NCT06486207
Effects of Kendall Exercise VS Gong's Mobilization on Pain, Range of Motion, Function, and Strength in Cases With UCS No drug interventions health_services_research Not Available active_not_recruiting NCT05392309
Manual Ankle Rocking Training on Postural Control and Foot Function in Children With Down Syndrome No drug interventions treatment Not Available completed NCT06459440
Effect of Group-Task-Oriented Training on GMFM and ADL in Children With DS No drug interventions treatment Not Available completed NCT01889550
Use of eHealth in Communication With Patients About Prenatal Diagnosis No drug interventions supportive_care Not Available completed NCT01699711
Normalization of dyrk1A and APP Function as an Approach to Improve Cognitive Performance and Decelerate AD Progression in DS Subjects: Epigallocatechin Gallate as Therapeutic Tool No drug interventions treatment 2 completed NCT01379443
Rehabilitation of Children With Multiple Disabilities No drug interventions health_services_research 1 completed NCT00001178
Brain Study of Patients With Frontal Lobe Dementia and Parkinsonian Disorders No drug interventions Not Available Not Available terminated NCT01758718
Eyelash Line Resection for Entropion Associated With Down's Syndrome No drug interventions treatment Not Available completed NCT06176755
Treadmill Training With and Without Weighted Ankle Cuffs on Gait Parameters No drug interventions health_services_research Not Available completed NCT01794013
DIR/ Floortime™ Parent Training Intervention for the Children With Developmental Disabilities No drug interventions treatment Not Available completed NCT05392322
Effect of Virtual Video Reality Gaming on Fine Motor Skills in Children With Down's Syndrome No drug interventions treatment Not Available unknown_status NCT00240760
Memantine and Down's Syndrome treatment Not Available unknown_status NCT03551418
Learning by Repetitive Viewing of Peer Modeling Patient Education Videos by Adults With Down Syndrome No drug interventions health_services_research Not Available terminated NCT05004337
Verification of Risk Assignment for Whole Chromosome Using SNP-based NIPT in Vanishing Twin Pregnancies No drug interventions Not Available Not Available completed NCT04747275
Use of Liquid Stable Levothyroxine in Trisomy 21 Pediatric Patients other 4 terminated NCT04737070
Study of High Risk Non Invasive Prenatal Test Population No drug interventions Not Available Not Available unknown_status NCT02109770
Development of Non-invasive Prenatal Test for Microdeletion and Other Genetic Syndromes Based on Cell Free DNA No drug interventions Not Available Not Available completed NCT01256606
Prenatal Test for Fetal Aneuploidy Detection No drug interventions Not Available Not Available completed NCT02278536
Multiple Gestation Study No drug interventions Not Available Not Available completed NCT06200519
Assessment of Diastolic Function During the Transitional Period and Infancy Using Serial Echocardiography No drug interventions Not Available Not Available not_yet_recruiting NCT01511458
Non-invasive Chromosomal Examination of Trisomy Study No drug interventions Not Available Not Available completed NCT02872948
Diagnosis Accuracy of Noninvasive Screening by PCR Digital for Down Syndrom No drug interventions Not Available Not Available completed NCT02381457
SNP-based Microdeletion and Aneuploidy RegisTry (SMART) No drug interventions Not Available Not Available completed NCT05970965
Periodontitis and Inflammation in Children With Down Syndrome/Trisomy 21: Study on Biological Samples No drug interventions basic_science Not Available not_yet_recruiting NCT01966991
Prenatal Screening for Down Syndrome With DNAFirst No drug interventions Not Available Not Available completed NCT02201862
Non-Invasive Chromosomal Evaluation of Trisomy Study No drug interventions Not Available Not Available completed NCT05307523
Use of Partial Body Weight Support Play Environment to Encourage Mobility and Exploration in Infants With Down Syndrome No drug interventions other Not Available completed NCT01852708
Development of Non-invasive Prenatal Screening Test for Microdeletions Based on Fetal DNA Isolated From Maternal Blood No drug interventions Not Available Not Available completed NCT02864108
The Crnic Institute Human Trisome Project Biobank No drug interventions Not Available Not Available recruiting NCT05981521
Paternal Age and Fetal Aneuploidy No drug interventions Not Available Not Available active_not_recruiting NCT01837979
Down Syndrome Screening Based on Dried Blood Spots and Cell-free Fetal DNA No drug interventions Not Available Not Available unknown_status NCT05527652
Self-Supporting Nasopharyngeal Airway (ssNPA) Treating Upper Airway Obstruction in Hypotonia No drug interventions treatment Not Available recruiting NCT01821300
Down Syndrome Metabolic Health Study No drug interventions Not Available Not Available completed NCT01925742
Study of the Efficacy of New Non-invasive Prenatal Tests for Screening for Fetal Trisomies Using Maternal Blood No drug interventions screening Not Available completed NCT03687866
Non-invasive Screening of Fetal Trisomy 21 by Digital PCR No drug interventions Not Available Not Available terminated NCT01545674
Prenatal Non-invasive Aneuploidy Test Utilizing SNPs Trial No drug interventions Not Available Not Available terminated NCT02278874
High Risk Multiple Gestation Study No drug interventions Not Available Not Available completed NCT03559374
