Mixed Phenotype Acute Leukemia (MPAL) (DBCOND0071898)

Identifiers

Synonyms
Mixed Phenotype Acute Leukemia / Acute Mixed-Phenotype Leukemia / Acute Mixed Lineage Leukemia / Mixed Lineage Acute Leukemia / Mixed-Lineage Acute Leukemias / Mixed phenotype acute leukemia (disorder) / Mixed phenotype acute leukemia (morphologic abnormality) / Acute leukemia of unspecified cell type / Acute bilineal leukaemia / Acute bilineal leukemia / Acute biphenotypic leukemia (morphologic abnormality) / Acute biphenotypic leukaemia / Leukemia, Biphenotypic, Acute / Acute biphenotypic leukemia / Acute biphenotypic leukemia (disorder)

Associated Data

Indicated Drugs and Targets
Not Available
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT04827745
Blinatumomab for Treatment of R/R or MRD-positive CD19-Positive MPALtreatment2active_not_recruiting
NCT02212561
Selinexor With Fludarabine and Cytarabine for Treatment of Refractory or Relapsed Leukemia or Myelodysplastic Syndrometreatment1completed
NCT05322850
Phase I/II Trial: Engineered Donor Graft (Orca Q) for Pediatric Hematopoietic Cell Transplant (HCT)No drug interventionstreatment1 / 2recruiting
NCT06390319
Adding Dasatinib Or Venetoclax To Improve Responses In Children With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia (ALL) Or Lymphoma (T-LLY) Or Mixed Phenotype Acute Leukemia (MPAL)treatment2not_yet_recruiting
NCT04128501
Venetoclax and Azacitidine for the Treatment of Acute Myeloid Leukemia in the Post-Transplant Settingtreatment2recruiting
NCT06289673
Identification of Necessary Information for Treatment Induction in Newly Diagnosed Acute Lymphoblastic Leukemia/Lymphomatreatment4not_yet_recruiting
NCT05327894
Interfant-21 Treatment Protocol for Infants Under 1 Year with KMT2A-rearranged ALL or Mixed Phenotype Acute Leukemiatreatment3recruiting
NCT04726241
The Pediatric Acute Leukemia (PedAL) Screening Trial - A Study to Test Bone Marrow and Blood in Children With Leukemia That Has Come Back After Treatment or Is Difficult to Treat - A Leukemia & Lymphoma Society and Children's Oncology Group StudyNo drug interventionsscreening1 / 2recruiting
NCT05457556
Mismatched Related Donor Versus Matched Unrelated Donor Stem Cell Transplantation for Children, Adolescents, and Young Adults With Acute Leukemia or Myelodysplastic Syndrometreatment3recruiting
NCT05602194
Studying the Effect of Levocarnitine in Protecting the Liver From Chemotherapy for Leukemia or Lymphomasupportive_care3recruiting
NCT04872790
Venetoclax, Dasatinib, Prednisone, Rituximab and Blinatumomab for the Treatment of Newly Diagnosed or Relapsed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia or Mixed Phenotype Acute Leukemiatreatment1recruiting
NCT03326921
HA-1 T TCR T Cell Immunotherapy for the Treatment of Patients With Relapsed or Refractory Acute Leukemia After Donor Stem Cell Transplanttreatment1suspended
NCT04195633
Donor Stem Cell Transplant With Treosulfan, Fludarabine, and Total-Body Irradiation for the Treatment of Hematological Malignanciestreatment2recruiting
NCT02921061
Decitabine With GCLAM for Adults With Newly Diagnosed, Relapsed, or Refractory AML or High-Risk MDStreatment1 / 2completed
NCT03404193
Venetoclax and Decitabine in Treating Participants With Relapsed/Refractory Acute Myeloid Leukemia or Relapsed High-Risk Myelodysplastic Syndrometreatment2active_not_recruiting
NCT03957915
Study of Escalating Doses of INA03 Administered Intravenously as Single Agent in Adult Patients With Relapse/Refractory Acute LeukemiaNo drug interventionstreatment0recruiting
NCT05476770
Tagraxofusp in Pediatric Patients With Relapsed or Refractory CD123 Expressing Hematologic Malignanciestreatment1recruiting
NCT00723099
Donor Umbilical Cord Blood Transplant in Treating Patients With Hematologic Cancertreatment2completed
NCT04067336
First in Human Study of Ziftomenib in Relapsed or Refractory Acute Myeloid Leukemiatreatment1 / 2recruiting
NCT03198234
Use of T-allo10 in Hematopoietic Stem Cell Transplantation (HSCT) for Blood DisordersNo drug interventionstreatment1terminated
