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Displaying results 1071 - 1080 of 3735 in total
  1. Target

    Baculoviral IAP repeat-containing protein 2

    go.drugbank.com/bio_entities/BE0010675
    TargetHumans

    Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition

    Polypeptides: Baculoviral IAP repeat-containing protein 2
  2. Target

    Ciliary neurotrophic factor receptor subunit alpha

    go.drugbank.com/bio_entities/BE0012974
    TargetHumans

    Functions either as a membrane-anchored non-signaling receptor via a GPI anchor or, after proteolytic release, as a soluble ligand-binding chaperone, and mediates signaling of CNTF-related cytokines, including … Functions within the ciliary neurotrophic factor receptor (CNTFR) complex as a membrane-anchored non-signaling receptor subunit associated with two other signaling receptor subunits IL6ST/gp130 and LIFR

    Polypeptides: Ciliary neurotrophic factor receptor subunit alphaSynonyms: CNTF receptor subunit alpha
  3. Target

    G protein-coupled receptor kinase 5

    go.drugbank.com/bio_entities/BE0013072
    TargetHumans

    Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. … Phosphorylation of ST13 regulates internalization of the chemokine receptor. Phosphorylates rhodopsin (RHO) (in vitro) and a non G protein-coupled receptor, LRP6 during Wnt signaling (in vitro)

    Polypeptides: G protein-coupled receptor kinase 5Synonyms: G protein-coupled receptor kinase GRK5
  4. Target

    Interleukin-12 receptor subunit beta-1

    go.drugbank.com/bio_entities/BE0013218
    TargetHumans

    Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. … Also associates with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade

    Polypeptides: Interleukin-12 receptor subunit beta-1Synonyms: IL-12 receptor beta component, IL-12 receptor subunit beta-1
  5. Target

    Short transient receptor potential channel 1

    go.drugbank.com/bio_entities/BE0013282
    TargetHumans

    Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:11139478, PubMed:15016832, PubMed:39478185).

    Polypeptides: Short transient receptor potential channel 1Synonyms: Transient receptor protein 1
  6. Target

    Interleukin-12 receptor subunit beta-2

    go.drugbank.com/bio_entities/BE0018860
    TargetHumans

    Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells.

    Polypeptides: Interleukin-12 receptor subunit beta-2Synonyms: IL-12 receptor subunit beta-2
  7. Target

    Taste receptor type 2 member 10

    go.drugbank.com/bio_entities/BE0020463
    TargetHumans

    Gustducin-coupled strychnine receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract.

    Polypeptides: Taste receptor type 2 member 10Synonyms: Taste receptor family B member 2
  8. Target

    Short transient receptor potential channel 4

    go.drugbank.com/bio_entities/BE0020751
    TargetHumans

    Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:11042129, PubMed:11713258, PubMed:16144838, PubMed:39478185).

    Polypeptides: Short transient receptor potential channel 4
  9. Target

    Short transient receptor potential channel 5

    go.drugbank.com/bio_entities/BE0021113
    TargetHumans

    Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:16284075, PubMed:38959890, PubMed:37137991). … Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with PLSCR1 (By similarity).

    Polypeptides: Short transient receptor potential channel 5Synonyms: Transient receptor protein 5
  10. Target

    Taste receptor type 2 member 14

    go.drugbank.com/bio_entities/BE0023216
    TargetHumans

    Likely plays a role in sensing the chemical composition of the gastrointestinal content and other extra-oral tissues via the inhibitory G protein pathways (PubMed:38600377, PubMed:38776963) … Gustducin-linked G protein-coupled receptor that plays a role in the perception of bitterness (PubMed:38600377, PubMed:38776963).

    Polypeptides: Taste receptor type 2 member 14Synonyms: Taste receptor family B member 1