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Displaying results 91 - 100 of 524 in total
  1. Target

    Gamma-aminobutyric acid receptor subunit theta

    go.drugbank.com/bio_entities/BE0003597
    TargetHumans

    GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit … Theta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:10449790, PubMed:16412217).

    Polypeptides: Gamma-aminobutyric acid receptor subunit theta
  2. Target

    Gamma-aminobutyric acid receptor subunit delta

    go.drugbank.com/bio_entities/BE0003599
    TargetHumans

    Delta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:35355020). … of sleep and wakefulness (PubMed:35355020)

    Polypeptides: Gamma-aminobutyric acid receptor subunit delta
  3. Target

    Asc-type amino acid transporter 1

    go.drugbank.com/bio_entities/BE0004709
    TransporterHumans

    Associates with SLC3A2/4F2hc to form a functional heterodimeric complex that translocates small neutral L- and D-amino acids across the plasma membrane. … At the spinal cord and brainstem regulates glycine metabolism and glycinergic inhibitory neurotransmission by providing for glycine de novo synthesis from L-serine and glycine recycling from astrocytes

    Polypeptides: Asc-type amino acid transporter 1Function: L-amino acid transmembrane transporter activity
  4. Target

    Y+L amino acid transporter 2

    go.drugbank.com/bio_entities/BE0009872
    TransporterHumans

    Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids such as L-arginine from inside the cells in exchange with neutral amino acids … like L-leucine, L-glutamine and isoleucine, plus sodium ions and may participate in nitric oxide synthesis (PubMed:10903140, PubMed:11311135, PubMed:14603368, PubMed:15756301, PubMed:16785209, PubMed:

    Polypeptides: Y+L amino acid transporter 2Synonyms: y(+)L-type amino acid transporter 2, Cationic amino acid transporter, y+ system
  5. Target

    Lysosomal acid lipase/cholesteryl ester hydrolase

    go.drugbank.com/bio_entities/BE0010879
    EnzymeTargetHumans

    Catalyzes the deacylation of cholesteryl ester core lipids of endocytosed low density lipoproteins to generate free fatty acids and cholesterol (PubMed:15269241, PubMed:1718995, PubMed:7204383, PubMed: … Hydrolyzes triglycerides (1,2,3-triacylglycerol) and diglycerides (such as 1,2-diacylglycerol and 1,3-diacylglycerol) with preference for the acyl moieties at the sn-1 or sn-3 positions (PubMed:7204383

    Polypeptides: Lysosomal acid lipase/cholesteryl ester hydrolaseSynonyms: Acid cholesteryl ester hydrolase
  6. Target

    Neutral amino acid transporter B(0)

    go.drugbank.com/bio_entities/BE0000236
    TargetTransporterHumans

    The preferred substrate is the essential amino acid L-glutamine, a precursor for biosynthesis of proteins, nucleotides and amine sugars as well as an alternative fuel for mitochondrial oxidative phosphorylation … Displays sodium- and amino acid-dependent but uncoupled channel-like anion conductance with a preference SCN(-) >> NO3(-) > I(-) > Cl(-) (By similarity).

    Polypeptides: Neutral amino acid transporter B(0)Synonyms: Sodium-dependent neutral amino acid transporter type 2
  7. Target

    Branched-chain-amino-acid aminotransferase, cytosolic

    go.drugbank.com/bio_entities/BE0000517
    TargetEnzymeHumans

    Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine

    Polypeptides: Branched-chain-amino-acid aminotransferase, cytosolicFunction: branched-chain-amino-acid
  8. Target

    14 kDa fatty acid-binding protein

    go.drugbank.com/bio_entities/BE0001566
    TargetBlood fluke

    May play a role in the transport of fatty acids. Binds various fatty acids, such as arachidonic, oleic, palmitic and linolenic acid (in vitro).

    Polypeptides: 14 kDa fatty acid-binding proteinFunction: fatty acid binding
  9. Target

    Long-chain fatty acid transport protein

    go.drugbank.com/bio_entities/BE0001610
    TargetEscherichia coli (strain K12)

    Involved in translocation of long-chain fatty acids across the outer membrane. It is a receptor for the bacteriophage T2. FadL may form a specific channel.

    Polypeptides: Long-chain fatty acid transport protein
  10. Target

    Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1

    go.drugbank.com/bio_entities/BE0001809
    TargetHumans

    For the pyrophosphorolytic activity, prefers NAD(+) and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively … Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency (PubMed:17402747).

    Polypeptides: Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1