efficacy, Safety and Immunogenicity of GlaxoSmithKline (GSK) Biologicals' Herpes Zoster (HZ) Vaccine GSK1437173A in Adults Aged 70 Years and Older	Human varicella-zoster immune globulin Varicella zoster vaccine (recombinant)	prevention	3	completed
NCT02058589	Immunogenicity and Safety of GlaxoSmithKline (GSK) Biologicals' Herpes Zoster Subunit (HZ/su) Vaccine in Adults 18 Years of Age or Older With Renal Transplant	Human varicella-zoster immune globulin Varicella zoster vaccine (recombinant)	prevention	3	completed
NCT01327144	Efficacy of Oral Famciclovir Versus Aciclovir Treatment in Patients With Herpes Zoster	Acyclovir Famciclovir	treatment	3	completed
NCT01767467	Study to Assess the Safety and Immunogenicity of GlaxoSmithKline (GSK) Biologicals' Herpes Zoster Subunit (HZ/su) Vaccine in Adults Aged 18 Years and Older With Blood Cancers	Human varicella-zoster immune globulin Varicella zoster vaccine (recombinant)	prevention	3	completed
NCT00007501	Shingles Prevention Study	Human varicella-zoster immune globulin Varicella zoster vaccine (live/attenuated)	prevention	3	completed
NCT01137669	ZOSTAVAX® in Renal Transplant Patients	Human varicella-zoster immune globulin Varicella zoster vaccine (live/attenuated)	prevention	1	completed
NCT01391546	Immunogenicity and Safety Study of ZOSTAVAX Administered by Intramuscular or Subcutaneous Route to Participants Aged From 50 Years Old (V211-045)	Varicella zoster vaccine (live/attenuated)	prevention	3	completed
NCT04523246	Training the Innate Immune System Against SARS-CoV-2 (COVID-19) Using the Shingrix Vaccine in Nursing Home Residents	Human varicella-zoster immune globulin Varicella zoster vaccine (recombinant)	basic_science	0	completed
NCT00115310	Study of NGX-4010 for the Treatment of Postherpetic Neuralgia	Capsaicin	treatment	3	completed
NCT01213810	Prevention of Varicella Zoster Virus (VZV)-Reactivation in HIV-positive Individuals Enrolled in a Prospective Immunogenicity and Safety Trial of VZV Vaccine: PROVE-IT-Study	Varicella zoster vaccine (live/attenuated)	prevention	1 / 2	withdrawn
NCT00068081	Controlled Study of NGX-4010 for the Treatment of Postherpetic Neuralgia	Capsaicin	treatment	3	completed
NCT02180295	A Lot-to-Lot Consistency Study to Evaluate Safety, Tolerability, and Immunogenicity of Inactivated Varicella Zoster Virus (VZV) Vaccine in Healthy Adults (V212-014)	No drug interventions	prevention	3	withdrawn
NCT01610414	Study to Evaluate Efficacy, Safety, and Immunogenicity of GlaxoSmithKline (GSK) Biologicals' Herpes Zoster Vaccine GSK1437173A	Human varicella-zoster immune globulin Varicella zoster vaccine (recombinant)	prevention	3	completed
NCT00492323	An Effectiveness and Safety Study With RWJ-333369 (Carisbamate) for the Study of Postherpetic Neuralgia (PHN).	Carisbamate	treatment	2	completed
NCT04006808	A Study to Test GlaxoSmithKline's (GSK) Candidate Vaccine-GSK1437173A for Prevention of Shingles in Children With Kidney Transplant	No drug interventions	prevention	2	recruiting
NCT03314103	Efficacy Trial of a Vaccine to Prevent Herpes Zoster in Adults Over 40 Years of Age	No drug interventions	prevention	3	completed
NCT00004390	Phase III Randomized Controlled Study of Morphine and Nortriptyline in the Management of Postherpetic Neuralgia	Desipramine Methadone Morphine Nortriptyline	treatment	3	completed
NCT00802464	Immunogenicity and Safety Study of GSK Biologicals' Herpes Zoster Vaccine With Various Formulations in Adults >= 50 Years	Human varicella-zoster immune globulin Varicella zoster vaccine (recombinant)	prevention	2	completed
