Partial-Onset Seizures (DBCOND0032900)

Identifiers

Synonyms
Seizure, Partial / Focal Onset Seizure / Partial-onset Seizures With or Without Secondary Generalisation / Partial Onset Epilepsy / Partial Seizures With or Without Secondary Generalization / Partial Seizures / Focal-Onset Seizures / Epilepsy With Partial-onset Seizures / Partial Seizures (With or Without Secondary Generalized Seizures) / Focal Onset Epilepsy / Focal-Onset Seizure / Focal Seizures / Epilepsy With Partial Onset Seizures With or Without Secondary Generalization / Focal Onset Seizures / Epilepsy With Partial On-set Seizures / Seizure Disorder, Partial / Partial Seizure Disorder / Partial Seizure / Partial onset Seizure Epilepsy / Partial onset Seizures / Partial onset Seizure / Partial-onset Seizures / Focal seizure / Focal fits / Convulsions local / Seizures, Focal / Focal onset epileptic seizure (finding) / Partial seizures NOS / Localisation related epilepsy / Focal epilepsy / Localization related epilepsy / Focal epilepsy (disorder) / Partial epilepsy / Epilepsies, Partial

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Brivaracetam
An anticonvulsant used for the treatment of partial-onset seizures that functions by binding to synaptic vesicle glycoprotein 2A (SV2A) in the brain.
Carbamazepine
An anticonvulsant used to treat various types of seizures and pain resulting from trigeminal neuralgia.
Cenobamate
A small molecule drug indicated to treat partial onset seizures in adults.
Clorazepic acid
A benzodiazepine used to treat anxiety, partial seizures, and alcohol withdrawal.
Eslicarbazepine acetate
An anticonvulsant agent used as an adjunct to treat partial-onset seizures in patients with inadequate clinical response to conventional antiepileptic therapy.
Gabapentin
An anticonvulsant medication used in the management of peripheral neuropathic pains, postherpetic neuralgia, and partial-onset seizures.
Gamma-amino-beta-hydroxybutyric acid
An anticonvulsant indicated to treat convulsions in children and epilepsy.
No drug targets
Lacosamide
An antiepileptic drug used to treat partial-onset seizures and primary generalized tonic-clonic seizures.
Lamotrigine
A phenyltriazine antiepileptic used to treat some types of epilepsy and bipolar I disorder.
Levetiracetam
A novel anticonvulsant agent used as an adjunct medication to manage partial onset, myoclonic, and generalized tonic-clonic seizures in patients with epilepsy.
Methyl salicylate
A topical counter-irritant used for the symptomatic relief of acute musculoskeletal pain in the muscles, joints, and tendons.
Oxcarbazepine
An anti-epileptic used in the treatment of partial-onset seizures.
Perampanel
A non-competitive AMPA glutamate receptor antagonist used to treat partial-onset seizures with or without secondarily generalized seizures, and as adjunctive treatment of primary generalized tonic-clonic seizures in patients with epilepsy.
Phenobarbital
A long-lasting barbiturate and anticonvulsant used in the treatment of all types of seizures, except for absent seizures.
Phenytoin
An anticonvulsant drug used in the prophylaxis and control of various types of seizures.
Pregabalin
An anticonvulsant drug used to treat neuropathic pain conditions and fibromyalgia, and for the treatment of partial onset seizures in combination with other anticonvulsants.
Primidone
An antiepileptic used to treat grand mal, psychomotor, and focal epileptic seizures.
Tiagabine
An antiepileptic used to treat partial seizures.
Topiramate
An anticonvulsant drug used in the control of epilepsy and in the prophylaxis and treatment of migraines.
