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Displaying results 1171 - 1180 of 10000 in total
  1. Drug

    Furosemide

    go.drugbank.com/drugs/DB00695
    ApprovedInvestigationalVet approved

    Furosemide is a potent loop diuretic that acts on the kidneys to ultimately increase water loss from the body. It is an anthranilic acid derivative. … [A182495] The use of furosemide is particularly beneficial in clinical settings that require a drug with a higher diuretic potential.

    Mixtures: SPIRO D TABLINEN 100MG, Lasitace 5 mg/40 mg KapselnSynonyms: 4-Chloro-N-(2-furylmethyl)-5-sulfamoylanthranilic acid, 2-Furfurylamino-4-chloro-5-sulfamoylbenzoic acid
  2. Drug

    Agomelatine

    go.drugbank.com/drugs/DB06594
    ApprovedInvestigational

    Agomelatine was developed in Europe by Servier Laboratories Ltd. and submitted to the European Medicines Agency (EMA) in 2005. … Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors, tested in an animal model of depression.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesProducts: VALDOXAN® 25 MG, ALODIL®25 MGTABLETARECUBIERTA
  3. Drug

    Viloxazine

    go.drugbank.com/drugs/DB09185
    ApprovedInvestigationalWithdrawn

    Viloxazine is a selective norepinephrine reuptake inhibitor.[L41685] For decades, an immediate-release formulation of viloxazine has been used in Europe as an antidepressant. … In the US, viloxazine was assigned an orphan drug designation in 1984 under the brand name CATATROL: while this product was intended to treat cataplexy and narcolepsy, the drug was never approved for these

    Categories: MATE 1 Inhibitors, Cytochrome P-450 SubstratesSynonyms: 2-((2-Ethoxyphenoxy)methyl)morpholine
  4. Pathway

    Sarcosinemia

    smpdb.ca/view/SMP0125579
    Disease

    Sarcosine can also be formed in a reversible reaction from S-adenosylmethionine and glycine, using glycine N-methyltransferase as the enzyme, and forming S-adenosylhomocysteine as another product. … This, along with homocysteine, react using betaine-homocysteine S-methyltransferase to form L-methionine, as well as dimethylglycine.

    Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Pyruvic acid · Arginine · Adenosine phosphate +26 more
    Enzymes: Betaine--homocysteine S-methyltransferase 1
  5. Drug

    Branaplam

    go.drugbank.com/drugs/DB14918
    Investigational

    Branaplam is under investigation in clinical trial NCT02268552 (An Open Label Study of LMI070 (Branaplam) in Type 1 Spinal Muscular Atrophy (SMA)).

  6. Pathway

    Ritodrine B2-Adrenergic Myometrial Smooth Muscle Relaxation Action Pathway

    smpdb.ca/view/SMP0126043
    Drug action

    Ritodrine is a adrenergic beta agonist used for the treatment and prophylaxis of premature labour. Beta-2 adrenergic receptors are located at sympathetic neuroeffector junctions of many organs, including uterus. Ritodrine is beta-2 adren...

    Drugs: ATP · Ritodrine · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
  7. Drug

    Abiraterone decanoate

    go.drugbank.com/drugs/DB18905
    Investigational

    Abiraterone decanoate is under investigation in clinical trial NCT04729114 (Open-label, Multicenter Study of Intramuscular PRL-02 Depot in Patients With Advanced Prostate Cancer).

  8. Drug

    Parsaclisib

    go.drugbank.com/drugs/DB14867
    Investigational

    Parsaclisib is under investigation in clinical trial NCT03126019 (An Open-Label Study of Parsaclisib in Relapsed or Refractory Follicular Lymphoma (CITADEL-203)).

    Categories: Heterocyclic Compounds, 1-Ring, Phosphatidylinositol-3-kinase (Pi3K) inhibitors
  9. Pathway

    Dimethylglycine Dehydrogenase Deficiency

    smpdb.ca/view/SMP0125578
    Disease

    Dimethylglycine dehydrogenase deficiency, also called DMGDH deficiency and dimethylglycinuria, is a rare inborn error of metabolism (IEM) and autosomal recessive disorder of glycine metabolism caused by a defective DMGDH gene. DMGDH code...

    Drugs: Pyridoxal phosphate · Tetrahydrofolic acid · Ademetionine · Pyruvic acid · Arginine · Adenosine phosphate +26 more
    Enzymes: Betaine--homocysteine S-methyltransferase 1
  10. Drug

    Sodium zirconium cyclosilicate

    go.drugbank.com/drugs/DB14048
    ApprovedInvestigational

    [L2933] Approval of the medication is supported by data from three double-blind, placebo-controlled trials and two open-label trials which showed that the onset of action was approximately 1.0 hour and … acts as a highly selective potassium removing agent.

    Categories: Compounds used in a research, industrial, or household settingProducts: SIMKELMA 5 G ORAL SÜSPANSİYON HAZIRLAMAK İÇİN TOZ, 28 ADET, SIMKELMA 5 G ORAL SÜSPANSİYON HAZIRLAMAK İÇİN TOZ, 11 ADET