NCT03120364	Immunogenicity and Safety of NBP608 Compared to Zostavax in Healthy Adult Aged 50 and Over	Varicella zoster vaccine (live/attenuated)	prevention	3	completed
NCT01777321	Safety and Immunogenicity Study of GSK Biologicals' Herpes Zoster Subunit (HZ/su) Vaccine GSK1437173A When Administered Subcutaneously Intramuscularly in Adults Aged ≥50 Years	Human varicella-zoster immune globulin Varicella zoster vaccine (recombinant)	prevention	3	completed
NCT04239521	The Epidemiology, Management, and the Associated Burden of Related Conditions in Alopecia Areata	No drug interventions	Not Available	Not Available	completed
NCT06447779	Efficacy, Safety and Immunogenicity Study of Recombinant Zoster Vaccine(CHO Cell) in Adults Aged 40 Years and Older	Human varicella-zoster immune globulin	prevention	3	not_yet_recruiting
NCT02114333	Comparison of a Live Herpes Zoster Vaccine and a Recombinant Vaccine in 50-59 and 70-85 Year Olds	Varicella zoster vaccine (live/attenuated)	basic_science	1	completed
NCT05811754	Safety of Herpes Zoster Subunit (HZ/su) Vaccine During Pregnancy in Adult Women With Immunocompromised Conditions	No drug interventions	Not Available	Not Available	not_yet_recruiting
NCT01556451	ZOSTAVAX™ Safety and Immunogenicity in Korean Adults (V211-034)	Human varicella-zoster immune globulin Varicella zoster vaccine (live/attenuated)	prevention	4	completed
NCT00352651	Study to Find Out if Therapy With the Drug Pregabalin Relieves Pain During Shingles Compared With Placebo	Pregabalin	treatment	2	terminated
NCT05304351	Safety and Immunogenicity of CRV-101 Vaccine for the Prevention of Herpes Zoster in Adults Aged 50 Years and Older	Varicella zoster vaccine (recombinant)	prevention	2	active_not_recruiting
NCT04091451	A Study to Evaluate the Safety and Immunogenicity of GlaxoSmithKline's Herpes Zoster Subunit Vaccine (HZ/su) When Given on a Two-dose Schedule to Adults at Least 50 Years of Age (YOA) Who Had Prior Episode of Shingles	Human varicella-zoster immune globulin Varicella zoster vaccine (recombinant)	prevention	3	active_not_recruiting
NCT05219253	A Study on the Immune Response and Safety of a Vaccine Against Herpes Zoster in Adults Aged 50 Years and Older in India	No drug interventions	prevention	3	completed
NCT01505647	Safety and Immunogenicity of Zoster Vaccine (ZOSTAVAX™) Made With an Alternative Manufacturing Process (AMP) (V211-042 AM1)	Human varicella-zoster immune globulin Varicella zoster vaccine (live/attenuated)	prevention	3	completed
NCT03178747	Tzanck Smear With Methylene Blue Stain for Herpes	No drug interventions	diagnostic	3	unknown_status
NCT06449547	Risk Factors of Anxiety and Depression in Patients With Herpes Zoster Neuralgia	No drug interventions	Not Available	Not Available	recruiting
NCT02958345	Placebo Controlled Evaluation of the Cell Mediated Immune Response of Cirrhotic Subjects to Zostavax™	Human varicella-zoster immune globulin Varicella zoster vaccine (live/attenuated)	prevention	4	completed
NCT02526745	Safety and Immunogenicity Study of Live Attenuated Vaccine Against Herpes Zoster in Chinese Adults Aged 50 Years and Older	No drug interventions	prevention	1 / 2	completed
NCT01527383	A Study to Evaluate the Safety and Immunogenicity of Inactivated Varicella Zoster Virus (VZV) Vaccine in Adults With Autoimmune Disease (V212-009)	Human varicella-zoster immune globulin Varicella zoster vaccine (live/attenuated)	prevention	2	completed
NCT01250561	Reduction of Postherpetic Neuralgia in Herpes Zoster	Gabapentin Valaciclovir	treatment	Not Available	completed
