Histone deacetylase 10
Details
- Name
- Histone deacetylase 10
- Synonyms
- 3.5.1.98
- HD10
- Gene Name
- HDAC10
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0006798|Histone deacetylase 10 MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEEL GLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTG AVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQ YLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVA AFLHLLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAV LEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQ DVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPD ITLVLPPDVIQQEASALREETEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIA ATPASAAAATLDVAVRRGLSHGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALS MFHVSTPLPVMTGGFLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGL AGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKM LQCHPHLVA
- Number of residues
- 669
- Molecular Weight
- 71444.08
- Theoretical pI
- 5.58
- GO Classification
- Functionsenzyme binding / histone deacetylase activity / histone deacetylase binding / NAD-dependent histone deacetylase activity (H3-K14 specific) / protein deacetylase activityProcesseschromatin organization / histone deacetylation / negative regulation of transcription from RNA polymerase II promoter / negative regulation of transcription, DNA-templated / oligodendrocyte development / protein deacetylation / regulation of transcription, DNA-templated / transcription, DNA-templatedComponentscytoplasm / histone deacetylase complex / nucleoplasm / nucleus
- General Function
- Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
- Specific Function
- Enzyme binding
- Pfam Domain Function
- Hist_deacetyl (PF00850)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0051551|Histone deacetylase 10 (HDAC10) ATGGGGACCGCGCTTGTGTACCATGAGGACATGACGGCCACCCGGCTGCTCTGGGACGAC CCCGAGTGCGAGATCGAGCGTCCTGAGCGCCTGACCGCAGCCCTGGATCGCCTGCGGCAG CGCGGCCTGGAACAGAGGTGTCTGCGGTTGTCAGCCCGCGAGGCCTCGGAAGAGGAGCTG GGCCTGGTGCACAGCCCAGAGTATGTATCCCTGGTCAGGGAGACCCAGGTCCTAGGCAAG GAGGAGCTGCAGGCGCTGTCCGGACAGTTCGACGCCATCTACTTCCACCCGAGTACCTTT CACTGCGCGCGGCTGGCCGCAGGGGCTGGACTGCAGCTGGTGGACGCTGTGCTCACTGGA GCTGTGCAAAATGGGCTTGCCCTGGTGAGGCCTCCCGGGCACCATGGCCAGAGGGCGGCT GCCAACGGGTTCTGTGTGTTCAACAACGTGGCCATAGCAGCTGCACATGCCAAGCAGAAA CACGGGCTACACAGGATCCTCGTCGTGGACTGGGATGTGCACCATGGCCAGGGGATCCAG TATCTCTTTGAGGATGACCCCAGCGTCCTTTACTTCTCCTGGCACCGCTATGAGCATGGG CGCTTCTGGCCTTTCCTGCGAGAGTCAGATGCAGACGCAGTGGGGCGGGGACAGGGCCTC GGCTTCACTGTCAACCTGCCCTGGAACCAGGTTGGGATGGGAAACGCTGACTACGTGGCT GCCTTCCTGCACCTGCTGCTCCCACTGGCCTTTGAGTTTGACCCTGAGCTGGTGCTGGTC TCGGCAGGATTTGACTCAGCCATCGGGGACCCTGAGGGGCAAATGCAGGCCACGCCAGAG TGCTTCGCCCACCTCACACAGCTGCTGCAGGTGCTGGCCGGCGGCCGGGTCTGTGCCGTG CTGGAGGGCGGCTACCACCTGGAGTCACTGGCGGAGTCAGTGTGCATGACAGTACAGACG CTGCTGGGTGACCCGGCCCCACCCCTGTCAGGGCCAATGGCGCCATGTCAGAGTGCCCTA GAGTCCATCCAGAGTGCCCGTGCTGCCCAGGCCCCGCACTGGAAGAGCCTCCAGCAGCAA GATGTGACCGCTGTGCCGATGAGCCCCAGCAGCCACTCCCCAGAGGGGAGGCCTCCACCT CTGCTGCCTGGGGGTCCAGTGTGTAAGGCAGCTGCATCTGCACCGAGCTCCCTCCTGGAC CAGCCGTGCCTCTGCCCCGCACCCTCTGTCCGCACCGCTGTTGCCCTGACAACGCCGGAT ATCACATTGGTTCTGCCCCCTGACGTCATCCAACAGGAAGCGTCAGCCCTGAGGGAGGAG