Study of Vanadis® NIPT for Non-invasive Prenatal Screening of Trisomies (T21, T18 and T13) No drug interventions Not Available Not Available unknown_status NCT00877292
A New Prenatal Blood Test for Down Syndrome No drug interventions Not Available Not Available completed NCT01931644
At-Home Research Study for Patients With Autoimmune, Inflammatory, Genetic, Hematological, Infectious, Neurological, CNS, Oncological, Respiratory, Metabolic Conditions No drug interventions Not Available Not Available completed NCT01725438
Non Invasive Prenatal Diagnosis of Trisomy 21 by Genetic Analysis of Circulating Fetal Cells No drug interventions diagnostic Not Available unknown_status NCT05748405
Phase 1/2 Trial of AEF0217 in Participants With Down Syndrome No drug interventions treatment 1 / 2 completed NCT02895802
Assessing the Feasibility of the Use of Visual Aids in Patient Education in Adults With Down Syndrome (DS) No drug interventions health_services_research Not Available completed NCT03135236
Parents as the Primary Sexuality Educators for Their Young Adults With Down Syndrome No drug interventions treatment Not Available completed NCT03914625
A Study to Investigate Blinatumomab in Combination With Chemotherapy in Patients With Newly Diagnosed B-Lymphoblastic Leukemia treatment 3 active_not_recruiting NCT05146739
Highest Dose of Uproleselan in Combination With Fludarabine and Cytarabine for Patients With Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Mixed Phenotype Acute Leukemia Relapsed or Refractory and That Expresses E-selectin Ligand on the Cell Membrane treatment 1 active_not_recruiting NCT05196984
Gamma Frequency Stimulation in Individuals With Down Syndrome No drug interventions supportive_care Not Available recruiting NCT05985486
Brain Outcomes With Lifestyle Change in Down Syndrome No drug interventions prevention Not Available recruiting NCT04546399
A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL) treatment 2 suspended NCT04801771
Effects of Hypoglossal Nerve Stimulation on Cognition and Language in Down Syndrome and Obstructive Sleep Apnea No drug interventions treatment 3 recruiting NCT05144373
Role of Early Motor Experience in Infants With Down Syndrome No drug interventions basic_science Not Available recruiting NCT05702645
A Study to Learn More About the Health of Persons With Down Syndrome After Treatment for Acute Leukemia No drug interventions Not Available Not Available recruiting NCT06146907
A Comparison of Cognitive-Motor Dual-Task Exercise and Exergaming on Balance, Functional Mobility, and Executive Function in Down Syndrome Children No drug interventions treatment Not Available recruiting NCT06591559
Up, Down, and All Around: Evaluating Mobility Devices for Young Children with Down Syndrome No drug interventions supportive_care Not Available not_yet_recruiting NCT06617637
Effects of Aerobic-Based Virtual Reality Exercise Training and Traditional Aerobic Exercise Training on Physical Fitness, Functional Capacity and Cognitive Function in Individuals with Down Syndrome No drug interventions treatment Not Available not_yet_recruiting NCT06592404
The (Cost)Effectiveness of a Social Robot for Persons with Problems in Daily Structure and Planning in Disability Care No drug interventions supportive_care Not Available recruiting NCT02484703
A Study of RO5186582 in Down Syndrome Among Children 6 to 11 Years of Age treatment 2 terminated NCT05912803
Effects of Simulated Equestrian Therapy on Motor Proficiency and Gait Parameters Among Down Syndrome Children No drug interventions treatment Not Available completed NCT05933603
Medications for Obstructive Sleep Apnea to Improve Cognition in Children With Down Syndrome treatment 2 recruiting NCT02158390
Phenotypic Specific Communication Intervention for Children With Down Syndrome No drug interventions treatment Not Available completed NCT00394290
Down Syndrome and Continuous Positive Pressure Therapy No drug interventions treatment Not Available completed NCT04390321
Application of LLM Care and Related Affective Computing Systems on Persons With Special Needs No drug interventions other Not Available completed NCT02288702
Comparison of Bispectral Index Values in Patients With and Without Down's Syndrome No drug interventions Not Available Not Available terminated NCT04020302
Self-Monitoring Shopping Intervention No drug interventions treatment Not Available completed NCT05458479
Fluoxetine Treatment of Depression in Down Syndrome treatment 4 completed NCT02759887
Relationship Between Down Syndrome (DS) and Alzheimer's Disease (AD) No drug interventions diagnostic Not Available completed NCT01920633
A Screening Protocol to Assess Adults and Adolescents With Down Syndrome for Eligibility For Upcoming Study of RG1662 (Study BP27832) No drug interventions Not Available Not Available completed NCT04059354
Down Syndrome Speech Intelligibility Diagnostic Treatment Study No drug interventions treatment Not Available completed NCT00952354
Oral Language in Children With Down Syndrome No drug interventions Not Available Not Available unknown_status NCT02561754
Weight Management for Adolescents With IDD No drug interventions treatment Not Available completed NCT05191654
Investigation of Cardiopulmonary Parameters, Motor Development and Muscle Strength in DS With and Without CHD No drug interventions Not Available Not Available completed NCT06352151
Effects of Orofacial Therapy and Therapeutic Yoga in Children With Down Syndrome No drug interventions treatment Not Available recruiting NCT05152251
Activities and Participation of Children With Down Syndrome No drug interventions Not Available Not Available unknown_status NCT04647851
Remote Exercise Study for Individuals With Down Syndrome No drug interventions supportive_care Not Available completed NCT06263777
Early Detection of Children With Developmental Disabilities in Assiut Governorate No drug interventions health_services_research Not Available completed NCT05312177
Congenital Heart Disease: Impact on Learning and Development in Down Syndrome (CHILD-DS) No drug interventions Not Available Not Available completed NCT06336577
Infectious and Non-infectious Lower Respiratory Diseases in Children With Down Syndrome Followed in Pediatric Pulmonology Consultations in Ile-de-France No drug interventions Not Available Not Available completed NCT00006445
Down Syndrome - Comparison of Screening Methods in the 1st and 2nd Trimesters No drug interventions diagnostic Not Available unknown_status NCT02882698
Performance Analysis in Down Syndrome on Mobile Phone No drug interventions supportive_care Not Available completed NCT05231798
Cholinergic Integrity in Down Syndrome in Association With Aging, Alzheimer's Disease Pathology, and Cognition No drug interventions other 2 recruiting NCT03084497
Effects of Infant Massage on Development of Down Syndrome Babies No drug interventions treatment Not Available completed NCT04227197
An Online Health Tool About Down Syndrome: Down Syndrome Clinic to You No drug interventions health_services_research Not Available completed NCT01112683
Efficacy and Safety of Memantine Hydrochloride in Enhancing the Cognitive Abilities of Young Adults With Down Syndrome treatment 4 completed NCT06196983
Effects of Rhythmic Aerobic Exercises on Functional Balance in Children With Down Syndrome No drug interventions treatment Not Available completed NCT04787861
Motorized Movement Therapy & Pulmonary Functions in Down Syndrome No drug interventions treatment Not Available completed NCT03764761
Storybook Reading in Individuals With Down Syndrome No drug interventions device_feasibility Not Available terminated NCT05301361
Sensitivity of the NIH Toolbox to Stimulant Treatment in Intellectual Disabilities other 1 enrolling_by_invitation NCT03901261
Cohort Study of Adult Patients With Down Syndrome at Risk of Developing Alzheimer's Disease (TriAL21) No drug interventions diagnostic Not Available recruiting NCT00570128
Evaluating The Efficacy And Safety Of Donepezil Hydrochloride (HCl) (Aricept) In Treating Cognitive Dysfunction Exhibited By Children With Down Syndrome treatment 2 completed NCT05662228
Therapies for Down Syndrome Regression Disorder treatment 2 recruiting NCT02651493
Digital Dysmorphology Project No drug interventions health_services_research Not Available recruiting NCT05508971
Treatment of Obstructive Sleep Apnea With Personalized Surgery in Children With Down Syndrome (TOPS-DS) No drug interventions treatment Not Available recruiting NCT02141971
Down Syndrome Biomarker Initiative (DSBI) No drug interventions Not Available Not Available completed NCT03602378
QoL and Stress in Parents of Children With Developmental Disabilities and Chronic Disease No drug interventions Not Available Not Available unknown_status NCT00689988
Augmentative and Alternative Communication (AAC) and Lexical Gain in Children With Down Syndrome No drug interventions treatment Not Available completed NCT06450509
Proactive Speech and Language Intervention for Infants With Down Syndrome No drug interventions prevention Not Available recruiting NCT05769556
Effect Of Brain Gym Exercises On Postural Stability In Children With Down Syndrome No drug interventions treatment Not Available completed NCT03441685
Strategies for Teaching Verbs No drug interventions treatment Not Available completed NCT02127515
Non Invasive Prenatal Testing of Down Syndrome No drug interventions diagnostic Not Available completed NCT02226315
Clinical Performance of the MaterniT21 PLUS LDT in Multiple Gestation Pregnancies No drug interventions Not Available Not Available terminated NCT03522337
Oral Health Promotion Among Preschool Children With Special Needs No drug interventions prevention Not Available completed NCT05702632
TheraTogs Versus Reciprocal Electrical Stimulation on Children With Diplegic Cerebral Palsy: a Randomized Controlled Trial No drug interventions treatment Not Available completed NCT05198232
The Effects of Virtual Zumba® in Individuals With Developmental Disabilities No drug interventions other Not Available completed NCT05098600
The Epidemiology, Management and Comorbidities in Alopecia Areata in Czech Republic No drug interventions Not Available Not Available completed NCT03087500
Physiological Abnormalities Associated with Down Syndrome No drug interventions Not Available Not Available withdrawn NCT00844259
Functional Communicative Profile of Children With Down Syndrome No drug interventions Not Available Not Available completed NCT03210675
Early Detection and Treatment of Respiratory Sleep Disorders in Children With Down Syndrome No drug interventions prevention Not Available active_not_recruiting NCT02996175
Treatment of Sleep Disturbances in School-age Children With Down Syndrome No drug interventions treatment Not Available completed NCT01684670