NCT03584061	Treatment of Chronic Postherpetic Pain With Fat Grafting	No drug interventions	treatment	Not Available	completed
NCT05225493	HIV Indicator Diseases in Hospital and Primary Care	No drug interventions	Not Available	Not Available	unknown_status
NCT00130793	A Study to Evaluate Safety, Tolerability, and Immunogenicity of an Investigational Zoster Vaccine In Subjects With a History of Varicella (Chickenpox)(V211-010)(COMPLETED)	Human varicella-zoster immune globulin	prevention	3	completed
NCT02690207	Cross-vaccination Study of GSK Biologicals' Herpes Zoster Subunit (HZ/su) Vaccine (GSK 1437173A) in Subjects Who Previously Received Placebo in ZOSTER-006 (NCT01165177) and ZOSTER-022 (NCT01165229) Studies.	Human varicella-zoster immune globulin Varicella zoster vaccine (recombinant)	prevention	3	completed
NCT00696709	A Study to Test the Safety and Antibody Response of V212 in Healthy Adults (V212-004)(COMPLETED)	No drug interventions	prevention	1	completed
NCT04169009	Persistence of Protection by Shingrix	Varicella zoster vaccine (live/attenuated) Varicella zoster vaccine (recombinant)	basic_science	1	completed
NCT00118885	Shingles: Immune Effects of Tai Chi	No drug interventions	treatment	2	completed
NCT02075515	Consistency, Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Herpes Zoster (HZ) Vaccine GSK1437173A in Adults ≥ 50 Years of Age	Human varicella-zoster immune globulin Varicella zoster vaccine (recombinant)	prevention	3	completed
NCT05718037	Phase I Clinical Trial of a Candidate Herpes Zoster Vaccine	Human varicella-zoster immune globulin Varicella zoster vaccine (recombinant)	prevention	1	not_yet_recruiting
NCT03903237	Herpes Zoster: Risk Factors, Complications and Special Situations	No drug interventions	Not Available	Not Available	completed
NCT00501670	VZV PCR Sampling Validation Study	No drug interventions	Not Available	Not Available	completed
NCT02615470	Enhancing a Sustainable Pharmacy-based Immunization Program in Two States	No drug interventions	health_services_research	Not Available	completed
NCT01527370	Safety, Tolerability, and Immunogenicity of Zoster Vaccine Live (ZOSTAVAX™) in Healthy Adults in India (V211-025)	Human varicella-zoster immune globulin Varicella zoster vaccine (live/attenuated)	prevention	3	completed
NCT03604406	The Immunogenicity and Safety of Zostavax® and Shingrix® in Rheumatoid Arthritis Patients Using Abatacept	Human varicella-zoster immune globulin Varicella zoster vaccine (live/attenuated) Varicella zoster vaccine (recombinant)	prevention	2	active_not_recruiting
NCT05636436	Safety and Immunogenicity of Recombinant Herpes Zoster Vaccine (CHO Cells) in Healthy Subjects Aged 18 Years and Above	Human varicella-zoster immune globulin Varicella zoster vaccine (recombinant)	prevention	1	active_not_recruiting
NCT00535236	A Study of an Investigational V212/Heat-Treated Varicella-Zoster Virus (VZV) Vaccine in Immunocompromised Adults (V212-002)	No drug interventions	prevention	1	completed
NCT05806918	Non-inferiority Study of ZK-A03 in Treatment of Herpes Zoster Before and After the Alteration of the Active Ingredient Manufacturer	Interferon alfa-2b	treatment	3	not_yet_recruiting
NCT00920218	Safety & Immunogenicity of GlaxoSmithKline Biologicals' Herpes Zoster Vaccine 1437173A	Human varicella-zoster immune globulin	prevention	2	completed
NCT01460719	A Study to Evaluate the Safety and Immunogenicity of Inactivated Varicella-Zoster Virus (VZV) Vaccine in Adults With Hematologic Malignancies (HM) Receiving Treatment With Anti-Cluster of Differentiation (CD) 20 Monoclonal Antibodies (V212-013)	Human varicella-zoster immune globulin Varicella zoster vaccine (live/attenuated)	prevention	1	completed
