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Hyaluronan and proteoglycan link protein 3
go.drugbank.com/bio_entities/BE0004935TargetHumansMay function in hyaluronic acid binding
Polypeptides: Hyaluronan and proteoglycan link protein 3Calcium and integrin-binding protein 1
go.drugbank.com/bio_entities/BE0008691TargetHumansForms a complex with TMC6/EVER1 and TMC8/EVER2 in lymphocytes and keratynocytes where CIB1 stabilizes TMC6 and TMC8 levels and reciprocally (PubMed:30068544, PubMed:32917726) … Also promotes cancer cell survival and proliferation. May regulate cell cycle and differentiation of spermatogenic germ cells, and/or differentiation of supporting Sertoli cells.
Polypeptides: Calcium and integrin-binding protein 1Synonyms: Calcium- and integrin-binding proteinMultidrug and toxin extrusion protein 2
go.drugbank.com/bio_entities/BE0004752TransporterHumansMediates the efflux of endogenous compounds such as, creatinine, thiamine and estrone-3-sulfate. … Plays a physiological role in the excretion of drugs, toxins and endogenous metabolites through the kidney
Polypeptides: Multidrug and toxin extrusion protein 2Nucleolar and coiled-body phosphoprotein 1
go.drugbank.com/bio_entities/BE0005819TargetHumansIt has intrinsic GTPase and ATPase activities (PubMed:9016786) … processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832).
Polypeptides: Nucleolar and coiled-body phosphoprotein 1Cysteine and glycine-rich protein 1
go.drugbank.com/bio_entities/BE0009098TargetHumansCould play a role in neuronal development
Polypeptides: Cysteine and glycine-rich protein 1TRAF2 and NCK-interacting protein kinase
go.drugbank.com/bio_entities/BE0009399TargetHumansMAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed … Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development.
Polypeptides: TRAF2 and NCK-interacting protein kinaseSignal transducer and activator of transcription 5B
go.drugbank.com/bio_entities/BE0000891TargetHumansSignal transducer and transcription activator that mediates cellular responses to cytokines, hormones and growth factors (PubMed:29844444, PubMed:9188471). … Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation.
Polypeptides: Signal transducer and activator of transcription 5BDisintegrin and metalloproteinase domain-containing protein 10
go.drugbank.com/bio_entities/BE0002404TargetHumansInvolved in the development and maturation of glomerular and coronary vasculature (By similarity). … Mediates the proteolytic cleavage of IL6R and IL11RA, leading to the release of secreted forms of IL6R and IL11RA (PubMed:26876177). Enhances the cleavage of CHL1 by BACE1 (By similarity).
Polypeptides: Disintegrin and metalloproteinase domain-containing protein 10Disintegrin and metalloproteinase domain-containing protein 28
go.drugbank.com/bio_entities/BE0003872TargetHumansMay play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L.
Polypeptides: Disintegrin and metalloproteinase domain-containing protein 28Synonyms: Metalloproteinase-like, disintegrin-like, and cysteine-rich protein L, Epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein IICalcium and integrin-binding family member 2
go.drugbank.com/bio_entities/BE0008698TargetHumansRequired for the maintenance of auditory hair cell stereocilia bundle morphology and function and for hair-cell survival in the cochlea (By similarity). … Critical for proper photoreceptor cell maintenance and function (By similarity).
Polypeptides: Calcium and integrin-binding family member 2