Intensive Dysarthria Sessions in Adults and Children With Down Syndrome No drug interventions treatment Not Available completed NCT04241042
Clinical Validation of the Bordeaux Maze Test No drug interventions Not Available Not Available unknown_status NCT04132999
PAP for Children With DS and OSAS No drug interventions treatment Not Available recruiting NCT06131099
Effects of Dohsa Hou Exercises on Functional Mobility No drug interventions treatment Not Available completed NCT06576206
Effects of Bin Therapy on Finger Gnosia And Fine Motor Skill No drug interventions treatment Not Available completed NCT05297149
Effect of Hippotherapy in Children With Down Syndrome No drug interventions supportive_care Not Available completed NCT04751136
the Effect of Cerebrolysin on Physical and Mental Functions of Down Syndrome treatment 2 completed NCT06531213
Visual Perception Intervention Programmes Impact on Down Syndrome Affiliate Children's Fine Motor and Visual Perception. No drug interventions treatment Not Available completed NCT01176019
An Interactive Informed Consent and Education Program for Pregnant Women No drug interventions health_services_research 1 completed NCT05330741
Whole-Body Vibration Versus Gravity Force Stimulation on Postural Stability in Children With Down Syndrome No drug interventions treatment Not Available unknown_status NCT03200041
Clinical Evaluation of the IONA Test for Non-invasive Pre Natal Screening in Twin Pregnancies No drug interventions screening Not Available completed NCT00891917
Liq-NOL Efficacy in Pediatric Patients With Down Syndrome No drug interventions treatment 2 withdrawn NCT02431117
Non-drug Study to Assess the Suitability of Assessment Scales in Japanese Individuals With Down Syndrome Aged 6-30 No drug interventions Not Available Not Available completed NCT00287417
Early Ultrasound and Maternal Biochemical Markers to Evaluate the Risk of Down Syndrome During the First Trimester No drug interventions Not Available Not Available completed NCT04811534
Qualitative Exploratory Study Among Reunionese Women and Their Partners Who Have a Child With Trisomy 21 No drug interventions Not Available Not Available recruiting NCT05767216
Genetic and Epigenetic Variations in Heterokaryotypic Monozygotic Twins Discordant for Down Syndrome No drug interventions basic_science Not Available recruiting NCT01390558
Gait Parameters of Persons With Down Syndrome With and Without Orthotics Using GaitRite No drug interventions Not Available Not Available completed NCT02787486
Expanded Noninvasive Genomic Medical Assessment: The Enigma Study No drug interventions Not Available Not Available completed NCT03698539
How Stuttering and Gestures Influence the Intelligibility of Individuals With Down Syndrome No drug interventions Not Available Not Available completed NCT04854122
Blood Flow Regulation in Individuals With Down Syndrome - Training Study No drug interventions supportive_care Not Available recruiting NCT03538925
Building Sentences With Preschoolers Who Use AAC No drug interventions treatment 2 completed NCT01791725
A 4-Week Safety Study of Oral ELND005 in Young Adults With Down Syndrome Without Dementia treatment 2 completed NCT01190930
Risk-Adapted Chemotherapy in Treating Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia or Localized B-Lineage Lymphoblastic Lymphoma treatment 3 active_not_recruiting NCT05145348
Prospective Monitoring of Antibody Response Following COVID-19 Vaccination in Patients With Down Syndrome. Not Available Not Available unknown_status NCT02451657
Non-drug Study to Evaluate the Suitability of Neurocognitive Tests and Functioning Scales for the Measurement of Cognitive and Functioning Changes in Children With Down Syndrome No drug interventions Not Available Not Available completed NCT03087357
VAlidation of a Lower Cost aneUploidy scrEen No drug interventions Not Available Not Available completed NCT05020366
Promoting Health Through Parent Empowerment and the Activation of Routines (PrO-PEAR) No drug interventions prevention Not Available completed NCT02317965
Non-Invasive Screening for Fetal Aneuploidy No drug interventions Not Available Not Available unknown_status NCT03590665
Blood Flow in Individuals With Down Syndrome No drug interventions screening Not Available terminated NCT04735874
Vascular Health and Risk Factors in Children With Down Syndrome No drug interventions Not Available Not Available completed NCT04293120
Training Balance Among People With Neurodevelopmental Disabilities No drug interventions treatment Not Available terminated NCT05969873
Effect Of Pilates On Postural Control And Balance In Children With Down's Syndrome No drug interventions treatment Not Available completed NCT02421276
Depressed AIRE Gene Expression Causes Immune Cell Dysfunction & Autoimmunity in Down Syndrome No drug interventions basic_science Not Available completed NCT02612376
Rocky Mountain Alzheimer's Disease Center Longitudinal Biomarker and Clinical Phenotyping Study No drug interventions Not Available Not Available recruiting NCT04022460
Using Personal Mobile Technology to Identify Obstructive Sleep Apnea in Children With Down Syndrome (UPLOAD) No drug interventions Not Available Not Available unknown_status NCT05719662
Weight Bearing Exercises With and Without Jaffrey's Core Stability Exercise Training in Children With Down Syndrome. No drug interventions treatment Not Available not_yet_recruiting NCT06061562
Down Syndrome, Physical Activity and Sleep Apnea No drug interventions Not Available Not Available recruiting NCT05915780
