Lactams
- Name
- Lactams
- Accession Number
- DBCAT000570
- Description
Cyclic AMIDES formed from aminocarboxylic acids by the elimination of water. Lactims are the enol forms of lactams.
- Drugs
Drug Drug Description Ampicillin A penicillin derivative used for the treatment of a variety of infections caused by gram-positive and gram-negative bacteria as well as some anaerobes. Phenoxymethylpenicillin A penicillin antibiotic used to prevent and treat mild to moderately severe infections in the respiratory tract, skin, and soft tissues. Ceftazidime An injected broad-spectrum third-generation cephalosporin beta-lactam antibiotic used to treat or prevent a variety of bacterial infections, including pneumonia, gynecological infections, bone and joint infections, and septicemia, among others. Cefdinir A third generation cephalosporin used to treat susceptible Gram negative and Gram positive bacterial infections. Cephalexin A first generation cephalosporin used to treat certain susceptible bacterial infections. Clavulanic acid A beta lactamase inhibitor used to enhance the effectiveness of beta lactam antibiotics. Benzylpenicillin A penicillin used for the treatment of infections caused by gram-positive cocci, in particular streptococcal infections. This form of penicillin is typically used in intravenous or long-acting injectable formulations due to poor oral absorption. Amoxicillin A penicillin derivative used for the treatment of infections caused by gram-positive bacteria, in particular streptococcal bacteria causing upper respiratory tract infections. Cloxacillin An antibiotic agent used for the treatment of beta-hemolytic streptococcal and pneumococcal infections as well as staphylococcal infections. Ceftriaxone A broad-spectrum cephalosporin antibiotic used for the treatment of bacterial infections in various locations, such as in the respiratory tract, skin, soft tissue, and urinary tract. Ceftizoxime A third-generation cephalosporin antibiotic used in the treatment of various bacterial infections, including lower respiratory tract infection, urinary tract infection, and gonorrhea. Imipenem A carbapenem antibiotic normally administered with cilastatin to treat a variety of infections. Tazobactam A beta lactamase inhibitor administered with antibiotics such as piperacillin and ceftolozane to prevent their degradation, resulting in increased efficacy. Ticarcillin A beta lactam antibiotic used to treat a variety of infections in the body. Ceftaroline fosamil An antibacterial agent used to treat various bacterial infections, such as acute bacterial skin and skin structure infections and community-acquired bacterial pneumonia. Lorlatinib An anaplastic lymphoma kinase inhibitor used to treat anaplastic lymphoma kinase positive metastatic non small cell lung cancer. Cefiderocol A cephalosporin antibiotic used in complicated urinary tract infections. Piperacillin A penicillin antibiotic combined with tazobactam to treat piperacillin-resistant, piperacillin/tazobactam susceptible, β-lactamase generating strains of several bacteria. Hetacillin Hetacillin is a beta-lactam antibiotic prodrug used to treat bacterial infections. In the body it gets converted to ampicillin. Benzylpenicilloyl polylysine A penicillin derivative used to determine penicillin allergies. Amdinocillin Used in the treatment of urinary tract infections caused by some strains of E. coli and klebsiella and enterobacter species. Used mainly against Gram negative organisms. Bacampicillin An ampicillin prodrug used to treat various susceptible bacterial infections in the body, such as respiratory infections and skin and subcutaneous tissue infections. Pivmecillinam A prodrug of the beta lactam antibiotic mecillinam, indicated for the treatment of uncomplicated urinary tract infections (UTIs). Isopenicillin N Not Available Faropenem medoxomil Investigated for use/treatment in bacterial infection, bronchitis, otitis media, and pediatric indications. Azidocillin For treatment of infection (Respiratory, GI, UTI and meningitis) due to E. coli, P. mirabilis, enterococci, Shigella, S. typhosa and other Salmonella, nonpenicillinase-producing N. gononhoeae, H. influenzae, staphylococci, streptococci including... Sultamicillin A mutual prodrug of ampicillin and sulbactam useful in the treatment of infections caused by beta-lactamase-producing bacteria. Faropenem Faropenem has been used in trials studying the treatment of Tuberculosis, Pulmonary Tuberculosis, and Community Acquired Pneumonia. Temocillin Temocillin has been investigated in Infection, Liver Dysfunction, and Urinary Tract Infection. Epicillin Not Annotated Penamecillin Not Annotated Aspoxicillin Not Annotated Metampicillin Metampicillin is a penicillin antibiotic prepared by the reaction of ampicillin with formaldehyde. It is hydrolysed in aqueous solution to form ampicillin. Hydrolysis is rapid under acid conditions like the... Cefotiam A cephalosporin antibiotic used to treat a variety of bacterial infections. Cefmenoxime Used to treat female gynecologic and obstetric infections caused by susceptible aerobic (including the gonococcus) and anaerobic bacteria. Cefmetazole A