NCT01959841	Phase III Study of ASP2151 in Herpes Zoster Patients	Amenamevir Valaciclovir	treatment	3	completed
NCT05750017	A Study to Evaluate Safety and Tolerability of a Recombinant Herpes Zoster Vaccine	Human varicella-zoster immune globulin	prevention	1	recruiting
NCT00921934	Intravenous Vitamin C in the Treatment of Viral Infection, Especially in the Treatment of Shingles	No drug interventions	Not Available	Not Available	completed
NCT01132716	Bioequivalency Study of Valacyclovir Hydrochloride 1000 mg Under Fed Conditions	Valaciclovir	treatment	Not Available	completed
NCT00231816	A Study of an Investigational Zoster Vaccine in Subjects With a History of Varicella (Chickenpox) Given Concomitantly With Another Vaccine (V211-011)	Haemagglutinin-strain A(H1N1) Haemagglutinin-strain A(H3N2) Haemagglutinin-strain B Influenza A virus A/California/7/2009 X-179A (H1N1) antigen (formaldehyde inactivated) Influenza A virus A/Victoria/210/2009 X-187 (H3N2) antigen (formaldehyde inactivated) Influenza B virus B/Brisbane/60/2008 antigen (formaldehyde inactivated) Varicella zoster vaccine (live/attenuated)	prevention	3	completed
NCT00082316	Tolerability of Three Local Anesthetic Formulations in Conjunction With NGX-4010 for the Treatment of Neuropathic Pain	Capsaicin	treatment	2	completed
NCT02832986	Herpes Zoster Prevalence in Frailty Consultations	No drug interventions	Not Available	Not Available	completed
NCT04748939	Shingrix in Patients With Rheumatic Diseases: a Double-blind Placebo-controlled RCT	Human varicella-zoster immune globulin Varicella zoster vaccine (recombinant)	prevention	4	not_yet_recruiting
NCT01827839	Immunogenicity and Safety of GlaxoSmithKline (GSK) Biologicals' Herpes Zoster Subunit (HZ/su) Vaccine GSK1437173A in Adults With a Prior Episode of Herpes Zoster	Human varicella-zoster immune globulin Varicella zoster vaccine (recombinant)	prevention	3	completed
NCT04258930	Occlusion vs Standard Treatment for the Treatment of Herpes Zoster	No drug interventions	treatment	Not Available	unknown_status
NCT00535730	ZOSTAVAX™ Administered Concomitantly With PNEUMOVAX™ 23 (V211-012)(COMPLETED)	Human varicella-zoster immune globulin Streptococcus pneumoniae type 1 capsular polysaccharide antigen Streptococcus pneumoniae type 10a capsular polysaccharide antigen Streptococcus pneumoniae type 11a capsular polysaccharide antigen Streptococcus pneumoniae type 12f capsular polysaccharide antigen Streptococcus pneumoniae type 14 capsular polysaccharide antigen Streptococcus pneumoniae type 15b capsular polysaccharide antigen Streptococcus pneumoniae type 17f capsular polysaccharide antigen Streptococcus pneumoniae type 18c capsular polysaccharide antigen Streptococcus pneumoniae type 19a capsular polysaccharide antigen Streptococcus pneumoniae type 19f capsular polysaccharide antigen Streptococcus pneumoniae type 2 capsular polysaccharide antigen Streptococcus pneumoniae type 20 capsular polysaccharide antigen Streptococcus pneumoniae type 22f capsular polysaccharide antigen Streptococcus pneumoniae type 23f capsular polysaccharide antigen Streptococcus pneumoniae type 3 capsular polysaccharide antigen Streptococcus pneumoniae type 33f capsular polysaccharide antigen Streptococcus pneumoniae type 4 capsular polysaccharide antigen Streptococcus pneumoniae type 5 capsular polysaccharide antigen Streptococcus pneumoniae type 6b capsular polysaccharide antigen Streptococcus pneumoniae type 7f capsular polysaccharide antigen Streptococcus pneumoniae type 8 capsular polysaccharide antigen Streptococcus pneumoniae type 9n capsular polysaccharide antigen Streptococcus pneumoniae type 9v capsular polysaccharide antigen Varicella zoster vaccine (live/attenuated)	prevention	3	completed
