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Displaying results 1071 - 1080 of 1711 in total
  1. Target

    C-X-C chemokine receptor type 2

    go.drugbank.com/bio_entities/BE0010516
    TargetHumans

    Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor (PubMed:1891716). Binding of IL-8 to the receptor causes activation of neutrophils.

    Polypeptides: C-X-C chemokine receptor type 2Synonyms: GRO/MGSA receptor, IL-8 receptor type 2
  2. Target

    Tumor necrosis factor receptor superfamily member 16

    go.drugbank.com/bio_entities/BE0010540
    TargetHumans

    Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. … Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (PubMed:24908487).

    Polypeptides: Tumor necrosis factor receptor superfamily member 16Synonyms: NGF receptor, Low affinity neurotrophin receptor p75NTR
  3. Target

    Antiviral innate immune response receptor RIG-I

    go.drugbank.com/bio_entities/BE0012418
    TargetHumans

    Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and pro-inflammatory cytokines (PubMed:15208624

    Polypeptides: Antiviral innate immune response receptor RIG-ISynonyms: RIG-I-like receptor 1
  4. Target

    Tumor necrosis factor receptor superfamily member 13C

    go.drugbank.com/bio_entities/BE0018598
    TargetHumans

    B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response

    Polypeptides: Tumor necrosis factor receptor superfamily member 13CSynonyms: BAFF receptor, BLyS receptor 3
  5. Target

    Tumor necrosis factor receptor superfamily member 12A

    go.drugbank.com/bio_entities/BE0020009
    TargetHumans

    Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins

    Polypeptides: Tumor necrosis factor receptor superfamily member 12ASynonyms: Tweak-receptor
  6. Target

    Acetylcholine receptor subunit alpha-type acr-16

    go.drugbank.com/bio_entities/BE0027703
    TargetCaenorhabditis elegans

    A subunit of the levamisole-insensitive nicotinic receptor.

    Polypeptides: Acetylcholine receptor subunit alpha-type acr-16
  7. Drug

    Ipecac

    go.drugbank.com/drugs/DB13293
    ApprovedWithdrawn

    [L1113] The FDA does not have currently any approved product containing ipecac, however, ipecac as an ingredient is accepted to be sold over the counter in packages of 1 fluid ounce (30 ml) for the emergency

  8. Drug

    Cyproheptadine

    go.drugbank.com/drugs/DB00434
    ApprovedInvestigational

    Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in ...

    Categories: Serotonin Receptor Antagonists, Serotonin 5-HT2 Receptor Antagonists
  9. Drug

    gamma-Hydroxybutyric acid

    go.drugbank.com/drugs/DB01440
    ApprovedIllicitInvestigational

    Gamma hydroxybutyric acid, commonly abbreviated GHB, is a therapeutic drug which is illegal in multiple countries. It is currently regulated in the US and sold by Jazz Pharmaceuticals under the name Xyrem. However, it is important to not...

  10. Drug

    Danicopan

    go.drugbank.com/drugs/DB15401
    ApprovedInvestigational

    Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired hematologic disease characterized by hemolysis, thrombophilia, and bone marrow dysfunction. Both hemolysis and thrombophilia are mediated primarily by the complement system. St...