Refractory Plasma Cell Myeloma (DBCOND0030431)

Identifiers

Synonyms
Plasma Cell Myeloma Refractory

Associated Data

Indicated Drugs and Targets
Not Available
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT04643002
Isatuximab in Combination With Novel Agents in RRMM - Master Protocoltreatment1 / 2recruiting
NCT06356571
A Study to Investigate Subcutaneous Isatuximab in Combination With Weekly Carfilzomib and Dexamethasone in Adult Participants With Relapsed and/or Refractory Multiple Myelomatreatment2not_yet_recruiting
NCT04892264
Belantamab Mafodotin, Lenalidomide, and Daratumumab for the Treatment of Relapsed, Refractory, or Previously Untreated Multiple Myelomatreatment1 / 2completed
NCT04956302
Panobinostat in Combination With Daratumumab, Bortezomib and Dexamethasone for the Treatment of Relapsed/Refractory Multiple Myelomatreatment1terminated
NCT00082784
Bortezomib and Flavopiridol in Treating Patients With Recurrent or Refractory Indolent B-Cell Neoplasmstreatment1completed
NCT04640779
Low-Dose Selinexor and Choline Salicylate for Non-Hodgkin or Hodgkin Lymphoma, Histiocytic/Dendritic Cell Neoplasm, or Relapsed or Refractory Multiple Myelomatreatment1recruiting
NCT01689987
Hydroxychloroquine, Cyclophosphamide, Dexamethasone, and Sirolimus in Treating Patients With Relapsed or Refractory Multiple Myelomatreatment1completed
NCT02765854
Ixazomib and Dexamethasone Versus Ixazomib, Dexamethasone and Lenalidomide, Randomized With NFKB2 Rearrangementtreatment2active_not_recruiting
NCT03502577
BCMA-Specific CAR T-Cells Combined With a Gamma Secretase Inhibitor (JSMD194) to Treat Relapsed or Persistent Multiple Myelomatreatment1terminated
NCT03256045
Panobinostat, Carfilzomib, and Dexamethasone in Patients With Relapsed or Refractory Multiple Myelomatreatment2terminated
NCT02948283
Metformin Hydrochloride and Ritonavir in Treating Patients With Relapsed or Refractory Multiple Myeloma or Chronic Lymphocytic Leukemiatreatment1completed
NCT03202628
Ixazomib Citrate, Pomalidomide, Dexamethasone, Stem Cell Transplant in Treating Relapsed or Refractory Multiple Myelomatreatment2completed
NCT00966693
Lenalidomide, Thalidomide and Dexamethasone in Treating Participants With Relapsed or Refractory Multiple Myelomatreatment1 / 2completed
NCT04205409
Nivolumab for Relapsed, Refractory, or Detectable Disease Post Chimeric Antigen Receptor T-cell Treatment in Patients With Hematologic Malignanciestreatment2active_not_recruiting
NCT01605032
Busulfan, Melphalan, and Bortezomib Before First-Line Stem Cell Transplant in Treating Patients With Multiple Myelomatreatment2completed
NCT03457142
Abatacept, Ixazomib Citrate, and Dexamethasone in Treating Patients With Multiple Myeloma Resistant to Chemotherapytreatment2active_not_recruiting
NCT04407442
Daratumumab, Azacitidine, and Dexamethasone for Treatment of Patients With Recurrent or Refractory Multiple Myeloma Previously Treated With Daratumumabtreatment2terminated
NCT04850599
Isatuximab, Carfilzomib, and Pomalidomide for the Treatment of Relapsed or Refractory Multiple Myelomatreatment2active_not_recruiting
NCT02095834
Carfilzomib, Bendamustine Hydrochloride, and Dexamethasone in Treating Patients With Relapsed or Refractory Multiple Myelomatreatment1completed
NCT01794039
Pomalidomide or Lenalidomide and Dexamethasone in Treating Patients With Relapsed or Refractory Multiple Myeloma Previously Treated With Lenalidomidetreatment2completed
NCT01330173
Vismodegib After Stem Cell Transplant in Treating Patients With High-Risk First Remission or Relapsed Multiple Myelomatreatment1completed
NCT00789776
Fludarabine Phosphate, Cyclophosphamide, Total-Body Irradiation, and Donor Bone Marrow Transplant Followed by Donor Natural Killer Cell Therapy, Mycophenolate Mofetil, and Tacrolimus in Treating Patients With Hematologic Cancertreatment1 / 2completed
NCT03713294
Dexamethasone, Elotuzumab, and Pomalidomide in Treating Patients With Refractory Multiple Myelomatreatment2active_not_recruiting
NCT03763162
Daratumumab, Bortezomib, and Dexamethasone Followed by Daratumumab, Ixazomib, and Dexamethasone in Treating Patients With Relapsed or Refractory Multiple Myelomatreatment2active_not_recruiting
NCT00793572
Autologous or Syngeneic Stem Cell Transplant Followed by Donor Stem Cell Transplant and Bortezomib in Treating Patients With Newly Diagnosed High-Risk, Relapsed, or Refractory Multiple Myelomatreatment2completed
NCT01251172