ACAGAAGCCTGGGCCAGGCCACACGAGTCCCTGGCCCGGGAGGAGGCCCTCACTGCACTT GGGAAGCTCCTGTACCTCTTAGATGGGATGCTGGATGGGCAGGTGAACAGTGGTATAGCA GCCACTCCAGCCTCTGCTGCAGCAGCCACCCTGGATGTGGCTGTTCGGAGAGGCCTGTCC CACGGAGCCCAGAGGCTGCTGTGCGTGGCCCTGGGACAGCTGGACCGGCCTCCAGACCTC GCCCATGACGGGAGGAGTCTGTGGCTGAACATCAGGGGCAAGGAGGCGGCTGCCCTATCC ATGTTCCATGTCTCCACGCCACTGCCAGTGATGACCGGTGGTTTCCTGAGCTGCATCTTG GGCTTGGTGCTGCCCCTGGCCTATGGCTTCCAGCCTGACCTGGTGCTGGTGGCGCTGGGG CCTGGCCATGGCCTGCAGGGCCCCCACGCTGCACTCCTGGCTGCAATGCTTCGGGGGCTG GCAGGGGGCCGAGTCCTGGCCCTCCTGGAGGAGAACTCCACACCCCAGCTAGCAGGGATC CTGGCCCGGGTGCTGAATGGAGAGGCACCTCCTAGCCTAGGCCCTTCCTCTGTGGCCTCC CCAGAGGACGTCCAGGCCCTGATGTACCTGAGAGGGCAGCTGGAGCCTCAGTGGAAGATG TTGCAGTGCCATCCTCACCTGGTGGCTTGA
- Chromosome Location
- 22
- Locus
- 22q13.33
- External Identifiers
Resource Link UniProtKB ID Q969S8 UniProtKB Entry Name HDA10_HUMAN GenBank Gene ID AL512711 GenAtlas ID HDAC10 HGNC ID HGNC:18128 - General References
- Tong JJ, Liu J, Bertos NR, Yang XJ: Identification of HDAC10, a novel class II human histone deacetylase containing a leucine-rich domain. Nucleic Acids Res. 2002 Mar 1;30(5):1114-23. [Article]
- Guardiola AR, Yao TP: Molecular cloning and characterization of a novel histone deacetylase HDAC10. J Biol Chem. 2002 Feb 1;277(5):3350-6. Epub 2001 Nov 28. [Article]
- Kao HY, Lee CH, Komarov A, Han CC, Evans RM: Isolation and characterization of mammalian HDAC10, a novel histone deacetylase. J Biol Chem. 2002 Jan 4;277(1):187-93. Epub 2001 Oct 24. [Article]
- Fischer DD, Cai R, Bhatia U, Asselbergs FA, Song C, Terry R, Trogani N, Widmer R, Atadja P, Cohen D: Isolation and characterization of a novel class II histone deacetylase, HDAC10. J Biol Chem. 2002 Feb 22;277(8):6656-66. Epub 2001 Dec 5. [Article]
- Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I: A genome annotation-driven approach to cloning the human ORFeome. Genome Biol. 2004;5(10):R84. Epub 2004 Sep 30. [Article]
- Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al.: The DNA sequence of human chromosome 22. Nature. 1999 Dec 2;402(6761):489-95. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [Article]
- Hillman RT, Green RE, Brenner SE: An unappreciated role for RNA surveillance. Genome Biol. 2004;5(2):R8. Epub 2004 Feb 2. [Article]
- Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB05015 Belinostat approved, investigational yes inhibitor Details DB06603 Panobinostat approved, investigational yes inhibitor Details DB02546 Vorinostat approved, investigational unknown inhibitor Details DB12847 Pyroxamide investigational unknown inhibitor Details DB00313 Valproic acid approved, investigational unknown inhibitor Details DB11841 Entinostat investigational yes inhibitor Details DB06819 Phenylbutyric acid approved, investigational unknown inhibitor Details DB12645 Givinostat investigational unknown inhibitor Details DB06176 Romidepsin approved, investigational unknown inhibitor Details DB01262 Decitabine approved, investigational unknown inhibitor Details DB12565 Abexinostat investigational unknown inhibitor Details DB03766 Propanoic acid approved, vet_approved unknown inhibitor Details DB13346 Bufexamac approved, withdrawn unknown inhibitor Details