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Displaying results 1051 - 1060 of 10000 in total
  1. Pathway

    Norelgestromin Action Pathway

    smpdb.ca/view/SMP0126539
    Drug action

    Norelgestromin is a synthetic progestational hormone indicated in women to prevent pregnancy. This drug is also used in menopausal hormonal therapy. This drug is administered as a contraceptive pill or as a transdermal patch. This drug i...

    Drugs: NADH · ATP · Progesterone · Testosterone · Estrone · Potassium cation +9 more
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
  2. Pathway

    Ziprasidone Dopamine Antagonist Action Pathway

    smpdb.ca/view/SMP0126472
    Drug action

    Ziprasidone is an atypical antipsychotic used to treat schizophrenia, bipolar mania, and acute agitation in schizophrenic patients. It also indicated improvement on the manic syndrome subscale that measures symptoms of mania such as mood...

    Drugs: Pyridoxal phosphate · Tyrosine · Ziprasidone · Sapropterin · Dopamine · Levodopa +2 more
    Enzymes: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
  3. Pathway

    Etonogestrel Action Pathway

    smpdb.ca/view/SMP0126525
    Drug action

    Etonogestrel is a synthetic metabolite of progestin desosgestrel. This drug is a long-acting progestin contraceptive used mostly in intradermal implants that are releasing 40 mcg/day of the drug for 3 years. Etonogestrel binds strongly t...

    Drugs: NADH · ATP · Etonogestrel · Progesterone · Testosterone · Estrone +9 more
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
  4. Pathway

    Progesterone Action Pathway

    smpdb.ca/view/SMP0126529
    Drug action

    Progesterone is a hormone naturally occurring in females. This molecule is essential for endometrial receptivity, embryo implantation, and the successful establishment of pregnancy. It is used as an oral drug as a contraceptive to preven...

    Drugs: NADH · ATP · Progesterone · Testosterone · Estrone · Potassium cation +8 more
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
  5. Pathway

    Norethisterone Action Pathway

    smpdb.ca/view/SMP0126536
    Drug action

    Norethisterone, also known as norethindrone, is a synthetic progestational hormone used for contraception, prevention of endometrial hyperplasia (hormone replacement therapy), and in the treatment of other hormone-related illnesses. This...

    Drugs: NADH · ATP · Progesterone · Testosterone · Estrone · Norethisterone +9 more
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
  6. Pathway

    Segesterone acetate Action Pathway

    smpdb.ca/view/SMP0126542
    Drug action

    Segesterone acetate, also known as Annovera, is a synthetic progestin derived from 19-norprogesterone. This drug is very potent; it mediates progestational activity 100 times higher than that of progesterone. It is used as a contraceptiv...

    Drugs: NADH · ATP · Progesterone · Testosterone · Estrone · Potassium cation +9 more
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
  7. Drug

    Zongertinib

    go.drugbank.com/drugs/DB18762
    ApprovedInvestigational

    Zongertinib is a selective, irreversible tyrosine kinase inhibitor that targets human epidermal growth factor receptor 2 (HER2). … [L53873,A274363] On August 8, 2025, the US FDA granted accelerated approval to zongertinib for the treatment of advanced forms of non-small cell lung cancer (NSCLC) with HER2 tyrosine kinase domain

    Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-Ring
  8. Pathway

    Pramipexole Mechanism of Action Action Pathway

    smpdb.ca/view/SMP0126459
    Drug action

    Pramipexole is indicated for the management of Parkinson's disease and symptomatic treatment of moderate to severe primary Restless Legs Syndrome (RLS). Pramipexole likely restores balance to the dopaminergic system, controlling the symp...

    Drugs: Pyridoxal phosphate · Tyrosine · ATP · Pramipexole · Dopamine · Levodopa +5 more
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
  9. Pathway

    Neuronal Dopamine Gs Cascade

    smpdb.ca/view/SMP0126952
    Physiological

    Actions of the neurotransmitter dopamine in the brain are mediated by dopamine receptors that belong to the superfamily of G protein-coupled receptors (GPCRs). Mammals have five dopamine receptor subtypes, D1 through D5. D1 and D5 couple...

    Drugs: Pyridoxal phosphate · Tyrosine · ATP · Dopamine · Levodopa · Calcium +4 more
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
  10. Target

    Mitogen-activated protein kinase kinase kinase 4

    go.drugbank.com/bio_entities/BE0009468
    TargetHumans

    Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6

    Synonyms: MEKK 4, MEK kinase 4