This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Guanoxabenz
DrugBank Accession Number
DB13410
Background

Not Available

Type
Small Molecule
Groups
Experimental
Structure
Weight
Average: 247.08
Monoisotopic: 246.0075163
Chemical Formula
C8H8Cl2N4O
Synonyms
  • Guanoxabenz

Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AcebutololAcebutolol may increase the hypotensive activities of Guanoxabenz.
AceclofenacThe therapeutic efficacy of Guanoxabenz can be decreased when used in combination with Aceclofenac.
AcemetacinThe therapeutic efficacy of Guanoxabenz can be decreased when used in combination with Acemetacin.
Acetylsalicylic acidAcetylsalicylic acid may decrease the antihypertensive activities of Guanoxabenz.
AlclofenacThe therapeutic efficacy of Guanoxabenz can be decreased when used in combination with Alclofenac.
AldesleukinAldesleukin may increase the hypotensive activities of Guanoxabenz.
AlfentanilAlfentanil may decrease the antihypertensive activities of Guanoxabenz.
AlfuzosinAlfuzosin may increase the hypotensive activities of Guanoxabenz.
AliskirenAliskiren may increase the hypotensive activities of Guanoxabenz.
AlmotriptanAlmotriptan may decrease the antihypertensive activities of Guanoxabenz.
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Food Interactions
Not Available

Categories

ATC Codes
C02CC07 — Guanoxabenz
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as dichlorobenzenes. These are compounds containing a benzene with exactly two chlorine atoms attached to it.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Benzene and substituted derivatives
Sub Class
Halobenzenes
Direct Parent
Dichlorobenzenes
Alternative Parents
N-hydroxyguanidines / Aryl chlorides / Organopnictogen compounds / Organochlorides / Organic oxygen compounds / Hydrocarbon derivatives
Substituents
1,3-dichlorobenzene / Aromatic homomonocyclic compound / Aryl chloride / Aryl halide / Guanidine / Hydrocarbon derivative / N-hydroxyguanidine / Organic nitrogen compound / Organic oxygen compound / Organochloride
Molecular Framework
Aromatic homomonocyclic compounds
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
P9HIK5V7WK
CAS number
24047-25-4
InChI Key
QKIQJNNDIWGVEH-UUILKARUSA-N
InChI
InChI=1S/C8H8Cl2N4O/c9-6-2-1-3-7(10)5(6)4-12-13-8(11)14-15/h1-4,15H,(H3,11,13,14)/b12-4+
IUPAC Name
N'-[(E)-[(2,6-dichlorophenyl)methylidene]amino]-N-hydroxyguanidine
SMILES
ONC(=N)N\N=C\C1=C(Cl)C=CC=C1Cl

References

General References
Not Available
ChemSpider
7842543
ChEMBL
CHEMBL461343
ZINC
ZINC000005784328
Wikipedia
Guanoxabenz

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0951 mg/mLALOGPS
logP2.29ALOGPS
logP2.24Chemaxon
logS-3.4ALOGPS
pKa (Strongest Acidic)14.79Chemaxon
pKa (Strongest Basic)6.25Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count5Chemaxon
Hydrogen Donor Count4Chemaxon
Polar Surface Area80.5 Å2Chemaxon
Rotatable Bond Count2Chemaxon
Refractivity91.32 m3·mol-1Chemaxon
Polarizability22.36 Å3Chemaxon
Number of Rings1Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Drug created at June 23, 2017 20:41 / Updated at February 21, 2021 18:54