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Heparan sulfate glucosamine 3-O-sulfotransferase 3A1
go.drugbank.com/bio_entities/BE0001541TargetHumansThe substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry (PubMed:10520990). … Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate
Polypeptides: Heparan sulfate glucosamine 3-O-sulfotransferase 3A1Synonyms: Heparan sulfate 3-O-sulfotransferase 3A1, Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1Heparan sulfate glucosamine 3-O-sulfotransferase 1
go.drugbank.com/bio_entities/BE0004436TargetHumansCatalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact) (PubMed:8900198, PubMed:9988768). … Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan (PubMed:8900198, PubMed:9346953, PubMed:9988768
Polypeptides: Heparan sulfate glucosamine 3-O-sulfotransferase 1Synonyms: Heparan sulfate 3-O-sulfotransferase 1, Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1Peroxisome proliferator-activated receptor alpha
go.drugbank.com/bio_entities/BE0000071TargetHumansFunctions as a transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. … Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids.
Polypeptides: Peroxisome proliferator-activated receptor alphaMitogen-activated protein kinase 4
go.drugbank.com/bio_entities/BE0009476TargetHumansPhosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. … then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4.
Polypeptides: Mitogen-activated protein kinase 45'-AMP-activated protein kinase
go.drugbank.com/bio_entities/BE0011011TargetRatCatalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:14511394). … Activated via SIRT3, represses sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance.
Polypeptides: 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit beta-2Synonyms: 5'-AMP-activated protein kinase 40 kDa subunitEpithelial sodium channel subunit beta
go.drugbank.com/bio_entities/BE0000024TargetTransporterHumansThis is one of the three pore-forming subunits of the heterotrimeric epithelial sodium channel (ENaC), a critical regulator of sodium balance and fluid homeostasis (PubMed:30251954, PubMed:32729833, PubMed … Additionally, ENaC is essential for airway surface liquid homeostasis, which is crucial for proper mucus clearance (PubMed:24124190)
Polypeptides: Epithelial sodium channel subunit betaSynonyms: Amiloride-sensitive sodium channel subunit beta, Nonvoltage-gated sodium channel 1 subunit betaHepatic sodium/bile acid cotransporter
go.drugbank.com/bio_entities/BE0003644TransporterTargetHumansIt exhibits broad substrate specificity and transports various bile acids, such as taurocholate, cholate, as well as non-bile acid organic compounds, such as estrone sulfate (PubMed:14660639, PubMed:34060352 … fat and fat-soluble vitamins (PubMed:14660639, PubMed:24867799, PubMed:34060352, PubMed:8132774).
Polypeptides: Hepatic sodium/bile acid cotransporterSynonyms: Sodium/taurocholate cotransporting polypeptideSodium-driven chloride bicarbonate exchanger
go.drugbank.com/bio_entities/BE0004683TransporterHumansSodium/bicarbonate cotransporter which plays an important role in regulating intracellular pH (PubMed:18319254). … Controls neuronal pH and may contribute to the secretion of cerebrospinal fluid (By similarity).
Polypeptides: Sodium-driven chloride bicarbonate exchangerFunction: sodium,bicarbonateSodium-coupled monocarboxylate transporter 1
go.drugbank.com/bio_entities/BE0004708TransporterHumansActs as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate … Can mediate the transport of chloride, bromide, iodide and nitrate ions when the external concentration of sodium ions is reduced (PubMed:19864324). Part of D-serine transport systems.
Polypeptides: Sodium-coupled monocarboxylate transporter 1Synonyms: Sodium iodide-related cotransporter, Electrogenic sodium monocarboxylate cotransporterPeroxisome proliferator-activated receptor gamma
go.drugbank.com/bio_entities/BE0000215TargetHumansLigand-activated transcription factor that forms obligate heterodimers with the retinoic acid receptor and acts as a key regulator of biological processes, such as adipocyte differentiation, lipid metabolism … Activated by lipid ligands: binds peroxisome proliferators, such as hypolipidemic drugs, and fatty acids, such as prostaglandin J2 metabolites (PubMed:16150867, PubMed:20829347, PubMed:23525231, PubMed
Polypeptides: Peroxisome proliferator-activated receptor gamma