Colorectal Cancer (CRC) Completed Phase 3 Trials for Leucovorin (DB00650)

Back to Colorectal Cancer (CRC)

Also known as: Malignant Neoplasm of Colorectum / CRC, Colorectal Cancer / Colorectal Cancer / Cancer, Colorectal / CRC (Colorectal Cancer) / Colorectal, Cancer / Colo-rectal Cancer / Colorectal Cancers / A. Colorectal Cancer / Cancer Colorectal / Gastrointestinal Cancers - Colorectal / CRC / CRCS / Malignant colorectal neoplasm / Malignant neoplasm of cecum and/or colon and/or rectum / Malignant neoplasm of caecum and/or colon and/or rectum / Malignant neoplasm of cecum and/or colon and/or rectum (disorder) / Malignant neoplasm of large intestine / Malignant tumor of large intestine / Malignant tumour of large intestine / Malignant neoplasm of large intestine (disorder) / Malignant neoplasm of colon, unspecified / Malignant large intestinal neoplasm NOS / Cancer of large intestine / Malignant neoplasm of large intestine, NOS / Cancer of large bowel / CA - Cancer of large bowel / Colorectal neoplasms malignant / Malignant neoplasm of colon and/or rectum (disorder) / Large intestine carcinoma / Colorectal carcinoma / Colorectal cancer NOS

Indication	Status	Phase
DBCOND0031867 (Colorectal Cancer (CRC))	Completed	3

clinicaltrials.gov Identifier	Title	Purpose	Drugs
NCT02753127	A Study of Napabucasin (BBI-608) in Combination With FOLFIRI in Adult Patients With Previously Treated Metastatic Colorectal Cancer	Treatment	Bevacizumab (DB00112) Fluorouracil (DB00544) Irinotecan (DB00762) Leucovorin (DB00650) Napabucasin (DB12155)
NCT02162563	Treatment Strategies in Colorectal Cancer Patients With Initially Unresectable Liver-only Metastases	Treatment	Bevacizumab (DB00112) Fluorouracil (DB00544) Irinotecan (DB00762) Leucovorin (DB00650) Oxaliplatin (DB00526) Panitumumab (DB01269)
NCT00003287	Combination Chemotherapy in Treating Patients With Recurrent or Metastatic Colorectal Cancer	Treatment	Fluorouracil (DB00544) Leucovorin (DB00650) Oxaliplatin (DB00526)
NCT00002551	SWOG-9304 Chemotherapy Plus Radiation Therapy in Treating Patients With Rectal Cancer That Has Been Surgically Removed	Treatment	Fluorouracil (DB00544) Leucovorin (DB00650) Levamisole (DB00848)
NCT00642577	A Study of Avastin (Bevacizumab) in Combination With Chemotherapy in Chinese Patients With Metastatic Colorectal Cancer.	Treatment	Bevacizumab (DB00112) Fluorouracil (DB00544) Irinotecan (DB00762) Leucovorin (DB00650)
NCT02251977	Effect of GM1 in Prevention of Oxaliplatin Induced Neurotoxicity in Stage II/III Colorectal Cancer	Prevention	Capecitabine (DB01101) Fluorouracil (DB00544) Ganglioside GM1 (DB16948) Leucovorin (DB00650)
NCT00905047	Xeloda or UFT (Tegafur-uracil) With Folinic Acid in Advanced or Metastatic Colorectal Cancer	Treatment	Capecitabine (DB01101) Leucovorin (DB00650) Propylthiouracil (DB00550) Tegafur (DB09256)
NCT01150045	Oxaliplatin, Leucovorin Calcium, and Fluorouracil With or Without Celecoxib in Treating Patients With Stage III Colon Cancer Previously Treated With Surgery	Treatment	Celecoxib (DB00482) Fluorouracil (DB00544) Leucovorin (DB00650) Oxaliplatin (DB00526)
NCT00268398	Combination Chemotherapy in Treating Patients With Colorectal Cancer and Resectable Metastases	Treatment	Fluorouracil (DB00544) Irinotecan (DB00762) Leucovorin (DB00650) Oxaliplatin (DB00526)
NCT00303771	Combination Chemotherapy as First-Line Therapy in Treating Older Patients With Metastatic Colorectal Cancer That Cannot Be Removed By Surgery	Treatment	Fluorouracil (DB00544) Irinotecan (DB00762) Leucovorin (DB00650)
NCT00004885	Fluorouracil and Leucovorin With or Without Irinotecan in Treating Patients With Metastatic Colorectal Cancer	Treatment	Fluorouracil (DB00544) Irinotecan (DB00762) Leucovorin (DB00650)
NCT00061815	Study of Cetuximab, Oxaliplatin, 5-FU/LV Versus Oxaliplatin, 5-FU/LV in Patients With Previously Treated Metastatic, EGFR-Positive Colorectal Cancer	Treatment	Cetuximab (DB00002) Fluorouracil (DB00544) Leucovorin (DB00650) Oxaliplatin (DB00526)