NCT01254630	A Study to Evaluate the Safety and Efficacy of Inactivated Varicella-zoster Vaccine (VZV) as a Preventative Treatment for Herpes Zoster (HZ) and HZ-related Complications in Adult Participants With Solid Tumor or Hematologic Malignancy (V212-011)	Human varicella-zoster immune globulin Varicella zoster vaccine (live/attenuated)	prevention	3	completed
NCT03439657	Immunogenicity and Safety Study of GSK Biologicals' Herpes Zoster Vaccine GSK1437173A When Co-administered With Prevenar13 in Adults Aged 50 Years and Older	Varicella zoster vaccine (recombinant)	prevention	3	completed
NCT00089557	An Open-Label Extension Study of NGX-4010 for the Treatment of Neuropathic Pain	Capsaicin	treatment	2	terminated
NCT01385566	A Study of Intradermal Administration of ZOSTAVAX™ (V211-051 AM2)	Human varicella-zoster immune globulin Varicella zoster vaccine (live/attenuated)	prevention	1	completed
NCT01873365	A Study to Assess the Burden of Herpes Zoster and Postherpetic Neuralgia in Japanese Adults Aged Sixty Years and Above	No drug interventions	Not Available	Not Available	completed
NCT01911065	T Cell Responses to Varicella Zoster Virus (VZV) Vaccine SLVP020	Human varicella-zoster immune globulin Varicella zoster vaccine (live/attenuated)	prevention	4	completed
NCT01573182	Herpes Zoster Vaccine for Bone Marrow Transplant Donors	Varicella zoster vaccine (live/attenuated)	prevention	2	completed
NCT05348382	The Efficacy and Safety of Intradermal Acupuncture for Acute Herpes Zoster	No drug interventions	treatment	Not Available	recruiting
NCT00006131	Randomized Study of Two Doses of Oral Valacyclovir in Immunocompromised Patients With Uncomplicated Herpes Zoster	Valaciclovir	treatment	Not Available	completed
NCT00681031	Zostavax® at Minimum Release Specification Approaching Expiry (V211-044)	Varicella zoster vaccine (live/attenuated)	prevention	4	completed
NCT00061776	NGX-4010 for the Treatment of Postherpetic Neuralgia	Capsaicin	treatment	2 / 3	completed
NCT01772160	Study to Estimate the Burden of Herpes Zoster (HZ) and Post-herpetic Neuralgia (PHN) in Italy	No drug interventions	Not Available	Not Available	completed
NCT03116594	Immunogenicity and Safety of Two Lots of NBP608 Compared to Zostavax in Healthy Adult Aged 50 and Over	Varicella zoster vaccine (live/attenuated)	prevention	2 / 3	completed
NCT05492591	A Study Exploring Efficacy of Peginterferon in Patients With Herpes Zoster	Valaciclovir	treatment	2	completed
NCT03120962	Effect of Early Use of Oxycodone During the Acute Phase of Herpes Zoster on Preventing Postherpetic Neuralgia	Famciclovir Gabapentin Oxycodone	treatment	Not Available	unknown_status
NCT01132729	Bioequivalency Study of Valacyclovir Hydrochloride 1000 mg Under Fasting Conditions	Valaciclovir	treatment	Not Available	completed
NCT00001344	Dextromethorphan Versus Placebo for Neuropathic Pain	Dextromethorphan	treatment	2	completed
NCT02151240	Efficacy and Safety of Foscarnet Sodium and Sodium Chloride Injection in Patients With Herpes Zoster	Acyclovir Foscarnet	treatment	4	completed
NCT01229267	A Study to Evaluate the Safety and Efficacy of Inactivated Varicella-zoster Vaccine (VZV) as a Preventative Treatment for Herpes Zoster (HZ) and HZ-related Complications in Participants Undergoing Hematopoietic Cell Transplants (HCTs) (V212-001)	Human varicella-zoster immune globulin Varicella zoster vaccine (live/attenuated)	prevention	3	completed
