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Lonapegsomatropin
go.drugbank.com/drugs/DB16220ApprovedInvestigationalLonapegsomatropin, also known as TransCon hGH or ACP 001, is a methoxypegylated prodrug of human growth hormone ([somatropin]) indicated for the treatment of children 1 year and older, weighing at least … [L36380] It was later approved by the European Commission on 13 January 2022.[L39900]
Categories: P-glycoprotein substrates, Cytochrome P-450 CYP1A2 InducersALTU-135
go.drugbank.com/drugs/DB05330InvestigationalALTU-135 has been granted orphan drug and fast-track designation as well as CMA Pilot 2 program status by the Food and Drug Administration (FDA). … This consistent and pure enzyme combination is designed to improve fat, protein and carbohydrate absorption in pancreatic insufficient individuals.
Lacosamide
go.drugbank.com/drugs/DB06218ApprovedInvestigationalLacosamide is an antiepileptic drug used to treat seizures. As a chiral functionalized amino acid, it works by blocking slowly inactivating components of voltage-gated sodium currents. … Lacosamide exhibits a stereoselective mode of interaction with sodium channels.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesSynonyms: (R)-2-acetamido-N-benzyl-3- methoxypropionamide, (R)-LACOSAMIDE 1Pergolide Mechanism of Action Action Pathway
smpdb.ca/view/SMP0126635Drug actionThe dopamine D2 receptor is a 7-transmembrane G-protein coupled receptor associated with Gi proteins. In lactotrophs, stimulation of dopamine D2 receptor causes inhibition of adenylyl cyclase, which decreases intracellular cAMP concentra...
Enzymes: Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortDarvadstrocel
go.drugbank.com/drugs/DB16581ApprovedInvestigationalWithdrawn[L39759] It is the first mesenchymal stem cell therapy approved in Europe for this therapeutic indication. … Perianal fistula is a common manifestation of Crohn’s disease and is often difficult to manage, as it may be associated with complex presentations and symptoms.
Selpercatinib
go.drugbank.com/drugs/DB15685ApprovedInvestigationalIt is currently marketed under the brand name RETEVMO™ by Loxo Oncology Inc.[L13604] Selpercatinib is also approved by the European Commission. … Selpercatinib is a kinase inhibitor with enhanced specificity for RET tyrosine kinase receptors (RTKs) over other RTK classes.
Categories: MATE 1 Inhibitors, P-glycoprotein inhibitorsSynonyms: 6-(2-hydroxy-2-methylpropoxy)-4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrileFlupirtine
go.drugbank.com/drugs/DB06623InvestigationalFlupirtine is a pyridine derivative that is in clinical use as a nonopioid analgesic. It was approved for the treatment of pain in 1984 in Europe. … It is not approved for use in the U.S. or Canada, but is currently in phase II trials for the treatment of fibromyalgia.
Categories: Heterocyclic Compounds, 1-RingDuloxetine SNRI - Dopamine Norepinephrine Inhibition Action Pathway
smpdb.ca/view/SMP0126450Drug actionDuloxetine is a serotonin norepinephrine reuptake inhibitor used to treat generalized anxiety disorder, neuropathic pain, osteoarthritis, and stress incontinence. It blocks both sodium dependent serotonin and sodium dependent norepinephr...
Enzymes: Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortSolriamfetol Action Pathway
smpdb.ca/view/SMP0126346Drug actionSolriamfetol, also known as Sunosi, is a dopamine and norepinephrine reuptake inhibitor (DNRI). This drug is indicated for the daytime treatment of sleepiness associated with narcolepsy or obstructive sleep apnea. Solriamfetol was given ...
Enzymes: Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortCaffeine Cardiac Contraction Action Pathway
smpdb.ca/view/SMP0126520Drug actionCaffeine is a stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. The cardiovascular effects are extensive and can help with headaches, migraines, or other types of pain in certain ci...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1