This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Summary
Methylprednisolone aceponate is a corticosteroid indicated in the treatment of corticosteroid-responsive dermatoses.
- Generic Name
- Methylprednisolone aceponate
- DrugBank Accession Number
- DB14643
- Background
Not Available
- Type
- Small Molecule
- Groups
- Approved, Vet approved
- Structure
Structure for Methylprednisolone aceponate (DB14643)
- Weight
- Average: 472.578
Monoisotopic: 472.246103499 - Chemical Formula
- C27H36O7
- Synonyms
- Aceponato de metilprednisolona
- Methylprednisolone aceponate
- Methylprednisoloni aceponas
- External IDs
- BRN 5663614
- SH-440
- ZK91588
Pharmacology
- Indication
Not Available
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- Contraindications & Blackbox Warnings
Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
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Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAcarbose The risk or severity of hyperglycemia can be increased when Methylprednisolone aceponate is combined with Acarbose. Aceclofenac The risk or severity of gastrointestinal irritation can be increased when Methylprednisolone aceponate is combined with Aceclofenac. Acemetacin The risk or severity of gastrointestinal irritation can be increased when Methylprednisolone aceponate is combined with Acemetacin. Acenocoumarol Methylprednisolone aceponate may increase the anticoagulant activities of Acenocoumarol. Acetohexamide The risk or severity of hyperglycemia can be increased when Methylprednisolone aceponate is combined with Acetohexamide. Acetyldigitoxin The risk or severity of adverse effects can be increased when Methylprednisolone aceponate is combined with Acetyldigitoxin. Acetylsalicylic acid The risk or severity of gastrointestinal irritation can be increased when Methylprednisolone aceponate is combined with Acetylsalicylic acid. Albiglutide The risk or severity of hyperglycemia can be increased when Methylprednisolone aceponate is combined with Albiglutide. Alclofenac The risk or severity of gastrointestinal irritation can be increased when Methylprednisolone aceponate is combined with Alclofenac. Alfacalcidol The therapeutic efficacy of Alfacalcidol can be decreased when used in combination with Methylprednisolone aceponate. 
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- Not Available
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- International/Other Brands
- Advantan
Categories
- ATC Codes
- D07AC14 — Methylprednisolone aceponate
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as gluco/mineralocorticoids, progestogins and derivatives. These are steroids with a structure based on a hydroxylated prostane moiety.
- Kingdom
- Organic compounds
- Super Class
- Lipids and lipid-like molecules
- Class
- Steroids and steroid derivatives
- Sub Class
- Pregnane steroids
- Direct Parent
- Gluco/mineralocorticoids, progestogins and derivatives
- Alternative Parents
- Steroid esters / 20-oxosteroids / 3-oxo delta-1,4-steroids / 11-beta-hydroxysteroids / Delta-1,4-steroids / Alpha-acyloxy ketones / Dicarboxylic acids and derivatives / Secondary alcohols / Cyclic ketones / Cyclic alcohols and derivatives show 3 more
- Substituents
- 11-beta-hydroxysteroid / 11-hydroxysteroid / 20-oxosteroid / 3-oxo-delta-1,4-steroid / 3-oxosteroid / Alcohol / Aliphatic homopolycyclic compound / Alpha-acyloxy ketone / Carbonyl group / Carboxylic acid derivative show 15 more
- Molecular Framework
- Aliphatic homopolycyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- ET54W9J4U2
- CAS number
- 86401-95-8
- InChI Key
- DALKLAYLIPSCQL-YPYQNWSCSA-N
- InChI
- InChI=1S/C27H36O7/c1-6-23(32)34-27(22(31)14-33-16(3)28)10-8-19-18-11-15(2)20-12-17(29)7-9-25(20,4)24(18)21(30)13-26(19,27)5/h7,9,12,15,18-19,21,24,30H,6,8,10-11,13-14H2,1-5H3/t15-,18-,19-,21-,24+,25-,26-,27-/m0/s1
- IUPAC Name
- (1R,3aS,3bS,5S,9aR,9bS,10S,11aS)-1-[2-(acetyloxy)acetyl]-10-hydroxy-5,9a,11a-trimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl propanoate
- SMILES
- [H][C@@]12CC[C@](OC(=O)CC)(C(=O)COC(C)=O)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])C[C@H](C)C2=CC(=O)C=C[C@]12C
References
- General References
- AIFA Package Leaflet: ADVANTAN (Methylprednisolone aceponate) for cutaneous use [Link]
- External Links
- ChemSpider
- 56717
- ChEBI
- 135762
- ChEMBL
- CHEMBL1697782
- ZINC
- ZINC000004213828
- Wikipedia
- Methylprednisolone_aceponate
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Completed Prevention Atopic Dermatitis 1 4 Completed Treatment Atopic Dermatitis 1 1 Completed Basic Science Normal Physiology 1 1 Completed Supportive Care Eczema; Contact, Allergic 1 Not Available Completed Treatment Psoriasis Vulgaris (Plaque Psoriasis) 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Cream Cutaneous 1 mg/g Cream Cutaneous 1.000 mg Solution Topical 1 mg/ml Emulsion Topical 0.1 g Cream Topical Ointment Topical Cream Topical 0.1 % Ointment Topical 0.1 % Ointment Topical 0.1 percent Cream Topical 30 g Solution Oral 0.1 % Emulsion Topical 0.1 % Emulsion Topical Solution Topical 0.1 % Lotion Topical 0.1 % Lotion Topical 100 gr Lotion Topical 50 gr Lotion Topical 100 mg Solution Oral 1 MG/ML Emulsion Topical 1 MG/G Solution Topical - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.00637 mg/mL ALOGPS logP 2.92 ALOGPS logP 3.14 Chemaxon logS -4.9 ALOGPS pKa (Strongest Acidic) 14.8 Chemaxon pKa (Strongest Basic) -2.9 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 106.97 Å2 Chemaxon Rotatable Bond Count 7 Chemaxon Refractivity 125.97 m3·mol-1 Chemaxon Polarizability 50.86 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
Drug created at September 01, 2018 21:20 / Updated at May 14, 2021 01:07