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Displaying results 91 - 100 of 134078 in total
  1. Pathway

    Metabolism and Physiological Effects of N-Acetyl-3-Methylhistidine

    smpdb.ca/view/SMP0126795
    Metabolic

    N-Acetyl-3-methylhistidine, an N-acetyl-L-amino acid, belongs to the class of organic compounds known as histidine and derivatives. … N-Acetyl-3-methylhistidine is an acetylated derivative of 3-methylhistidine and a very strong basic compound (based on its pKa).

    Drugs: Histidine · Ademetionine
  2. Pathway

    Metabolism and Physiological Effects of N-alpha-Acetyl-L-arginine

    smpdb.ca/view/SMP0125530
    Metabolic

    Arginnosuccinate is synthesized from citrulline and aspartic acid by the enzyme argininosuccinate synthase. That is catalyzed by argininosuccinate lyase to produce arginine and fumaric acid. … In the blood it works as a uremic toxin to cause kidney damage, cardiovascular disease and neurological deficits.

    Drugs: Pyridoxal phosphate · Arginine · Aspartic acid · Ornithine · L-Glutamine · Adenosine phosphate +10 more
  3. Pathway

    Ziconotide NMDA and Substance P Receptor Pain Inhibition Action Pathway

    smpdb.ca/view/SMP0126347
    Drug action

    such as intrathecal morphine and systemic analgesics. … This causes downstream nociceptive neuronal activity and pain perception. Substance P and CGRP both also induce inflammation, further exasperating chronic pain.

    Drugs: Glutamic acid · Calcium · Sar9, Met (O2)11-Substance P · Ziconotide
  4. Pathway

    Icosapent Prostaglandin G/H synthase 1 and 2 anti-inflammatory Action Pathway

    smpdb.ca/view/SMP0126557
    Drug action

    This molecule also inhibits the arachidonic acid conversion into the thromboxane-2 and prostaglandin-2 families because it inhibits the prostaglandin G/H synthase 1 and 2 (COX-1 and COX-2). … Then icosapent shows anti-atherogenic and anti-thrombotic effects in cells. EPA serves as a substrate for Prostaglandin-endoperoxide synthase 1 and 2.

    Drugs: Glutathione · Icosapent · Dinoprostone · Calcium · Mesoheme · Prostaglandin G2 +1 more
  5. Pathway

    Fish oil Prostaglandin G/H synthase 1 and 2 anti-inflammatory Action Pathway

    smpdb.ca/view/SMP0126563
    Drug action

    EPA and DHA do competition with arachidonic acids for both COX-1 and COX-2 enzymes. … Fish oil is made of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA).

    Drugs: Glutathione · Icosapent · Dinoprostone · Calcium · Mesoheme · Prostaglandin G2 +1 more
  6. Pathway

    Peginterferon alfa-2a Action Pathway

    smpdb.ca/view/SMP0125981
    Drug action

    Peginterferon alfa-2a activate interferon alpha receptors 1 and 2 (IFNAR1 and IFNAR2) which are associated with tyrosine kinase 2 (TYK2) and JAK1 respectively. … They act through IKKa and IKKb to drive NFKB induction of genes associated with survival signals, antigen processing and presentation, and proliferation.

    Drugs: Peginterferon alfa-2a
    Enzymes: Signal transducer and activator of transcription 3, Signal transducer and activator of transcription 2
  7. Pathway

    Peginterferon alfa-2b Action Pathway

    smpdb.ca/view/SMP0126026
    Drug action

    Its immunomodulatory effects are the enhancement of the phagocytic activity, the activation of NK cells, the stimulation of cytotoxic T-lymphocytes, and the upregulation of the Th1 T-helper cell subset … It is also used as an adjuvant treatment of melanoma with microscopic or gross nodal involvement within 84 days of definitive surgical resection.

    Drugs: Peginterferon alfa-2b
    Enzymes: Signal transducer and activator of transcription 3, Signal transducer and activator of transcription 2
  8. Pathway

    Interferon beta-1a Action Pathway

    smpdb.ca/view/SMP0126027
    Drug action

    They act through IKKa and IKKb to drive NFKB induction of genes associated with survival signals, antigen processing and presentation, and proliferation. … These transphosphorylate themselves and phosphorylate the IFNAR and IFNAR2c. This receptor complex also phosphorylates STAT3 homodimers.

    Drugs: Interferon beta-1a
    Enzymes: Signal transducer and activator of transcription 3, Signal transducer and activator of transcription 2
  9. Pathway

    Triflusal Action Pathway (new)

    smpdb.ca/view/SMP0126547
    Drug action

    Due to the anticoagulant and antiplatelet nature, herbs and supplements with similar activity should be avoided such as garlic, ginger, bilberry, danshen, piracetam and ginkgo biloba. … Triflusal is administered orally and acts as an antithrombotic anticoagulant that irreversibly inhibits cyclooxygenase-1(COX-1) also known as prostaglandin g/h synthase 1.

    Drugs: Adenosine phosphate · ATP · Magnesium cation · Zinc · Cyclic adenosine monophosphate · Mesoheme +2 more
    Enzymes: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
  10. Pathway

    Cardiolipin Biosynthesis CL(10:0/10:0/14:0/21:0)

    smpdb.ca/view/SMP0175412
    Metabolic

    Sixth, phosphatidylglycerophosphatase and protein-tyrosine phosphatase dephosphorylates PGP to form phosphatidylglycerol (PG). … Cardiolipin (CL) is an important component of the inner mitochondrial membrane where it constitutes about 20% of the total lipid composition.

    Drugs: NADH · Cytidine-5'-Triphosphate · sn-glycerol 3-phosphate · Pyrophosphoric acid · Dihydroxyacetone phosphate
    Enzymes: Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1