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Imipramine Action Pathway (New)
smpdb.ca/view/SMP0126359Drug actionImipramine binds to the sodium-dependent serotonin transporter and to the sodium-dependent norepinephrine transporter reducing the reuptake of norepinephrine and serotonin by presynaptic neurons. … Depression has been linked to a lack of stimulation of the post-synaptic neuron by norepinephrine and serotonin.
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Tryptophan · Sapropterin · Norepinephrine +7 moreNortriptyline Action Pathway
smpdb.ca/view/SMP0126345Drug actionNortriptyline exerts antidepressant functions by inhibiting the reuptake of serotonin and norepinephrine in the neurons.
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Tryptophan · Sapropterin · Norepinephrine +7 moreDesipramine Action Pathway (New)
smpdb.ca/view/SMP0126352Drug actionSecondary amine TCAs, such as desipramine, are more potent inhibitors of norepinephrine reuptake than tertiary amine TCAs.
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Tryptophan · Sapropterin · Norepinephrine +7 moreNicotine Action Pathway
smpdb.ca/view/SMP0000431Drug actionNicotine is a stimulant drug that acts as an agonist at nicotinic acetylcholine receptors. These are ionotropic receptors composed of five homomeric or heteromeric subunits. In the brain, nicotine binds to nicotinic acetylcholine recepto...
Regulation of Lipolysis
smpdb.ca/view/SMP0573273SignalingBy contrast, during fasting or cold exposure sympathetic nerves release norepinephrine, which binds β‑adrenergic receptors on adipocytes to activate Gs proteins and adenylyl cyclase, raising cAMP levels
Clomipramine Action Pathway (New)
smpdb.ca/view/SMP0126354Drug actionIt blocks both sodium-dependent serotonin and sodium-dependent norepinephrine transporters from removing serotonin and norepinephrine respectively from the synaptic clefts in the brain.
Phentermine Action Pathway
smpdb.ca/view/SMP0125178Drug actionIn these synaptic vesicles, phentermine displaces the norepinephrine stored, and stimulates VMAT2 to spew out the stored norepinephrine into the cytosol. … The norepinephrine in the synapse activates beta-2 and alpha-1 adrenergic receptors on post-synaptic neurons.
Pargyline Action Pathway
smpdb.ca/view/SMP0126708Drug actionThe first one is found in cells located in the periphery and breakdown serotonin, norepinephrine, epinephrine, dopamine, and tyramine. … The second one, the B isoform, breakdowns phenylethylamine, norepinephrine, epinephrine, dopamine, and tyramine. This isoform is found in the extracellular tissues and mainly in the brain.
Methamphetamine Dopamine Reuptake Inhibitor Action Pathway
smpdb.ca/view/SMP0125231Drug actionOnce in the brain it acts on dopamine, norepinephrine, and serotonin neurological pathways.
Drugs: Pyridoxal phosphate · Ademetionine · Ascorbic acid · Tyrosine · Tryptophan · Sapropterin +9 moreBupropion Action Pathway
smpdb.ca/view/SMP0125268Drug actionNorepinephrine is synthesized in the locus ceruleus from dopamine which is catalyzed by Dopamine beta-hydroxylase into norepinephrine. … Norepinephrine's effects on MDD is less studied and less understood than dopamine.