Effect of Aerobic Exercises on Static & Dynamic Balance No drug interventions treatment Not Available completed NCT00056329
Vitamin E in Aging Persons With Down Syndrome treatment 3 unknown_status NCT02046889
A Bicycle Training Intervention No drug interventions treatment Not Available completed NCT01429389
Specimen Collection From Pregnant Women at Increased Risk for Fetal Aneuploidy No drug interventions Not Available Not Available recruiting NCT06234644
Effects of Maze Activities in Down's Syndrome No drug interventions treatment Not Available completed NCT03544840
Investigating Trunk Control in Young Children With Down Syndrome No drug interventions treatment Not Available completed NCT04035967
Investigation of Parents' Anxiety Level and Health Related Quality of Life in Different Types of Physical Disabilities No drug interventions Not Available Not Available completed NCT00928304
Phase II Study of Florbetaben (BAY94-9172) PET Imaging for Detection/Exclusion of Cerebral β-amyloid. diagnostic 2 completed NCT06036069
Effect of Whole Body Vibration Versus Core Stability Exercises on Balance and Muscle Strength in Children With Down Syndrome No drug interventions treatment Not Available recruiting NCT04767412
Inspiratory Muscle Training and Physical Fitness in Children With Down Syndrome Randomized Control Trial No drug interventions treatment Not Available completed NCT05332912
Assessing Malleability of Spatial Abilities in Down Syndrome No drug interventions basic_science Not Available recruiting NCT05492981
Does an Educational Video for Aneuploidy Screening Improve Informed Choice Among Pregnant Women? No drug interventions screening Not Available unknown_status NCT00643955
Neuromuscular Characteristics of Individuals With Down Syndrome (DS) No drug interventions Not Available Not Available terminated NCT02738450
Safety, Tolerability and Immunogenicity of ACI-24 Vaccine in Adults With Down Syndrome No drug interventions treatment 1 completed NCT01598350
Gait in Children With Down Syndrome While Wearing Orthoses No drug interventions treatment Not Available completed NCT01663350
Comparison of Aneuploidy Risk Evaluations No drug interventions Not Available Not Available completed NCT05995223
Oxygen Uptake Kinetics During Submaximal Exercise in Adults With Down Syndrome No drug interventions screening Not Available completed NCT06465823
Efficacy of Bumetanide to Improve Cognitive Functions in Down Syndrome treatment 2 recruiting NCT06244108
Occupational Therapy Home Programs in Children With Down Syndrome No drug interventions treatment Not Available completed NCT04966403
Effects of Stretch-shortening Cycle Exercises Postural Control in Down Syndrome No drug interventions treatment Not Available completed NCT05767203
Genetic Markers and Biomarkers in Patients With Intellectual Disabilities of Genetic Origin No drug interventions basic_science Not Available recruiting NCT00005190
Reproduction and Survival After Cardiac Defect Repair No drug interventions Not Available Not Available completed NCT06125990
Video Based Breathing Exercise Rehabilitation No drug interventions treatment Not Available completed NCT00847990
Non-Invasive Screening for Fetal Aneuploidy No drug interventions Not Available Not Available completed NCT06213090
Patterns of Neurodevelopmental Disorders No drug interventions Not Available Not Available recruiting NCT05755464
Evaluation of Patients With Down Syndrome Compliance to Dental Therapy No drug interventions Not Available Not Available suspended NCT04394221
OHRQoL and Parental Perception in a Group of Children and Adolescents With Down Syndrome: A Cross No drug interventions Not Available Not Available completed NCT05904821
Relationship Between BMI, Physical Fitness and Motor Skills in Children With Down's Syndrome No drug interventions Not Available Not Available completed NCT01148121
Assessment of Bone Density and Bone Turnover Markers in Patients With Down Syndrome and Comparison to the Ts65Dn Model No drug interventions Not Available Not Available completed NCT02304302
Down Syndrome Memantine Follow-up Study treatment 2 completed NCT03267602
Role of Sleep Apnea in the Neuropsychological Function in Down Syndrome People No drug interventions treatment Not Available completed NCT01580384
A Non-Drug Study of The Suitability of Neurocognitive Tests And Functioning Scales For The Measurement of Cognitive And Functioning Changes in Individuals With Down Syndrome No drug interventions Not Available Not Available completed NCT02430584
Whole Blood Specimen Collection From Pregnant Subjects No drug interventions Not Available Not Available unknown_status NCT04037579
Protocol for a Non-randomized Survey in Down Syndrome People Who Practice Sports. Self and Observers´ Perception. No drug interventions Not Available Not Available unknown_status NCT01303133
Natural History of Amyloid Deposition in Adults With Down Syndrome No drug interventions Not Available Not Available completed NCT02971254
The Effects of Inhalational Anaesthetics in Cognitive Functions in Down Syndrome Patients supportive_care 2 completed NCT01832753
Treatment Trial of Subclinical Hypothyroidism in Down Syndrome treatment Not Available completed NCT02094053
A Double-blind, Placebo-controlled Comparative Study and Open-label Extension Study to Confirm the Efficacy and Safety of E2020 in Subjects With Down Syndrome Having Regression Symptoms and Disabled Activities of Daily Living. treatment 2 completed NCT05473247
