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D-Arginine and D-Ornithine Metabolism
smpdb.ca/view/SMP0000036MetabolicDAAO is highly specific towards D-amino acids and favours free neutral D-amino acids or those with hydrophobic, polar or aromatic groups. Acidic amino acids are not catalyze by DAOO. … D-Amino acids have been show to be present in high concentrations in humans and play a role in biological functions.
Enzymes: D-amino-acid oxidaseMetabolism and Physiological Effects of Phenylacetylglutamine
smpdb.ca/view/SMP0123208Metabolicacid. … It has been shown that over 50% of urine phenylacetylglutamine may be derived from kidney conjugation of free plasma phenylacetic acid and/or from the kidney's preferential filtration of conjugated phenylacetic
Drugs: Phenylalanine · L-Glutamine · Adenosine phosphate · ATP · Magnesium cation · Phenylpyruvic acid +1 moreEnzymes: Y+L amino acid transporter 1, Excitatory amino acid transporter 3Metabolism and Physiological Effects of Phenol
smpdb.ca/view/SMP0123255MetabolicPhenol is shown to cause cardiovascular disease and enhance the production of reactive oxygen species and cause oxidative stress. … Phenol can get further metabolized in a liver hepatocyte to Phenyl sulphate and Phenyl glucuronide. However phenol itself is shown to be a major uremic toxin through high levels of retention.
Metabolism and Physiological Effects of Choline
smpdb.ca/view/SMP0124739MetabolicCholine is obtained from foods like poultry, meat, fish, dairy and eggs. … TMAO has negative effects on organs such as the heart, kidney and vascular system by contributing to cardiovascular disease, atherosclerosis, endothelial dysfunction and kidney disease.
Metabolism and Physiological Effects of Dimethylglycine
smpdb.ca/view/SMP0124873MetabolicDimethylglycine (DMG) is an amino acid derivative found in the cells of all plants and animals and can be obtained in the diet in small amounts from grains and meat. … Dimethylglycine enters the bloodstream and can cause toxic effects on the cardiovascular system.
Drugs: Choline · Methionine · NADH · Zinc · N,N-dimethylglycine · Flavin adenine dinucleotide +1 moreMetabolism and Physiological Effects of Phenylacetylglycine
smpdb.ca/view/SMP0126858MetabolicPhenylacetylglycine or PAG is a glycine conjugate of phenylacetic acid. Phenylacetic acid may arise from exposure to styrene (plastic) or through the consumption of fruits and vegetables. … Phenylacetic acid is used in some perfumes, possessing a honey-like odour in low concentrations, and is also used in penicillin G production. PAG is a putative biomarker of phospholipidosis.
Drugs: GlycineMetabolism and Physiological Effects of Phenyl glucuronide
smpdb.ca/view/SMP0123227MetabolicPhenyl glucuronide is a phenolic compound that is formed through gut microbial metabolism from dietary tyrosine and a glucuronidation reaction in liver hepatic cells.
Metabolism and Physiological Effects of Indoxyl glucuronide
smpdb.ca/view/SMP0123239MetabolicIndoxyl glucuronide is an indole compound that is formed through gut microbial metabolism from dietary tryptophan and a glucuronidation reaction in liver hepatic cells.
Metabolsim and Physiological Effects of 4-Ethylphenylsulfate
smpdb.ca/view/SMP0125541Metabolicacid. … This is metabolized into phenylpyruvic acid Phenylacetic acid which is then metabolized into 3-(3-Hydroxyphenyl)propanoic acid.
Drugs: Pyridoxal phosphate · Phenylalanine · Tyrosine · Iron · Oxogluric acid · Propanoic acid +3 moreEnzymes: Aromatic-amino-acid aminotransferaseMetabolism and Physiological Effects of N-Acetylphenylalanine
smpdb.ca/view/SMP0126720MetabolicN-Acetyl-L-phenylalanine can also be classified as an alpha amino acid or a derivatized alpha amino acid. … The human NatA complex co-translationally acetylates N-termini that bear a small amino acid (A, S, T, C, and occasionally V and G).
Drugs: Phenylalanine