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Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone
smpdb.ca/view/SMP0000333SignalingIn the ovary, the FSH receptor is necessary for follicular development and is expressed on the granulosa cells.
Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/Choriogonadotropin
smpdb.ca/view/SMP0000338SignalingLHCGRs are found in the ovary, testis, and many extragonadal tissues.In the ovary, the LHCG receptor is necessary for follicular maturation and ovulation, as well as luteal function. … In the male the LHCGR has been identified on the Leydig cells that are critical for testosterone production, and support spermatogenesis.
Metabolism and Physiological Effects of N-Acetyl-3-Methylhistidine
smpdb.ca/view/SMP0126795MetabolicN-Acetyl-3-methylhistidine, an N-acetyl-L-amino acid, belongs to the class of organic compounds known as histidine and derivatives. … N-Acetyl-3-methylhistidine is an acetylated derivative of 3-methylhistidine and a very strong basic compound (based on its pKa).
Metabolism and Physiological Effects of N-alpha-Acetyl-L-arginine
smpdb.ca/view/SMP0125530MetabolicArginnosuccinate is synthesized from citrulline and aspartic acid by the enzyme argininosuccinate synthase. That is catalyzed by argininosuccinate lyase to produce arginine and fumaric acid. … In the blood it works as a uremic toxin to cause kidney damage, cardiovascular disease and neurological deficits.
Drugs: Pyridoxal phosphate · Arginine · Aspartic acid · Ornithine · L-Glutamine · Adenosine phosphate +10 moreZiconotide NMDA and Substance P Receptor Pain Inhibition Action Pathway
smpdb.ca/view/SMP0126347Drug actionTherefore substance P, CGRP, and glutamate are not released into the synapse and cannot activate the substance P receptors, CGRP receptors, or the N-Methyl-D-aspartic acid receptors on the post-synaptic … such as intrathecal morphine and systemic analgesics.
Icosapent Prostaglandin G/H synthase 1 and 2 anti-inflammatory Action Pathway
smpdb.ca/view/SMP0126557Drug actionIcosapent is an important polyunsaturated fatty acid (eicosapentaenoic acid (EPA)). It is mostly found in fish oils. … This molecule also inhibits the arachidonic acid conversion into the thromboxane-2 and prostaglandin-2 families because it inhibits the prostaglandin G/H synthase 1 and 2 (COX-1 and COX-2).
Menthyl salicylate Action Pathway
smpdb.ca/view/SMP0126552Drug actionMenthyl salicylate, also known as Max-freeze, is an ester of menthol and salicylic acid, therefore it is a member of the salicylates drug class (NSAIDs). … The menthol part of the molecule dilates blood vessels while the salicylate portion provides a topical anesthetic and analgesic action on the applied area of the skin/muscle.
Drugs: Glutathione · Dinoprostone · Calcium · Mesoheme · Prostaglandin G2 · Arachidonic Acid +1 moreMenthyl salicylate Predicted Metabolism Pathway
smpdb.ca/view/SMP0174544MetabolicMetabolites of Menthyl salicylate are predicted with biotransformer.
Acylcarnitine 3-[(2R)-2-hydroxy-3-methyl-3-[(phosphonooxy)methyl]butanamido]propanoylcarnitine
smpdb.ca/view/SMP0123534MetabolicThis reaction can occur in both directions, and L-acetylcarnitine and CoA can react to form acetyl-CoA and L-carnitine in certain circumstances. … to once again form 3-[(2R)-2-hydroxy-3-methyl-3-[(phosphonooxy)methyl]butanamido]propanoyl-CoA and L-carnitine. 3-[(2R)-2-hydroxy-3-methyl-3-[(phosphonooxy)methyl]butanamido]propanoyl-CoA then enters
Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 moreAcylcarnitine 3-(3-methyl-5-pentylfuran-2-yl)propanoylcarnitine
smpdb.ca/view/SMP0123509MetabolicThis reaction can occur in both directions, and L-acetylcarnitine and CoA can react to form acetyl-CoA and L-carnitine in certain circumstances. … 3-(3-methyl-5-pentylfuran-2-yl)propanoylcarnitine is an acylcarnitine.
Drugs: Biotin · Adenosine phosphate · ATP · Levocarnitine · Magnesium cation · Pyrophosphoric acid +1 more