cephalosporin antibiotic used to treat a variety of bacterial infections. Flucloxacillin A narrow spectrum penicillin antibiotic that exerts specific activity against Gram positive organisms in skin and soft tissue infections, except those caused by methicillin resistant staphylococcus aureus (MRSA). Ertapenem A carbapenem antibiotic used for the treatment of moderate to severe infections caused by susceptible bacteria. Aztreonam A beta-lactam antibiotic used to treat select aztreonam sensitive gram negative bacteria. Cefpiramide For treatment of severe infections caused by susceptible bacteria such as P. aeruginosa. Loracarbef Used to treat upper respiratory tract bacterial infections, chronic bronchitis, pneumonia, sinusitis, pharyntitis and tonsillitis, skin absceses, urinary tract infections and pyelonephritis caused by E. coli, S. pyogenes, S. aureus,... Cefalotin A broad-spectrum cephalosporin antibiotic used for the treatment of serious bacterial infections in various locations, such as the urinary tract, skin, bone, and lower respiratory tract. Dicloxacillin A penicillin used to treat penicillinase-producing bacterial infections that are susceptible to the drug. Cefotaxime A third generation cephalosporin used to treat susceptible Gram negative and Gram positive bacterial infections. Carbenicillin For the treatment of acute and chronic infections of the upper and lower urinary tract and in asymptomatic bacteriuria due to susceptible strains of bacteria. Nafcillin A penicillin derivative antibiotic used to treat susceptible staphylococcal infections. Cefixime A third generation cephalosporin used to treat susceptible Gram negative and Gram positive bacterial infections. Cephaloglycin For treatment of severe infections caused by susceptible bacteria. Oxacillin A penicillin antibiotic used to treat a number of susceptible bacterial infections. Meropenem A carbapenem antibiotic used to treat a wide variety of infections in the body. Cefaclor A second generation cephalosporin used to treat a wide variety of infections in the body. Ceforanide For the treatment of infections caused by susceptible organisms. Mezlocillin Used to treat serious gram–negative infections of the lungs, urinary tract, and skin. Cyclacillin For the treatment of bacterial infections caused by susceptible organisms. Azlocillin For the treatment of infections caused by Pseudomonas aeruginosa, Escherichia coli, and Haemophilus influenzae. Cefditoren A broad-spectrum third-generation cephalosporin antibiotic typically used to treat bacterial infections of the skin and respiratory tract. Cefuroxime A cephalosporin indicated for the treatment of a variety of infections including acute bacterial otitis media, several upper respiratory tract infections, skin infections, urinary tract infections, gonorrhea, early Lyme disease, and impetigo. Cefapirin A first generation cephalosporin indicated in the treatment of susceptible bacterial infections. Cefadroxil A cephalosporin antibiotic used in the treatment of various bacterial infections, such as urinary tract infections, skin and skin structure infections, and tonsillitis. Cefprozil A cephalosporin antibiotic used in the treatment of various bacterial infections, such as pharyngitis, tonsillitis, otitis media, and uncomplicated skin infections. Cefamandole A beta-lactam antibiotic used in the treatment of various infections caused by susceptible strains of bacteria, such as lower respiratory infections, urinary tract infections, skin infections, and bone and joint infections. Cefazolin A broad-spectrum cephalosporin antibiotic mainly used for the treatment of skin bacterial infections and other moderate to severe bacterial infections in the lung, bone, joint, stomach, blood, heart valve, and urinary tract. Cefonicid For the treatment of bacterial infections caused by susceptible microorganisms. Cefoperazone A broad-spectrum cephalosporin antibiotic used for the treatment of bacterial infections in various locations, including the respiratory tract, abdomen, skin, and female genital tracts. Cefotetan An antibiotic medication used for the prophylaxis and treatment of various bacterial infections, including urinary tract infections, bone and joint infection, and lower respiratory tract infections. Cefoxitin A semi-synthetic, broad-spectrum antibiotic for parenteral administration used for the treatment of serious bacterial infections, such as urinary tract infection, blood infection, bone and joint infection, and lower respiratory tract infection. Cefradine A first-generation cephalosporin antibiotic used in the treatment of bacterial infections of the respiratory and urinary tracts and of the skin and soft tissues. Cefepime A fourth-generation cephalosporin antibiotic used in the treatment of infections caused by susceptible bacteria, such as pneumonia, urinary tract infections, and skin infections. Cefacetrile A broad-spectrum first-generation cephalosporin used for the treatment of susceptible bacterial infections. Ceftibuten A third-generation cephalosporin antibiotic commonly used in the treatment of acute bacterial exacerbations of chronic bronchitis (ABECB), acute bacterial