Faropenem
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Explore a selection of our essential drug information below, or:
Identification
- Generic Name
- Faropenem
- DrugBank Accession Number
- DB12190
- Background
Faropenem has been used in trials studying the treatment of Tuberculosis, Pulmonary Tuberculosis, and Community Acquired Pneumonia.
- Type
- Small Molecule
- Groups
- Investigational
- Structure
- Weight
- Average: 285.316
Monoisotopic: 285.067093285 - Chemical Formula
- C12H15NO5S
- Synonyms
- Faropenem
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
Target Actions Organism ADihydropteroate synthase inhibitorEscherichia coli (strain K12) - Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- Product Ingredients
Ingredient UNII CAS InChI Key Faropenem Sodium 7O46G914RQ 122547-49-3 ICSAXRANXQSPQP-VUKDEKJYSA-M
Categories
- ATC Codes
- J01DI03 — Faropenem
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as alpha amino acids and derivatives. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon), or a derivative thereof.
- Kingdom
- Organic compounds
- Super Class
- Organic acids and derivatives
- Class
- Carboxylic acids and derivatives
- Sub Class
- Amino acids, peptides, and analogues
- Direct Parent
- Alpha amino acids and derivatives
- Alternative Parents
- Thiazolecarboxylic acids and derivatives / Penems / Vinylogous thioesters / Thiazolines / Tetrahydrofurans / Tertiary carboxylic acid amides / Azetidines / Thioenol ethers / Secondary alcohols / Azacyclic compounds show 10 more
- Substituents
- Alcohol / Aliphatic heteropolycyclic compound / Alpha-amino acid or derivatives / Azacycle / Azetidine / Beta-lactam / Carbonyl group / Carboxamide group / Carboxylic acid / Dialkyl ether show 22 more
- Molecular Framework
- Aliphatic heteropolycyclic compounds
- External Descriptors
- faropenem (CHEBI:51257)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- F52Y83BGH3
- CAS number
- 106560-14-9
- InChI Key
- HGGAKXAHAYOLDJ-FHZUQPTBSA-N
- InChI
- InChI=1S/C12H15NO5S/c1-5(14)7-10(15)13-8(12(16)17)9(19-11(7)13)6-3-2-4-18-6/h5-7,11,14H,2-4H2,1H3,(H,16,17)/t5-,6-,7+,11-/m1/s1
- IUPAC Name
- (5R,6S)-6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(2R)-oxolan-2-yl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
- SMILES
- [H][C@]12SC([C@H]3CCCO3)=C(N1C(=O)[C@@H]2[C@@H](C)O)C(O)=O
References
- General References
- Not Available
- External Links
- Human Metabolome Database
- HMDB0041892
- PubChem Compound
- 65894
- PubChem Substance
- 347828475
- ChemSpider
- 59303
- ChEBI
- 51257
- ChEMBL
- CHEMBL556262
- ZINC
- ZINC000003959242
- PDBe Ligand
- FPM
- Wikipedia
- Faropenem
- PDB Entries
- 3bff / 4hky
Clinical Trials
- Clinical Trials
Clinical Trial & Rare Diseases Add-on Data Package
Explore 4,000+ rare diseases, orphan drugs & condition pairs, clinical trial why stopped data, & more. Preview package Phase Status Purpose Conditions Count Start Date Why Stopped 100+ additional columns Unlock 175K+ rows when you subscribe.View sample data3 Unknown Status Treatment Community Acquired Pneumonia (CAP) 1 somestatus stop reason just information to hide 2 Completed Treatment Community Acquired Pneumonia (CAP) 1 somestatus stop reason just information to hide 2 Completed Treatment Pulmonary Tuberculosis (TB) 2 somestatus stop reason just information to hide 1 Completed Treatment Tuberculosis (TB) 1 somestatus stop reason just information to hide
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 14.7 mg/mL ALOGPS logP 0.24 ALOGPS logP -0.75 Chemaxon logS -1.3 ALOGPS pKa (Strongest Acidic) 3.97 Chemaxon pKa (Strongest Basic) -2.8 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 87.07 Å2 Chemaxon Rotatable Bond Count 3 Chemaxon Refractivity 69.26 m3·mol-1 Chemaxon Polarizability 28.16 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted GC-MS Spectrum - GC-MS Predicted GC-MS splash10-0006-9030000000-71dce16fcdf8d65d622c Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-000i-0090000000-2e62936e0d244db951e9 Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-001i-0390000000-24a73c8c0d0001c0d158 Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-0gbi-1190000000-ee802ec76572aeed016b Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-0frx-0950000000-5fba62b9f195d438a810 Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-0frb-2940000000-ca25e73482070ff51af2 Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-00ke-6950000000-3af6a60d284ed112bf91 Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 171.3602426 predictedDarkChem Lite v0.1.0 [M-H]- 172.1363426 predictedDarkChem Lite v0.1.0 [M-H]- 171.86546 predictedDeepCCS 1.0 (2019) [M+H]+ 170.3005426 predictedDarkChem Lite v0.1.0 [M+H]+ 173.9254426 predictedDarkChem Lite v0.1.0 [M+H]+ 174.22346 predictedDeepCCS 1.0 (2019) [M+Na]+ 170.6615426 predictedDarkChem Lite v0.1.0 [M+Na]+ 171.9929426 predictedDarkChem Lite v0.1.0 [M+Na]+ 181.3822 predictedDeepCCS 1.0 (2019)
Targets
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1. DetailsDihydropteroate synthase
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Yes
- Actions
- Inhibitor
- General Function
- Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
- Specific Function
- dihydropteroate synthase activity
- Gene Name
- folP
- Uniprot ID
- P0AC13
- Uniprot Name
- Dihydropteroate synthase
- Molecular Weight
- 30614.855 Da
References
- Zhou Y, Zhang Y, Zhao D, Yu X, Shen X, Zhou Y, Wang S, Qiu Y, Chen Y, Zhu F: TTD: Therapeutic Target Database describing target druggability information. Nucleic Acids Res. 2024 Jan 5;52(D1):D1465-D1477. doi: 10.1093/nar/gkad751. [Article]
Drug created at October 20, 2016 21:34 / Updated at August 27, 2024 19:15