Zonisamide
A sulfonamide anticonvulsant used to treat partial seizures.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT06534502
Study of the Pharmacokinetics, Safety, and Tolerability of ZONISADE in Children 1 Month to 17 Years of Age With Partial-onset Seizurestreatment4not_yet_recruiting
NCT05159908
A Study to Investigate How Effective, Safe and Tolerable the Drug NBI-921352 is When Used With Anti-seizure Medications in Adults With Focal Onset Seizurestreatment2completed
NCT06453213
Open-label Study of Cenobamate Monotherapy in Adult Subjects With Newly Diagnosed or Recurrent Partial-Onset Epilepsytreatment4recruiting
NCT05747001
This is a Retrospective Study on the Use of CENOBAMATE as Adjunctive Treatment in Patients Suffering From Epilepsy in Early Access Program in Germany, France and UKNo drug interventionsNot AvailableNot Availablecompleted
NCT05493293
Extension Study to Evaluate the Safety and Tolerability of NBI-921352 When Used With Anti-seizure Medications in Adults With Focal Onset Seizurestreatment2terminated
NCT04095182
Clinical Trial for Zebinix (Eslicarbazepine Acetate) in Healthy Korean and Caucasian Adulttreatment1completed
NCT01240187
A Study to Demonstrate Bioequivalence Between 6 x 2 mg Tablets of Perampanel and a Single 12 mg Tablet of Perampanel in Healthy Subjectstreatment1completed
NCT01209858
A Study to Investigate the Potential Pharmacokinetic Interaction of Perampanel With Oral Contraceptives in Healthy Female Subjectstreatment1completed
NCT03250377
A Study to Test the Safety/ Efficacy of Brivaracetam (BRV) Used as Adjunctive Treatment in Subjects >=16 Years of Age With Partial Seizures With or Without Secondary Generalizationtreatment3enrolling_by_invitation
NCT00220415
A Multicenter, Double-blind, Randomized, Placebo-controlled, Parallel Group Trial to Investigate the Efficacy and Safety of SPM 927 (200mg/Day and 400mg/Day) as Adjunctive Therapy in Subjects With Partial Seizures With or Without Secondary Generalizationtreatment3completed
NCT03685630
A Study to Evaluate the Safety and Tolerability of Intravenous Brivaracetam (BRV) as Replacement for Oral Brivaracetam in Japanese Subjects >=16 Years of Age With Partial Seizures With or Without Secondary Generalizationtreatment3completed
NCT03083665
A Study to Evaluate the Efficacy and Safety of Brivaracetam in Study Participants (>=16 to 80 Years of Age) With Epilepsytreatment3completed
NCT03340064
A Study of Levetiracetam as Monotherapy or Adjunctive Treatment of Partial Seizures in Pediatric Epileptic Subjects Ranging From 1 Month to Less Than 4 Years of Agetreatment3completed
NCT01063764
An Open Label Study of Levetiracetam in Japanese Pediatric Patients With Partial Seizurestreatment3completed
NCT00407797
Pregabalin In Partial Seizures (PREPS): An Open-Label, Multicenter Add On Therapy Trialtreatment4terminated
NCT04557085
Randomized, Double-blind Study to Evaluate Efficacy and Safety of Cenobamate Adjunctive Therapy in POStreatment3active_not_recruiting
NCT00141258
Pregabalin Epilepsy Add-On Trialtreatment3completed
NCT01630057
Evaluation of the Efficacy and Safety of Adjunctive Zonisamide vs Replacement With Zonisamide of the Last Added Antiepileptic Drugtreatment4completed
NCT04839601
RNS System RESPONSE StudyNo drug interventionstreatmentNot Availablerecruiting
NCT01392768
Efficacy and Safety of Levetiracetam in Partial Seizures Control, With or Without Secondary Generalizationtreatment3completed
NCT01954121
Open-label, Randomized, Active-controlled Study of LEV Used as Monotherapy in Patients With Partial-Onset Seizurestreatment3completed
NCT01136954
A Study to Assess the Efficacy and Safety of Adjunctive Zonisamide in Paediatric Partial Onset Seizures (CATZ Extension Study)treatment3completed
NCT01262677
Once-A-Day Pregabalin For Partial Seizurestreatment3completed
NCT05622370
An Open Label, Balanced, Randomized, 3×3 Latin Square Design Comparing of Brivaracetam Sustained-release Tablets and Brivaracetam Tablets in the Oral Comparative Pharmacokinetic(PK) Study in Chinese Healthy Adult Subjects Under Fasting Conditions.basic_science1active_not_recruiting
NCT00102713
A Study for Treatment of Partial Seizures in Childrentreatment3completed
NCT00327717
Evaluating the Efficacy and Safety of Zonisamide in the Treatment of Partial Seizurestreatment3completed
NCT04257604
A Study of Perampanel as Add-on Therapy in Adult and Adolescent Participants With Focal SeizuresNot AvailableNot Availablecompleted