RO4929097 After Autologous Stem Cell Transplant in Treating Patients With Multiple Myelomatreatment2withdrawn
NCT02119468
Ixazomib Plus Pomalidomide and Dexamethasone in Treating Patients With Relapsed or Relapsed/Refractory Multiple Myelomatreatment1 / 2completed
NCT03333746
Lenalidomide and Nivolumab in Treating Patients With Relapsed or Refractory Multiple Myelomatreatment2terminated
NCT04439214
Testing Nivolumab as a Potential Targeted Treatment in Cancers With Mismatch Repair Deficiency (MATCH-Subprotocol Z1D)treatment2completed
NCT01085214
AZD6244 (Selumetinib) in Treating Patients With Multiple Myelomatreatment2completed
NCT04579523
²¹¹At-OKT10-B10 and Fludarabine Alone or in Combination With Cyclophosphamide and Low-Dose TBI Before Donor Stem Cell Transplant for the Treatment of Newly Diagnosed, Recurrent, or Refractory High-Risk Multiple Myelomatreatment1not_yet_recruiting
NCT05514990
Bortezomib and Pembrolizumab With or Without Pelareorep for the Treatment of Relapsed or Refractory Multiple Myeloma, AMBUSH Trialtreatment1 / 2recruiting
NCT01936090
Bortezomib, Melphalan, and Total-Body Irradiation Before Stem Cell Transplant in Treating Patients With Multiple Myelomatreatment1completed
NCT04508790
Leflunomide, Pomalidomide, and Dexamethasone for the Treatment of Relapsed or Refractory Multiple Myelomatreatment2recruiting
NCT03701321
Daratumumab, Bortezomib, and Dexamethasone With or Without Venetoclax in Treating Patients With Relapsed or Refractory Multiple Myelomatreatment1 / 2withdrawn
NCT03710421
CS1-CAR T Therapy Following Chemotherapy in Treating Patients With Relapsed or Refractory CS1 Positive Multiple Myelomatreatment1recruiting
NCT03506802
TCR Genetically Engineered PBMC and PBSC After Melphalan Conditioning Regimen in Treating Participants With Relapsed and Refractory Multiple Myelomatreatment1withdrawn
NCT01326702
Veliparib, Bendamustine Hydrochloride, and Rituximab in Treating Patients With Relapsed or Refractory Lymphoma, Multiple Myeloma, or Solid Tumorstreatment1 / 2completed
NCT01989598
Trametinib and Akt Inhibitor GSK2141795 in Treating Patients With Relapsed or Refractory Multiple Myelomatreatment2completed
NCT04439305
Testing Dasatinib as a Potential Targeted Treatment in Cancers With DDR2 Genetic Changes (MATCH-Subprotocol X)treatment2withdrawn
NCT05411497
Genetically Engineered Cells (MUC1-Activated T-Cells) for the Treatment of MUC1 Positive Recurrent or Refractory Multiple Myelomatreatment1recruiting
NCT05363111
Radioimmunotherapy (111Indium/225Actinium-DOTA-daratumumab) for the Treatment of Relapsed/Refractory Multiple Myelomatreatment1recruiting
NCT01903811
S1304, Carfilzomib and Dexamethasone for Treating Patients With Relapsed or Refractory Myelomatreatment2completed
NCT03267888
Pembrolizumab and Radiation Therapy in Patients With Relapsed or Refractory Multiple Myelomatreatment1 / 2completed
NCT01301807
Panobinostat and Carfilzomib in Treating Participants With Relapsed or Refractory Multiple Myelomatreatment1completed
NCT01946152
Pomalidomide, Dexamethasone, and Filgrastim-sndz in Treating Patients With Relapsed or Refractory Multiple Myelomatreatment1 / 2terminated
NCT02086552
Sonidegib and Lenalidomide After Stem Cell Transplant in Treating Patients With Multiple Myelomatreatment2completed
NCT02509052
Leflunomide in Treating Patients With Relapsed or Refractory Multiple Myelomatreatment1 / 2completed
NCT02506959
Panobinostat, Gemcitabine Hydrochloride, Busulfan, and Melphalan Before Stem Cell Transplant in Treating Patients With Refractory or Relapsed Multiple Myelomatreatment2completed
NCT03128359
High Dose Cyclophosphamide, Tacrolimus, and Mycophenolate Mofetil in Preventing Graft Versus Host Disease in Patients With Hematological Malignancies Undergoing Myeloablative or Reduced Intensity Donor Stem Cell Transplantsupportive_care2completed
NCT01503242
90 Y-BC8-DOTA Monoclonal Antibody, Fludarabine Phosphate, and Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Multiple Myelomatreatment1completed
NCT03328936
Study of Personalized Melphalan Dosing in the Setting of Autologous Transplanttreatment2withdrawn
NCT01955434
SMAC Mimetic LCL161 Alone or With Cyclophosphamide in Treating Patients With Relapsed or Refractory Multiple Myelomatreatment2completed
NCT02109224
Ibrutinib in Treating Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma in Patients With HIV Infectiontreatment1terminated
NCT03878524
