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Displaying results 1061 - 1070 of 3735 in total
  1. Target

    Cation-independent mannose-6-phosphate receptor

    go.drugbank.com/bio_entities/BE0003623
    TargetTransporterHumans

    The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer (PubMed:18817523). This receptor also binds IGF2 (PubMed:18046459). … Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal

    Polypeptides: Cation-independent mannose-6-phosphate receptorSynonyms: IGF-II receptor, CI Man-6-P receptor
  2. Target

    Non-receptor tyrosine-protein kinase TYK2

    go.drugbank.com/bio_entities/BE0004146
    TargetHumans

    The heterodimeric cytokine receptor complexes are composed of (1) a TYK2-associated receptor chain (IFNAR1, IL12RB1, IL10RB or IL13RA1), and (2) a second receptor chain associated either with JAK1 or JAK2 … Involved in the oncostatin-M-mediated signaling pathway through both type I OSM receptor complex (heterodimers composed of LIFR and IL6ST) and type II OSM receptor complex (heterodimers composed of OSMR

    Polypeptides: Non-receptor tyrosine-protein kinase TYK2
  3. Target

    Interleukin-1 receptor-associated kinase 4

    go.drugbank.com/bio_entities/BE0004344
    TargetHumans

    Involved in Toll-like receptor (TLR) and IL-1R signaling pathways (PubMed:17878374). … Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2.

    Polypeptides: Interleukin-1 receptor-associated kinase 4
  4. Target

    Adhesion G protein-coupled receptor D1

    go.drugbank.com/bio_entities/BE0005510
    TargetHumans

    Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed … Acts as a 5alpha-DHT receptor in muscle cells, thereby increasing intracellular cyclic AMP (cAMP) levels and enhancing muscle strength (PubMed:39884271)

    Polypeptides: Adhesion G protein-coupled receptor D1Synonyms: G protein-coupled receptor 133, G protein-coupled receptor PGR25
  5. Target

    Signal recognition particle receptor subunit beta

    go.drugbank.com/bio_entities/BE0009230
    TargetPlasmodium falciparum (isolate 3D7)

    Polypeptides: Signal recognition particle receptor subunit betaSynonyms: Signal recognition particle receptor, beta subunit
  6. Target

    Tyrosine-protein kinase receptor Tie-1

    go.drugbank.com/bio_entities/BE0009396
    TargetHumans

    Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis

    Polypeptides: Tyrosine-protein kinase receptor Tie-1
  7. Target

    Interleukin-1 receptor-associated kinase 3

    go.drugbank.com/bio_entities/BE0009453
    TargetHumans

    Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex (By similarity).

    Polypeptides: Interleukin-1 receptor-associated kinase 3Synonyms: IL-1 receptor-associated kinase M, Inactive IL-1 receptor-associated kinase 3
  8. Target

    C-C chemokine receptor type 4

    go.drugbank.com/bio_entities/BE0009787
    TargetHumans

    High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. … The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system.

    Polypeptides: C-C chemokine receptor type 4
  9. Target

    Killer cell immunoglobulin-like receptor 2DL3

    go.drugbank.com/bio_entities/BE0010665
    TargetHumans

    Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis

    Polypeptides: Killer cell immunoglobulin-like receptor 2DL3Synonyms: p58 NK receptor CL-6, Killer inhibitory receptor cl 2-3
  10. Target

    Baculoviral IAP repeat-containing protein 3

    go.drugbank.com/bio_entities/BE0010674
    TargetHumans

    Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition

    Polypeptides: Baculoviral IAP repeat-containing protein 3