- Accession Number
Drugs used to prevent SEIZURES or reduce their severity.
- ATC Classification
Drug Drug Description Pregabalin An anticonvulsant drug used to treat neuropathic pain conditions and fibromyalgia, and for the treatment of partial onset seizures in combination with other anticonvulsants. Phenytoin An anticonvulsant drug used in the prophylaxis and control of various types of seizures. Topiramate An anticonvulsant drug used in the control of epilepsy and in the prophylaxis and treatment of migraines. Valproic acid An anticonvulsant used to control complex partial seizures and both simple and complex absence seizures. Trimethadione An anticonvulsant agent indicated for the control of treatment-refractory petit mal seizures. Mephenytoin A phenylhydantoin used to treat refractory partial epilepsy. Lamotrigine A phenyltriazine antiepileptic used to treat some types of epilepsy and bipolar I disorder. Carbamazepine An anticonvulsant used to treat various types of seizures and pain resulting from trigeminal neuralgia. Ethosuximide An anticonvulsant used to treat petit mal seizures. Ethotoin A hydantoin antiepileptic used to control tonic-clonic and complex partial seizures. Oxcarbazepine An anti-epileptic used in the treatment of partial-onset seizures. Progabide Indicated for the treatment of epilepsy. Tiagabine An antiepileptic used to treat partial seizures. Zonisamide A sulfonamide anticonvulsant used to treat partial seizures. Felbamate An anticonvulsant used to treat severe epilepsy. Gabapentin An anticonvulsant medication used in the management of peripheral neuropathic pains, postherpetic neuralgia, and partial-onset seizures. Clonazepam A long-acting benzodiazepine with intermediate onset commonly used to treat panic disorders, severe anxiety, and seizures. Vigabatrin An irreversible GABA transaminase inhibitor used as an adjunct therapy to treat refractory complex partial seizures in patients ≥2 years unresponsive to alternatives. May also be used as monotherapy to treat infantile spasms in infants 1 month to 2 years. Levetiracetam A novel anticonvulsant agent used as an adjunct medication to manage partial onset, myoclonic, and generalized tonic-clonic seizures in patients with epilepsy. Fosphenytoin An antiepileptic agent used for the management of generalized convulsive status epilepticus and prevention and treatment of seizures occurring during neurosurgery. Valpromide A valproic acid derivative used to treat epilepsy and as adjunct therapy for psychomotor agitation, depression, and manic episodes of bipolar disorder. Ezogabine An antiepileptic agent used as an adjuvant treatment of partial-onset seizures. Methsuximide A succinimide anticonvulsant that increases the seizure threshold. Primarily used for childhood absence seizures. Functions by suppressing paroxysmal spike-and-wave patterns associated with lapses of consciousness in absence seizures. Lacosamide An antiepileptic drug used to treat partial onset seizures in adults. Perampanel A non-competitive AMPA glutamate receptor antagonist used to treat partial-onset seizures with or without secondarily generalized seizures, and as adjunctive treatment of primary generalized tonic-clonic seizures in patients with epilepsy. Stiripentol An antiepileptic agent used in combination with other anticonvulsants to treat seizures associated with Dravet syndrome. Eslicarbazepine acetate An anticonvulsant agent used as an adjunct to treat partial-onset seizures in patients with inadequate clinical response to conventional antiepileptic therapy. Sulthiame A carbonic anhydrase inhibitor used primarily in benign focal epilepsies of childhood that may be useful as an adjunct therapy in a variety of other refractory epilepsies. Pheneturide Not Annotated Lorazepam A short-acting benzodiazepine commonly used to treat panic disorders, severe anxiety, and seizures. Clobazam A benzodiazepine used as adjunct treatment in seizures associated with Lennox-Gastaut syndrome. Thiopental A barbiturate used to induce general anesthesia, treat convulsions, and reduce intracranial pressure. Clorazepic acid A benzodiazepine used to treat anxiety, partial seizures, and alcohol withdrawal. Magnesium sulfate A drug used to treat convulsions during pregnancy, nephritis in children, magnesium deficiency, and tetany. Tizanidine An alpha-2 adrenergic agonist used for the short-term treatment of muscle spasticity. Riluzole A glutamate antagonist used to treat amyotrophic lateral sclerosis. Primidone An antiepileptic used to treat grand mal, psychomotor, and focal epileptic seizures. Acetazolamide A carbonic anhydrase inhibitor used to treat edema from heart failure or medications, certain types of epilepsy, and glaucoma. Diazepam A long-acting benzodiazepine with rapid onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawal, and seizures. Methylphenobarbital For the relief of anxiety, tension, and apprehension, also used as an anticonvulsant for the treatment of epilepsy. Zaleplon A sedative used for short term treatment of insomnia in adults. Phenobarbital A long-lasting barbiturate and anticonvulsant used in the treatment of all types of seizures, except for absent seizures. Estazolam A benzodiazepine used for the short-term management of insomnia. Delorazepam A benzodiazepine used to manage severe anxiety disorders and insomnia. Nitrazepam A long-acting benzodiazepine with intermediate onset commonly used to treat panic disorders, severe anxiety, insomnia, and seizures. 7-Nitroindazole Not Available Flunarizine A selective calcium-entry blocker used as migraine prophylaxis in patients with severe and frequent episodes who have not responded adequately to more common treatments. Remacemide Investigated for use/treatment in epilepsy, huntington's disease, and parkinson's disease. Clomethiazole Investigated for use/treatment in strokes. Deramciclane Investigated for use/treatment in anxiety disorders. Tramiprosate Investigated for use/treatment in strokes and alzheimer's disease. Gaboxadol Investigated for use/treatment in sleep disorders and insomnia. Ifenprodil N-methyl-D-aspartate (NMDA) receptors (NMDARs) are members of the ionotropic glutamate receptor family, with key roles in brain development and neurological function.[A220118, A220128] NMDARs are heterotetramers that typically involve a dimer... Paraldehyde A central nervous system depressant previously used to control convulsions due to various clinical causes, including tetanus, status epilepticus, and convulsive drugs. Doramectin Doramectin is a veterinary drug approved by the Food and Drug Administration for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice and mange mites in... Tiletamine This drug is a dissociative anesthetic agent that falls under the drug category of NMDA receptor antagonists. Tiletamine is chemically similar to another dissociative anesthetic, ketamine. Tiletamine hydrochloride, the salt... Etiracetam Etiracetam is under investigation in clinical trial NCT01137110 (Comparison of Short Duration Levetiracetam to Extended Course for Seizure Prophylaxis After Subarachnoid Hemorrhage (SAH)). Vinpocetine A synthetic derivative of a vinca alkaloid used to treat neurological symptoms of cerebrovascular disease. Medazepam A long-acting benzodiazepine used for its sedative and anxiolytic properties. Phenibut Not Annotated Metharbital Metharbital is used for the treatment of epilepsy. Paramethadione Used for the control of absence (petit mal) seizures that are refractory to treatment with other medications. Phensuximide For the treatment of epilepsy. Phenacemide Used to control certain seizures in the treatment of epilepsy. Brivaracetam An anticonvulsant used for the treatment of partial-onset seizures that functions by binding to synaptic vesicle glycoprotein 2A (SV2A) in the brain. Rufinamide An antiepileptic drug used as adjunctive therapy to treat seizures associated with Lennox-Gastaut Syndrome (LGS). Barbexaclone Created for the treatment for epilepsy, with the intent of creating an antiepileptic with less sedative properties than phenobarbital. Beclamide Has been used in the management of epilepsy and epilepsy related behavioural disorders. It was used for generalised tonic-clonic seizures, and was not effective for absence seizures. More recently focus... Carisbamate Carisbamate has been investigated in Alcohol Abuse, Substance Abuse, and Alcohol Dependence. Neocitrullamon Not Annotated Ethadione Not Annotated Methohexital An anesthetic used to induce deep sedation. Secobarbital A barbiturate used for the short-term treatment of insomnia. Pentobarbital A barbiturate drug used to induce sleep, cause sedation, and control certain types of seizures. Thiamylal Used for the production of complete anaesthesia of short duration, for the induction of general anaesthesia, and for inducing a hypnotic state. Amobarbital A barbiturate derivative used for the induction of sedation during procedures, short-term management of insomnia, and acute management of refractory tonic-clonic seizures. Hexobarbital For the induction of anesthesia prior to the use of other general anesthetic agents and for induction of anesthesia for short surgical, diagnostic, or therapeutic procedures associated with minimal painful... Barbital A long-acting barbiturate that depresses most metabolic processes at high doses. It is used as a hypnotic and sedative and may induce dependence. Barbital is also used in veterinary practice... Cannabidivarin Cannabidivarin does not currently have any FDA or Health Canada approved indications, however in October 2017 CBDV was given orphan designation by the European Medicines Agency for use in Rett... Butalbital A barbiturate drug used for symptomatic treatment of tension-type headache in various combinations with acetaminophen, aspirin, caffeine, and codeine. Eslicarbazepine An antiepileptic indicated as a monotherapy or adjunct therapy in the treatment of epilepsy. Cannabidiol An active cannabinoid used as an adjunctive treatment for the management of seizures associated with Lennox-Gastaut syndrome or Dravet syndrome and symptomatic relief of moderate to severe neuropathic pain or other painful conditions, like cancer. Brexanolone Brexanolone is a synthetic neuroactive steroid gamma-aminobutyric acid A (GABA(a)) receptor positive modulator indicated for the treatment of postpartum depression (PPD) in adult women [FDA Label][A176080, A176083, F4063, F4066, F4072]. JNJ-26489112 JNJ-26489112 is under investigation in clinical trial NCT00579384 (A Study of the Effects of JNJ-26489112 on the Photic Induced Paroxysmal Electroencephalogram (EEG) Response in Patients With Photosensitive Epilepsy). Cenobamate A small molecule drug indicated to treat partial onset seizures in adults. Butabarbital A barbiturate drug used as a sedative and hypnotic. Padsevonil Padsevonil is under investigation in clinical trial NCT03695094 (A Study in Participants With Epilepsy, to Evaluate the Pharmacokinetics, Safety and Tolerability of Oxcarbazepine on Padsevonil). Fenfluramine Fenfluramine is a phenethylamine that is structurally similar to serotonin. Due to its ability to increase extracellular serotonin levels, modulate serotonergic and other neurologic receptors, and control neurotransmission, it is effective in treating pharmacoresistant seizures. Ganaxolone A neuroactive steroid GABA-A receptor modulator used for the treatment of seizures associated with CDKL5 deficiency disorder (CDD).
- Drugs & Drug Targets