NCT00537238
Pregabalin Versus Levetiracetam In Partial Seizurestreatment3completed
NCT06377930
Study Evaluating the Safety and Efficacy of RAP-219 in Adult Participants With Refractory Focal EpilepsyNo drug interventionstreatment2recruiting
NCT05614063
A Randomized Study of XEN1101 Versus Placebo in Focal-Onset SeizuresNo drug interventionstreatment3recruiting
NCT05716100
A Randomized Study of XEN1101 Versus Placebo in Focal-Onset Seizures (X-TOLE3)No drug interventionstreatment3recruiting
NCT04836559
A Study to Investigate JNJ-40411813 in Combination With Levetiracetam or Brivaracetam in Epilepsytreatment2completed
NCT05473442
Study of EQU-001 for Uncontrolled Focal Onset SeizuresNo drug interventionstreatment2terminated
NCT03370120
Study to Test the Safety and Efficacy of Padsevonil as Adjunctive Treatment of Focal-onset Seizures in Adult Subjects With Drug-resistant Epilepsytreatment2terminated
NCT03739840
A Study to Test the Efficacy and Safety of Padsevonil as Treatment of Focal-onset Seizures in Adult Subjects With Drug-resistant Epilepsytreatment3terminated
NCT03373383
Study to Test the Efficacy and Safety of Padsevonil as Adjunctive Treatment of Focal-onset Seizures in Adults With Drug-resistant Epilepsytreatment2completed
NCT02477839
Efficacy and Safety of Lacosamide as Adjunctive Therapy in Subjects ≥1 Month to <4 Years With Partial-onset Seizurestreatment3completed
NCT01147003
Efficacy and Safety of BGG492 as Adjunctive Treatment in Patients With Partial Onset Seizurestreatment2completed
NCT02124564
A Trial to Evaluate the Long Term Safety and Tolerability of Lacosamide Taken as Monotherapy in Adults With Partial-onset Seizurestreatment3completed
NCT01871233
An Extended Access Program for PerampanelNot AvailableNot Availableno_longer_available
NCT01338805
Phase II BGG492 Capsule Extension for Partial Epilepsytreatment2completed
NCT01830400
A Post-marketing Study Evaluating Eslicarbazepine Acetate (ESL) as Adjunctive Treatment in Partial-Onset Seizures (Study E2093-E044-404) (EPOS)Not AvailableNot Availablecompleted
NCT02072824
A Safety, Efficacy, and Tolerability Trial of Pregabalin as Add-On Treatment in Pediatric Subjects <4 Years of Age With Partial Onset Seizures.treatment3completed
NCT01167335
Evaluate the Efficacy of BGG492 as Adjunctive Treatment in Patients With Refractory Partial Onset Seizurestreatment2withdrawn
NCT00655486
Study to Assess the Long-term Safety of Oral Lacosamide in Subjects With Partial-onset Seizurestreatment3completed
NCT01710657
A Trial to Evaluate the Efficacy and Safety of Adjunctive Therapy With Lacosamide in Adults With Partial-Onset Seizurestreatment3completed
NCT01506882
An Open Label Study of Levetiracetam Monotherapy in Patients With Newly Diagnosed Focal Epilepsytreatment3completed
NCT02736162
Study to Investigate Dosage, Efficacy, and Safety of Perampanel Given as Monotherapy in Patients With EpilepsyNo drug interventionsNot AvailableNot Availablecompleted
NCT04252846
A Study to Investigate Dosage, Effectiveness, and Safety of Perampanel When Used as First Add-on Therapy in Participants >=12 Years With Partial Onset Seizures With or Without Secondary Generalization or With Primary Generalized Tonic-Clonic Seizures Associated With Idiopathic Generalized EpilepsyNot AvailableNot Availablecompleted
NCT01832038
Study to Evaluate the Safety, Tolerability, and Efficacy of Long-term Adjunctive Therapy With Lacosamide in Adults With Partial-onset Seizurestreatment3completed
NCT00655551
Safety of Intravenous Lacosamide Dose Followed by Twice Daily Oral Lacosamide in Subjects With Partial-onset Seizurestreatment3completed
NCT01051193
Long-term Safety and Tolerability of TRI476 (Oxcarbazepine) in Children With Inadequately Controlled Partial Onset Seizurestreatment2 / 3completed
NCT00975715
Efficacy, Safety and Tolerability of TRI476 (Oxcarbazepine) in Children With Inadequately Controlled Partial Onset SeizuresNo drug interventionstreatment2 / 3completed
NCT03201900
Study for Verification of Efficacy and Safety for Perampanel Monotherapy in Untreated Participants With Partial Onset Seizures (Including Secondarily Generalized Seizures (FREEDOM Study)treatment3completed
NCT04015141
A Study to Evaluate Efficacy and Safety of Perampanel Administered as an Adjunctive Therapy in Pediatric Participants With Childhood Epilepsytreatment2recruiting
NCT03836924
