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Nortriptyline Action Pathway
smpdb.ca/view/SMP0126345Drug actionNortriptyline is a tricyclic antidepressant used to treat major depression. Nortriptyline hydrochloride, the active metabolite of amitriptyline, is a tricyclic antidepressant (TCA). This drug is also used off-label and it includes the tr...
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Tryptophan · Sapropterin · Norepinephrine +7 moreEnzymes: Aromatic-L-amino-acid decarboxylaseDesipramine Action Pathway (New)
smpdb.ca/view/SMP0126352Drug actionDesipramine, also known as Norpramin, is a dibenzazepine-derivative tricyclic antidepressant (TCA) used in the treatment of depression. In non-depressed individuals, desipramine does not affect mood but may cause sedation. In depressed i...
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Tryptophan · Sapropterin · Norepinephrine +7 moreEnzymes: Aromatic-L-amino-acid decarboxylaseDoxepin Norepinephrine Reuptake Inhibitor Action Pathway (New)
smpdb.ca/view/SMP0126355Drug actionDoxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is used for the treatment of depression, anxiety, manic-depressive disorder, and insomnia. Similar to other tricyclic antidepressants, doxepin decreases th...
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Tryptophan · Sapropterin · Norepinephrine +7 moreEnzymes: Aromatic-L-amino-acid decarboxylaseLevodopa Metabolism Pathway
smpdb.ca/view/SMP0125329MetabolicThe primary metabolites are 3,4-dihydroxyphenylacetic acid (13-47%) and homovanillic acid (23-39%). … Once levodopa is converted to dopamine, it is converted to sulfated or glucuronidated metabolites, epinephrine E, or homovanillic acid through various metabolic processes.
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · NADH · Norepinephrine · Epinephrine +6 moreEnzymes: Aromatic-L-amino-acid decarboxylase, Neutral and basic amino acid transport protein rBATBupropion Action Pathway
smpdb.ca/view/SMP0125268Drug actionDopamine is synthesized from tyrosine which is catalyzed by Tyrosine 3-monooxygenase into L-dopa which is catalyzed by Aromatic-L-amino-acid decarboxylase into dopamine.
Enzymes: Aromatic-L-amino-acid decarboxylaseClomipramine Action Pathway (New)
smpdb.ca/view/SMP0126354Drug actionClomipramine, also known as Anafranil, is a tricyclic antidepressant used in the treatment of obsessive-compulsive disorder and disorders with an obsessive-compulsive component, such as depression, schizophrenia, and Tourette’s disorder....
Enzymes: Aromatic-L-amino-acid decarboxylaseMethylphenidate Norepinephrine Reuptake Inhibitor Action Pathway
smpdb.ca/view/SMP0126572Drug actionMethylphenidate, known commonly as Ritalin, is a central nervous system stimulant used mainly for ADHD, but also for narcolepsy. ADHD is caused by an abnormality in the dopamine transporter gene (DAT1), the D4 receptor gene (DRD-4), and/...
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · ATP · Norepinephrine · Methylphenidate +7 moreEnzymes: Aromatic-L-amino-acid decarboxylaseAmine Oxidase Norepinephrine
smpdb.ca/view/SMP0130460PhysiologicalThe monoamine oxidase is an enzyme that catalyzes the oxidative deamination of many amines like serotonin, norepinephrine, epinephrine, and dopamine. There are 2 isoforms of this protein: A and B. The first one is found in cells located ...
Enzymes: Aromatic-L-amino-acid decarboxylaseMetabolsim and Physiological Effects of 4-Ethylphenylsulfate
smpdb.ca/view/SMP0125541Metabolicacid. … This is metabolized into phenylpyruvic acid Phenylacetic acid which is then metabolized into 3-(3-Hydroxyphenyl)propanoic acid.
Drugs: Pyridoxal phosphate · Phenylalanine · Tyrosine · Iron · Oxogluric acid · Propanoic acid +3 moreEnzymes: Aromatic-amino-acid aminotransferasePhentermine Action Pathway
smpdb.ca/view/SMP0125178Drug actionPhentermine is an oral sympathomimetic anorectic drug used as a short-term adjunct therapy that is included in a regimen of weight reduction in cases of exogenous obesity. Phentermine is indicated, alone or in combination with topiramate...
Enzymes: Aromatic-L-amino-acid decarboxylase