Serial Measurements of Molecular and Architectural Responses to Therapy (SMMART) PRIME Trialtreatment1terminated
NCT01028716
Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignanciestreatment2terminated
NCT01163357
Bortezomib, Total Marrow Irradiation, Fludarabine Phosphate, and Melphalan in Treating Patients Undergoing Donor Peripheral Blood Stem Cell Transplant For High-Risk Stage I or II Multiple Myelomatreatment1active_not_recruiting
NCT01899326
Desipramine Hydrochloride and Filgrastim For Stem Cell Mobilization in Patients With Multiple Myeloma Undergoing Stem Cell TransplanttreatmentNot Availableterminated
NCT03017820
VSV-hIFNbeta-NIS in Treating Patients With Relapsed or Refractory Multiple Myeloma, Acute Myeloid Leukemia or Lymphomatreatment1recruiting
NCT03829020
Metformin, Nelfinavir, and Bortezomib in Treating Patients With Relapsed and/or Refractory Multiple Myelomatreatment1completed
NCT01415882
Ixazomib Citrate in Treating Patients With Relapsed Multiple Myeloma That Is Not Refractory to Bortezomibtreatment2active_not_recruiting
NCT02514382
Wild-Type Reovirus, Bortezomib, and Dexamethasone in Treating Patients With Relapsed or Refractory Multiple Myelomatreatment1completed
NCT01533194
Viral Therapy in Treating Patients With Relapsed or Refractory Multiple Myelomatreatment1completed
NCT01646762
Paclitaxel Albumin-Stabilized Nanoparticle Formulation in Treating Patients With Relapsed or Refractory Multiple Myelomatreatment2terminated
NCT01008462
Autologous Peripheral Blood Stem Cell Transplant Followed by Donor Bone Marrow Transplant in Treating Patients With High-Risk Hodgkin Lymphoma, Non-Hodgkin Lymphoma, Multiple Myeloma, or Chronic Lymphocytic Leukemiatreatment2completed
NCT05288062
Immunomodulatory Drugs (Lenalidomide With or Without Pomalidomide) in Combination With a Corticosteroid Drug (Dexamethasone) for the Treatment of Multiple Myelomatreatment2active_not_recruiting
NCT00445692
Lenalidomide, Dexamethasone, and Clarithromycin in Treating Patients Who Have Undergone Stem Cell Transplant for Multiple Myelomatreatment2completed
NCT03015792
Ibrutinib, Lenalidomide, and Dexamethasone in Treating Patients With Multiple Myeloma Ineligible for Transplanttreatment1 / 2terminated
NCT04439240
Testing AZD4547 as a Potential Targeted Treatment in Cancers With FGFR Genetic Changes (MATCH-Subprotocol W)treatment2completed
NCT01372540
Filanesib and Carfilzomib in Treating Patients With Relapsed or Refractory Multiple Myeloma or Plasma Cell Leukemiatreatment1completed
NCT04756401
Selinexor, Daratumumab, Carfilzomib and Dexamethasone for the Treatment of High-Risk, Recurrent or Refractory Multiple Myelomatreatment2recruiting
NCT00105001
Tacrolimus and Mycophenolate Mofetil With or Without Sirolimus in Preventing Acute Graft-Versus-Host Disease in Patients Who Are Undergoing Donor Stem Cell Transplant for Hematologic Cancertreatment2completed
NCT03338972
Immunotherapy With BCMA CAR-T Cells in Treating Patients With BCMA Positive Relapsed or Refractory Multiple Myelomatreatment1completed
NCT05191472
Pembrolizumab for the Treatment of Relapsed or Refractory Multiple Myeloma After Anti-BCMA CAR-T Therapiestreatment2terminated
NCT02353468
Bortezomib, Lenalidomide, and Dexamethasone in Treating Patients With Multiple Myeloma Undergoing Stem Cell Transplanttreatment2terminated
NCT03856112
Ixazomib and Dexamethasone With or Without Venetoclax in Treating Patients With Non-t(11;14) Relapsed or Refractory Multiple Myelomatreatment1 / 2withdrawn
NCT02971410
Simvastatin in Overcoming Chemotherapy Resistance in Patients With Relapsed or Refractory Multiple Myelomatreatment0withdrawn
NCT00450814
Vaccine Therapy With or Without Cyclophosphamide in Treating Patients With Recurrent or Refractory Multiple Myelomatreatment1 / 2completed
NCT04409314
Hypoxia-Specific Imaging to Predict Outcomes of Chimeric Antigen Receptor T-cell TherapyNot AvailableNot Availablecompleted
NCT05312255
Non-chemotherapeutic Interventions for the Improvement of Quality of Life and Immune Function in Patients With Multiple MyelomatreatmentNot Availablerecruiting
NCT05391750
Venetoclax and Tocilizumab for the Treatment of Patients With Relapsed or Refractory t(11;14) Multiple Myelomatreatment1recruiting
NCT01842308
Carfilzomib and Melphalan Before Stem Cell Transplant in Treating Patients With Multiple Myelomatreatment1 / 2completed
NCT00066638
FR901228 in Treating Patients With Relapsed or Refractory Multiple Myelomatreatment2completed