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Tyrosine-protein phosphatase non-receptor type 11
go.drugbank.com/bio_entities/BE0001071TargetHumansActs downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus (PubMed:10655584, PubMed:14739280, PubMed:18559669 … Acts as an effector of PDCD1-mediated inhibition of T-cell response: recruited by phosphorylated PDCD1, mediating dephosphorylation of key T-cell receptor (TCR) proximal signaling molecules, leading to
Polypeptides: Tyrosine-protein phosphatase non-receptor type 11Proto-oncogene tyrosine-protein kinase receptor Ret
go.drugbank.com/bio_entities/BE0002411TargetHumansActs as a dependence receptor via the GDNF-GFRA1 signaling: in the presence of the ligand GDNF in somatotrophs within pituitary, promotes survival and down regulates growth hormone (GH) production, but … Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner (PubMed:20702524, PubMed:21357690).
Polypeptides: Proto-oncogene tyrosine-protein kinase receptor RetTumor necrosis factor receptor superfamily member 8
go.drugbank.com/bio_entities/BE0003479TargetHumansReceptor for TNFSF8/CD30L (PubMed:8391931). May play a role in the regulation of cellular growth and transformation of activated lymphoblasts.
Polypeptides: Tumor necrosis factor receptor superfamily member 8Synonyms: CD30L receptorParathyroid hormone/parathyroid hormone-related peptide receptor
go.drugbank.com/bio_entities/BE0003508TargetHumansG protein-coupled receptor for parathyroid hormone (PTH) and for parathyroid hormone-related peptide (PTHLH) (PubMed:10913300, PubMed:11773434, PubMed:18375760, PubMed:19674967, PubMed:27160269, PubMed … Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (cAMP
Polypeptides: Parathyroid hormone/parathyroid hormone-related peptide receptorSynonyms: PTH1 receptor, PTH/PTHr receptorGamma-aminobutyric acid receptor subunit gamma-1
go.drugbank.com/bio_entities/BE0003593TargetHumansGamma subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:10449790). GABA-gated chloride channels, also named GABA(A) receptors (...
Polypeptides: Gamma-aminobutyric acid receptor subunit gamma-1Synonyms: GABA(A) receptor subunit gamma-1Gamma-aminobutyric acid receptor subunit rho-3
go.drugbank.com/bio_entities/BE0003619TargetHumansRho subunit of the pentameric ligand-gated chloride channels responsible for mediating the effects of gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain (By similarity). Rho-containing GABA-gated chloride ...
Polypeptides: Gamma-aminobutyric acid receptor subunit rho-3Synonyms: GABA(C) receptor, GABA(A) receptor subunit rho-3Acetylcholine receptor subunit alpha-type unc-63
go.drugbank.com/bio_entities/BE0004926TargetCaenorhabditis elegansAlpha subunit of nicotinic acetylcholine receptor (nAChR) (PubMed:15280391, PubMed:15990870, PubMed:20027209).
Polypeptides: Acetylcholine receptor subunit alpha-type unc-63G protein-coupled bile acid receptor 1
go.drugbank.com/bio_entities/BE0005788TargetHumansG protein-coupled receptor for bile acid (PubMed:12419312, PubMed:12524422, PubMed:32698187, PubMed:32747649, PubMed:35858343). … Bile acid-binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase
Polypeptides: G protein-coupled bile acid receptor 1Synonyms: G protein-coupled receptor GPCR19, Membrane-type receptor for bile acidsLymphatic vessel endothelial hyaluronic acid receptor 1
go.drugbank.com/bio_entities/BE0010044TargetHumansLigand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding ...
Polypeptides: Lymphatic vessel endothelial hyaluronic acid receptor 1Synonyms: Hyaluronic acid receptorNuclear receptor subfamily 4immunitygroup A member 1
go.drugbank.com/bio_entities/BE0010494TargetHumansOrphan nuclear receptor. Binds the NGFI-B response element (NBRE) 5'-AAAGGTCA-3' (PubMed:18690216, PubMed:8121493, PubMed:9315652).
Polypeptides: Nuclear receptor subfamily 4immunitygroup A member 1Synonyms: Testicular receptor 3, Orphan nuclear receptor HMR