GameSquad for Adults With Down Syndrome No drug interventions treatment Not Available not_yet_recruiting NCT03677245
Balance Bike Training in Down Syndrome No drug interventions treatment Not Available completed NCT01975545
Fluor Varnish With Silver Nanoparticles for Dental Remineralization in Patients With Trisomy 21 prevention 2 unknown_status NCT01576705
Efficacy Assessment of Systematic Treatment With Folinic Acid and Thyroid Hormone on Psychomotor Development of Down Syndrome Young Children treatment 3 completed NCT05228405
Awareness Levels of Caregivers of Disabled Children No drug interventions Not Available Not Available completed NCT03508583
Turkish Version of The Measure of Processes of Care (MPOC) No drug interventions Not Available Not Available unknown_status NCT00864461
Frequency of Metabolic Syndrome in Down Syndrome Patients No drug interventions Not Available Not Available completed NCT03778528
Evaluation of Ocular Lens Proteins in Cataract From Individuals With Down Syndrome No drug interventions Not Available Not Available terminated NCT06117228
Gynaecological Follow-up of Women With Down Syndrom Aged 18 to 30 in France No drug interventions Not Available Not Available not_yet_recruiting NCT06293911
Clinical Comparison of a Postbiotic-gel With Placebo Gel for Gingival Inflammation in Patients With Down Syndrome No drug interventions treatment Not Available enrolling_by_invitation NCT00294593
Efficacy Study of Folinic Acid to Improve Mental Development of Children With Down Syndrome treatment 2 / 3 completed NCT02521493
Response-Based Chemotherapy in Treating Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndrome in Younger Patients With Down Syndrome treatment 3 active_not_recruiting NCT04124471
Investigating the Experience of Living With Down Syndrome and Obstructive Sleep Apnea Syndrome (Stage 1) No drug interventions supportive_care Not Available completed NCT04115878
Medications for Obstructive Sleep Apnea In Children With Down Syndrome treatment 2 completed NCT04754178
Assessment of Skills and Behaviors in Children With Down Syndrome No drug interventions Not Available Not Available unknown_status NCT05978778
Effects of Active Video Gaming on Pre-handwriting Skills of Children With Down Syndrome. No drug interventions treatment Not Available completed NCT01052688
Noninvasive Screening for Affected Pregnancies: Assay Development & Optimization in Affected Pregnancies No drug interventions Not Available Not Available completed NCT01902407
Computer Models of Airways in Children and Young Adults With Sleep Apnea and Down Syndrome No drug interventions Not Available Not Available enrolling_by_invitation NCT04156607
The Effects of Kinesiotaping on Balance in Children With Down Syndrome. No drug interventions treatment Not Available completed NCT03188107
Interrater Reliability of Infant Motor Profile No drug interventions Not Available Not Available unknown_status NCT00748007
Efficacy of Rivastigmine in Patients With Down Syndrome treatment Not Available completed NCT04165109
Trial-Ready Cohort-Down Syndrome (TRC-DS) No drug interventions Not Available Not Available recruiting NCT04816409
Effect of Neuro Developmental Therapy in Infants With Down Syndrome No drug interventions treatment Not Available completed NCT03624556
Pediatric Exploratory Research Study of EGCG Use and Safety (PERSEUS) No drug interventions treatment Not Available completed NCT04208685
Evaluating Cognitive Outcomes in Down Syndrome No drug interventions Not Available Not Available active_not_recruiting NCT04631237
Developing a Down Syndrome Health Instrument No drug interventions Not Available Not Available recruiting NCT04818437
Effect of Core Stability Exercises and Balance Training in Postural Control Among Down Syndrome No drug interventions treatment Not Available completed NCT04583332
Efficacy of AAC for Functional Communication No drug interventions treatment Not Available completed NCT04603352
Impact of an Orthotic Garment on Gross Motor Skills for Infants With Down Syndrome No drug interventions treatment Not Available active_not_recruiting NCT00754052
Evaluating The Efficacy And Safety Of Donepezil Hydrochloride (Aricept) In The Treatment Of The Cognitive Dysfunction Exhibited By Children With Down Syndrome, Aged 11 To 17 treatment 3 terminated NCT06502652
Hippotherapy Versus Balance Therapy on Funvtional Mobility in Down Syndrome No drug interventions treatment Not Available completed NCT00643552
Muscle Strength, Physical Work Capacity and Functional Performance in Individuals With Down Syndrome No drug interventions Not Available Not Available completed NCT05310552
Elucidating Age-related Comorbidity Patterns in Down Syndrome (DS) No drug interventions Not Available Not Available recruiting NCT02719600
Motor Learning Through Virtual Reality Task in Individuals With Down Syndrome No drug interventions health_services_research Not Available completed NCT03836300
Parent and Infant Inter(X)Action Intervention (PIXI) No drug interventions treatment Not Available enrolling_by_invitation NCT04048759
The Promotion of Physical Activity for the Prevention of Alzheimer's Disease in Adults With Down Syndrome No drug interventions prevention Not Available completed NCT00825175
Treadmill Training and Orthotic Use in Infants With Down Syndrome No drug interventions treatment Not Available completed NCT01663675
