Search
Ephrin type-A receptor 8
go.drugbank.com/bio_entities/BE0009440TargetHumansDuring development of the nervous system also plays a role in axon guidance. … The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation.
Polypeptides: Ephrin type-A receptor 8Carboplatin
go.drugbank.com/drugs/DB00958ApprovedInvestigationalCarboplatin is an organoplatinum antineoplastic alkylating agent used in the treatment of advanced ovarian carcinoma.[L32253] Early clinical studies of carboplatin were performed in 1982. … [A230523] Carboplatin was developed as an analog of [cisplatin] with reduced nephrotoxicity and vomiting.[A230463,A230523] Carboplatin was granted FDA approval on 3 March 1989.[L32248]
Synonyms: Cis-(1,1-cyclobutanedicarboxylato)diammineplatinum(II), Cis-diammine(1,1-cyclobutanedicarboxylato)platinum(II)International brands: Paraplatin AQ, Paraplatin-AQPhenytoin
go.drugbank.com/drugs/DB00252ApprovedInvestigationalVet approvedPhenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants. … [A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for several other indications
Mixtures: Dilantin W Phenobarbital 15mg, Dilantin W Phenobarbital 30mg CapCategories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP2A6 Substrates with a Narrow Therapeutic IndexNeutral amino acid transporter A
go.drugbank.com/bio_entities/BE0000480TargetHumansInvolved in homeostasis of D-serine, a coagonist of synaptic NMDA receptors. … In a tri-substrate transport cycle, exchanges neutral amino acids between the extracellular and intracellular compartments, coupled to the inward cotransport of at least one sodium ion (PubMed:24808181
Polypeptides: Neutral amino acid transporter AU1 small nuclear ribonucleoprotein A
go.drugbank.com/bio_entities/BE0002708TargetHumansIn a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs
Polypeptides: U1 small nuclear ribonucleoprotein ASynonyms: U1-A, U1 snRNP ADNA topoisomerase 4 subunit A
go.drugbank.com/bio_entities/BE0003726TargetStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)Performs the decatenation events required during the replication of a circular DNA molecule.
Polypeptides: DNA topoisomerase 4 subunit ASynonyms: Topoisomerase IV subunit AMyocardin-related transcription factor A
go.drugbank.com/bio_entities/BE0004156TargetHumansActivity is also regulated by filamentous actin (F-actin) in the nucleus … The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics.
Polypeptides: Myocardin-related transcription factor ASynonyms: MRTF-AEphrin type-A receptor 5
go.drugbank.com/bio_entities/BE0005587TargetHumansTogether with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. … Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5.
Polypeptides: Ephrin type-A receptor 5Ephrin type-A receptor 4
go.drugbank.com/bio_entities/BE0009438TargetHumansIn addition to its role in axonal guidance plays a role in synaptic plasticity. … In the nervous system, also plays a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation.
Polypeptides: Ephrin type-A receptor 4Acyl-coenzyme A thioesterase 1
go.drugbank.com/bio_entities/BE0016368EnzymeHumansCatalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels.
Polypeptides: Acyl-coenzyme A thioesterase 1Synonyms: Palmitoyl-coenzyme A thioesterase, Inducible cytosolic acyl-coenzyme A thioester hydrolase