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Displaying results 101 - 110 of 1841 in total
  1. Pathway

    Bumetanide Diruretic Action Pathway

    smpdb.ca/view/SMP0124517
    Drug action

    Bumetanide is a loop diuretic drug, administered orally or intravenously the treatment of edema associated with congestive heart failure, hepatic and renal disease including the nephrotic syndrome. It targets the nephrons of the kidney, ...

    Drugs: Bumetanide · Potassium cation
    Enzymes: Chloride channel protein ClC-Ka, Sodium/potassium-transporting ATPase subunit alpha-1
  2. Pathway

    Amiloride Action Pathway (New)

    smpdb.ca/view/SMP0126243
    Drug action

    Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with diuretics to spare potassium loss. … This promotes the loss of sodium and water from the body, but without depleting potassium.

    Drugs: Amiloride · Potassium cation · Urea
    Enzymes: Chloride channel protein ClC-Ka, Sodium/potassium-transporting ATPase subunit alpha-1
  3. Pathway

    Bendroflumethiazide Action Pathway (New)

    smpdb.ca/view/SMP0123062
    Drug action

    In the distal convoluted tubule (DCT), the regulation of ions such as sodium, potassium, calcium, chloride, and magnesium occurs. … transporter which transports chloride into the interstitium-blood.

    Drugs: Bendroflumethiazide · Potassium cation · Calcium
    Enzymes: Chloride channel protein ClC-Ka, Sodium/potassium-transporting ATPase subunit alpha-1
  4. Pathway

    Chlorothiazide Action Pathway

    smpdb.ca/view/SMP0123141
    Drug action

    In the distal convoluted tubule (DCT), the regulation of ions such as sodium, potassium, calcium, chloride and magnesium occurs. … transporter which transports chloride into the interstitium-blood.

    Drugs: Chlorothiazide · Potassium cation · Calcium
    Enzymes: Chloride channel protein ClC-Ka, Sodium/potassium-transporting ATPase subunit alpha-1
  5. Pathway

    Methyclothiazide Diuretic Action Pathway

    smpdb.ca/view/SMP0123143
    Drug action

    In the distal convoluted tubule (DCT), the regulation of ions such as sodium, potassium, calcium, chloride and magnesium occur. … transporter which transports chloride into the interstitium-blood.

    Drugs: Methyclothiazide · Potassium cation · Calcium
    Enzymes: Chloride channel protein ClC-Ka, Sodium/potassium-transporting ATPase subunit alpha-1
  6. Pathway

    Trichlormethiazide Action Pathway (New)

    smpdb.ca/view/SMP0123150
    Drug action

    In the distal convoluted tubule (DCT), the regulation of ions such as sodium, potassium, calcium, chloride, and magnesium occurs. … transporter which transports chloride into the interstitium-blood.

    Drugs: Trichlormethiazide · Potassium cation · Calcium
    Enzymes: Chloride channel protein ClC-Ka, Sodium/potassium-transporting ATPase subunit alpha-1
  7. Pathway

    Metolazone Action Pathway

    smpdb.ca/view/SMP0123151
    Drug action

    In the distal convoluted tubule (DCT), the regulation of ions such as sodium, potassium, calcium, chloride and magnesium occur. … transporter which transports chloride into the interstitium-blood.

    Drugs: Metolazone · Potassium cation · Calcium
    Enzymes: Chloride channel protein ClC-Ka, Sodium/potassium-transporting ATPase subunit alpha-1
  8. Drug

    Acetazolamide

    go.drugbank.com/drugs/DB00819
    ApprovedInvestigationalVet approved

    Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition

  9. Pathway

    Lafutidine H2 Anti-Histamine Action Pathway

    smpdb.ca/view/SMP0051038
    Drug action

    Lafutidine (also known as INN) is a second generation histamine H2 receptor antagonist that can be used for treating ulcers and reflux. Inhibition of histamine H2 receptor can inhibit histamine-stimulated gastric acid secretion which wil...

    Drugs: ATP · Potassium cation · Zinc · Acetylcholine · Lafutidine
    Enzymes: Chloride intracellular channel protein 2, Potassium-transporting ATPase alpha chain 1
  10. Pathway

    Hydrochlorothiazide Action Pathway

    smpdb.ca/view/SMP0000100
    Drug action

    Solute carrier family 12 member 3 transports chloride and sodium from lumen to epithelial cell, and sodium/potassium ATPases facilitate the export of sodium to basolateral interstitium to provide sodium … It can inhibit the solute carrier family 12 member 3 (also known as sodium-chloride symporter) in the nephron to prevent water reabsorption.

    Drugs: Cysteine · Hydrochlorothiazide · Potassium cation · Urea
    Enzymes: Chloride channel protein ClC-Ka, Sodium- and chloride-dependent transporter XTRP3