NCT05326516
A Study of Revumenib in Combination With Chemotherapy in Participants With R/R Acute Leukemiatreatment1completed
NCT02135874
Clofarabine, Idarubicin, Cytarabine, Vincristine Sulfate, and Dexamethasone in Treating Patients With Newly Diagnosed or Relapsed Mixed Phenotype Acute Leukemiatreatment2completed
NCT04797767
Venetoclax and CLAG-M for the Treatment of Acute Myeloid Leukemia and High-Grade Myeloid Neoplasmstreatment1suspended
NCT05316701
Precision-T: A Randomized Study of Orca-T in Recipients Undergoing Allogeneic Transplantation for Hematologic MalignanciesNo drug interventionstreatment3active_not_recruiting
NCT03802695
A Phase 1 Study of Orca-Q in Recipients Undergoing Allogeneic Transplantation for Hematologic MalignanciesNo drug interventionstreatment1recruiting
NCT06013423
Cord Blood Transplant, Cyclophosphamide, Fludarabine, and Total-Body Irradiation in Treating Patients With High-Risk Hematologic Diseasestreatment2recruiting
NCT06551584
Phase I Trial for Patients w/ Advanced Hematologic Malignancies Undergoing Allogeneic HCTtreatment1not_yet_recruiting
NCT05735184
A Study to Investigate the Safety and Tolerability of Ziftomenib in Combination With Venetoclax/Azacitidine, Venetoclax, or 7+3 in Patients With AMLtreatment1recruiting
NCT01887587
Vincristine, Doxorubicin, And Dexamethasone + Ixazomib in Acute Lymphoblastic Leukemia (ALL), Lymphoblastic Lymphoma Or Mixed Phenotype Acute Leukemiatreatment1terminated
NCT03779854
Naive T Cell Depletion for Preventing Chronic Graft-versus-Host Disease in Children and Young Adults With Blood Cancers Undergoing Donor Stem Cell Transplanttreatment2recruiting
NCT03007147
Imatinib Mesylate and Combination Chemotherapy in Treating Patients With Newly Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemiatreatment3active_not_recruiting
NCT03843528
Vorinostat Dose-escalation After Allogeneic Hematopoietic Cell Transplantationtreatment1recruiting
NCT04872478
Pharmacokinetic and Safety Study of MRX-2843 in Adolescents and Adults With Relapsed/Refractory AML, ALL, or MPALNo drug interventionstreatment1recruiting
NCT04904588
HLA-Mismatched Unrelated Donor Hematopoietic Cell Transplantation With Post-Transplantation Cyclophosphamidetreatment2recruiting
NCT04762485
Humanized CD7 CAR T-cell Therapy for r/r CD7+ Acute LeukemiaNo drug interventionstreatment1 / 2unknown_status
NCT03959085
Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and B-LLytreatment3recruiting
NCT05433532
Study of Azacitidine,Venetoclax,and Flumatinib in Newly Diagnosed Ph-positive Acute Leukemia and CML-AP/BP Patientstreatment2completed
NCT06034470
Combination Chemotherapy (FLAG-Ida) With Pivekimab Sunirine (PVEK [IMGN632]) for the Treatment of Newly Diagnosed Adverse Risk Acute Myeloid Leukemia and Other High-Grade Myeloid Neoplasmstreatment1recruiting
NCT04065399
A Study of Revumenib in R/R Leukemias Including Those With an MLL/KMT2A Gene Rearrangement or NPM1 Mutationtreatment1 / 2recruiting
NCT03128034
211^At-BC8-B10 Before Donor Stem Cell Transplant in Treating Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndrome, or Mixed-Phenotype Acute Leukemiatreatment1 / 2suspended
NCT02828358
Azacitidine and Combination Chemotherapy in Treating Infants With Acute Lymphoblastic Leukemia and KMT2A Gene Rearrangementtreatment2active_not_recruiting
NCT03599869
Management of Mixed-Phenotype Acute Leukemia in the East of FranceNo drug interventionsNot AvailableNot Availableunknown_status
NCT05153330
Study of BMF-219, a Covalent Menin Inhibitor, in Adult Patients With AML, ALL (With KMT2A/ MLL1r, NPM1 Mutations), DLBCL, MM, and CLL/SLLNo drug interventionstreatment1recruiting
NCT05918692
A Phase 1, Study of BMF-500 in Adults With Acute LeukemiaNo drug interventionstreatment1recruiting
NCT02419755
Bortezomib and Vorinostat in Younger Patients With Refractory or Relapsed MLL Rearranged Hematologic Malignanciestreatment2terminated
NCT02799147
GVHD Prophylaxis With Post-transplantation Bendamustine in Refractory Leukemiatreatment1 / 2completed