Tenofovir exalidex

DB14925InvestigationalSmall molecule

Tenofovir exalidex is under investigation in clinical trial NCT01080820 (A Safety, Tolerability and Pharmacokinetic Study of a Single Dose of CMX157 in Healthy Volunteers).

Mechanism: Pharmacologically active on Reverse transcriptase/RNaseH
Curator reviewed
Formula / weight: C₂₈H₅₂N₅O₅P · 569.728 g/mol (avg)
Code names: CMX157

Resolves to

Compound

UNIIK7J545MEMACAS911208-73-6ChEMBLCHEMBL515564

Structure

InChIKeySCTJKHUUZLXJIP-RUZDIDTESA-NSMILESCCCCCCCCCCCCCCCCOCCCOP(O)(=O)CO[C@H](C)CN1C=NC2=C1N=CN=C2N

Targets

Q72547polP03366gag-pol

What you can answer from here — as of June 15, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

5Clinical trialsPhase, status and sponsor resolved per trial

3+ReferencesStructured and connected to the statements they support

Which drugs share a target with Tenofovir exalidex, and which of those have an active Phase 3 trial?

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