Trisomy 21 in Adulthood No drug interventions Not Available Not Available unknown_status NCT06198075
Action Observation Therapy on Balance in Children With Down Syndrome No drug interventions treatment Not Available completed NCT05131542
Assessment of Hypotonia in Children With Down Syndrome No drug interventions Not Available Not Available completed NCT04536506
Bobath and Vojta Therapy for DS No drug interventions treatment Not Available completed NCT05528549
Blood Flow and Blood Pressure Investigation in Down Syndrome No drug interventions prevention 3 completed NCT06030349
Clinical Outcomes From Treatment and Evaluation of Obstructive Sleep Apnoea in Children With Down Syndrome No drug interventions Not Available Not Available recruiting NCT05928949
Pilates Exercises and Down Syndrome No drug interventions health_services_research Not Available recruiting NCT00754013
Evaluating The Efficacy And Safety Of Donepezil Hydrochloride (Aricept) In The Treatment Of The Cognitive Dysfunction Exhibited By Children With Down Syndrome, Aged 6 To 10 treatment 3 terminated NCT05849818
Virtual Reality Technology For Cognitive Functions Of Children With Down Syndrome No drug interventions treatment Not Available recruiting NCT05861141
Effect of Aerobic Training on Sleep Problems and Pulmonary Functions in Children With Down Syndrome No drug interventions treatment Not Available recruiting NCT05059041
Dilated Versus Non-Dilated Wavefront Corrections for Patients With Down Syndrome No drug interventions treatment 2 recruiting NCT00966017
Glucose Metabolic, Amyloid, and Tau Brain Imaging in Down Syndrome and Dementia No drug interventions Not Available Not Available unknown_status NCT05482334
Trial to Evaluate Safety and Efficacy of GM-CSF /Sargramostim in Down Syndrome treatment 2 recruiting NCT03286634
ASIA Down Syndrome Acute Lymphoblastic Leukemia 2016 treatment 2 recruiting NCT00971334
Noninvasive Screening for Fetal Aneuploidy: A New Maternal Plasma Marker No drug interventions Not Available Not Available completed NCT06206824
Leucettinib-21 First-in-Human Phase 1 in Healthy Volunteers and Subjects With Down Syndrome and Alzheimer's Disease No drug interventions treatment 1 recruiting NCT01950624
DS-Connect {TM}: The Down Syndrome Registry No drug interventions Not Available Not Available recruiting NCT04791124
Assessment of Neural Oscillations in Adult Subjects With Down Syndrome and Typically Developing Subjects in Resting State and While Conducting Cognitive Tasks No drug interventions Not Available Not Available unknown_status NCT02432716
Investigation of the Safety of Intranasal Glulisine in Down Syndrome treatment 1 completed NCT04373616
A Study of ACI-24 in Adults With Down Syndrome No drug interventions treatment 2 withdrawn NCT01394796
Egcg, a dyrk1a Inhibitor as Therapeutic Tool for Reversing Cognitive Deficits in Down Syndrome Individuals. No drug interventions treatment 2 completed NCT06461858
Effects of Cuevas Medek Exercises on Trunk Control and Balance in Children With Down Syndrome No drug interventions treatment Not Available not_yet_recruiting NCT00965835
Amyloid Plaque and Tangle Imaging in Alzheimer's Disease and Down Syndrome No drug interventions Not Available Not Available unknown_status NCT04539535
Infants With Down Syndrome on a Different Surface No drug interventions other Not Available completed NCT06197035
The Coping With and Caring for Infants With Special Needs Intervention in Down Syndrome Infants No drug interventions treatment Not Available recruiting NCT01084135
Rivastigmine Study in Adolescents With Down Syndrome treatment 1 / 2 completed NCT01597063
Clinical Evaluation of the SEQureDx Trisomy Test in Low Risk Pregnancies No drug interventions Not Available Not Available completed NCT06219863
Harness-based Mobility Intervention for Infants With Down Syndrome No drug interventions other Not Available recruiting NCT01313325
Hippotherapy to Improve the Balance of Children With Movement Disorders No drug interventions treatment Not Available completed NCT00675025
Evaluating The Safety Of Donepezil Hydrochloride (Aricept) For Up To 1 Year In The Treatment Of The Cognitive Dysfunction Exhibited By Children With Down Syndrome - Follow-Up To A 10-Week, Double-Blind, Placebo-Controlled Trial treatment 2 terminated NCT00951730
Evaluation of a Simplified Method for Diagnosis of Sleep Apnea in Children and Adults With Down Syndrome No drug interventions Not Available Not Available completed NCT06537648
Decreasing Alzheimer's Risk Through oNline Choreographed Exercise - Down Syndrome No drug interventions other Not Available recruiting NCT03206957
Correlation Between Optic Nerve Vessel Anomalies, Serum Angiogenic Factors and Renal Anomalies in Down Syndrome Children No drug interventions diagnostic Not Available unknown_status NCT03903666
Anomalies of Nocturnal Gaz Exchanges in Patients With Down Syndrome No drug interventions diagnostic Not Available completed NCT03922165
Healthy Sleep for Children With Down Syndrome No drug interventions Not Available Not Available completed NCT02481765
Feasibility and Dose Tolerability of HD-tDCS in Healthy Adults and Children With Down Syndrome No drug interventions device_feasibility Not Available completed NCT05583565
Effect of the Sensory Integration Approach on Balance and Motor Coordination in Children With Down Syndrome No drug interventions treatment Not Available completed NCT03935620
