| DB00316 | Acetaminophen | An analgesic drug used alone or in combination with opioids for pain management, and as an antipyretic agent. |
| DB00945 | Acetylsalicylic acid | A salicylate used to treat pain, fever, inflammation, migraines, and reducing the risk of major adverse cardiovascular events. |
| DB00921 | Buprenorphine | A partial opioid agonist used for management of severe pain that is not responsive to alternative treatments. Also used for maintenance treatment of opioid addiction. |
| DB00611 | Butorphanol | An opioid agonist-antagonist used to treat moderate to severe pain. |
| DB09061 | Cannabidiol | An active cannabinoid used as an adjunctive treatment for the management of seizures associated with Lennox-Gastaut syndrome or Dravet syndrome and symptomatic relief of moderate to severe neuropathic pain or other painful conditions, like cancer. |
| DB00318 | Codeine | An opioid analgesic used to treat moderate to severe pain when the use of an opioid is indicated. |
| DB01551 | Dihydrocodeine | An opioid analgesic agent used for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate. |
| DB00956 | Hydrocodone | An opioid agonist used as an analgesic and antitussive agent. |
| DB01050 | Ibuprofen | An NSAID and non-selective COX inhibitor used to treat mild-moderate pain, fever, and inflammation. |
| DB00854 | Levorphanol | An opioid analgesic used to treat moderate to severe pain. |
| DB00454 | Meperidine | An opioid agonist with analgesic and sedative properties used to manage severe pain. |
| DB00333 | Methadone | An opioid analgesic indicated for management of severe pain that is not responsive to alternative treatments. Also used to aid in detoxification and maintenance treatment of opioid addiction. |
| DB01028 | Methoxyflurane | For use in the induction and maintenance of general anesthesia |
| DB00295 | Morphine | An opioid agonist used for the relief of moderate to severe acute and chronic pain. |
| DB00844 | Nalbuphine | An opioid agonist-antagonist used to treat pain, for pre and postoperative analgesia, and for analgesia in labor and delivery. |
| DB01183 | Naloxone | An opioid receptor antagonist used to rapidly reverse an opioid overdose. Also included in some drug formulations as an abuse deterrent to prevent injection. |
| DB00704 | Naltrexone | A narcotic antagonist used in opioid overdose. |
| DB00497 | Oxycodone | An opioid used in the management of moderate to severe pain. |
| DB01192 | Oxymorphone | An opioid analgesic used in the management of moderate-to-severe pain and for analgesic therapies. |
| DB00652 | Pentazocine | An analgesic used to treat moderate to severe pain. |
| DB12492 | Piritramide | Piritramide is under investigation for the treatment of Colon Cancer and Minimal Residual Disease. Piritramide has been investigated for the supportive care of Pain, Postoperative and Postoperative Nausea and Vomiting. |
| DB13787 | Tilidine | Not Annotated |
| DB00193 | Tramadol | A centrally-acting opioid agonist and SNRI (serotonin/norepinephrine reuptake inhibitor) used for the management of moderate to severe pain in adults. |
| DB09120 | Zucapsaicin | A topical analgesic used as an adjunct to relieve severe pain of osteoarthritis of the knee in selected adult patients. |