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Displaying results 1171 - 1180 of 3735 in total
  1. Target

    Gamma-aminobutyric acid receptor subunit rho-2

    go.drugbank.com/bio_entities/BE0003598
    TargetHumans

    Rho subunit of the pentameric ligand-gated chloride channels responsible for mediating the effects of gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain (By similarity). Rho-containing GABA-gated chloride ...

    Polypeptides: Gamma-aminobutyric acid receptor subunit rho-2Synonyms: GABA(C) receptor, GABA(A) receptor subunit rho-2
  2. Target

    Acetylcholine receptor subunit beta-type unc-29

    go.drugbank.com/bio_entities/BE0004928
    TargetCaenorhabditis elegans

    Non-alpha subunit of nicotinic acetylcholine receptor (nAChR). Involved in nAChR sensitivity to nicotine and levasimole.

    Polypeptides: Acetylcholine receptor subunit beta-type unc-29
  3. Target

    Receptor-interacting serine/threonine-protein kinase 2

    go.drugbank.com/bio_entities/BE0009532
    TargetHumans

    Also involved in adaptive immunity: plays a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation (PubMed:14638696). … Acts as a key effector of NOD1 and NOD2 signaling pathways: upon activation by bacterial peptidoglycans, NOD1 and NOD2 oligomerize and recruit RIPK2 via CARD-CARD domains, leading to the formation of RIPK2

    Polypeptides: Receptor-interacting serine/threonine-protein kinase 2Synonyms: Receptor-interacting protein 2
  4. Target

    Tyrosine-protein phosphatase non-receptor type 6

    go.drugbank.com/bio_entities/BE0009941
    TargetHumans

    Within the nucleus, negatively regulates the activity of some transcription factors such as NFAT5 via direct dephosphorylation. … Modulates the signaling of several cytokine receptors including IL-4 receptor (PubMed:9065461).

    Polypeptides: Tyrosine-protein phosphatase non-receptor type 6
  5. Target

    Tumor necrosis factor receptor superfamily member 17

    go.drugbank.com/bio_entities/BE0010010
    TargetHumans

    Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK

    Polypeptides: Tumor necrosis factor receptor superfamily member 17Function: signaling receptor activity
  6. Target

    C-X-C chemokine receptor type 2

    go.drugbank.com/bio_entities/BE0010516
    TargetHumans

    Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor (PubMed:1891716). Binding of IL-8 to the receptor causes activation of neutrophils. … This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:8662698). Binds to IL-8 with high affinity.

    Polypeptides: C-X-C chemokine receptor type 2Synonyms: GRO/MGSA receptor, IL-8 receptor type 2
  7. Target

    Tumor necrosis factor receptor superfamily member 16

    go.drugbank.com/bio_entities/BE0010540
    TargetHumans

    Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. … Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (PubMed:24908487).

    Polypeptides: Tumor necrosis factor receptor superfamily member 16Synonyms: NGF receptor, Low affinity neurotrophin receptor p75NTR
  8. Target

    Antiviral innate immune response receptor RIG-I

    go.drugbank.com/bio_entities/BE0012418
    TargetHumans

    Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and pro-inflammatory cytokines (PubMed:15208624

    Polypeptides: Antiviral innate immune response receptor RIG-ISynonyms: RIG-I-like receptor 1
  9. Target

    Tumor necrosis factor receptor superfamily member 13C

    go.drugbank.com/bio_entities/BE0018598
    TargetHumans

    B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response

    Polypeptides: Tumor necrosis factor receptor superfamily member 13CSynonyms: BAFF receptor, BLyS receptor 3
  10. Target

    Tumor necrosis factor receptor superfamily member 12A

    go.drugbank.com/bio_entities/BE0020009
    TargetHumans

    Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins

    Polypeptides: Tumor necrosis factor receptor superfamily member 12ASynonyms: Tweak-receptor