ADP-ribosylation factor 6

Details

Name
ADP-ribosylation factor 6
Synonyms
Not Available
Gene Name
ARF6
Organism
Humans
Amino acid sequence
>lcl|BSEQ0019545|ADP-ribosylation factor 6
MGKVLSKIFGNKEMRILMLGLDAAGKTTILYKLKLGQSVTTIPTVGFNVETVTYKNVKFN
VWDVGGQDKIRPLWRHYYTGTQGLIFVVDCADRDRIDEARQELHRIINDREMRDAIILIF
ANKQDLPDAMKPHEIQEKLGLTRIRDRNWYVQPSCATSGDGLYEGLTWLTSNYKS
Number of residues
175
Molecular Weight
20082.01
Theoretical pI
9.32
GO Classification
Functions
GTP binding / GTPase activity / thioesterase binding
Processes
cell adhesion / cell cycle / cell division / cortical actin cytoskeleton organization / establishment of epithelial cell polarity / hepatocyte apoptotic process / liver development / movement of cell or subcellular component / myeloid cell apoptotic process / negative regulation of dendrite development / negative regulation of receptor-mediated endocytosis / positive regulation of actin filament polymerization / positive regulation of establishment of protein localization to plasma membrane / protein localization to cell surface / protein localization to endosome / protein transport / regulation of dendritic spine development / regulation of filopodium assembly / regulation of Rac protein signal transduction / ruffle organization / small GTPase mediated signal transduction / vesicle-mediated transport
Components
cell cortex / cleavage furrow / early endosome / endocytic vesicle / endosome / extracellular exosome / filopodium membrane / focal adhesion / Golgi apparatus / membrane / midbody / myelin sheath / plasma membrane / recycling endosome membrane / ruffle
General Function
Thioesterase binding
Specific Function
GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling. Required for normal completion of mitotic cytokinesis. Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers. May also modulate vesicle budding and uncoating within the Golgi apparatus. Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension. Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Golgi apparatus
Gene sequence
>lcl|BSEQ0019546|ADP-ribosylation factor 6 (ARF6)
ATGGGGAAGGTGCTATCCAAAATCTTCGGGAACAAGGAAATGCGGATCCTCATGTTGGGC
CTGGACGCGGCCGGCAAGACAACAATCCTGTACAAGTTGAAGCTGGGCCAGTCGGTGACC
ACCATTCCCACTGTGGGTTTCAACGTGGAGACGGTGACTTACAAAAATGTCAAGTTCAAC
GTATGGGATGTGGGCGGCCAGGACAAGATCCGGCCGCTCTGGCGGCATTACTACACTGGG
ACCCAAGGTCTCATCTTCGTAGTGGACTGCGCCGACCGCGACCGCATCGATGAGGCTCGC
CAGGAGCTGCACCGCATTATCAATGACCGGGAGATGAGGGACGCCATAATCCTCATCTTC
GCCAACAAGCAGGACCTGCCCGATGCCATGAAACCCCACGAGATCCAGGAGAAACTGGGC
CTGACCCGGATTCGGGACAGGAACTGGTATGTGCAGCCCTCCTGTGCCACCTCAGGGGAC
GGACTCTATGAGGGGCTCACATGGTTAACCTCTAACTACAAATCTTAA
Chromosome Location
14
Locus
14q21.3
External Identifiers
ResourceLink
UniProtKB IDP62330
UniProtKB Entry NameARF6_HUMAN
GenBank Protein ID178989
GenBank Gene IDM57763
HGNC IDHGNC:659
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB018645'-Guanosine-Diphosphate-MonothiophosphateexperimentalunknownDetails
DB04315Guanosine-5'-DiphosphateexperimentalunknownDetails
DB08231Myristic acidexperimentalunknownDetails