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Flavin reductase (NADPH)
go.drugbank.com/bio_entities/BE0000595TargetEnzymeHumansS-nitroso-CoA-dependent nitrosyltransferase activity is mediated via a 'ping-pong' mechanism: BLVRB first associates with both S-nitroso-CoA and protein substrate, nitric oxide group is then transferred … from S-nitroso-CoA to Cys-109 and Cys-188 residues of BLVRB and from S-nitroso-BLVRB to the protein substrate (PubMed:38056462).
Synonyms: SNO-CoA-assisted nitrosyltransferase, S-nitroso-CoA-assisted nitrosyltransferase5'-AMP-activated protein kinase
go.drugbank.com/bio_entities/BE0004907TargetTransporterHumansRegulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA … Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA
Synonyms: Acetyl-CoA carboxylase kinase, Acetyl-CoA carboxylase kinaseFunction: [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity, [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activityComplement C4-A
go.drugbank.com/bio_entities/BE0004685TargetHumansPrecursor of non-enzymatic components of the classical, lectin and GZMK complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune ...
Synonyms: CO4Complement C4-B
go.drugbank.com/bio_entities/BE0004686TargetHumansPrecursor of non-enzymatic components of the classical, lectin and GZMK complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune ...
Synonyms: CO4Thioesterase 1/protease 1/lysophospholipase L1
go.drugbank.com/bio_entities/BE0002014TargetEscherichia coli (strain K12)TesA functions as a thioesterase specific for fatty acyl thioesters of greater than ten carbons, with highest activity on palmitoyl-CoA, cis-vaccenoyl-CoA and palmitoleoyl-CoA (PubMed:10423542, PubMed:
Synonyms: Acyl-CoA thioesterase 1, Acyl-CoA thioesterase IPyruvate:flavodoxin oxidoreductase
go.drugbank.com/bio_entities/BE0002361TargetEscherichia coli (strain K12)Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin.
Synonyms: CoA-acylating pyruvate:flavodoxin oxidoreductaseHuman Cyclooxygenases
go.drugbank.com/bio_entities/BE0010085TargetHumansDual cyclooxygenase and peroxidase that plays an important role in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate, AA, C20:4(n-6)), with a particular ...
Synonyms: COX-1, COX-2Serine palmitoyltransferase 1
go.drugbank.com/bio_entities/BE0000441TargetHumansThe SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA … commonly palmitoyl-CoA) to form long-chain bases.
Synonyms: Serine-palmitoyl-CoA transferase 1Aldo-keto reductase family 1 member A1
go.drugbank.com/bio_entities/BE0004352TargetEnzymeHumansAlso acts as an inhibitor of protein S-nitrosylation by mediating degradation of S-nitroso-coenzyme A (S-nitroso-CoA), a cofactor required to S-nitrosylate proteins (PubMed:30538128). … S-nitroso-CoA reductase activity is involved in reprogramming intermediary metabolism in renal proximal tubules, notably by inhibiting protein S-nitrosylation of isoform 2 of PKM (PKM2) (By similarity)
Synonyms: S-nitroso-CoA reductaseProstaglandin G/H synthase 1
go.drugbank.com/bio_entities/BE0000017TargetEnzymeHumansDual cyclooxygenase and peroxidase that plays an important role in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate, AA, C20:4(n-6)), with a particular ...
Synonyms: COX-1