Mitogen-activated protein kinase 9
Details
- Name
- Mitogen-activated protein kinase 9
- Synonyms
- 2.7.11.24
- c-Jun N-terminal kinase 2
- JNK-55
- JNK2
- MAP kinase 9
- MAPK 9
- PRKM9
- SAPK1A
- Stress-activated protein kinase 1a
- Stress-activated protein kinase JNK2
- Gene Name
- MAPK9
- UniProtKB Entry
- P45984Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0007238|Mitogen-activated protein kinase 9 MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNF MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQ LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSK MLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEV MDWEERSKNGVVKDQPSDAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTGPL EGCR
- Number of residues
- 424
- Molecular Weight
- 48138.655
- Theoretical pI
- 5.34
- GO Classification
- Functionsprotein serine kinase activity / protein serine/threonine kinase activity / protein serine/threonine/tyrosine kinase activityProcessesapoptotic signaling pathway / cellular response to cadmium ion / cellular response to reactive oxygen species / cellular senescence / inflammatory response to wounding / modulation of chemical synaptic transmission / positive regulation of cytokine production involved in inflammatory response / positive regulation of podosome assembly / positive regulation of proteasomal ubiquitin-dependent protein catabolic process / positive regulation of protein ubiquitination / protein localization to tricellular tight junctionComponentscytoplasm / nuclear speck / nucleus / plasma membrane / Schaffer collateral - CA1 synapse
- General Function
- Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death (PubMed:10376527, PubMed:15805466, PubMed:17525747, PubMed:19675674, PubMed:20595622, PubMed:21364637, PubMed:22441692, PubMed:34048572). Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2 (PubMed:10376527, PubMed:15805466, PubMed:17525747, PubMed:19675674, PubMed:20595622, PubMed:21364637, PubMed:22441692, PubMed:34048572). In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity (PubMed:10376527). In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3 (PubMed:15805466). Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1 (PubMed:17525747, PubMed:21364637). In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells (PubMed:19290929). Upon T-cell receptor (TCR) stimulation, is activated by CARMA1, BCL10, MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels (PubMed:19290929). Plays an important role in the osmotic stress-induced epithelial tight-junctions disruption (PubMed:20595622). When activated, promotes beta-catenin/CTNNB1 degradation and inhibits the canonical Wnt signaling pathway (PubMed:19675674). Participates also in neurite growth in spiral ganglion neurons (By similarity). Phosphorylates the CLOCK-BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692). Phosphorylates POU5F1, which results in the inhibition of POU5F1's transcriptional activity and enhances its proteasomal degradation (By similarity). Phosphorylates ALKBH5 in response to reactive oxygen species (ROS), promoting ALKBH5 sumoylation and inactivation (PubMed:34048572)
- Specific Function
- ATP binding
- Pfam Domain Function
- Pkinase (PF00069)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0021865|Mitogen-activated protein kinase 9 (MAPK9) ATGAGCGACAGTAAATGTGACAGTCAGTTTTATAGTGTGCAAGTGGCAGACTCAACCTTC ACTGTCCTAAAACGTTACCAGCAGCTGAAACCAATTGGCTCTGGGGCCCAAGGGATTGTT TGTGCTGCATTTGATACAGTTCTTGGGATAAATGTTGCAGTCAAGAAACTAAGCCGTCCT TTTCAGAACCAAACTCATGCAAAGAGAGCTTATCGTGAACTTGTCCTCTTAAAATGTGTC AATCATAAAAATATAATTAGTTTGTTAAATGTGTTTACACCACAAAAAACTCTAGAAGAA TTTCAAGATGTGTATTTGGTTATGGAATTAATGGATGCTAACTTATGTCAGGTTATTCAC ATGGAGCTGGATCATGAAAGAATGTCCTACCTTCTTTACCAGATGCTTTGTGGTATTAAA CATCTGCATTCAGCTGGTATAATTCATAGAGATTTGAAGCCTAGCAACATTGTTGTGAAA TCAGACTGCACCCTGAAGATCCTTGACTTTGGCCTGGCCCGGACAGCGTGCACTAACTTC ATGATGACCCCTTACGTGGTGACACGGTACTACCGGGCGCCCGAAGTCATCCTGGGTATG GGCTACAAAGAGAACGTTGATATCTGGTCAGTGGGTTGCATCATGGGAGAGCTGGTGAAA GGTTGTGTGATATTCCAAGGCACTGACCGTATCCTTCCCCGCGACCTTGGCCCCGCCATG CTTTCTTAA
- Chromosome Location
- 5
- Locus
- 5q35.3
- External Identifiers
Resource Link UniProtKB ID P45984 UniProtKB Entry Name MK09_HUMAN GenBank Protein ID 598183 GenBank Gene ID L31951 GeneCard ID MAPK9 HGNC ID HGNC:6886 PDB ID(s) 3E7O, 3NPC, 7CML, 7N8T, 8ELC KEGG ID hsa:5601 IUPHAR/Guide To Pharmacology ID 1497 NCBI Gene ID 5601 - General References
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Associated Data
- Bio-Entities
Bio-Entity Type Mitogen-activated protein kinase 9 (Humans) protein primaryMitogen-activated Protein Kinases (Humans) protein c-Jun N-terminal kinases (Humans) protein - Drug Relations
Drug Drug group Pharmacological action? Type Actions Details N-{3-[5-(1H-1,2,4-triazol-3-yl)-1H-indazol-3-yl]phenyl}furan-2-carboxamide experimental unknown target Details Fostamatinib approved, investigational unknown target inhibitor Details Encorafenib approved, investigational yes target inhibitor Details Pyrazolanthrone experimental yes target inhibitor Details CC-401 investigational yes target modulator Details Tanzisertib investigational yes target modulator Details NP-51 investigational yes target inhibitor Details D-JNKI-1 investigational yes target modulator Details Minocycline approved, investigational unknown target inhibitor Details Halicin experimental unknown target inhibitor Details