otitis media, pharyngitis, and tonsillitis. Cefpodoxime A third-generation cephalosporin antibiotic used in the treatment of various bacterial infections, including gonorrhea, community acquired pneumonia, and sinusitis. Meticillin Used to treat infections caused by susceptible Gram-positive bacteria, particularly beta-lactamase-producing organisms such as Staphylococcus aureus that would otherwise be resistant to most penicillins. Pivampicillin An ampicillin prodrug used to treat a variety of infections. Geldanamycin Not Available Cephalosporin C Not Available Deacetoxycephalosporin C Not Available Paratoulene phosphate Not Available Latamoxef Latamoxef is an oxacephem antibiotic usually grouped with the cephalosporins. It is used to treat bacterial infections. Latamoxef is primarily indicated in conditions like Bone and joint infection, GI infections,... Ceftobiprole A cephalosporin antibiotic used to treat both community and hospital-acquired pneumonia caused by susceptible bacteria. Tanespimycin Investigated for use/treatment in leukemia (myeloid) and solid tumors. Retaspimycin Investigated for use/treatment in gastric cancer, lung cancer, and multiple myeloma. Cefilavancin Investigated for use/treatment in bacterial infection, skin infections/disorders, and staph bacterial infections. Doripenem An antibiotic of the penem class used to treat complicated intra-abdominal and urinary tract infections. Cefaloridine Cephaloridine or cefaloridine is a first generation semisynthetic cephalosporin. It is derived from cephalosporin C and is a zwitterion at physiological pH. Cefminox Cefminox (INN) is a second generation cephalosporin antibiotic. It is approved for use in Japan. Paritaprevir A direct acting antiviral agent used in combination with other antiviral agents for the treatment of Hepatitis C Virus (HCV) infections. Carindacillin A penicillin antibiotic used to treat a variety of infections, but is no longer marketed in the USA. Procaine benzylpenicillin A local anesthetic and antibiotic combination for intramuscular injection to treat a variety of bacterial infections while reducing pain from a deep intramuscular injection. Sulbactam An beta-lactamase inhibitor antibiotic combined with other antibiotics to treat a variety of susceptible bacterial infections. Cefroxadine Was used for the treatment of bacterial infections. Cefalonium Not Annotated Ceftiofur Ceftiofur is a third generation cephalosporin antibiotic, first described in 1987, and now used in veterinary medicine. It is marketed by pharmaceutical company Zoetis as Excenel, and is the active... Cefovecin Cefovecin is a cephalosporin antibiotic used for the treatment of skin infections in cats and dogs. It is the first single-dose injectable antibiotic for dogs and cats that assures owner... Nitrocefin Nitrocefin is a chromogenic cephalosporin substrate used to detect the presence of beta-lactamase enzymes, an important mediator of bacterial antibiotic resistance. While other detection methods exist, such as PCR, nitrocefin... Danoprevir Danoprevir has been used in trials studying the treatment of Hepatitis C, Chronic. Vaniprevir Vaniprevir has been used in trials studying the treatment and diagnostic of Hepatitis C, Chronic Hepatitis C, Hepatitis C, Chronic, Chronic Hepatitis C Infection, and Chronic Genotype 1 Hepatitis C... Flomoxef Flomoxef has been used in trials studying the treatment of Urinary Tract Infection. Voxilaprevir A nonstructural protein 3 and 4a protease inhibitor used to treat Hepatitis C infections. Alvespimycin Investigated for use as an antineoplastic agent for solid tumors, advanced solid tumours or acute myeloid leukaemia. Razupenem Razupenem has been used in trials studying the treatment of Skin Infections. IPI-493 IPI-493 has been used in trials studying the treatment of Advanced Malignancies. Biapenem A carbapenem antibiotic indicated in the treatment of bacterial infections. Penimepicycline Penimepicycline is a tetracycline-class antibiotic. It is mentioned on List A produced by the Government of Canada, which is a list of antimicrobial active pharmaceutical ingredients . In the classification... Cefatrizine Not Annotated Cefodizime A broad-spectrum, third-generation cephalosporin used to treat serious infections caused by susceptible bacteria. Cefsulodin Not Annotated Cefetamet Not Annotated Carfecillin Not Annotated Carumonam Not Annotated Cefbuperazone Not Annotated Propicillin Not Annotated Cefozopran Not Annotated Cefpirome An antibiotic indicated in the treatment of a wide variety of infections in the body. Sulbenicillin Not Annotated Cefazedone Not Annotated Talampicillin Not Annotated Ceftezole Not Annotated Glecaprevir A Hepatitis C NS3/4A protease inhibitor used to treat Hepatitis C. 7-Aminodesacetoxycephalosporanic acid Not Annotated Cefamandole nafate A second generation cephalosporin indicated in the prevention of infections during surgery. Ceftobiprole medocaril A cephalosporin indicated in the treatment of pneumonia. Sulbactam pivoxil A prodrug of a beta-lactamase inhibitor used to improve the efficacy of beta lactam antibiotics Tebipenem pivoxil Not Annotated - Drugs & Drug Targets