NCT00425152	Fluorouracil and Leucovorin and/or Levamisole After Surgery In Treating Patients With Dukes' B Or Dukes' C Colon Cancer	Treatment	Fluorouracil (DB00544) Leucovorin (DB00650) Levamisole (DB00848)
NCT00070213	Leucovorin and Fluorouracil With or Without Oxaliplatin Compared to Capecitabine With or Without Oxaliplatin in Treating Patients With Metastatic Colorectal Cancer	Treatment	Capecitabine (DB01101) Fluorouracil (DB00544) Leucovorin (DB00650) Oxaliplatin (DB00526)
NCT00378716	Combination Chemotherapy in Treating Patients With Resected Colon Cancer	Treatment	Fluorouracil (DB00544) Leucovorin (DB00650) Propylthiouracil (DB00550) Tegafur (DB09256)
NCT00002716	Combination Chemotherapy in Treating Patients With Liver Metastases From Colorectal Cancer	Treatment	Dexamethasone (DB01234) Floxuridine (DB00322) Fluorouracil (DB00544) Leucovorin (DB00650)
NCT03750786	A Study to Compare the Efficacy of Arfolitixorin Versus Leucovorin in Combination With 5 Fluorouracil, Oxaliplatin, and Bevacizumab in Patients With Advanced Colorectal Cancer	Treatment	Bevacizumab (DB00112) Fluorouracil (DB00544) Leucovorin (DB00650) Modufolin (DB12676) Oxaliplatin (DB00526)
NCT00115765	PACCE: Panitumumab Advanced Colorectal Cancer Evaluation Study	Treatment	Bevacizumab (DB00112) Fluorouracil (DB00544) Irinotecan (DB00762) Leucovorin (DB00650) Oxaliplatin (DB00526) Panitumumab (DB01269)
NCT01718873	Optimization of Bevacizumab Scheduling With Chemotherapy for Metastatic Colorectal Cancer	Treatment	Bevacizumab (DB00112) Capecitabine (DB01101) Fluorouracil (DB00544) Leucovorin (DB00650) Levoleucovorin (DB11596) Oxaliplatin (DB00526)
NCT00008060	Combination Chemotherapy in Treating Patients With Unresectable Metastatic Colorectal Cancer	Treatment	Fluorouracil (DB00544) Irinotecan (DB00762) Leucovorin (DB00650) Oxaliplatin (DB00526)
NCT00660894	Tegafur-Uracil and Leucovorin or S-1 in Treating Patients With Stage III Colon Cancer That Has Been Completely Removed by Surgery	Treatment	Gimeracil (DB09257) Leucovorin (DB00650) Potassium (DB14500) Tegafur (DB09256) Tegafur-uracil (DB09327)
NCT00069095	A Study of Capecitabine (Xeloda) and Bevacizumab as a First-line Therapy in Patients With Metastatic Colorectal Cancer	Treatment	Bevacizumab (DB00112) Capecitabine (DB01101) Fluorouracil (DB00544) Leucovorin (DB00650) Oxaliplatin (DB00526)
NCT00069108	A Study of Xeloda (Capecitabine) in Patients With Metastatic Colorectal Cancer	Treatment	Capecitabine (DB01101) Fluorouracil (DB00544) Leucovorin (DB00650) Oxaliplatin (DB00526)
NCT00006103	Combination Chemotherapy in Treating Patients With Colorectal Cancer	Treatment	Fluorouracil (DB00544) Irinotecan (DB00762) Leucovorin (DB00650)
NCT00069121	A Study of Xeloda (Capecitabine) Plus Oxaliplatin in Patients With Colon Cancer	Treatment	Capecitabine (DB01101) Fluorouracil (DB00544) Leucovorin (DB00650) Oxaliplatin (DB00526)
NCT00005979	Combination Chemotherapy With or Without Irinotecan in Treating Patients With Stage III Colon Cancer	Treatment	Fluorouracil (DB00544) Irinotecan (DB00762) Leucovorin (DB00650)
NCT00769405	Systemic Chemotherapy With or Without Intraperitoneal Chemohyperthermia in Treating Patients Undergoing Surgery for Peritoneal Carcinomatosis From Colorectal Cancer	Treatment	Fluorouracil (DB00544) Leucovorin (DB00650) Oxaliplatin (DB00526)
NCT00719797	Combination Chemotherapy and Bevacizumab as First-Line Therapy in Treating Patients With Metastatic Colorectal Cancer	Treatment	Bevacizumab (DB00112) Fluorouracil (DB00544) Irinotecan (DB00762) Leucovorin (DB00650) Oxaliplatin (DB00526)
NCT00002593	S9415 Chemotherapy in Patients With Stage II or III Colon Cancer That Has Been Surgically Removed	Treatment	Fluorouracil (DB00544) Leucovorin (DB00650) Levamisole (DB00848)
NCT00126256	Trial Comparing Two Strategies of Chemotherapy for Metastatic Colorectal Cancer	Treatment	Fluorouracil (DB00544) Irinotecan (DB00762) Leucovorin (DB00650) Oxaliplatin (DB00526)
NCT00009737	A Study of Xeloda (Capecitabine) Compared With 5-Fluorouracil in Combination With Low-Dose Leucovorin in Patients Who Have Undergone Surgery for Colon Cancer	Treatment	Capecitabine (DB01101) Fluorouracil (DB00544) Leucovorin (DB00650)
