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Displaying results 1131 - 1140 of 6949 in total
  1. Drug

    Octocrylene

    go.drugbank.com/drugs/DB09535
    Approved

    Because of its effectiveness, the chemical has been approved across the globe for use in cosmetics and skin care products, but the concentrations of this ingredient are usually limited to no more than … However, the use of this chemical doesn’t just stop with sunscreen for face and arms, but can extend to a variety of other products, like hair spray, tannin oil, BB cream, conditioner, and CC cream, among

    Mixtures: Jergens Natural Glow Face Daily Moisturizer for Medium/Tan Skin, Key West Tan SPF15
  2. Drug

    Rosiglitazone

    go.drugbank.com/drugs/DB00412
    ApprovedInvestigational

    Recent research has suggested that rosiglitazone may also be of benefit to a subset of patients with Alzheimer's disease not expressing the ApoE4 allele. … Like other thiazolidinediones, the mechanism of action of rosiglitazone is by activation of the intracellular receptor class of the peroxisome proliferator-activated receptors (PPARs), specifically PPARγ

    Categories: Peroxisome Proliferator Receptor gamma Agonist, Peroxisome Proliferator-activated Receptor Activity
  3. Drug

    Folic acid

    go.drugbank.com/drugs/DB00158
    ApprovedInvestigationalNutraceuticalVet approved

    [DB00650] (also known as folinic acid) supplementation is typically used for high-dose MTX regimens for the treatment of cancer. … When used in high doses such as for cancer therapy, or in low doses such as for Rheumatoid Arthritis or psoriasis, [DB00563] impedes the body's ability to create folic acid.

    Mixtures: Se-Tan DHA, Se-Tan DHA
  4. Drug

    Sulfamethoxazole

    go.drugbank.com/drugs/DB01015
    ApprovedInvestigational

    [L11830] In this combination, sulfamethoxazole is useful for the treatment of a variety of bacterial infections, including those of the urinary, respiratory, and gastrointestinal tracts. … which inhibits a sequential step in bacterial folic acid synthesis - these agents work synergistically to block two consecutive steps in the biosynthesis of nucleic acids and proteins which are necessary for

    Mixtures: Eusaprim orale Suspension für Kinder, Sulfamethoxazole and Trimethoprim for Injection, USPCategories: Antibacterials for Systemic Use, Antiinfectives for Systemic Use
  5. Target

    Type-1 angiotensin II receptor

    go.drugbank.com/bio_entities/BE0000062
    TargetHumans

    Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney (PubMed:15611106, PubMed:1567413, PubMed:25913193, PubMed:26420482 … The activated receptor in turn couples to G-alpha proteins G(q) (GNAQ, GNA11, GNA14 or GNA15) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers

    Polypeptides: Type-1 angiotensin II receptorSynonyms: AT1 receptor, Angiotensin II type-1 receptor
  6. Target

    Peroxisome proliferator-activated receptor gamma

    go.drugbank.com/bio_entities/BE0000215
    TargetHumans

    Ligand-activated transcription factor that forms obligate heterodimers with the retinoic acid receptor and acts as a key regulator of biological processes, such as adipocyte differentiation, lipid metabolism … Ligand-binding results in a conformational change in the receptor, promoting dissociation of repressors and recruitment of coactivators, and subsequent activation of target gene expression (PubMed:16150867

    Polypeptides: Peroxisome proliferator-activated receptor gammaSynonyms: Nuclear receptor subfamily 1 group C member 3
  7. Target

    Interferon alpha/beta receptor 2

    go.drugbank.com/bio_entities/BE0000385
    TargetHumans

    Together with IFNAR1, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa) (PubMed:10049744, PubMed:10556041, PubMed:21854986, PubMed:26424569

    Polypeptides: Interferon alpha/beta receptor 2Synonyms: IFN-alpha/beta receptor 2, Type I interferon receptor 2
  8. Target

    Glutamate receptor ionotropic, NMDA 2C

    go.drugbank.com/bio_entities/BE0000454
    TargetHumans

    Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:26875626, PubMed:36309015). Particip...

    Polypeptides: Glutamate receptor ionotropic, NMDA 2CSynonyms: N-methyl D-aspartate receptor subtype 2C, Glutamate [NMDA] receptor subunit epsilon-3
  9. Target

    Atrial natriuretic peptide receptor 1

    go.drugbank.com/bio_entities/BE0000556
    TargetHumans

    Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis (PubMed:39543315).

    Polypeptides: Atrial natriuretic peptide receptor 1Synonyms: Atrial natriuretic peptide receptor type A
  10. Target

    Free fatty acid receptor 1

    go.drugbank.com/bio_entities/BE0000688
    TargetHumans

    G protein-coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. … May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (By similarity).

    Polypeptides: Free fatty acid receptor 1Synonyms: G protein-coupled receptor 40