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Displaying results 91 - 100 of 301 in total
  1. Target

    Diamine oxidase [copper-containing]

    go.drugbank.com/bio_entities/BE0000351
    TargetEnzymeHumans

    Catalyzes the oxidative deamination of primary amines to the corresponding aldehydes with the concomitant production of hydrogen peroxide and ammonia (PubMed:12072962, PubMed:19764817, PubMed:239684, PubMed:8144586). Its preferred substr...

    Polypeptides: Diamine oxidase [copper-containing]Synonyms: Amine oxidase copper domain-containing protein 1
  2. Target

    Copper transport protein ATOX1

    go.drugbank.com/bio_entities/BE0002833
    TargetCarrierHumans

    Multifunctional copper-sensing protein that operates both as a cytosolic copper chaperone and as a copper-dependent transcription factor. … In the cytosol, transfers copper to the copper-transporting ATPase ATP7A at the trans-Golgi network, which is required for activation of secretory copper enzymes including lysyl oxidase (LOX) and SOD3.

    Polypeptides: Copper transport protein ATOX1
  3. Target

    Copper-transporting ATPase 1

    go.drugbank.com/bio_entities/BE0003666
    TransporterHumans

    ATP-driven copper (Cu(+)) ion pump that plays an important role in intracellular copper ion homeostasis (PubMed:10419525, PubMed:11092760, PubMed:28389643). … In the melanosomes of pigmented cells, provides copper cofactor to TYR to form an active TYR holoenzyme for melanin biosynthesis (By similarity)

    Polypeptides: Copper-transporting ATPase 1Synonyms: Copper pump 1
  4. Drug

    Pixofisiran

    go.drugbank.com/drugs/DB17294
    Experimental

    Synonyms: Rna, (a-g-a-a-g-u-u-g-g-c-a-u-g-g-u-a-g-c-c-c-u-u-g-g-g), complex with rna (c-c-c-a-a-g-g-g-c-u-a-c-c-a-u-g-c-c-a-a-c-u-u-c-u) (1:1)
  5. Target

    Proteasome activator complex subunit 1

    go.drugbank.com/bio_entities/BE0008976
    TargetHumans

    The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome

    Polypeptides: Proteasome activator complex subunit 1Synonyms: 11S regulator complex subunit alpha
  6. Target

    MHC class II protein complex

    go.drugbank.com/bio_entities/BE0011001
    TargetHumans

  7. Indication

    Tuberous Sclerosis Complex with Subependymal Giant Cell Astrocytoma

    go.drugbank.com/conditions/DBCOND0025535
    Drugs: Everolimus
    Synonyms: Tuberous Sclerosis Complex with Subependymal Giant Cell Astrocytoma
  8. Drug

    Mometasone furoate

    go.drugbank.com/drugs/DB14512
    ApprovedInvestigationalVet approved

    Mometasone furoate is a corticosteroid drug that can be used for the treatment of asthma, rhinitis, and certain skin conditions[FDA Label] . It has a glucocorticoid receptor binding affinity 22 times stronger than dexamethasone and highe...

  9. Target

    Copper chaperone for superoxide dismutase

    go.drugbank.com/bio_entities/BE0005815
    CarrierTargetHumans

    Delivers copper to copper zinc superoxide dismutase (SOD1)

    Polypeptides: Copper chaperone for superoxide dismutaseSynonyms: Superoxide dismutase copper chaperone
  10. Target

    Cytochrome c oxidase copper chaperone

    go.drugbank.com/bio_entities/BE0008686
    CarrierHumans

    Copper metallochaperone involved in the assembly of cytochrome c oxidase (respiratory chain complex IV, CIV) (PubMed:15229189, PubMed:19393246, PubMed:31903891, PubMed:35750769). … Binds two copper ions and delivers them to metallochaperones SCO1 and SCO2, which co-chaperone the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2), and to metallochaperone

    Polypeptides: Cytochrome c oxidase copper chaperoneFunction: copper chaperone activity