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Metabolism and Physiological Effects of Phenylacetylglycine
smpdb.ca/view/SMP0126858MetabolicPhenylacetylglycine or PAG is a glycine conjugate of phenylacetic acid. Phenylacetic acid may arise from exposure to styrene (plastic) or through the consumption of fruits and vegetables. … Phenylacetic acid is used in some perfumes, possessing a honey-like odour in low concentrations, and is also used in penicillin G production. PAG is a putative biomarker of phospholipidosis.
Drugs: GlycineMetabolism and Physiological Effects of Phenyl glucuronide
smpdb.ca/view/SMP0123227MetabolicPhenyl glucuronide is a phenolic compound that is formed through gut microbial metabolism from dietary tyrosine and a glucuronidation reaction in liver hepatic cells.
Metabolism and Physiological Effects of Indoxyl glucuronide
smpdb.ca/view/SMP0123239MetabolicIndoxyl glucuronide is an indole compound that is formed through gut microbial metabolism from dietary tryptophan and a glucuronidation reaction in liver hepatic cells.
Metabolsim and Physiological Effects of 4-Ethylphenylsulfate
smpdb.ca/view/SMP0125541Metabolicacid. … It has also been found to be related to cardiovascular mortality and to cause cell apoptosis.
Drugs: Pyridoxal phosphate · Phenylalanine · Tyrosine · Iron · Oxogluric acid · Propanoic acid +3 moreEnzymes: Aromatic-amino-acid aminotransferaseMetabolism and Physiological Effects of N-Acetylphenylalanine
smpdb.ca/view/SMP0126720MetabolicThe human NatA complex co-translationally acetylates N-termini that bear a small amino acid (A, S, T, C, and occasionally V and G). … N-Acetyl-L-phenylalanine can also be classified as an alpha amino acid or a derivatized alpha amino acid.
Drugs: PhenylalanineMetabolism and Physiological Effects of Phenol sulphate
smpdb.ca/view/SMP0126844MetabolicIn experimental models of diabetes, phenol sulphate administration has been shown to induce albuminuria and podocyte damage. … Phenol sulphate can be found in most mammals (mice, rats, sheep, dogs, humans) and likely most animals. Phenol sulphate is a uremic toxin.
Metabolism and Physiological Effects of Androsterone sulfate
smpdb.ca/view/SMP0127012MetabolicSubsequently, 3α-androstanediol and 3α-etiocholanediol are converted by 17β-HSD into androsterone and etiocholanolone, which is followed by their conjugation and excretion. … Then, 5α-DHT and 5β-DHT are converted by 3α-HSD into 3α-androstanediol and 3α-etiocholanediol, respectively.
Drugs: Testosterone2-Hydroxyglutric Aciduria (D and L Form)
smpdb.ca/view/SMP0000136DiseaseA deficiency in this enzyme results in accumulation of D-2-Hydroxyglutaric acid in plasma, spinal fluid, and urine; oxoglutaric acid in urine; and gabba-aminobutyric acid in spinal fluid. … A deficiency in this enzyme results in accumulation of L-2-Hydroxyglutaric acid in plasma, spinal fluid, and urine; and L-lysine in plasma and spinal fluid.
Drugs: Pyridoxal phosphate · Pyruvic acid · Biotin · Aspartic acid · L-Glutamine · Adenosine phosphate +17 moreIntracellular Signalling Through Prostacyclin Receptor and Prostacyclin
smpdb.ca/view/SMP0000354SignalingProstacyclin binding to its receptor increases vasodilation and decreases platelet aggregation. … The receptor is a G-protein coupled receptor, upon its binding it activates G proteins causing the activation of adenylyl cyclase and production of cAMP messenger molecules. cAMP activates PKA (protein
Metabolism and Physiological Effects of Phenyl sulfate
smpdb.ca/view/SMP0123213MetabolicPhenyl sulphate is shown to cause albuminuria and diabetic kidney disease. … Phenyl sulphate is a phenolic compound that is formed through gut microbial metabolism from dietary tyrosine and a sulfation reaction in liver hepatic cells.