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N-succinylamino acid racemase
go.drugbank.com/bio_entities/BE0003211TargetDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)Catalyzes both N-succinylamino acid racemization and OSB synthesis at equivalent rates (PubMed:24872444). … Acts as a N-succinylamino acid racemase (NSAR) that catalyzes the racemization of N-succinyl-L-phenylglycine and N-succinyl-D/L-phenylalanine (PubMed:24872444, PubMed:25875730).
Synonyms: o-succinylbenzoate synthase, o-succinylbenzoic acid synthaseArylamine N-acetyltransferase 1
go.drugbank.com/bio_entities/BE0003608EnzymeHumansXenobiotic-metabolizing enzyme that catalyzes both N-acetylation (usually detoxification) and O-acetylation (usually bioactivation) of a wide range of species-specific substrates including hydrazines, … Plays a significant role in the bioactivation and detoxification of many drugs and carcinogens (Probable) (PubMed:9168895)
Synonyms: Aromatic-hydroxylamine O-acetyltransferase NAT1, N-hydroxyarylamine O-acetyltransferase NAT1NADH dehydrogenase
go.drugbank.com/bio_entities/BE0003040TargetThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)Can oxidize either NADH or NADPH with a preference for NADH. Can catalyze electron transfer from NADH to various electron acceptors which include, in addition to molecular oxygen, cytochrome c, 2,6 dichlorphenolindophenol, methylene blue...
Synonyms: H(2)O(2)-forming NADH oxidaseATP synthase peripheral stalk subunit OSCP, mitochondrial
go.drugbank.com/bio_entities/BE0009097TargetHumansPart of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity … These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256).
Synonyms: ATP synthase subunit ON-succinylamino acid racemase
go.drugbank.com/bio_entities/BE0002494TargetAmycolatopsis sp.Acts as a N-succinylamino acid racemase (NSAR) that catalyzes the racemization of N-succinyl-phenylglycine and N-succinyl-methionine (PubMed:14705949, PubMed:24955846). … Catalyzes both N-succinylamino acid racemization and OSB synthesis at equivalent rates (PubMed:14705949, PubMed:24955846). NSAR is probably the biological function of this enzyme (Probable).
Synonyms: o-succinylbenzoate synthase, o-succinylbenzoic acid synthaseAlpha-ketoglutarate-dependent dioxygenase FTO
go.drugbank.com/bio_entities/BE0005795TargetHumansMediates demethylation of N(6),2'-O-dimethyladenosine cap (m6A(m)), by demethylating the N(6)-methyladenosine at the second transcribed position of mRNAs and U6 snRNA (PubMed:28002401, PubMed:30197295) … RNA demethylase that mediates oxidative demethylation of different RNA species, such as mRNAs, tRNAs and snRNAs, and acts as a regulator of fat mass, adipogenesis and energy homeostasis (PubMed:22002720
Synonyms: Fat mass and obesity-associated protein, mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTOLysophosphatidylcholine acyltransferase 2
go.drugbank.com/bio_entities/BE0016122TargetEnzymeHumansAlso converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAF precursor (By similarity). … Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine
Synonyms: 1-acylglycerol-3-phosphate O-acyltransferase 11, 1-acylglycerophosphocholine O-acyltransferaseFunction: 1-acylglycerol-3-phosphate O-acyltransferase activityXylosyltransferase 1
go.drugbank.com/bio_entities/BE0016339EnzymeHumansCatalyzes the first step in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans, such as DCN. … Required for normal maturation of chondrocytes during bone development, and normal onset of ossification (By similarity)
Synonyms: Peptide O-xylosyltransferase 1Leucine carboxyl methyltransferase 1
go.drugbank.com/bio_entities/BE0000450TargetHumansMethylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues
Synonyms: Protein-leucine O-methyltransferaseFunction: protein C-terminal carboxyl O-methyltransferase activityAdiponectin receptor
go.drugbank.com/bio_entities/BE0010287TargetHumansRequired for normal glucose and fat homeostasis and for maintaining a normal body weight. … Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:12802337, PubMed:25855295). Required for normal body fat and glucose homeostasis.
Synonyms: Progestin and adipoQ receptor family member 1, Progestin and adipoQ receptor family member I