Methylprednisolone aceponate

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Summary

Methylprednisolone aceponate is a corticosteroid indicated in the treatment of corticosteroid-responsive dermatoses.

Generic Name
Methylprednisolone aceponate
DrugBank Accession Number
DB14643
Background

Not Available

Type
Small Molecule
Groups
Approved, Vet approved
Structure
Thumb
Weight
Average: 472.578
Monoisotopic: 472.246103499
Chemical Formula
C27H36O7
Synonyms
  • Aceponato de metilprednisolona
  • Methylprednisolone aceponate
  • Methylprednisoloni aceponas
External IDs
  • BRN 5663614
  • SH-440
  • ZK91588

Pharmacology

Indication

Not Available

Pharmacology
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Associated Conditions
Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Adverseeffects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AcarboseThe risk or severity of hyperglycemia can be increased when Methylprednisolone aceponate is combined with Acarbose.
AceclofenacThe risk or severity of gastrointestinal irritation can be increased when Methylprednisolone aceponate is combined with Aceclofenac.
AcemetacinThe risk or severity of gastrointestinal irritation can be increased when Methylprednisolone aceponate is combined with Acemetacin.
AcenocoumarolMethylprednisolone aceponate may increase the anticoagulant activities of Acenocoumarol.
AcetohexamideThe risk or severity of hyperglycemia can be increased when Methylprednisolone aceponate is combined with Acetohexamide.
AcetyldigitoxinThe risk or severity of adverse effects can be increased when Methylprednisolone aceponate is combined with Acetyldigitoxin.
Acetylsalicylic acidThe risk or severity of gastrointestinal irritation can be increased when Methylprednisolone aceponate is combined with Acetylsalicylic acid.
AlbiglutideThe risk or severity of hyperglycemia can be increased when Methylprednisolone aceponate is combined with Albiglutide.
AlclofenacThe risk or severity of gastrointestinal irritation can be increased when Methylprednisolone aceponate is combined with Alclofenac.
AlfacalcidolThe therapeutic efficacy of Alfacalcidol can be decreased when used in combination with Methylprednisolone aceponate.
Interactions
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Food Interactions
Not Available

Products

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International/Other Brands
Advantan

Categories

ATC Codes
D07AC14 — Methylprednisolone aceponate
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as gluco/mineralocorticoids, progestogins and derivatives. These are steroids with a structure based on a hydroxylated prostane moiety.
Kingdom
Organic compounds
Super Class
Lipids and lipid-like molecules
Class
Steroids and steroid derivatives
Sub Class
Pregnane steroids
Direct Parent
Gluco/mineralocorticoids, progestogins and derivatives
Alternative Parents
Steroid esters / 20-oxosteroids / 3-oxo delta-1,4-steroids / 11-beta-hydroxysteroids / Delta-1,4-steroids / Alpha-acyloxy ketones / Dicarboxylic acids and derivatives / Secondary alcohols / Cyclic ketones / Cyclic alcohols and derivatives
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Substituents
11-beta-hydroxysteroid / 11-hydroxysteroid / 20-oxosteroid / 3-oxo-delta-1,4-steroid / 3-oxosteroid / Alcohol / Aliphatic homopolycyclic compound / Alpha-acyloxy ketone / Carbonyl group / Carboxylic acid derivative
show 15 more
Molecular Framework
Aliphatic homopolycyclic compounds
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
ET54W9J4U2
CAS number
86401-95-8
InChI Key
DALKLAYLIPSCQL-YPYQNWSCSA-N
InChI
InChI=1S/C27H36O7/c1-6-23(32)34-27(22(31)14-33-16(3)28)10-8-19-18-11-15(2)20-12-17(29)7-9-25(20,4)24(18)21(30)13-26(19,27)5/h7,9,12,15,18-19,21,24,30H,6,8,10-11,13-14H2,1-5H3/t15-,18-,19-,21-,24+,25-,26-,27-/m0/s1
IUPAC Name
(1R,3aS,3bS,5S,9aR,9bS,10S,11aS)-1-[2-(acetyloxy)acetyl]-10-hydroxy-5,9a,11a-trimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl propanoate
SMILES
[H][C@@]12CC[C@](OC(=O)CC)(C(=O)COC(C)=O)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])C[C@H](C)C2=CC(=O)C=C[C@]12C

References

General References
  1. AIFA Package Leaflet: ADVANTAN (Methylprednisolone aceponate) for cutaneous use [Link]
ChemSpider
56717
ChEBI
135762
ChEMBL
CHEMBL1697782
ZINC
ZINC000004213828
Wikipedia
Methylprednisolone_aceponate

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedPreventionDermatitis, Dermatitis Atopic1
4CompletedTreatmentDermatitis, Dermatitis Atopic1
1CompletedSupportive CareEczema; Contact, Allergic1
1RecruitingBasic ScienceNormal Physiology1
Not AvailableCompletedTreatmentPsoriasis Vulgaris (Plaque Psoriasis)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
CreamCutaneous1 mg/g
SolutionTopical
EmulsionTopical0.1 g
CreamTopical
OintmentTopical
CreamTopical0.1 %
OintmentTopical0.1 %
OintmentTopical0.1 percent
SolutionOral0.1 %
EmulsionTopical0.1 %
EmulsionTopical
LotionTopical
LotionTopical100 gr
LotionTopical50 gr
LotionTopical100 mg
SolutionOral1 MG/ML
EmulsionTopical1 MG/G
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00637 mg/mLALOGPS
logP2.92ALOGPS
logP3.14ChemAxon
logS-4.9ALOGPS
pKa (Strongest Acidic)14.8ChemAxon
pKa (Strongest Basic)-2.9ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area106.97 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity125.97 m3·mol-1ChemAxon
Polarizability50.86 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created on September 01, 2018 21:20 / Updated on May 14, 2021 01:07