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Displaying results 111 - 120 of 184 in total
  1. Target

    F-box/WD repeat-containing protein 1A

    go.drugbank.com/bio_entities/BE0021224
    TargetHumans

    SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription (PubMed:10066435, PubMed:10497169 … Recognizes and binds to phosphorylated target proteins (PubMed:10066435, PubMed:10497169, PubMed:10644755, PubMed:10835356, PubMed:11158290, PubMed:11238952, PubMed:11359933, PubMed:11994270, PubMed:12791267

    Synonyms: F-box and WD repeats protein beta-TrCP
  2. Target

    Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

    go.drugbank.com/bio_entities/BE0000377
    TargetHumans

    Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10) (PubMed:10231530, PubMed:11489939 … Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion

    Synonyms: Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase
  3. Target

    Cytohesin-2

    go.drugbank.com/bio_entities/BE0002654
    TargetHumans

    Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Activates ARF factors through replacement of GDP with GTP (By similarity). … The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane (PubMed:17398095). Involved in neurite growth (By similarity)

    Synonyms: PH, SEC7 and coiled-coil domain-containing protein 2
  4. Target

    Excitatory amino acid transporter 3

    go.drugbank.com/bio_entities/BE0001054
    TargetTransporterHumans

    Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:26690923, PubMed:8857541). … Contributes to glutathione biosynthesis and protection against oxidative stress via its role in L-glutamate and L-cysteine transport (By similarity). Negatively regulated by ARL6IP5 (By similarity)

    Synonyms: Neuronal and epithelial glutamate transporter
  5. Target

    Ribosomal protein S6 kinase alpha-4

    go.drugbank.com/bio_entities/BE0004614
    TargetHumans

    Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. … that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes.

    Synonyms: Nuclear mitogen- and stress-activated protein kinase 2
  6. Target

    Zinc transporter ZIP12

    go.drugbank.com/bio_entities/BE0009897
    TransporterHumans

    May play a role in neurulation and neurite extension. … Uniporter that promotes Zn(2+) import from the extracellular space to the cytoplasm across the cell membrane. The transport activity is temperature dependent.

    Synonyms: Zrt- and Irt-like protein 12
  7. Target

    Zinc transporter ZIP13

    go.drugbank.com/bio_entities/BE0009900
    TransporterHumans

    Functions as a zinc transporter transporting Zn(2+) from the Golgi apparatus to the cytosol and thus influences the zinc level at least in areas of the cytosol (PubMed:21917916, PubMed:23213233).

    Synonyms: Zrt- and Irt-like protein 13
  8. Target

    Zinc transporter ZIP1

    go.drugbank.com/bio_entities/BE0009902
    TransporterHumans

    Transporter for the divalent cation Zn(2+). Mediates the influx of Zn(2+) into cells from extracellular space (PubMed:11301334, PubMed:12888280, PubMed:16844077). Functions as the major importer of zinc from circulating blood plasma into...

    Synonyms: Zrt- and Irt-like protein 1
  9. Target

    Scavenger receptor class B member 1

    go.drugbank.com/bio_entities/BE0000189
    TargetTransporterHumans

    Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. … Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux (PubMed:26965621).

    Synonyms: CD36 and LIMPII analogous 1
  10. Target

    Tumor necrosis factor ligand superfamily member 13

    go.drugbank.com/bio_entities/BE0010394
    TargetHumans

    Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes

    Synonyms: TNF- and APOL-related leukocyte expressed ligand 2