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Displaying results 91 - 100 of 178 in total
  1. Target

    Protein kinase C theta type

    go.drugbank.com/bio_entities/BE0001385
    TargetHumans

    May mediate inhibitory effects of free fatty acids on insulin signaling by phosphorylating IRS1, which in turn blocks IRS1 tyrosine phosphorylation and downstream activation of the PI3K/AKT pathway.

  2. Target

    Bile acid receptor

    go.drugbank.com/bio_entities/BE0001777
    TargetHumans

    Modulates glucose-stimulated insulin secretion and is involved in insulin resistance (PubMed:20447400). Involved in intestinal innate immunity.

  3. Target

    Sodium channel protein type 3 subunit alpha

    go.drugbank.com/bio_entities/BE0002082
    TargetHumans

    For instance, it controls the release of serotonin/5-hydroxytryptamine by enterochromaffin cells and is required for both glucagon- and glucose-induced insulin secretion in pancreatic endocrine cells (

  4. Target

    Interleukin-4 receptor subunit alpha

    go.drugbank.com/bio_entities/BE0002420
    TargetHumans

    In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2

  5. Target

    Fructose-1,6-bisphosphatase 1

    go.drugbank.com/bio_entities/BE0002431
    TargetHumans

    Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver.

  6. Target

    Leptin receptor

    go.drugbank.com/bio_entities/BE0003376
    TargetHumans

    In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity

  7. Target

    G protein-coupled estrogen receptor 1

    go.drugbank.com/bio_entities/BE0003446
    TargetHumans

    Plays a role in blood glucose homeostasis contributing to the insulin secretion response by pancreatic beta cells. Triggers mitochondrial apoptosis during pachytene spermatocyte differentiation.

  8. Target

    Signal transducer and activator of transcription 3

    go.drugbank.com/bio_entities/BE0003462
    TargetHumans

    Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion (By similarity).

  9. Target

    Nischarin

    go.drugbank.com/bio_entities/BE0003580
    TargetHumans

    Involved in association with IRS4 in the enhancement of insulin activation of MAPK1 and MAPK3.

  10. Target

    Cyclin-dependent kinase 16

    go.drugbank.com/bio_entities/BE0004077
    TargetHumans

    Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro)