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Displaying results 1021 - 1030 of 2674 in total
  1. Drug

    Scopolamine

    go.drugbank.com/drugs/DB00747
    ApprovedInvestigational

    [A228773, L31578] Scopolamine was first approved by the FDA on December 31, 1979, and is currently available as both oral tablets and a transdermal delivery system.[L31578]

  2. Drug

    Deutetrabenazine

    go.drugbank.com/drugs/DB12161
    ApprovedInvestigational

    It was approved by FDA in April 2017 and is marketed under the trade name Austedo as oral tablets. … Deutetrabenazine is a racemic mixture containing RR-Deutetrabenazine and SS-Deutetrabenazine [FDA Label].

  3. Drug

    Eribulin

    go.drugbank.com/drugs/DB08871
    ApprovedInvestigational

    Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated ...

  4. Target

    High affinity immunoglobulin epsilon receptor subunit gamma

    go.drugbank.com/bio_entities/BE0000049
    TargetHumans

    As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells. … As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production by basophils, priming T-cells toward effector T-helper 2 subset.

    Polypeptides: High affinity immunoglobulin epsilon receptor subunit gammaSynonyms: Fc receptor gamma-chain, IgE Fc receptor subunit gamma
  5. Target

    Gamma-aminobutyric acid receptor subunit rho-1

    go.drugbank.com/bio_entities/BE0000129
    TargetHumans

    Rho subunit of the pentameric ligand-gated chloride channels responsible for mediating the effects of gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain (PubMed:37659407). Rho-containing GABA-gated chlorid...

    Polypeptides: Gamma-aminobutyric acid receptor subunit rho-1Synonyms: GABA(C) receptor, GABA(A) receptor subunit rho-1
  6. Target

    Mast/stem cell growth factor receptor Kit

    go.drugbank.com/bio_entities/BE0000453
    TargetHumans

    KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. … Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance

    Polypeptides: Mast/stem cell growth factor receptor Kit
  7. Target

    Gamma-aminobutyric acid receptor subunit alpha-4

    go.drugbank.com/bio_entities/BE0000478
    TargetHumans

    Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:35355020). GABA-gated chloride channels, also named GABA(A) receptors (...

    Polypeptides: Gamma-aminobutyric acid receptor subunit alpha-4Synonyms: GABA(A) receptor subunit alpha-4
  8. Target

    Tyrosine-protein phosphatase non-receptor type 1

    go.drugbank.com/bio_entities/BE0000623
    TargetHumans

    May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET

    Polypeptides: Tyrosine-protein phosphatase non-receptor type 1
  9. Target

    C-X-C chemokine receptor type 4

    go.drugbank.com/bio_entities/BE0000919
    TargetHumans

    Also acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels (PubMed:20228059). … Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation (PubMed:10074102, PubMed:10452968, PubMed:10644702

    Polypeptides: C-X-C chemokine receptor type 4Synonyms: SDF-1 receptor, Stromal cell-derived factor 1 receptor
  10. Target

    Low-density lipoprotein receptor-related protein 2

    go.drugbank.com/bio_entities/BE0000942
    TargetTransporterHumans

    Mediates receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B (By similarity). … Multiligand endocytic receptor (By similarity). Acts together with CUBN to mediate endocytosis of high-density lipoproteins (By similarity).

    Polypeptides: Low-density lipoprotein receptor-related protein 2