Delivering Early Intervention to Children With Down Syndrome No drug interventions treatment Not Available completed NCT00954382
Trends in Intellectual Development in Down Syndrome No drug interventions Not Available Not Available unknown_status NCT05120531
Down Syndrome Autonomic Nervous System Induction Bradycardia No drug interventions Not Available Not Available completed NCT04657276
Turkish Adaptation of Segmental Assessment of Trunk Control Scale No drug interventions Not Available Not Available completed NCT04398862
Pulmonary Health in Children With Down Syndrome No drug interventions Not Available Not Available recruiting NCT03445962
19/5000 (SYNAPSOT21) Predictive Factors of Sleep Apnea Syndrome in Down Syndrome No drug interventions Not Available Not Available completed NCT01034280
Correlations Phenotype / Genotype in Down Syndrome No drug interventions Not Available Not Available completed NCT00668980
Symbolic Representation in Young Children With Down Syndrome No drug interventions Not Available Not Available completed NCT04219280
Evaluating Treatment of ADHD in Children With Down Syndrome treatment 4 recruiting NCT04293380
Amniotic Fluid Ischemia Modified Albumin as a Novel e Prenatal Diagnostic Marker for Down Syndrome No drug interventions diagnostic Not Available completed NCT02859389
Neurocognitive and Psychosocial Outcomes in Survivors of Childhood Leukemia With Down Syndrome No drug interventions Not Available Not Available completed NCT02024789
A Study of RG1662 in Adults and Adolescents With Down Syndrome (CLEMATIS) treatment 2 completed NCT06043440
Oxygen Therapy in Children and Adolescents With Down Syndrome and Obstructive Sleep Apnea treatment 2 recruiting NCT03058640
Effects of Karate in Adolescents With Down Syndrome No drug interventions supportive_care Not Available completed NCT03192540
The Impact of an 8-week Supported Exercise Program on Fitness and Symptoms in Adolescents With Down Syndrome No drug interventions other Not Available completed NCT05271201
Exercise Intensity for Down Syndrome Children No drug interventions treatment Not Available completed NCT04668001
Transcranial Photobiomodulation With Near-Infrared Light for Language in Individuals With Down Syndrome No drug interventions treatment Not Available active_not_recruiting NCT04278404
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS) Not Available Not Available recruiting NCT04246372
Tofacitinib for Immune Skin Conditions in Down Syndrome treatment 2 active_not_recruiting NCT05343468
Life Skills Improved in Children With Down Syndrome After Using Assistive Technology No drug interventions supportive_care Not Available completed NCT06512168
Measuring Aided Language Development No drug interventions diagnostic Not Available not_yet_recruiting NCT03771469
Validation of Sleep Questionnaires in the Down Syndrome Population No drug interventions screening Not Available active_not_recruiting NCT04390646
GnRH Therapy on Cognition in Down Syndrome treatment 2 / 3 recruiting NCT03233646
Retinal Imaging in Neurodegenerative Disease No drug interventions Not Available Not Available recruiting NCT01778946
Nicotine Treatment of Cognitive Decline in Down Syndrome treatment 1 / 2 completed NCT01594346
Multicenter Vitamin E Trial in Aging Persons With Down Syndrome treatment 3 completed NCT01555346
Clinical Evaluation of the SEQureDx T21 Test In High Risk Pregnancies No drug interventions Not Available Not Available completed NCT05740046
Motor Intervention Whit the Intorus Tool on Children With Down Syndrome No drug interventions treatment Not Available completed NCT03684512
Promotion of Physical Activity in Adolescents With Intellectual and Developmental Disabilities No drug interventions prevention Not Available completed NCT01256112
Parent Supported Weight Reduction in Down Syndrome No drug interventions treatment Not Available completed NCT05638412
Investigating the Impact of JASPER Behavioral Therapy in Children With Down Syndrome No drug interventions treatment Not Available recruiting NCT05460910
Effects of Core Stability Exercises With and Without Treadmill Training on Balance in Children With Down Syndrome No drug interventions treatment Not Available unknown_status NCT05024110
Effect of Exercise Intensity on Vitamin D No drug interventions treatment Not Available completed NCT06407895
Effects of Lower Limb Fitness Program in Children With DS No drug interventions treatment Not Available completed NCT00695695
The Experience of Caregivers of Children With Down Syndrome No drug interventions Not Available Not Available completed NCT01436955
A Study of RG1662 in Individuals With Down Syndrome treatment 1 completed NCT06279208
Phosphoproteomic Profile of Children With Down Syndrome No drug interventions Not Available Not Available recruiting NCT02344108
A Pilot Study to Evaluate the Hypoglossal Nerve Stimulator in Adolescents With Down Syndrome and Obstructive Sleep Apnea No drug interventions treatment Not Available completed NCT01808508
Obstructive Sleep Apnea and Neurocognitive and Cardiovascular Function in Children With Down Syndrome No drug interventions treatment Not Available completed NCT02380638
Effects of Whole-body Vibration Training on Body Composition in Adolescents With and Without Down Syndrome No drug interventions prevention Not Available completed NCT05951543
Effects of Plyometric Exercises on Static and Dynamic Balance of Children With Down,s Syndrome. No drug interventions treatment Not Available completed