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Displaying results 1141 - 1150 of 1186 in total
  1. Target

    Integrin alpha-5

    go.drugbank.com/bio_entities/BE0008988
    TargetHumans

    ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430). … ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (PubMed:31331973).

    Synonyms: Fibronectin receptor subunit alpha
  2. Target

    Ephrin-B2

    go.drugbank.com/bio_entities/BE0010647
    TargetHumans

    Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. … The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling.

    Synonyms: EPH-related receptor tyrosine kinase ligand 5Function: ephrin receptor binding
  3. Target

    C-type lectin domain family 12 member A

    go.drugbank.com/bio_entities/BE0010945
    TargetHumans

    Also recognizes dead cells by acting as a receptor for monosodium urate crystals, leading to down-regulate neutrophil activation (PubMed:38367667, PubMed:38386511). … Also acts as a pattern-recognition receptor for pathogen-associated molecules, such as plasmodium hemozoin or mycobacterial micolic acid (PubMed:31269448, PubMed:36542980).

    Synonyms: Killer cell C-type lectin-like receptor L1, Myeloid inhibitory C-type lectin-like receptorFunction: pattern recognition receptor activity
  4. Target

    Integrin beta-2

    go.drugbank.com/bio_entities/BE0001041
    TargetHumans

    Integrin ITGAM:ITGB2 is also a receptor for factor X. Integrin ITGAD:ITGB2 is a receptor for ICAM3 and VCAM1 (PubMed:10438935, PubMed:8777714, PubMed:9841932). … Integrin ITGAM:ITGB2/MAC-1 complex functions as a signaling receptor for the ligand receptor ICAM1, ensuring adhesion between stimulated neutrophils and stimulated endothelial cells (PubMed:1980124).

    Synonyms: Complement receptor C3 subunit beta
  5. Target

    Sialic acid-binding Ig-like lectin 7

    go.drugbank.com/bio_entities/BE0001648
    TargetHumans

    In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through

    Synonyms: Adhesion inhibitory receptor molecule 1
  6. Target

    GTP-binding nuclear protein Ran

    go.drugbank.com/bio_entities/BE0004559
    TargetHumans

    GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs (PubMed:10400640, PubMed:17209048, PubMed:26272610, PubMed:27306458, PubMed:8276887, PubMed:8636225, Pu...

    Synonyms: Androgen receptor-associated protein 24
  7. Target

    Large ribosomal subunit protein uL16

    go.drugbank.com/bio_entities/BE0009104
    TargetHumans

    Component of the large ribosomal subunit (PubMed:26290468). Plays a role in the formation of actively translating ribosomes (PubMed:26290468). May play a role in the embryonic brain development (PubMed:25316788)

    Synonyms: Laminin receptor homolog
  8. Drug

    Adenosine

    go.drugbank.com/drugs/DB00640
    ApprovedInvestigational

    The structure of adenosine was first described in 1931, though the vasodilating effects were not described in literature until the 1940s. Adenosine is indicated as an adjunct to thallium-201 in myocardial perfusion scintigraphy, though i...

    Mixtures: Wonder Intensive BBCream 21 (Light), BOTA C ResetCategories: Purinergic P1 Receptor Agonists
  9. Target

    Integrin alpha-2

    go.drugbank.com/bio_entities/BE0012664
    TargetHumans

    Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen.

    Synonyms: Collagen receptor
  10. Target

    Integrin alpha-X

    go.drugbank.com/bio_entities/BE0009967
    TargetHumans

    Functions as a receptor of the erythrocyte-specific adhesion molecule ICAM4 and mediates erythrophagocytosis (PubMed:16985175) … Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses.

    Synonyms: Leukocyte adhesion receptor p150,95