Sulfotransferase 1B1
Details
- Name
- Sulfotransferase 1B1
- Synonyms
- 2.8.2.1
- ST1B1
- ST1B2
- Sulfotransferase 1B2
- Sulfotransferase family cytosolic 1B member 1
- SULT1B2
- Thyroid hormone sulfotransferase
- Gene Name
- SULT1B1
- UniProtKB Entry
- O43704Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0011826|Sulfotransferase 1B1 MLSPKDILRKDLKLVHGYPMTCAFASNWEKIEQFHSRPDDIVIATYPKSGTTWVSEIIDM ILNDGDIEKCKRGFITEKVPMLEMTLPGLRTSGIEQLEKNPSPRIVKTHLPTDLLPKSFW ENNCKMIYLARNAKDVSVSYYHFDLMNNLQPFPGTWEEYLEKFLTGKVAYGSWFTHVKNW WKKKEEHPILFLYYEDMKENPKEEIKKIIRFLEKNLNDEILDRIIHHTSFEVMKDNPLVN YTHLPTTVMDHSKSPFMRKGTAGDWKNYFTVAQNEKFDAIYETEMSKTALQFRTEI
- Number of residues
- 296
- Molecular Weight
- 34898.955
- Theoretical pI
- 7.07
- GO Classification
- Processesbiogenic amine metabolic process / ethanol catabolic processComponentscytoplasm
- General Function
- Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine (T3) and reverse triiodothyronine (rT3) (PubMed:28084139, PubMed:9443824, PubMed:9463486). May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system (PubMed:35165440)
- Specific Function
- aryl sulfotransferase activity
- Pfam Domain Function
- Sulfotransfer_1 (PF00685)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0011827|Sulfotransferase family cytosolic 1B member 1 (SULT1B1) ATGCTTTCCCCAAAAGATATTCTGCGAAAAGATCTGAAGTTGGTCCATGGTTATCCCATG ACCTGTGCTTTTGCAAGCAACTGGGAAAAAATTGAACAGTTCCATAGCAGACCAGATGAC ATTGTGATAGCCACTTATCCTAAATCAGGTACTACTTGGGTTAGTGAAATTATAGACATG ATTCTAAATGATGGAGATATTGAAAAATGTAAGCGAGGTTTTATTACTGAAAAAGTTCCA ATGTTGGAAATGACTCTCCCTGGATTAAGAACATCAGGTATAGAACAATTGGAGAAGAAT CCATCACCCCGGATTGTGAAAACACATCTACCGACTGATCTTCTTCCTAAATCTTTCTGG GAAAACAATTGCAAGATGATTTATCTGGCTCGTAATGCCAAGGATGTTTCAGTCTCATAT TACCATTTTGACTTAATGAATAATTTACAGCCTTTTCCTGGTACCTGGGAAGAATATCTG GAGAAATTCTTAACTGGAAAAGTGGCCTATGGTTCCTGGTTTACTCATGTTAAAAACTGG TGGAAGAAAAAGGAAGAACACCCAATACTTTTTTTGTACTATGAAGATATGAAAGAGAAT CCAAAGGAGGAAATCAAGAAGATCATTAGATTTCTAGAGAAGAACCTGAATGATGAGATC TTGGATAGGATCATCCATCACACCTCATTTGAAGTGATGAAGGACAATCCTTTGGTAAAT TATACACATCTACCAACTACAGTGATGGATCATAGCAAATCCCCTTTTATGCGTAAAGGG ACGGCTGGTGACTGGAAGAATTACTTCACCGTGGCCCAAAATGAGAAATTTGATGCTATT TATGAGACAGAAATGTCCAAAACTGCACTTCAATTCCGCACAGAGATTTAA
- Chromosome Location
- 4
- Locus
- 4q13.3
- External Identifiers
Resource Link UniProtKB ID O43704 UniProtKB Entry Name ST1B1_HUMAN GenBank Gene ID D89479 GeneCard ID SULT1B1 GenAtlas ID SULT1B1 HGNC ID HGNC:17845 PDB ID(s) 2Z5F, 3CKL KEGG ID hsa:27284 NCBI Gene ID 27284 - General References
- Fujita K, Nagata K, Ozawa S, Sasano H, Yamazoe Y: Molecular cloning and characterization of rat ST1B1 and human ST1B2 cDNAs, encoding thyroid hormone sulfotransferases. J Biochem. 1997 Nov;122(5):1052-61. [Article]
- Wang J, Falany JL, Falany CN: Expression and characterization of a novel thyroid hormone-sulfating form of cytosolic sulfotransferase from human liver. Mol Pharmacol. 1998 Feb;53(2):274-82. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Dombrovski L, Dong A, Bochkarev A, Plotnikov AN: Crystal structures of human sulfotransferases SULT1B1 and SULT1C1 complexed with the cofactor product adenosine-3'- 5'-diphosphate (PAP). Proteins. 2006 Sep 1;64(4):1091-4. [Article]
Associated Data
- Bio-Entities
Bio-Entity Type Sulfotransferase 1B1 (Humans) protein primarySulfotransferase (Humans) protein - Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Adenosine 3',5'-diphosphate experimental unknown target Details Curcumin sulfate experimental unknown enzyme substrate Details Thyroid, porcine approved unknown enzyme substrate Details Apomorphine approved, investigational unknown enzyme substrate Details Terbutaline approved unknown enzyme substrate Details Pindolol approved, investigational unknown enzyme substrate Details Methyldopa approved no enzyme substrate Details Ibrexafungerp approved, investigational unknown enzyme substrate Details Ritodrine approved, investigational no enzyme substrate Details Edaravone approved, investigational no enzyme substrate Details