NCT00004252	Leucovorin and Fluorouracil With or Without SU5416 in Treating Patients With Metastatic Colorectal Cancer	Treatment	Fluorouracil (DB00544) Leucovorin (DB00650) Semaxanib (DB06436)
NCT00002570	Immediate Compared With Delayed Chemotherapy in Advanced Colorectal Cancer Without Signs or Symptoms of Disease	Treatment	Fluorouracil (DB00544) Leucovorin (DB00650)
NCT00349336	A Study of Avastin (Bevacizumab) in Combination With XELOX or FOLFOX-4 in Patients With Metastatic Colorectal Cancer.	Treatment	Bevacizumab (DB00112) Fluorouracil (DB00544) Leucovorin (DB00650) Oxaliplatin (DB00526)
NCT00112918	Combination Chemotherapy With or Without Bevacizumab in Treating Patients Who Have Undergone Surgery for High Risk Stage II or Stage III Colon Cancer	Treatment	Bevacizumab (DB00112) Capecitabine (DB01101) Fluorouracil (DB00544) Leucovorin (DB00650) Oxaliplatin (DB00526)
NCT00085163	Celecoxib Combined With Fluorouracil and Leucovorin in Treating Patients With Resected Stage III Adenocarcinoma (Cancer) of the Colon	Treatment	Celecoxib (DB00482) Fluorouracil (DB00544) Leucovorin (DB00650)
NCT00003422	Radiation Therapy Before Surgery Compared With Chemotherapy Plus Radiation After Surgery in Treating Patients With Rectal Cancer That Can Be Surgically Removed	Treatment	Fluorouracil (DB00544) Leucovorin (DB00650)
NCT00062426	Oxaliplatin and Bevacizumab (Avastin™) With Either Fluorouracil and Leucovorin or Capecitabine in Treating Patients With Advanced Colorectal Cancer	Treatment	Bevacizumab (DB00112) Capecitabine (DB01101) Fluorouracil (DB00544) Leucovorin (DB00650) Oxaliplatin (DB00526)
NCT00026273	Fluorouracil and Leucovorin With or Without Irinotecan in Treating Patients Following Surgery for Stage III Colorectal Cancer	Treatment	Fluorouracil (DB00544) Irinotecan (DB00762) Leucovorin (DB00650)
NCT00003594	Combination Chemotherapy in Treating Patients With Advanced Colorectal Cancer	Treatment	Fluorouracil (DB00544) Irinotecan (DB00762) Leucovorin (DB00650) Oxaliplatin (DB00526)
NCT01183780	A Study in Second Line Metastatic Colorectal Cancer	Treatment	Fluorouracil (DB00544) Irinotecan (DB00762) Leucovorin (DB00650) Ramucirumab (DB05578)
NCT00212589	Patients Preference for Oral or i.v. Therapy	Treatment	Capecitabine (DB01101) Fluorouracil (DB00544) Leucovorin (DB00650)
NCT00020501	Chemotherapy With or Without Isolated Hepatic Perfusion With Melphalan in Treating Patients With Colorectal Cancer That Has Spread to the Liver	Treatment	Floxuridine (DB00322) Fluorouracil (DB00544) Irinotecan (DB00762) Leucovorin (DB00650) Melphalan (DB01042)
NCT00064181	Combination Chemotherapy With or Without Celecoxib in Treating Patients With Metastatic Colorectal Cancer	Treatment	Capecitabine (DB01101) Celecoxib (DB00482) Fluorouracil (DB00544) Irinotecan (DB00762) Leucovorin (DB00650)
NCT00265850	Cetuximab and/or Bevacizumab Combined With Combination Chemotherapy in Treating Patients With Metastatic Colorectal Cancer	Treatment	Bevacizumab (DB00112) Cetuximab (DB00002) Fluorouracil (DB00544) Irinotecan (DB00762) Leucovorin (DB00650) Oxaliplatin (DB00526)
NCT00004150	High-Dose Fluorouracil With or Without Leucovorin Compared With Standard Fluorouracil Plus Leucovorin Following Surgery in Treating Patients With Stage III Colon Cancer	Treatment	Fluorouracil (DB00544) Leucovorin (DB00650)
NCT00002523	Radiation Therapy, Surgery, and Chemotherapy in Treating Patients With Rectal Cancer That Can Be Surgically Removed	Treatment	Fluorouracil (DB00544) Leucovorin (DB00650)
NCT00296608	Radiation Therapy With or Without Chemotherapy Before Surgery in Treating Patients With Stage II or Stage III Rectal Cancer	Treatment	Fluorouracil (DB00544) Leucovorin (DB00650)
NCT00469443	Randomized Phase III Study of Folfiri+Avastin Versus Xeliri+Avastin as 1st Line Treatment of CRC	Treatment	Bevacizumab (DB00112) Capecitabine (DB01101) Fluorouracil (DB00544) Irinotecan (DB00762) Leucovorin (DB00650)