A Study to Assess Safety and Efficacy of Perampanel in Indian Participants as an Adjunctive Treatment in Partial Onset Seizures With or Without Secondary Generalized Seizures in Participants With Epilepsy Aged 12 Years or OlderNot AvailableNot Availablecompleted
NCT03288129
Study to Evaluate the Efficacy and Safety of Perampanel as Monotherapy or First Adjunctive Therapy in Subjects With Partial Onset Seizures With or Without Secondarily Generalized Seizures or With Primary Generalized Tonic-Clonic Seizurestreatment4completed
NCT04230044
A Study to Evaluate the Safety and Efficacy of Fycompa® (Perampanel) as Add-on Therapy in Participants With EpilepsyNot AvailableNot Availablecompleted
NCT01830868
A Post-marketing Observational Study Of The Use Of Zonisamide (ZNS) in the Adjunctive Treatment Of Adult Patients With Partial Onset Seizures (Study E2090-E044-410) (ZOOM)Not AvailableNot Availablecompleted
NCT01618695
A Study With an Open-label Extension Phase to Evaluate the Efficacy and Safety of Perampanel (E2007) Administered as an Adjunctive Therapy in Subjects With Refractory Partial-onset Seizurestreatment3completed
NCT02192814
Open-label Study to Evaluate the Safety and Tolerability of iv Lacosamide in Japanese Adults With Partial-onset Seizurestreatment3completed
NCT01407523
An Open Label Study of L059 Intravenous (IV) in Japanese Epilepsy Subjects With Partial Onset Seizurestreatment2completed
NCT03059329
Investigation of the Clinical Safety and Efficacy of Long-term Treatment With Fycompa Tablets in Adult Epilepsy Patients With Partial-onset Seizures (With or Without Secondary Generalized Seizures) or Primary Generalized Tonic-clonic SeizuresNot AvailableNot Availablecompleted
NCT03059381
Investigation of the Clinical Safety and Efficacy of Long-term Treatment With Fycompa Tablets in Adolescence Epilepsy Patients With Partial-onset Seizures (With or Without Secondary Generalized Seizures) or Primary Generalized Tonic-clonic SeizuresNot AvailableNot Availablecompleted
NCT01373190
Thermographic Examination of Skin Temperatures in Individuals With Focal Onset EpilepsyNo drug interventionsNot AvailableNot Availablecompleted
NCT04737837
A Real World Study on the Efficacy and Safety of Lacosamide as Add-on Therapy for Focal-onset EpilepsyNot AvailableNot Availableunknown_status
NCT05859854
Cenobamate in Adults With Focal-Onset SeizuresNo drug interventionsNot AvailableNot Availablerecruiting
NCT04770337
Pivotal-Safety and Therapeutic Measures of tDCS in Patients With Refractory Focal EpilepsyNo drug interventionstreatmentNot Availablerecruiting
NCT05738226
EpiCare@Home Validation Study for Focal Onset SeizuresNo drug interventionsdiagnosticNot Availablerecruiting
NCT03254680
Turmeric as Treatment in EpilepsyNo drug interventionstreatmentNot Availablewithdrawn
NCT05248269
Thermocoagulation in Drug Resistant Focal EpilepsyNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT02369471
A Study of GWP42006 in People With Focal Seizures - Part Atreatment2completed
NCT02705768
Effect of Carbamazepine and Oxcarbazepine on Serum Neuron-specific Enolase and S100B in Focal Seizurestreatment4completed
NCT02365610
A Study of GWP42006 in People With Focal Seizures - Part Btreatment2completed
NCT01620840
Lacosamid-i.v.-RegisterNot AvailableNot Availablecompleted
NCT03116828
A Study of a Drug to be Used in Addition With Another Drug to Treat Adults With Uncontrolled Partial-onset Seizurestreatment4completed
NCT00141388
To Evaluate the Long-Term Safety and Efficacy of Pregabalin in Patients With Partial Seizurestreatment3completed
NCT00141245
To Evaluate Long-Term Safety and Efficacy of Pregabalin in Patients With Partial Seizures.treatment3completed
NCT00150293
Evaluation of Long-Term Safety and Efficacy of Pregabalin in Patients With Partial Seizures.treatment3completed
NCT00141336
To Evaluate the Long-Term Safety and Efficacy of Pregabalin in Patients With Partial Seizures.treatment3completed
NCT00537940
Comparative Study Of Pregabalin And Gabapentin As Adjunctive Therapy In Subjects With Partial Seizurestreatment4completed
NCT00113815
Topiramate as Adjunctive Therapy in Infants 1-24 Months for the Control of Partial Onset Seizurestreatment3completed
NCT03712475
Pharmacokinetics of Two Formulation of Pregabalintreatment4completed
NCT00067431
A Study of the Safety and Efficacy of Depakote Sprinkle Capsules in the Treatment of Partial Seizures in Childrentreatment3terminated