NCT01077804	A Study to Evaluate Long-term Impact of VARIVAX Among Children and Adolescents (V210-036)(COMPLETED)	No drug interventions	Not Available	Not Available	completed
NCT02487472	Burden of Herpes Zoster and Post-herpetic Neuralgia Among People ≥ 50 Years Old in France	No drug interventions	Not Available	Not Available	completed
NCT03553472	Identifying Young Inflammatory Bowel Disease Patients at Risk for Herpes Zoster	No drug interventions	Not Available	Not Available	completed
NCT00098046	Famciclovir Oral Pediatric Formulation in Children 1-12 Years of Age With Varicella Zoster Infection	Famciclovir	treatment	3	completed
NCT06375512	A Study to Describe the Safety, Reactogenicity, and Immunogenicity of Herpes Zoster IN001 mRNA Vaccine (IN001) in Healthy Participants	Varicella zoster vaccine (recombinant)	prevention	1	recruiting
NCT00034710	Pilot Study of High-Dose Capsaicin Patches to Treat Postherpetic Neuralgia Pain	Capsaicin	treatment	2	completed
NCT02581410	Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Herpes Zoster Subunit (HZ/su) Vaccine (GSK1437173A) in Adults ≥ 65 Years of Age With and Without Zostavax® Vaccination at Least 5 Years Earlier	Human varicella-zoster immune globulin Varicella zoster vaccine (recombinant)	prevention	3	completed
NCT01166295	Development of a Bedside Pain Assessment Kit for Postherpetic Neuralgia	No drug interventions	Not Available	Not Available	unknown_status
NCT03820414	Safety, Tolerability, and Immunogenicity of CRV-101 in Healthy Adult Subjects	No drug interventions	prevention	1	completed
NCT03789955	The Superiority of Contralateral Oblique View for Mid-thoracic Epidural Assess	No drug interventions	diagnostic	Not Available	completed
NCT06137755	Safety and Immunogenicity of CVI-VZV-001 for Prevention of Herpes Zoster in Healthy Adults Age 50 Years and Above	Varicella zoster vaccine (recombinant)	prevention	1	recruiting
NCT00233155	Study of NGX-4010 for the Treatment of Painful HIV-Associated Neuropathy (HIV-AN) or Postherpetic Neuralgia (PHN)	Capsaicin	treatment	2	completed
NCT02519855	Study to Evaluate Immunogenicity, Safety, and Tolerability of ZOSTAVAX™ Vaccine (Zoster Vaccine Live, V211) Administered Concomitantly Versus Nonconcomitantly With Quadrivalent Influenza Virus Vaccine (Inactivated) in Participants ≥50 Years of Age (V211-062)	Haemagglutinin-strain A(H1N1) Haemagglutinin-strain A(H3N2) Haemagglutinin-strain B Influenza A virus A/California/7/2009 X-179A (H1N1) antigen (formaldehyde inactivated) Influenza A virus A/Victoria/210/2009 X-187 (H3N2) antigen (formaldehyde inactivated) Influenza B virus B/Brisbane/60/2008 antigen (formaldehyde inactivated) Varicella zoster vaccine (live/attenuated)	prevention	3	completed
NCT06569823	Safety and Immunogenicity of an Investigational Herpes Zoster Vaccine (Z-1018) Compared to Shingrix® in Healthy Adults	Varicella zoster vaccine (recombinant)	prevention	1 / 2	recruiting
NCT00576108	A 2 Week Study of Topical KD7040 in the Treatment of Postherpetic Neuralgia (PHN)	KD7040	treatment	2	completed
NCT04516408	Recombinant Zoster Vaccine in Stable SLE Patients	Human varicella-zoster immune globulin	treatment	Not Available	recruiting
NCT05245838	Trial to Evaluate the Safety, Tolerability, and Immunogenicity of an Investigational Herpes Zoster Vaccine (Z-1018) Compared to Shingrix® in Healthy Adult Volunteers	Varicella zoster vaccine (recombinant)	prevention	1	completed