- Accession Number
Derivatives of oxoacids RnE(=O)OH in which the hydroxy group is replaced by an amino group and the oxo group is replaced by =NR. Amidines include carboxamidines, sulfinamidines and phosphinamidines.
Drug Drug Description Creatine For nutritional supplementation, also for treating dietary shortage or imbalance. Bethanidine For the treatment of hypertension. Guanadrel Used to treat and control hypertension. Cimetidine A histamine H2 receptor antagonist used to manage GERD, peptic ulcer disease, and indigestion. Guanidine A strong organic base used to treat muscle weakness and fatigue associated with the myasthenic complications of Eaton-Lambert syndrome. Zanamivir A neuraminidase inhibitor used to treat influenza A and B. Guanabenz An alpha-2 adrenergic agonist used to treat hypertension. Pentamidine An antifungal agent used to treat Pneumocystis pneumonia in patients infected with HIV. Chlorhexidine An antiseptic used to sterilize for surgeries and in healthcare practice, to reduce pocket depth in periodontitis, and to treat gingivitis. Phenformin For the reatment of type II diabetes mellitus. Guanfacine An alpha-2A adrenergic receptor agonist used to treat ADHD. Proguanil A medication indicated for prophylaxis and treatment of Plasmodium falciparum malaria. Guanethidine An antihypertensive agent used in the management of moderate and severe hypertension, either alone or as an adjunct, and for the management of renal hypertension. 2-butyl-1-hydroxyguanidine Not Available Benzamidine Not Available Diminazene Diminazene, also known as Diminazine, 4,4'-(Diazoamino)benzamidine, 4,4'-(1-triazene-1,3-diyl)bis-benzenecarboximidamide, diminazine aceturate, or Diminazene aceturate, is a trypanocidal agent. Major brands of Diminazene are Berenil, Pirocide, Ganasag, and Azidin. This substance is a... SC45647 Not Available Buformin Buformin is an anti-diabetic drug of the biguanide class, chemically related to metformin and phenformin. It was withdrawn from the market in most countries due to a high risk of... GMX1777 Intended for the treatment of solid tumors and lymphomas. Cariporide Investigated for use/treatment in cardiac surgery. Pafuramidine Investigated for use/treatment in pneumonia, trypanosomiasis, malaria, HIV infection, and infectious and parasitic disease (unspecified). Brostallicin Investigated for use/treatment in solid tumors. Peramivir An intravenous antiviral agent used to treat acute uncomplicated influenza in patients aged 2 years and older who are shown to be symptomatic for no more than two days. Iobenguane A radiopharmaceutical agent used for the diagnosis of primary and metastatic pheochromocytoma or neuroblastoma. Pinacidil Pinacidil is a cyanoguanidine drug that acts by opening ATP-sensitive potassium channels, leading to peripheral vasodilatation of arterioles and decreasing peripheral vascular resistance. The above processes result in reduced blood... Agmatine Agmatine is being studied experimentally for several indications such as cardioprotection, diabetes, decreased kidney function, neuroprotection (stroke, severe CNS injuries, epilepsy, glaucoma, and neuropathic pain), and psychiatric conditions (depression, anxiety,... Febantel Not Annotated Robenidine Robenidine is identified as a coccidiostat drug, which slows both the growth and reproductive cycles of coccidian parasites. Robenidine is used to control coccidiosis, a lethal infection in poultry which... Laninamivir octanoate Laninamivir octanoate has been used in trials studying the treatment of Asthma. Polihexanide Polihexanide has been used in trials studying the treatment, prevention, and supportive care of Caries, Neoplasm, Skin Diseases, Nail Diseases, and Dental Plaque, among others. Chlorproguanil Chlorproguanil has been used in trials studying the treatment of MALARIA. It is a dichloro-derivative of chloroguanide. Nafamostat Used as an anticoagulant in patients with disseminative blood vessel coagulation, hemorrhagic lesions, and hemorrhagic tendencies. It prevents blood clot formation during extracorporeal circulation in patients undergoing continuous renal replacement... Gusperimus Gusperimus has been used in trials studying the treatment of Lupus Nephritis, Wegeners Granulomatosis, and Wegener's Granulomatosis. Laninamivir Laninamivir has been used in trials studying the treatment of Influenza. Gabexate No approved indication. Mitoguazone Mitoguazone has been used in trials studying the treatment of Lymphoma, HIV Infections, and Lymphoma, Non-Hodgkin. CHS-828 CHS-828 has been used in trials studying the treatment of Unspecified Adult Solid Tumor, Protocol Specific. Deoxyspergualin Deoxyspergualin has been used in trials studying the treatment of Lupus Nephritis, Chronic Rejection, and Diabetes Mellitus, Type 1. Phosphocreatine Phosphocreatine is a naturally occuring substance that is found predominantly in the skeletal muscles of vertebrates. Its primary utility within the body is to serve in the maintanence and recycling... Guanoxan Guanoxan is an antihypertensive agent similar in its mechanism of action to guanethidine; may cause liver damage. Guanoxan was approved in the UK but was withdrawn from the market due... Propamidine Not Annotated Guanoxabenz Not Annotated Dibrompropamidine Not Annotated Guanazodine Not Annotated Ambazone Not Annotated Sulfaguanidine Not Annotated Camostat A serine protease indicated in Japan to treat chronic pancreatitis. Guanoclor Not Annotated Diphenylguanidine Diphenylguanidine is approved for use within allergenic epicutaneous patch tests which are indicated for use as an aid in the diagnosis of allergic contact dermatitis (ACD) in persons 6 years... Metformin A biguanide drug used in conjunction with diet and exercise for glycemic control in type 2 diabetes mellitus and used off-label for insulin resistance in polycystic ovary syndrome (PCOS). Hexamidine Not Available Pimagedine Investigated for use/treatment in diabetic kidney disease. Hydroxystilbamidine Used in the treatment of nonprogressive blastomycosis of the skin and other mycoses. Cycloguanil Cycloguanil is the active metabolite of proguanil. Brilacidin Brilacidin is under investigation for the supportive care of Mucositis, Stomatitis, Mouth Diseases, and Head and Neck Neoplasms. N-hydroxyguanidine Not Available 4-guanidinobenzoic acid Not Available Polyaminopropyl biguanide Not Annotated
- Drugs & Drug Targets