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nAchR Smooth Muscle Contraction
smpdb.ca/view/SMP0126643PhysiologicalAcetylcholine released from neuromuscular neurons activates nicotinic acetylcholine receptors (nAchR) on smooth muscle membranes. This causes the receptor to open, causing sodium to flow into the smooth muscle myocyte. This high concentr...
Doxylamine H1 Antihistamine Smooth Muscle Relaxation Action Pathway
smpdb.ca/view/SMP0126730Drug actionDoxylamine is an ethanolamine class H1 antihistamine used to treat insomnia and allergy symptoms such as hay fever and hives. It is also used with pyridoxine in the treatment of nausea and vomiting in pregnancy. H1-antihistamines interfe...
Gq Serotonergic Smooth Muscle Contraction
smpdb.ca/view/SMP0126954PhysiologicalAlthough numerous GPCRs have the ability to couple to more than one heterotrimeric G protein, a given GPCR is typically classified based on the G protein subfamily (e.g., Gs, Gi/o, or Gq/11) it preferentially activates. Signaling via Gq-...
Triprolidine H1 Antihistamine Smooth Muscle Relaxation Action Pathway
smpdb.ca/view/SMP0174890Drug actionTriprolidine is an ethanolamine class H1 antihistamine used to treat insomnia and allergy symptoms such as hay fever and hives. It is also used with pyridoxine in the treatment of nausea and vomiting in pregnancy. H1-antihistamines inter...
Cyproheptadine H1 Antihistamine Smooth Muscle Relaxation Action Pathway
smpdb.ca/view/SMP0174891Drug actionCyproheptadine is an ethanolamine class H1 antihistamine used to treat insomnia and allergy symptoms such as hay fever and hives. It is also used with pyridoxine in the treatment of nausea and vomiting in pregnancy. H1-antihistamines int...
Tripelennamine H1 Antihistamine Smooth Muscle Relaxation Action Pathway
smpdb.ca/view/SMP0174897Drug actionTripelennamine is a first-generation ethanolamine H1-antihistamine. H1-antihistamines interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate inflammatory process in order to treat conditions s...
Cyclizine H1 Antihistamine Smooth Muscle Relaxation Action Pathway
smpdb.ca/view/SMP0174904Drug actionCyclizine is an H1 antihistamine and antiemetic drug used for the prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness, and vertigo. H1-antihistamines interfere with the agonist action of histamine ...
Phenindamine H1 Antihistamine Smooth Muscle Relaxation Action Pathway
smpdb.ca/view/SMP0174906Drug actionPhenindamine is an H1-antihistamine. H1-antihistamines interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate inflammatory process in order to treat conditions such as allergic rhinitis, aller...
Levocetirizine H1 Antihistamine Smooth Muscle Relaxation Action Pathway
smpdb.ca/view/SMP0174909Drug actionLevocetirizine is an H1-receptor antagonist used to treat symptoms associated with chronic allergic rhinitis and uncomplicated cases of chronic idiopathic urticaria. H1-antihistamines interfere with the agonist action of histamine at the...
Mepyramine H1 Antihistamine Smooth Muscle Relaxation Action Pathway
smpdb.ca/view/SMP0174910Drug actionMepyramine is an antihistamine agent used for the symptomatic treatment of allergy, hypersensitivity reactions, and pruritic skin disorders. H1-antihistamines interfere with the agonist action of histamine at the H1 receptor and are admi...