This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Surufatinib
DrugBank Accession Number
DB15106
Background

Surufatinib is under investigation in clinical trial NCT02588170 (Phase III Study of Surufatinib in Treating Advanced Extrapancreatic Neuroendocrine Tumors).

Type
Small Molecule
Groups
Investigational
Structure
Weight
Average: 480.59
Monoisotopic: 480.19435996
Chemical Formula
C24H28N6O3S
Synonyms
  • SULFATINIB
  • Surufatinib

Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
B2K5L1L8S9
CAS number
1308672-74-3
InChI Key
TTZSNFLLYPYKIL-UHFFFAOYSA-N
InChI
InChI=1S/C24H28N6O3S/c1-17-13-19-15-21(7-8-22(19)27-17)33-23-9-10-25-24(29-23)28-20-6-4-5-18(14-20)16-34(31,32)26-11-12-30(2)3/h4-10,13-15,26-27H,11-12,16H2,1-3H3,(H,25,28,29)
IUPAC Name
N-[2-(dimethylamino)ethyl]-1-[3-({4-[(2-methyl-1H-indol-5-yl)oxy]pyrimidin-2-yl}amino)phenyl]methanesulfonamide
SMILES
CN(C)CCNS(=O)(=O)CC1=CC(NC2=NC(OC3=CC4=C(NC(C)=C4)C=C3)=CC=N2)=CC=C1

References

General References
Not Available
ChemSpider
57583328
ZINC
ZINC000117218067

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3Active Not RecruitingTreatmentNeuroendocrine Tumors2
3RecruitingTreatmentAdvanced Neuroendocrine Carcinoma1
2CompletedTreatmentBiliary Tract Cancer (BTC)1
2CompletedTreatmentThyroid Carcinoma1
2Not Yet RecruitingTreatmentAdenocarcinoma of the Stomach1
2Not Yet RecruitingTreatmentAdvanced Colorectal Cancer1
2Not Yet RecruitingTreatmentBreast Cancer / Malignant Neoplasm of Female Breast1
2Not Yet RecruitingTreatmentIntrahepatic Cholangiocarcinoma1
2Not Yet RecruitingTreatmentMalignant Neoplasm of Pancreas1
2Not Yet RecruitingTreatmentNasopharyngeal Carcinoma (NPC)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0108 mg/mLALOGPS
logP3.15ALOGPS
logP3.17ChemAxon
logS-4.6ALOGPS
pKa (Strongest Acidic)10.46ChemAxon
pKa (Strongest Basic)7.5ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area112.24 Å2ChemAxon
Rotatable Bond Count9ChemAxon
Refractivity133.61 m3·mol-1ChemAxon
Polarizability51.94 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created at May 20, 2019 14:50 / Updated at February 21, 2021 18:55